المؤلفون: Taolin Yuan, Surinder Kumar, Mary E. Skinner, Ryan Victor-Joseph, Majd Abuaita, Jaap Keijer, Jessica Zhang, Thaddeus J. Kunkel, Yanghan Liu, Elyse M. Petrunak, Thomas L. Saunders, Andrew P. Lieberman, Jeanne A. Stuckey, Nouri Neamati, Fathiya Al-Murshedi, Majid Alfadhel, Johannes N. Spelbrink, Richard Rodenburg, Vincent C.J. de Boer, David B. Lombard

المصدر: iScience, Vol 27, Iss 6, Pp 109991- (2024)

مصطلحات موضوعية: health sciences, biochemistry, physiology, molecular biology, neuroscience, structural biology, Science

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224012161; https://doaj.org/toc/2589-0042

URL الوصول: https://doaj.org/article/1b3e08c25bb044469b8c3e5f02f889fd

المؤلفون: Elyse M. Petrunak, Aaron G. Bart, Hwei-Ming Peng, Richard J. Auchus, Emily E. Scott

المصدر: Journal of Biological Chemistry. 299:102999

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::44a742e7c82c8b7ecb48bcb04d0d5124
https://doi.org/10.1016/j.jbc.2023.102999

المؤلفون: Jeffrey Aubé, Steven A. Rogers, Emily E. Scott, Elyse M. Petrunak

المصدر: Drug Metabolism and Disposition. 45:635-645

مصطلحات موضوعية: 0301 basic medicine, Galeterone, Pharmaceutical Science, Naphthalenes, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Non-competitive inhibition, Catalytic Domain, Humans, Enzyme Inhibitors, CYP17A1 Inhibitor, Pharmacology, chemistry.chemical_classification, biology, Imidazoles, Steroid 17-alpha-Hydroxylase, Active site, Articles, Ligand (biochemistry), Lyase, Androstadienes, 030104 developmental biology, Enzyme, chemistry, Biochemistry, CYP17A1, 030220 oncology & carcinogenesis, biology.protein, Androstenes, Benzimidazoles, Steroids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17df91d27a99ffc272be8efd3f2c0df6
https://doi.org/10.1124/dmd.117.075317

المؤلفون: Weiyang Dai, Soma Samanta, Ding Xue, Elyse M. Petrunak, Jeanne A. Stuckey, Yanyan Han, Duxin Sun, Yong Wu, Nouri Neamati

المصدر: J Med Chem

مصطلحات موضوعية: Acrylamides, Molecular Structure, Crystallography, X-Ray, HCT116 Cells, Article, Mice, Structure-Activity Relationship, Catalytic Domain, Drug Design, Drug Discovery, Microsomes, Liver, Molecular Medicine, Animals, Humans, Enzyme Inhibitors, Glutathione Transferase, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56622350a121541805542e5fa59dc257
https://pubmed.ncbi.nlm.nih.gov/30735370

المؤلفون: Emily E. Scott, Patrick Porubsky, Elyse M. Petrunak, Natasha M. DeVore

المصدر: Journal of Biological Chemistry. 289:32952-32964

مصطلحات موضوعية: Models, Molecular, endocrine system, Cytochrome, Heme, Crystallography, X-Ray, Biochemistry, Protein Structure, Secondary, Substrate Specificity, chemistry.chemical_compound, Catalytic Domain, Cytochrome b5, medicine, Humans, Testosterone, Molecular Biology, Progesterone, Androstenols, Binding Sites, Molecular Structure, biology, 17-alpha-Hydroxyprogesterone, Steroid 17-alpha-Hydroxylase, Cytochrome P450, Estrogens, Hydrogen Bonding, Dehydroepiandrosterone, Cell Biology, Lyase, Kinetics, chemistry, CYP17A1, Pregnenolone, Mutation, Protein Structure and Folding, biology.protein, Androstenes, Steroids, Oxidation-Reduction, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c16fa34712a4986d8ae18ad6b3e920
https://doi.org/10.1074/jbc.m114.610998

المؤلفون: Sun Kyung Kim, Lindsey Barron, Cynthia S. Hinck, Elyse M. Petrunak, Kristin E. Cano, Avinash Thangirala, Brian Iskra, Molly Brothers, Machell Vonberg, Belinda Leal, Blair Richter, Ravindra Kodali, Alexander B. Taylor, Shoucheng Du, Christopher O. Barnes, Traian Sulea, Guillermo Calero, P. John Hart, Matthew J. Hart, Borries Demeler, Andrew P. Hinck

المصدر: The Journal of biological chemistry. 292(17)

مصطلحات موضوعية: 0301 basic medicine, Cell signaling, TGF alpha, Protein Folding, Amino Acid Motifs, Receptor, Transforming Growth Factor-beta Type I, Biology, Protein Serine-Threonine Kinases, Protein Engineering, Biochemistry, 03 medical and health sciences, Mice, 0302 clinical medicine, Transforming Growth Factor beta, Fluorescence Resonance Energy Transfer, Animals, Humans, Protein Isoforms, Editors' Picks, Molecular Biology, R-SMAD, ACVRL1, Cell Biology, Transforming growth factor beta, TGF beta receptor 2, Endoglin, Surface Plasmon Resonance, Cell biology, Extracellular Matrix, Kinetics, 030104 developmental biology, HEK293 Cells, Solubility, 030220 oncology & carcinogenesis, biology.protein, Disease Progression, Protein Multimerization, Receptors, Transforming Growth Factor beta, Ultracentrifugation, Transforming growth factor, Protein Binding, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcca23a4ac12f3b9d6318a5b9bd6695d
https://pubmed.ncbi.nlm.nih.gov/28228478

