المؤلفون: Giuseppina De Simone, Anna Di Fiore, Emanuela Truppo, Emma Langella, Daniela Vullo, Claudiu T. Supuran, Simona Maria Monti

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1506-1510 (2019)

مصطلحات موضوعية: cytosolic human carbonic anhydrases, catalytic activity, proton transfer, histidine cluster, site-specific mutagenesis, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/9f170bbeb47743aa83686eb06fe82839

المؤلفون: Annamaria Sandomenico, Silvia Scaramuzza, Fabio Selis, Emanuela Iaccarino, Luisa Calvanese, Andrea Esperti, Emanuela Truppo, Paolo Dell'Omo, Maria Cantile, Sandro De Falco, Lucia Falcigno, Menotti Ruvo, Andrea Caporale, Riccardo Sanna, Giancarlo Tonon, Annalia Focà

المساهمون: Selis, F., Sandomenico, A., Cantile, M., Sanna, R., Calvanese, L., Falcigno, L., Dell'Omo, P., Esperti, A., De Falco, S., Foca, A., Caporale, A., Iaccarino, E., Truppo, E., Scaramuzza, S., Tonon, G., Ruvo, M.

المصدر: International journal of biological macromolecules 164 (2020): 4516–4531. doi:10.1016/j.ijbiomac.2020.09.050
info:cnr-pdr/source/autori:Selis F.; Sandomenico A.; Cantile M.; Sanna R.; Calvanese L.; Falcigno L.; Dell'Omo P.; Esperti A.; De Falco S.; Foca A.; Caporale A.; Iaccarino E.; Truppo E.; Scaramuzza S.; Tonon G.; Ruvo M./titolo:Generation and testing of engineered multimeric Fabs of trastuzumab/doi:10.1016%2Fj.ijbiomac.2020.09.050/rivista:International journal of biological macromolecules/anno:2020/pagina_da:4516/pagina_a:4531/intervallo_pagine:4516–4531/volume:164

مصطلحات موضوعية: Models, Molecular, Immunoconjugates, Protein Conformation, Receptor, ErbB-2, Peptide, 02 engineering and technology, Protein Engineering, Biochemistry, law.invention, Structural Biology, law, Cytotoxic T cell, Internalization, media_common, chemistry.chemical_classification, Transglutamination, 0303 health sciences, biology, Chemistry, General Medicine, Antibody fragment, Bioconjugation, Trastuzumab, Recombinant Fab, 021001 nanoscience & nanotechnology, Recombinant Proteins, Recombinant DNA, Cystine, Female, Antibody, 0210 nano-technology, DNA, Complementary, media_common.quotation_subject, Breast Neoplasms, 03 medical and health sciences, Immunoglobulin Fab Fragments, Cell Line, Tumor, Escherichia coli, Humans, Amino Acid Sequence, Molecular Biology, 030304 developmental biology, Fluorescent Dyes, Transglutaminases, Carcinoma, Periplasmic space, Surface Plasmon Resonance, Peptide Fragments, Drug Design, biology.protein, Drug Screening Assays, Antitumor, Protein Multimerization, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c83f8eb5924b3f47cced55512ce8ab
http://hdl.handle.net/11588/825466

المؤلفون: Vincenzo Alterio, Alessio Innocenti, Claudiu T. Supuran, Simona Maria Monti, Emanuela Truppo, Anna Di Fiore, Giuseppina De Simone, Annamaria Sandomenico, Daniela Vullo

المصدر: Bioorganic & Medicinal Chemistry Letters
Bioorganic & medicinal chemistry letters
22 (2012): 1560–1564. doi:10.1016/j.bmcl.2011.12.134
info:cnr-pdr/source/autori:Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM./titolo:Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors/doi:10.1016%2Fj.bmcl.2011.12.134/rivista:Bioorganic & medicinal chemistry letters (Print)/anno:2012/pagina_da:1560/pagina_a:1564/intervallo_pagine:1560–1564/volume:22
Bioorganic & Medicinal Chemistry Letters; Vol 22

مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Molecular Sequence Data, Clinical Biochemistry, Phosphatase, Pharmaceutical Science, Biochemistry, Esterase, Inhibitory Concentration 50, 03 medical and health sciences, chemistry.chemical_compound, Cytosol, 0302 clinical medicine, In vivo, Carbonic anhydrase, Drug Discovery, Humans, Protein Isoforms, Amino Acid Sequence, Carbonic Anhydrase Inhibitors, Molecular Biology, Carbonic Anhydrases, 030304 developmental biology, chemistry.chemical_classification, Sulfonamides, 0303 health sciences, biology, Chemistry, Organic Chemistry, Wild type, Glutathione, Enzyme Activation, Enzyme, 030220 oncology & carcinogenesis, S-Nitrosoglutathione, biology.protein, Molecular Medicine, Sequence Alignment, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b14b4e55dd42f334c37d331ceaadc8

المؤلفون: DEL GIUDICE, RITA, MONTI, DARIA MARIA, ARCIELLO, ANGELA, Emanuela Truppo, Claudiu T. Supuran, Giuseppina De Simone, Simona Maria Monti

المساهمون: DEL GIUDICE, Rita, Monti, DARIA MARIA, Emanuela, Truppo, Arciello, Angela, Claudiu T., Supuran, Giuseppina De, Simone, Simona Maria, Monti

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000324050400009; volume:394; firstpage:1343; lastpage:1348; journal:BIOLOGICAL CHEMISTRY; http://hdl.handle.net/11588/564037; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84888113118

الاتاحة: http://hdl.handle.net/11588/564037
https://doi.org/10.1515/hsz-2013-0204

المؤلفون: Emanuela Truppo, Fatemeh Bootorabi, Simona Maria Monti, Giuseppina De Simone, Claudiu T. Supuran, Vincenzo Alterio, Seppo Parkkila, Anna Di Fiore, Nina A. Dathan

المصدر: Bioorganic & medicinal chemistry letters
20 (2010): 5023–5026. doi:10.1016/j.bmcl.2010.07.051
info:cnr-pdr/source/autori:Di Fiore A; Truppo E; Supuran CT; Alterio V; Dathan NA; Bootorabi F; Parkkila S; Monti SM; De Simone G./titolo:Crystal structure of the C183S%2FC217S mutant of human CA VII in complex with acetazolamide./doi:10.1016%2Fj.bmcl.2010.07.051/rivista:Bioorganic & medicinal chemistry letters (Print)/anno:2010/pagina_da:5023/pagina_a:5026/intervallo_pagine:5023–5026/volume:20

مصطلحات موضوعية: Models, Molecular, Molecular Sequence Data, Clinical Biochemistry, Pharmaceutical Science, Hippocampus, Drug design, Crystallography, X-Ray, Biochemistry, Protein Structure, Secondary, Drug Discovery, medicine, Humans, Amino Acid Sequence, Molecular Biology, Carbonic Anhydrases, chemistry.chemical_classification, Sequence Homology, Amino Acid, biology, Organic Chemistry, Lyase, Cortex (botany), Acetazolamide, Enzyme, chemistry, Enzyme inhibitor, Mutation, Neuropathic pain, biology.protein, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dac1699d372ce23f8c825f96db956f

المؤلفون: Carlo Pedone, Simona Maria Monti, Vincenzo Alterio, Emanuela Truppo, Giuseppina De Simone, Claudiu T. Supuran

المصدر: Organic & biomolecular chemistry 8 (2010): 3528–3533. doi:10.1039/b926832d
info:cnr-pdr/source/autori:Alterio V; Monti SM; Truppo E; Pedone C; Supuran CT; De Simone G./titolo:The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: the carbonic anhydrase I-topiramate complex./doi:10.1039%2Fb926832d/rivista:Organic & biomolecular chemistry/anno:2010/pagina_da:3528/pagina_a:3533/intervallo_pagine:3528–3533/volume:8

مصطلحات موضوعية: Models, Molecular, Carbonic Anhydrase I, medicine.drug_class, Stereochemistry, Molecular Sequence Data, Drug design, Fructose, Plasma protein binding, Crystallography, X-Ray, Biochemistry, Isozyme, Topiramate, Catalytic Domain, Carbonic anhydrase, REFINED STRUCTURE, medicine, Humans, Carbonic anhydrase inhibitor, CRYSTAL-STRUCTURE, Amino Acid Sequence, Physical and Theoretical Chemistry, Carbonic Anhydrase Inhibitors, biology, Chemistry, Organic Chemistry, ANTIEPILEPTIC DRUGS, Active site, Lyase, EXTRACELLULAR DOMAIN, Isoenzymes, biology.protein, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d930c17c76f2670de4c2ea13ce4b626
http://www.cnr.it/prodotto/i/14196