المؤلفون: Jennifer A. Fifita, Sandrine Chan Moi Fat, Emily P. McCann, Kelly L. Williams, Natalie A. Twine, Denis C. Bauer, Dominic B. Rowe, Roger Pamphlett, Matthew C. Kiernan, Vanessa X. Tan, Ian P. Blair, Gilles J. Guillemin

المصدر: Frontiers in Immunology, Vol 12 (2021)

مصطلحات موضوعية: sporadic amyotrophic lateral sclerosis (SALS), whole-genome sequence (WGS), tryptophan, kynurenine pathway (KP), serotonin, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.701550/full; https://doaj.org/toc/1664-3224

URL الوصول: https://doaj.org/article/10afac3979ec4c8fb35c574b87ed2308

المؤلفون: Beben Benyamin, Ji He, Qiongyi Zhao, Jacob Gratten, Fleur Garton, Paul J. Leo, Zhijun Liu, Marie Mangelsdorf, Ammar Al-Chalabi, Lisa Anderson, Timothy J. Butler, Lu Chen, Xiang-Ding Chen, Katie Cremin, Hong-Weng Deng, Matthew Devine, Janette Edson, Jennifer A. Fifita, Sarah Furlong, Ying-Ying Han, Jessica Harris, Anjali K. Henders, Rosalind L. Jeffree, Zi-Bing Jin, Zhongshan Li, Ting Li, Mengmeng Li, Yong Lin, Xiaolu Liu, Mhairi Marshall, Emily P. McCann, Bryan J. Mowry, Shyuan T. Ngo, Roger Pamphlett, Shu Ran, David C. Reutens, Dominic B. Rowe, Perminder Sachdev, Sonia Shah, Sharon Song, Li-Jun Tan, Lu Tang, Leonard H. van den Berg, Wouter van Rheenen, Jan H. Veldink, Robyn H. Wallace, Lawrie Wheeler, Kelly L. Williams, Jinyu Wu, Xin Wu, Jian Yang, Weihua Yue, Zong-Hong Zhang, Dai Zhang, Peter G. Noakes, Ian P. Blair, Robert D. Henderson, Pamela A. McCombe, Peter M. Visscher, Huji Xu, Perry F. Bartlett, Matthew A. Brown, Naomi R. Wray, Dongsheng Fan

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/522153208176401ebf7630ef7ecef4a7

المؤلفون: Kelly L. Williams, Simon Topp, Shu Yang, Bradley Smith, Jennifer A. Fifita, Sadaf T. Warraich, Katharine Y. Zhang, Natalie Farrawell, Caroline Vance, Xun Hu, Alessandra Chesi, Claire S. Leblond, Albert Lee, Stephanie L. Rayner, Vinod Sundaramoorthy, Carol Dobson-Stone, Mark P. Molloy, Marka van Blitterswijk, Dennis W. Dickson, Ronald C. Petersen, Neill R. Graff-Radford, Bradley F. Boeve, Melissa E. Murray, Cyril Pottier, Emily Don, Claire Winnick, Emily P. McCann, Alison Hogan, Hussein Daoud, Annie Levert, Patrick A. Dion, Jun Mitsui, Hiroyuki Ishiura, Yuji Takahashi, Jun Goto, Jason Kost, Cinzia Gellera, Athina Soragia Gkazi, Jack Miller, Joanne Stockton, William S. Brooks, Karyn Boundy, Meraida Polak, José Luis Muñoz-Blanco, Jesús Esteban-Pérez, Alberto Rábano, Orla Hardiman, Karen E. Morrison, Nicola Ticozzi, Vincenzo Silani, Jacqueline de Belleroche, Jonathan D. Glass, John B. J. Kwok, Gilles J. Guillemin, Roger S. Chung, Shoji Tsuji, Robert H. Brown, Alberto García-Redondo, Rosa Rademakers, John E. Landers, Aaron D. Gitler, Guy A. Rouleau, Nicholas J. Cole, Justin J. Yerbury, Julie D. Atkin, Christopher E. Shaw, Garth A. Nicholson, Ian P. Blair

المصدر: Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/1861832d934c49a490f60c7997786e48

المؤلفون: Lyndal Henden, Liam G. Fearnley, Natalie Grima, Emily P. McCann, Carol Dobson-Stone, Lauren Fitzpatrick, Kathryn Friend, Lynne Hobson, Sandrine Chan Moi Fat, Dominic B. Rowe, Susan D’Silva, John B. Kwok, Glenda M. Halliday, Matthew C. Kiernan, Srestha Mazumder, Hannah C. Timmins, Margaret Zoing, Roger Pamphlett, Lorel Adams, Melanie Bahlo, Ian P. Blair, Kelly L. Williams