المؤلفون: Bjarne Styrishave, Flemming Jørgensen, Cecilie Hurup Hansen, Silvia Bonomo, Emily E. Scott, Elyse M. Petrunak, Lars Olsen

المصدر: Bonomo, S, Hansen, C H, Petrunak, E M, Scott, E E, Styrishave, B, Jørgensen, F S & Olsen, L 2016, ' Promising Tools in Prostate Cancer Research : Selective Non-Steroidal Cytochrome P450 17A1 Inhibitors ', Scientific Reports, vol. 6, 29468 . https://doi.org/10.1038/srep29468
Scientific Reports

مصطلحات موضوعية: Male, 0301 basic medicine, CYP2D6, endocrine system, Cell Survival, Nitrogen, Pharmacology, Crystallography, X-Ray, Ligands, Mass Spectrometry, Article, Inhibitory Concentration 50, 03 medical and health sciences, Prostate cancer, Catalytic Domain, Cell Line, Tumor, medicine, Humans, CYP17A1 Inhibitor, chemistry.chemical_classification, Virtual screening, Multidisciplinary, biology, CYP3A4, Prostate, Prostatic Neoplasms, Steroid 17-alpha-Hydroxylase, Cytochrome P450, medicine.disease, Molecular Docking Simulation, 030104 developmental biology, Enzyme, Biochemistry, chemistry, CYP17A1, Drug Design, biology.protein, Androstenes, Steroids, Chromatography, Liquid, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a60760559ebb73a4b03349cd32e101
https://curis.ku.dk/ws/files/188957738/srep29468.pdf

المؤلفون: D. Fernando Estrada, Emily E. Scott, Elyse M. Petrunak, Rahul Yadav

المصدر: Molecular and cellular endocrinology. 441

مصطلحات موضوعية: 0301 basic medicine, endocrine system, Allosteric regulation, 030209 endocrinology & metabolism, Hydroxylation, Biochemistry, Article, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Cytochrome b5, medicine, Animals, Humans, Molecular Biology, Heme, Progesterone, chemistry.chemical_classification, biology, Chemistry, Active site, Steroid 17-alpha-Hydroxylase, Stereoisomerism, Lyase, 030104 developmental biology, Enzyme, CYP17A1, Pregnenolone, biology.protein, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bef66bb808c1b53d3f241aaf6649e18
https://pubmed.ncbi.nlm.nih.gov/27566228

المؤلفون: Heather F. Crouse, Ashley M. Donovan, Anna C. Merkle, Brandi L. Swartz, Swarna Basu, Elyse M. Petrunak

المصدر: Spectroscopy Letters. 44:369-374

مصطلحات موضوعية: Quenching (fluorescence), biology, Chemistry, Tryptophan, chemistry.chemical_element, Photochemistry, Human serum albumin, Fluorescence, Atomic and Molecular Physics, and Optics, Fluorescence spectroscopy, Analytical Chemistry, chemistry.chemical_compound, Chromium, biology.protein, medicine, Physical chemistry, Bovine serum albumin, Lysozyme, Spectroscopy, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8f2e1049a9a5c897a73c29cb8af6e64e
https://doi.org/10.1080/00387010.2010.546470

المؤلفون: Antonio González-Sarrías, Kylie B. Manning, Geneive E. Henry, Navindra P. Seeram, Elyse M. Petrunak, Michelle Lebo

المصدر: Phytochemistry. 72:662-667

مصطلحات موضوعية: biology, Traditional medicine, Xanthones, Hypericum perforatum, Clusiaceae, Plant Science, General Medicine, Phloroglucinol, Horticulture, Pharmacognosy, biology.organism_classification, Biochemistry, Human colon cancer, Inhibitory Concentration 50, chemistry.chemical_compound, Hypericum ellipticum, chemistry, Cell Line, Tumor, Botany, Xanthone, Humans, Molecular Biology, Hypericum, Human colon

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ecaa03fc5018197cd45ea3e1b7724f6
https://doi.org/10.1016/j.phytochem.2011.01.032

المؤلفون: Emily E. Scott, Elyse M. Petrunak

المصدر: The FASEB Journal. 29

مصطلحات موضوعية: Prostate cancer, business.industry, CYP17A1, Genetics, Cancer research, Medicine, business, medicine.disease, Molecular Biology, Biochemistry, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6894728115adbf72653995cd2967f23f
https://doi.org/10.1096/fasebj.29.1_supplement.945.13

المؤلفون: Emily E. Scott, Elyse M. Petrunak, Michelle R. Sukup Jackson

المصدر: The FASEB Journal. 26

مصطلحات موضوعية: Cytochrome, biology, Biochemistry, Chemistry, Genetics, biology.protein, Key (cryptography), Active site, Molecular Biology, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c4e98541a5ac0f9abc1d25634258ee5c
https://doi.org/10.1096/fasebj.26.1_supplement.lb127