المؤلفون: Britton Boras, Rhys M. Jones, Brandon J. Anson, Dan Arenson, Lisa Aschenbrenner, Malina A. Bakowski, Nathan Beutler, Joseph Binder, Emily Chen, Heather Eng, Holly Hammond, Jennifer Hammond, Robert E. Haupt, Robert Hoffman, Eugene P. Kadar, Rob Kania, Emi Kimoto, Melanie G. Kirkpatrick, Lorraine Lanyon, Emma K. Lendy, Jonathan R. Lillis, James Logue, Suman A. Luthra, Chunlong Ma, Stephen W. Mason, Marisa E. McGrath, Stephen Noell, R. Scott Obach, Matthew N. O’ Brien, Rebecca O’Connor, Kevin Ogilvie, Dafydd Owen, Martin Pettersson, Matthew R. Reese, Thomas F. Rogers, Romel Rosales, Michelle I. Rossulek, Jean G. Sathish, Norimitsu Shirai, Claire Steppan, Martyn Ticehurst, Lawrence W. Updyke, Stuart Weston, Yuao Zhu, Kris M. White, Adolfo García-Sastre, Jun Wang, Arnab K. Chatterjee, Andrew D. Mesecar, Matthew B. Frieman, Annaliesa S. Anderson, Charlotte Allerton

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/7c0ac56767d64fb5af7714d7f3a62322

المؤلفون: Chester Costales, Jian Lin, Emi Kimoto, Shinji Yamazaki, James R. Gosset, A. David Rodrigues, Sarah Lazzaro, Mark A. West, Michael West, Manthena V. S. Varma

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1018-1031 (2021)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2163-8306

URL الوصول: https://doaj.org/article/e787a5b4f6f2406192e276538d0ea466

المؤلفون: Shinji Yamazaki, Chester Costales, Sarah Lazzaro, Soraya Eatemadpour, Emi Kimoto, Manthena V. Varma

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 9, Pp 634-642 (2019)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2163-8306

URL الوصول: https://doaj.org/article/e2efb64d465b4efebe167697e4a2b216

المؤلفون: Amy Troop, Eugene Kadar, Emi Kimoto, A. David Rodrigues, Christopher Holliman

المصدر: Bioanalysis. 15:259-268

مصطلحات موضوعية: Medical Laboratory Technology, Clinical Biochemistry, General Medicine, General Pharmacology, Toxicology and Pharmaceutics, Analytical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::72fc0844246163a882a993b06f323db9
https://doi.org/10.4155/bio-2022-0228

المؤلفون: Jian Lin, Emi Kimoto, Shinji Yamazaki, Manoli Vourvahis, Arthur Bergman, A. David Rodrigues, Chester Costales, Rui Li, Manthena V. S. Varma

المصدر: Clinical Pharmacology & Therapeutics. 113:1058-1069

مصطلحات موضوعية: Pharmacology, Pharmacology (medical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec33a983697f277ef617d284fe872534
https://doi.org/10.1002/cpt.2829

المؤلفون: David A, Tess, Emi, Kimoto, Amanda, King-Ahmad, Manoli, Vourvahis, A David, Rodrigues, Arthur, Bergman, Ruolun, Qui, Veena, Somayaji, Yan, Weng, Kari R, Fonseca, John, Litchfield, Manthena V S, Varma

المصدر: Clinical Pharmacology & Therapeutics. 112:605-614

مصطلحات موضوعية: Fructokinases, Pharmacology, Liver-Specific Organic Anion Transporter 1, Atorvastatin, Humans, Drug Interactions, Pharmacology (medical), Risk Assessment, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35798cb3081f488864d3fc6e5ea68ef
https://doi.org/10.1002/cpt.2593

المؤلفون: Heather Eng, Alyssa L. Dantonio, Eugene P. Kadar, R. Scott Obach, Li Di, Jian Lin, Nandini C. Patel, Britton Boras, Gregory S. Walker, Jonathan J. Novak, Emi Kimoto, Ravi Shankar P. Singh, Amit S. Kalgutkar