المصدر: Science Advances. 9

مصطلحات موضوعية: Multidisciplinary

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2f7e922977e297828fc309ac4276362b
https://doi.org/10.1126/sciadv.ade2044

المؤلفون: Kelly L. Williams, Dominic B. Rowe, Natalie Grima, Sandrine Chan Moi Fat, Natalie A. Twine, Roger Pamphlett, Matthew C. Kiernan, Denis C. Bauer, Ian P. Blair, Lyndal Henden, Katharine Y. Zhang, Jennifer A. Fifita, Emily P. McCann

المصدر: Journal of Medical Genetics. 58:87-95

مصطلحات موضوعية: 0301 basic medicine, Genetics, medicine.medical_specialty, Genetic heterogeneity, Biology, medicine.disease, TARDBP, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, C9orf72, Molecular genetics, Genetic variation, medicine, Amyotrophic lateral sclerosis, Age of onset, Allele, 030217 neurology & neurosurgery, Genetics (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676ad2c75cc799a7bd5c7b859cd150bf
https://doi.org/10.1136/jmedgenet-2020-106866

المؤلفون: Marianne Hallupp, Colin D. Field, Kelly L. Williams, Emily P. McCann, Garth A. Nicholson, Claire E. Shepherd, John R. Hodges, John Landers, Agnes Luty, William S. Brooks, Thomas Fath, Glenda M. Halliday, Mark F. Bennett, Peter K. Panegyres, Peter R. Schofield, Jennifer A. Fifita, Bradley N. Smith, Ian P. Blair, Janice M. Fullerton, Esmeralda Paric, Neil Rajan, Olivier Piguet, John B.J. Kwok, Jane Hecker, Alex D. Shaw, Cathy L. Short, Melanie Bahlo, Carol Dobson-Stone, Shankaracharya, Audrey Ragagnin, Holly Stefen, Hamideh Shahheydari, Francine Carew-Jones, Elizabeth Thompson, Julie D. Atkin, Zac Chatterton, Peter C. Blumbergs, Simon Topp, Christopher Shaw

المصدر: Brain

مصطلحات موضوعية: 0301 basic medicine, Autophagy, HEK 293 cells, Original Articles, Biology, medicine.disease, 3. Good health, Pathogenesis, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, TANK-binding kinase 1, medicine, Cancer research, Missense mutation, Dementia, Neurology (clinical), Amyotrophic lateral sclerosis, 030217 neurology & neurosurgery, Frontotemporal dementia

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147cbcedfc0f7e3f90f58f18e7947926
https://doi.org/10.1093/brain/awaa039

المؤلفون: Denis C. Bauer, Britt A. Berning, Jennifer A. Fifita, Olivier Piguet, Julie D. Atkin, John B.J. Kwok, Adam K. Walker, Sarah E. Freckleton, Alison L. Hogan, Prachi Mehta, Sandrine Chan Moi Fat, Kelly L. Williams, Emily P. McCann, Shu Yang, Dominic B. Rowe, Garth A. Nicholson, Natalie A. Twine, Glenda M. Halliday, Matthew C. Kiernan, Ian P. Blair, Sharlynn Wu, Katharine Y. Zhang, Cyril J. Jagaraj, John R. Hodges, Jasmin Galper, Lyndal Henden, Natalie Grima

المصدر: Journal of Neurology, Neurosurgery & Psychiatry. 91:162-171

مصطلحات موضوعية: Male, Genetically modified mouse, Pathology, medicine.medical_specialty, Blotting, Western, Fluorescent Antibody Technique, Neurogenetics, Mice, Transgenic, Neuropathology, Gene mutation, Mitochondrial Proteins, Pathogenesis, Mice, 03 medical and health sciences, 0302 clinical medicine, Exome Sequencing, mental disorders, medicine, Animals, Humans, Amyotrophic lateral sclerosis, Aged, 030304 developmental biology, 0303 health sciences, Whole Genome Sequencing, business.industry, Amyotrophic Lateral Sclerosis, Australia, Motor Cortex, Brain, Genetic Variation, nutritional and metabolic diseases, Human brain, Middle Aged, medicine.disease, nervous system diseases, Psychiatry and Mental health, medicine.anatomical_structure, Spinal Cord, Frontotemporal Dementia, Female, Surgery, Neurology (clinical), business, 030217 neurology & neurosurgery, Frontotemporal dementia

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6993c64a687c626f6f430d0166f43c4
https://doi.org/10.1136/jnnp-2019-321790

المؤلفون: Shu Yang, Ian P. Blair, Emily P. McCann, Jasmin Galper, Sharlynn Wu, Sarah E. Freckleton, Fat Scm, Jennifer A. Fifita, Katharine Y. Zhang

المصدر: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 20:135-159

مصطلحات موضوعية: Candidate gene, Wild type, Transfection, Computational biology, Protein degradation, Biology, medicine.disease, Genetic analysis, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Neurology, Mendelian inheritance, symbols, medicine, Neurology (clinical), Amyotrophic lateral sclerosis, Gene, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e68228ea2e42f60e07f6df621861ed
https://doi.org/10.1080/21678421.2019.1646991

المؤلفون: Ram Maharjan, Lyndal Henden, Kelly L. Williams, Alison L. Hogan, Benjamin Heng, Ian P. Blair, Sandrine Chan Moi Fat, Ingrid S. Tarr, Natalie Grima, Shu Yang, Katharine Y. Zhang, Amy K. Cain, Qiongyi Zhao, Sharlynn Wu, Marco Morsch, Amanda L. Wright, Jennifer A. Fifita, Albert Lee, Stephanie L. Rayner, Zong-Hong Zhang, Emily P. McCann

المصدر: Neuropathology and applied neurobiologyREFERENCES. 47(7)

مصطلحات موضوعية: Histology, Proline, Glutamine, Pathology and Forensic Medicine, Splicing factor, Ubiquitin, Physiology (medical), medicine, Humans, Amyotrophic lateral sclerosis, Motor Neurons, biology, Binding protein, Amyotrophic Lateral Sclerosis, Intron, RNA, medicine.disease, Introns, Cell biology, Real-time polymerase chain reaction, Neurology, Frontotemporal Dementia, biology.protein, Neurology (clinical), RNA Splicing Factors, Genetic screen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d9536a5750fda5f41871d0d32f7ead
https://pubmed.ncbi.nlm.nih.gov/34288034

المؤلفون: Sandrine Chan Moi Fat, Matthew C. Kiernan, Ian P. Blair, Emily P. McCann, Lyndal Henden, Garth A. Nicholson, Kelly L. Williams, Dominic B. Rowe, Jennifer A. Fifita, Denis C. Bauer, Roger Pamphlett, Natalie A. Twine

المصدر: Neurobiology of aging. 101

مصطلحات موضوعية: 0301 basic medicine, Male, Aging, Disease, Biology, Genetic analysis, European descent, White People, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Genetic variation, Exome Sequencing, medicine, Humans, Amyotrophic lateral sclerosis, Gene, Whole genome sequencing, Genetics, Whole Genome Sequencing, General Neuroscience, Amyotrophic Lateral Sclerosis, Australia, Genetic Variation, Glycosyltransferases, medicine.disease, Phosphoproteins, 030104 developmental biology, Cohort, Female, Neurology (clinical), Geriatrics and Gerontology, Negative Results, 030217 neurology & neurosurgery, Developmental Biology, Genome-Wide Association Study

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a5f8af98e85f9ddcca680b32ef3301
https://pubmed.ncbi.nlm.nih.gov/33581934

المؤلفون: Lyndal Henden, Qiongyi Zhao, Benjamin Heng, Ram Maharjan, Shu Yang, Sharlynn Wu, Ian P. Blair, Amy K. Cain, Ingrid S. Tarr, Zong-Hong Zhang, Natalie Grima, Katharine Y. Zang, Emily P. McCann, Kelly L. Williams, Sandrine Chan Moi Fat, Alison L. Hogan, Jennifer A. Fifita, Marco Morsch, Amanda L. Wright

مصطلحات موضوعية: biology, Central nervous system, Intron, Paraspeckle, medicine.disease, Splicing factor, medicine.anatomical_structure, Ubiquitin, Gene expression, biology.protein, medicine, Cancer research, Amyotrophic lateral sclerosis, Genetic screen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::aef207e003688cad0957ec184671e642
https://doi.org/10.1101/2020.09.22.309062

المؤلفون: Lyndal, Henden, Natalie A, Twine, Piotr, Szul, Emily P, McCann, Garth A, Nicholson, Dominic B, Rowe, Matthew C, Kiernan, Denis C, Bauer, Ian P, Blair, Kelly L, Williams