المصدر: Drug Metabolism and Disposition. 50:576-590

مصطلحات موضوعية: Pharmacology, Ritonavir, Lactams, Proline, SARS-CoV-2, Administration, Oral, Pharmaceutical Science, Haplorhini, Rats, COVID-19 Drug Treatment, Leucine, Nitriles, Microsomes, Liver, Animals, Cytochrome P-450 CYP3A, Humans, Child, Peptide Hydrolases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7665fc87be6818aa4890655b732a8a9d
https://doi.org/10.1124/dmd.121.000801

المؤلفون: Kota Toshimoto, Yuichi Sugiyama, Renato J. Scialis, Nora Lee, Ryota Kikuchi, Hiroyuki Kusuhara, Ralf Lotz, Wooin Lee, Naoki Ishiguro, Xiaoyan Chu, Albert P. Li, Kazuya Maeda, Kiyoe Morita, Aya Kiriake, Manthena V.S. Varma, Takashi Yoshikado, Emi Kimoto, Hong Shen

المصدر: Journal of Pharmaceutical Sciences. 110:376-387

مصطلحات موضوعية: Organic Anion Transporters, Pharmaceutical Science, 02 engineering and technology, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Pitavastatin, Pravastatin, Uptake study, biology, Chemistry, Biological Transport, Cerivastatin, Transporter, 021001 nanoscience & nanotechnology, Molecular biology, Organic anion-transporting polypeptide, Liver, Hepatocytes, biology.protein, Efflux, Extended time, 0210 nano-technology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b650e5980587b146a3d1f18d3db7032d
https://doi.org/10.1016/j.xphs.2020.10.041

المؤلفون: Lauren Horlbogen, Vu Le, Hiroyuki Kusuhara, Yuichi Sugiyama, Kenichi Furihata, Manoli Vourvahis, Sumathy Mathialagan, Linda S. Wood, Lina Luo, Takeshi Miyake, Jillian G. Johnson, Emi Kimoto, A. David Rodrigues, Ragu Ramanathan, Chieko Muto

المصدر: Clinical Pharmacology and Therapeutics

مصطلحات موضوعية: Drug, Adult, Male, Organic Cation Transport Proteins, media_common.quotation_subject, Pharmacology, Kidney, 030226 pharmacology & pharmacy, Risk Assessment, Article, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Asian People, In vivo, Medicine, Humans, Hypoglycemic Agents, Pharmacology (medical), Drug Interactions, media_common, Creatinine, Cross-Over Studies, business.industry, Research, Kidney metabolism, Articles, Healthy Volunteers, Metformin, Pyrimethamine, HEK293 Cells, Drug development, chemistry, 030220 oncology & carcinogenesis, Biomarker (medicine), business, Biomarkers, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6455ac5f4a9ef9dd64c71f30d2c2832
http://europepmc.org/articles/PMC7891601

المؤلفون: Hiroyuki Kusuhara, Daiki Mori, Yusuke Kondo, Vu Le, Chieko Muto, Ragu Ramanathan, Amanda King-Ahmad, Jillian G. Johnson, Emi Kimoto, Kenichi Furihata, Brian Rago, Manoli Vourvahis, A. David Rodrigues, Yuichi Sugiyama, Linda S. Wood

المصدر: Clinical Pharmacology and Therapeutics

مصطلحات موضوعية: Adult, Male, Drug, media_common.quotation_subject, Atorvastatin, Cmax, Pharmacology, 030226 pharmacology & pharmacy, Article, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Drug Interactions, Pharmacology (medical), Rosuvastatin, Pitavastatin, Antibiotics, Antitubercular, media_common, Cross-Over Studies, Dose-Response Relationship, Drug, Liver-Specific Organic Anion Transporter 1, business.industry, Research, Articles, Healthy Volunteers, Valsartan, 030220 oncology & carcinogenesis, Drug Evaluation, Biomarker (medicine), Hydroxymethylglutaryl-CoA Reductase Inhibitors, Rifampin, business, Biomarkers, Rifampicin, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3aede43085a4ee45b776062d22c643d
https://doi.org/10.1002/cpt.1695

المؤلفون: Emi Kimoto, Soraya Eatemadpour, Shinji Yamazaki, Manthena V.S. Varma, Chester Costales, Sarah Lazzaro

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 9, Pp 634-642 (2019)
CPT: Pharmacometrics & Systems Pharmacology

مصطلحات موضوعية: Quinidine, Male, Physiologically based pharmacokinetic modelling, Digoxin, endocrine system diseases, Administration, Oral, Pharmacology, Models, Biological, Article, Propanolamines, chemistry.chemical_compound, Pharmacokinetics, In vivo, medicine, polycyclic compounds, Humans, Pharmacology (medical), Drug Interactions, ATP Binding Cassette Transporter, Subfamily B, Member 1, Intestinal Mucosa, P-glycoprotein, biology, integumentary system, Research, lcsh:RM1-950, Articles, In vitro, Healthy Volunteers, female genital diseases and pregnancy complications, Dabigatran, carbohydrates (lipids), lcsh:Therapeutics. Pharmacology, chemistry, Gene Expression Regulation, Modeling and Simulation, biology.protein, Female, Rifampin, Talinolol, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf0d23e3b51de891dd10f16ca8ff20c
https://doaj.org/article/e2efb64d465b4efebe167697e4a2b216

المؤلفون: John P. Umland, Yi-an Bi, Soraya Eatemadpour, Hui Zhang, Manthena V.S. Varma, David A. Tess, Mark A. West, Emi Kimoto, Laurie Tylaska, Sarah Lazzaro, Chester Costales, Renato J. Scialis, Larry M. Tremaine, A. David Rodrigues, Sumathy Mathialagan, Bo Feng

المصدر: Journal of Pharmacology and Experimental Therapeutics. 370:72-83

مصطلحات موضوعية: 0301 basic medicine, Quinidine, Liver cytology, Quantitative proteomics, Peptide, Pharmacology, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Drug Interactions, Solute Carrier Proteins, chemistry.chemical_classification, biology, HEK 293 cells, Biological Transport, Transporter, In vitro, Organic anion-transporting polypeptide, HEK293 Cells, Phenotype, 030104 developmental biology, Liver, Pharmaceutical Preparations, chemistry, Hepatocytes, biology.protein, Molecular Medicine, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Rifampin, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b378d1fc76d05c41e28f859d9de3123
https://doi.org/10.1124/jpet.119.257600

المؤلفون: Renato J. Scialis, Heather Eng, A. David Rodrigues, Manthena V.S. Varma, Manoli Vourvahis, Emi Kimoto

المصدر: Drug Metabolism and Disposition. 47:493-503

مصطلحات موضوعية: Physiologically based pharmacokinetic modelling, CYP3A, Pharmaceutical Science, Pharmacology, 030226 pharmacology & pharmacy, Intestinal absorption, Cell Line, Maraviroc, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Cytochrome P-450 CYP3A, Humans, Drug Interactions, ATP Binding Cassette Transporter, Subfamily B, Member 1, P-glycoprotein, biology, Liver-Specific Organic Anion Transporter 1, Chemistry, Membrane Transport Proteins, Biological Transport, Organic anion-transporting polypeptide, Kinetics, HEK293 Cells, Liver, 030220 oncology & carcinogenesis, Hepatocytes, Microsomes, Liver, biology.protein, Microsome, Efflux

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81559f2b2a26809a09d895833c1edbee
https://doi.org/10.1124/dmd.118.085241

المؤلفون: Mark A. West, Manoli Vourvahis, A. David Rodrigues, Emi Kimoto, Manthena V.S. Varma, Yi-an Bi, Chester Costales

المصدر: Clinical pharmacology and therapeutics. 111(2)

مصطلحات موضوعية: Drug, Physiologically based pharmacokinetic modelling, Coproporphyrins, media_common.quotation_subject, Pharmacology, Models, Biological, Risk Assessment, Pharmacokinetics, In vivo, Risk Factors, Membrane Transport Modulators, medicine, Atorvastatin, Humans, Pharmacology (medical), Computer Simulation, Drug Interactions, Rosuvastatin Calcium, Pitavastatin, IC50, media_common, biology, Chemistry, Liver-Specific Organic Anion Transporter 1, Probenecid, Organic anion-transporting polypeptide, HEK293 Cells, Liver, biology.protein, Biomarkers, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d00709cb4396176c058693aa4aba51
https://pubmed.ncbi.nlm.nih.gov/34605015

المؤلفون: James R. Gosset, Shinji Yamazaki, Mark A. West, Chester Costales, Manthena V.S. Varma, A. David Rodrigues, Emi Kimoto, Jian Lin, Sarah Lazzaro, Mike West

المصدر: CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1018-1031 (2021)