المصدر: NPJ Genomic Medicine

مصطلحات موضوعية: Haplotypes, Mutation, Amyotrophic lateral sclerosis, Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::a1381f39262504c94ca4f5de3f643879
https://pubmed.ncbi.nlm.nih.gov/32789025

المؤلفون: Ian P. Blair, Piotr Szul, Emily P. McCann, Natalie A. Twine, Kelly L. Williams, Lyndal Henden, Denis C. Bauer

مصطلحات موضوعية: Disease gene, 0303 health sciences, User Friendly, Multiple applications, food and beverages, Genome-wide association study, Computational biology, Biology, Pipeline (software), humanities, Sample quality, 03 medical and health sciences, 0302 clinical medicine, Mutation (genetic algorithm), population characteristics, Abstract Summary, 030217 neurology & neurosurgery, geographic locations, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ed58e4279642290d49b0039c709c5f

المؤلفون: Denis C. Bauer, Dominic B. Rowe, Kelly L. Williams, Lyndal Henden, Natalie A. Twine, Emily P. McCann, Garth A. Nicholson, Matthew C. Kiernan, Ian P. Blair, Piotr Szul

مصطلحات موضوعية: Genetics, 0303 health sciences, Mutation, Genetic counseling, Haplotype, Disease, Biology, medicine.disease, medicine.disease_cause, Penetrance, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Paralysis, medicine, medicine.symptom, Amyotrophic lateral sclerosis, Family history, 030217 neurology & neurosurgery, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a50c0880d806b767cf5422c2f059656
https://doi.org/10.1101/685925

المؤلفون: Ingrid S. Tarr, Roger Pamphlett, Shu Yang, Emily P. McCann, Garth A. Nicholson, Jennifer A. Fifita, Dominic B. Rowe, Ian P. Blair, Alison L. Hogan, Denis C. Bauer, Neil F. W. Saunders, Katharine Y. Zhang, Jasmin Galper, Kelly L. Williams

المصدر: Neurodegenerative Diseases. 17:304-312

مصطلحات موضوعية: Male, 0301 basic medicine, Pathology, medicine.medical_specialty, DNA Mutational Analysis, Neurogenetics, Neuropathology, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, C9orf72, Heterogeneous-Nuclear Ribonucleoprotein Group A-B, medicine, Humans, Amyotrophic lateral sclerosis, Motor Neurons, C9orf72 Protein, business.industry, Amyotrophic Lateral Sclerosis, Australia, medicine.disease, Multisystem proteinopathy, 030104 developmental biology, Spinal Cord, Neurology, Case-Control Studies, Female, Neurology (clinical), business, Trinucleotide repeat expansion, 030217 neurology & neurosurgery, Frontotemporal dementia

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494f5a97ca62df9531723711348b38ce
https://doi.org/10.1159/000481258

المؤلفون: Ingrid S. Tarr, Beben Benyamin, Natalie A. Twine, Denis C. Bauer, Emily P. McCann, Garth A. Nicholson, Qiongyi Zhao, Dominic B. Rowe, Tim J Peters, Ian P. Blair, Susan J. Clark, Kelly L. Williams, Katharine Y. Zhang, Zong Hong Zhang

المساهمون: Tarr, I, McCann, E, Benyamin, B, Peters, T, Twine, N, Zhang, K, Zhao, Q, Zhang, Z, Rowe, D, Nicholson, G, Bauer, D, Clark, S, Blair, I, Williams, K

المصدر: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, SOD1, lcsh:Medicine, Cell Cycle Proteins, Biology, Article, Epigenesis, Genetic, 03 medical and health sciences, 0302 clinical medicine, Gene expression analysis, C9orf72, Exome Sequencing, medicine, Diseases in Twins, Humans, Genetic Predisposition to Disease, Epigenetics, Amyotrophic lateral sclerosis, lcsh:Science, Exome sequencing, Genetic Association Studies, Aged, Genetics, Regulation of gene expression, Multidisciplinary, Triplets, DNA methylation, C9orf72 Protein, lcsh:R, Amyotrophic Lateral Sclerosis, Australia, Methylation, Twins, Monozygotic, Middle Aged, medicine.disease, 3. Good health, 030104 developmental biology, Phenotype, Gene Expression Regulation, Methylation analysis, lcsh:Q, Female, Gene expression, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6107b8d49a98eab6aca8fb86ca28622
https://hdl.handle.net/11541.2/138138

المؤلفون: Vanessa Tan, Gilles J. Guillemin, Emily P. McCann, Jennifer A. Fifita, Manal A. Farg, Vinod Sundaramoorthy, Kelly L. Williams, Ian P. Blair, Julie D. Atkin, Adam K. Walker