مصطلحات موضوعية: Drug, Adult, Male, Physiologically based pharmacokinetic modelling, Abcg2, Adolescent, media_common.quotation_subject, Organic Anion Transporters, RM1-950, Pharmacology, Kidney, Models, Biological, Article, Young Adult, Pharmacokinetics, medicine, Potency, ATP Binding Cassette Transporter, Subfamily G, Member 2, Humans, Pharmacology (medical), Rosuvastatin, Drug Interactions, Rosuvastatin Calcium, media_common, Aged, biology, Chemistry, Research, Articles, Middle Aged, In vitro, Neoplasm Proteins, Organic anion-transporting polypeptide, Intestines, HEK293 Cells, Liver, Modeling and Simulation, Area Under Curve, biology.protein, Female, Therapeutics. Pharmacology, Multidrug Resistance-Associated Proteins, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1950d388cb9616710f9ff2c6257c66e
https://pubmed.ncbi.nlm.nih.gov/34164937

المؤلفون: Heather Eng, Annaliesa S. Anderson, Norimitsu Shirai, Brandon J. Anson, James Logue, Stuart Weston, Marisa McGrath, Martyn D. Ticehurst, Rebecca E. O’Connor, Michelle Rossulek, Martin Pettersson, Matthew N O' Brien, Jean G. Sathish, Matthew B. Frieman, Emi Kimoto, Jun Wang, R. Scott Obach, Emily I. Chen, Robert Haupt, Yuao Zhu, Thomas F. Rogers, Andrew D. Mesecar, Suman Luthra, Adolfo García-Sastre, Dafydd R. Owen, Rhys M. Jones, Eugene P. Kadar, Chunlong Ma, Rob Kania, Lisa Aschenbrenner, Arnab K. Chatterjee, Charlotte Moira Norfor Allerton, Joseph John Binder, Kevin Ogilvie, Holly L. Hammond, Nathan Beutler, Claire M. Steppan, Jennifer Hammond, Stephen Noell, Romel Rosales, Robert M. Hoffman, Lillis Jonathan Richard, Matthew R. Reese, Stephen W. Mason, Dan Arenson, Malina A. Bakowski, Lawrence W. Updyke, Lorraine F. Lanyon, Kris M. White, Emma K. Lendy, Melanie G. Kirkpatrick, Britton Boras

المصدر: bioRxiv
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

مصطلحات موضوعية: Indoles, Science, medicine.medical_treatment, viruses, General Physics and Astronomy, Pharmacology, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Virus, Article, Mice, In vivo, Coronavirus 229E, Human, Leucine, Chlorocebus aethiops, medicine, Animals, Humans, Protease inhibitor (pharmacology), skin and connective tissue diseases, Infusions, Intravenous, Vero Cells, Coronavirus 3C Proteases, Coronavirus, ADME, Multidisciplinary, Protease, Alanine, Chemistry, SARS-CoV-2, fungi, COVID-19, Drug Synergism, General Chemistry, Prodrug, In vitro, Adenosine Monophosphate, Pyrrolidinones, respiratory tract diseases, COVID-19 Drug Treatment, body regions, Disease Models, Animal, Coronavirus Protease Inhibitors, Severe acute respiratory syndrome-related coronavirus, Drug Design, Drug Therapy, Combination, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a752e17863847bd64acf1c506536d2c9
https://pubmed.ncbi.nlm.nih.gov/32935104

المؤلفون: Kazuya Maeda, Nora Lee, Hong Shen, Ralf Lotz, Satoshi Koyama, Yuichi Sugiyama, Hiroyuki Kusuhara, Ryota Kikuchi, Kiyoe Morita, Naoki Ishiguro, Renato J. Scialis, Wooin Lee, Xiaoyan Chu, Larry M. Tremaine, Emi Kimoto, Aya Kiriake

المصدر: The AAPS Journal

مصطلحات موضوعية: Adult, Male, Initial uptake clearance, Human hepatocytes, media_common.quotation_subject, Primary Cell Culture, Cell, Drug Evaluation, Preclinical, Pharmaceutical Science, Organic anion transporting polypeptide (OATP), Models, Biological, Concentration ratio, medicine, Humans, Rosuvastatin, Child, Pitavastatin, Internalization, Cells, Cultured, media_common, Time course, biology, Liver-Specific Organic Anion Transporter 1, Chemistry, Statins, Cerivastatin, Culture Media, Hepatobiliary Elimination, Organic anion-transporting polypeptide, medicine.anatomical_structure, Hepatocytes, Biophysics, biology.protein, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Pravastatin, Research Article, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e53b53191420a7bbe53ebaa5f76e079
https://doi.org/10.1208/s12248-020-00512-6