المصدر: Human molecular genetics. 26(17)

مصطلحات موضوعية: 0301 basic medicine, Autophagosome, medicine.medical_specialty, Immunoprecipitation, Mutation, Missense, Cell Cycle Proteins, Biology, 03 medical and health sciences, symbols.namesake, Mice, Molecular genetics, Lysosome, Transcription Factor TFIIIA, Myosin, Genetics, medicine, Animals, Humans, Amyotrophic lateral sclerosis, Eye Proteins, Molecular Biology, Actin, Genetics (clinical), Cells, Cultured, Optineurin, Motor Neurons, Myosin Heavy Chains, Endoplasmic reticulum, Autophagy, Amyotrophic Lateral Sclerosis, Membrane Transport Proteins, General Medicine, Anatomy, Golgi apparatus, medicine.disease, Endoplasmic Reticulum Stress, Molecular biology, Cell biology, Blot, Protein Transport, 030104 developmental biology, medicine.anatomical_structure, Spinal Cord, biology.protein, Unfolded protein response, symbols, Antibody, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde00470b743d3612a18922da4e43ae1
https://pubmed.ncbi.nlm.nih.gov/25859013

المؤلفون: Kelly L. Williams, Stephen W. Reddel, Katharine Y. Zhang, Daisy Y. Shu, Shannon J. Das, Emily P. McCann, Ian P. Blair, William D. Phillips, Frank J. Lovicu, Archunan Visvanathan, Eva Kichkin

المصدر: Journal of neuromuscular diseases. 4(2)

مصطلحات موضوعية: 0301 basic medicine, Male, Hereditary spastic paraplegia, Transgene, Gene Expression, Mice, Transgenic, Hindlimb, Biology, Motor Endplate, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Spectrin, Spasticity, Transgenes, Gene, Body Weight, SPTBN4, Brain, medicine.disease, Phenotype, Molecular biology, Paresis, Mutagenesis, Insertional, 030104 developmental biology, Neurology, Muscle Spasticity, Female, Neurology (clinical), medicine.symptom, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f23ae533cc7844bb574126d7f6d1a1
https://pubmed.ncbi.nlm.nih.gov/28582869

المؤلفون: Jennifer A Fifita, Kelly L Williams, Vinod Sundaramoorthy, Emily P Mccann, Garth A Nicholson, Julie D Atkin, Ian P Blair

مصطلحات موضوعية: Clinical sciences not elsewhere classified, Neurosciences not elsewhere classified, Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences & Neurology, Optineurin, mutation, exome sequencing, Golgi fragmentation, ONLINE BIOINFORMATICS TOOL, MYOSIN VI, WILD-TYPE, MOTOR-NEURONS, CELL-DEATH, PROTEIN, APPARATUS, DISEASE, ALS, 3209 Neurosciences

Relation: http://hdl.handle.net/10536/DRO/DU:30136684; https://figshare.com/articles/journal_contribution/A_novel_amyotrophic_lateral_sclerosis_mutation_in_OPTN_induces_ER_stress_and_Golgi_fragmentation_in_vitro/20708761

الاتاحة: http://hdl.handle.net/10536/DRO/DU:30136684
https://figshare.com/articles/journal_contribution/A_novel_amyotrophic_lateral_sclerosis_mutation_in_OPTN_induces_ER_stress_and_Golgi_fragmentation_in_vitro/20708761

المؤلفون: Dominic B. Rowe, Ingrid S. Tarr, Kelly L. Williams, Emily P. McCann, Garth A. Nicholson, Ian P. Blair, Jody O'Connor, Jennifer A. Fifita

المصدر: Clinical genetics. 92(3)

مصطلحات موضوعية: 0301 basic medicine, Male, Genotype, Penetrance, Gene mutation, TARDBP, 03 medical and health sciences, 0302 clinical medicine, Superoxide Dismutase-1, Gene Frequency, C9orf72, Exome Sequencing, Genetics, medicine, Humans, Amyotrophic lateral sclerosis, Age of Onset, Genetics (clinical), Exome sequencing, Alleles, Genetic Association Studies, C9orf72 Protein, business.industry, Amyotrophic Lateral Sclerosis, Australia, Exons, Sequence Analysis, DNA, Middle Aged, medicine.disease, 030104 developmental biology, Phenotype, Mutation, Female, Age of onset, business, Trinucleotide repeat expansion, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf972d2367d111aabbd8893a0e2c29d4
https://pubmed.ncbi.nlm.nih.gov/28105640