المؤلفون: Emma K. Lendy, Martyn D. Ticehurst, Robert Steven Kania, Lisa Aschenbrenner, Chuang Ma, Michelle Rossulek, Emily I. Chen, Charlotte Moira Norfor Allerton, Rhys M. Jones, Stephen W. Mason, Kevin Ogilvie, Heather Eng, Dan Arenson, Lorraine F. Lanyon, Abhishek Chatterjee, Rob Haupt, Martin Pettersson, Britton Boras, Eugene P. Kadar, Malina A. Bakowski, Yuao Zhu, Obach Rs, Suman Luthra, Stuart Weston, Joseph John Binder, Lillis, Stephen Noell, Thomas F. Rogers, Dafydd R. Owen, O’Brien Mn, Claire M. Steppan, Lawrence W. Updyke, Jennifer Hammond, Jun Wang, Norimitsu Shirai, Brandon J. Anson, Nathan Beutler, Jean G. Sathish, Melanie G. Kirkpatrick, Annaliesa S. Anderson, James Logue, Matthew B. Frieman, Andrew D. Mesecar, Holly L. Hammond, Robert M. Hoffman, Reese Mr, Marisa McGrath, Rebecca E. O’Connor, Emi Kimoto

المصدر: Nature Communications

مصطلحات موضوعية: Protease, Coronavirus disease 2019 (COVID-19), SARS-CoV-2, Chemistry, medicine.medical_treatment, Prodrug, medicine.disease_cause, Virology, Article, In vitro, Virus, Pharmacodynamics, Preclinical research, In vivo, medicine, Pharmacokinetics, ADME, Coronavirus

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84bedafdf92a23451d3e8b9574a30f85
https://doi.org/10.1101/2020.09.12.293498

المؤلفون: Kota Toshimoto, Koji Chiba, Emi Kimoto, Hiroyuki Kusuhara, Takashi Yoshikado, Yuichi Sugiyama, Kazuya Maeda, A. David Rodrigues

المصدر: CPT: Pharmacometrics & Systems Pharmacology

مصطلحات موضوعية: Physiologically based pharmacokinetic modelling, Coproporphyrins, Statin, medicine.drug_class, Endogeny, Pharmacology, 030226 pharmacology & pharmacy, Models, Biological, Article, 03 medical and health sciences, Solute Carrier Organic Anion Transporter Family Member 1B3, 0302 clinical medicine, Pharmacokinetics, In vivo, medicine, Humans, Pharmacology (medical), Drug Interactions, biology, Chemistry, Liver-Specific Organic Anion Transporter 1, Research, Articles, In vitro, Organic anion-transporting polypeptide, Liver, 030220 oncology & carcinogenesis, Modeling and Simulation, Area Under Curve, biology.protein, Biomarker (medicine), Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9953d78038731999a47d953408cb8b40
http://europepmc.org/articles/PMC6263667

المؤلفون: Manthena V.S. Varma, Anna Vildhede, A. David Rodrigues, Emi Kimoto

المصدر: Molecular Pharmaceutics. 15:3227-3235

مصطلحات موضوعية: Adult, Male, Proteomics, 0301 basic medicine, medicine.medical_specialty, Organic anion transporter 1, Primary Cell Culture, Pharmaceutical Science, Peptide, Organic Anion Transporters, Sodium-Independent, 030226 pharmacology & pharmacy, Young Adult, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Pharmacokinetics, Tandem Mass Spectrometry, In vivo, Internal medicine, Drug Discovery, medicine, Humans, Child, Aged, chemistry.chemical_classification, biology, Chemistry, Age Factors, Transporter, Middle Aged, In vitro, HEK293 Cells, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Biological Variation, Population, Liver, Membrane protein, Hepatocyte, Hepatocytes, biology.protein, Molecular Medicine, Female, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d93fea273fa4bc1f87fdccea958142
https://doi.org/10.1021/acs.molpharmaceut.8b00320