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1Academic Journal
المؤلفون: Nan Wang, Shuo Zhang, Yafei Yuan, Hanwen Xu, Elisabeth Defossa, Hans Matter, Melissa Besenius, Volker Derdau, Matthias Dreyer, Nis Halland, Kaihui Hu He, Stefan Petry, Michael Podeschwa, Norbert Tennagels, Xin Jiang, Nieng Yan
المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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المؤلفون: Nan Wang, Shuo Zhang, Yafei Yuan, Hanwen Xu, Elisabeth Defossa, Hans Matter, Melissa Besenius, Volker Derdau, Matthias Dreyer, Nis Halland, Kaihui Hu He, Stefan Petry, Michael Podeschwa, Norbert Tennagels, Xin Jiang, Nieng Yan
المصدر: Nature communications. 13(1)
مصطلحات موضوعية: Glucose Transporter Type 1, Multidisciplinary, Glucose, Glucose Transporter Type 3, Glucose Transport Proteins, Facilitative, General Physics and Astronomy, Humans, Insulin, General Chemistry, General Biochemistry, Genetics and Molecular Biology
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المؤلفون: Elisabeth Defossa, Matthias Löhn, Matthias Schäfer, Pavel Safar, Dietmar Weitz, Kristin Breitschopf, Matthias Lohmann, María Méndez, David S Thorpe, Jens Riedel, Nils Rackelmann, Hartmut Mors, Hans Matter, Michael Kurz, Ziyu Li, Michael Podeschwa, Sylvain Lebreton
المصدر: Journal of Medicinal Chemistry. 63:2292-2307
مصطلحات موضوعية: Blood Glucose, Male, endocrine system, Allosteric modulator, Allosteric regulation, Pharmacology, 01 natural sciences, Glucagon-Like Peptide-1 Receptor, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, Allosteric Regulation, In vivo, Drug Discovery, Animals, Humans, Hypoglycemic Agents, Receptor, Cells, Cultured, 030304 developmental biology, ADME, 0303 health sciences, Chemistry, HEK 293 cells, Small molecule, In vitro, Rats, 0104 chemical sciences, Mice, Inbred C57BL, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Diabetes Mellitus, Type 2, Drug Design, Molecular Medicine
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المؤلفون: Jens Atzrodt, Friedemann Schmidt, Kerstin Wäse, Jacquelyn Dwyer, Wolfgang Holla, Martina Dorau, Alexander Amberg, Volker Derdau, József Pánczél, Angela Dudda, Ulrich Kürzel, Dietmar Weitz, Elisabeth Defossa, Catherine Arabeyre, Markus Kohlmann, Timothy Ackerson, Jens Riedel, Thomas Kissner, Shibani Rajanna
المصدر: Journal of Biochemical and Molecular Toxicology. 33
مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.drug_class, Health, Toxicology and Mutagenesis, Metabolite, Mitochondria, Liver, Caspase 3, Fatty Acids, Nonesterified, Pharmacology, Toxicology, Biochemistry, Receptors, G-Protein-Coupled, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Free fatty acid receptor 1, medicine, Animals, Humans, Sulfones, Cytotoxicity, Molecular Biology, Cells, Cultured, Benzofurans, 030102 biochemistry & molecular biology, General Medicine, Metabolism, Glutathione, Rats, Liver, chemistry, 030220 oncology & carcinogenesis, Hepatocytes, Microsomes, Liver, Molecular Medicine, Adenosine triphosphate
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5
المؤلفون: Michael Wagner, Elisabeth Defossa
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:2991-3000
مصطلحات موضوعية: Molecular Structure, Chemistry, Organic Chemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Incretin, Type 2 Diabetes Mellitus, Enteroendocrine cell, Type 2 diabetes, Pharmacology, medicine.disease, Biochemistry, Receptors, G-Protein-Coupled, Diabetes Mellitus, Type 2, Free fatty acid receptor 1, Drug Discovery, medicine, Humans, Hypoglycemic Agents, Molecular Medicine, Receptor, Molecular Biology, Glycemic, G protein-coupled receptor
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المؤلفون: Armin Walser, Silke Herok, Uwe Heinelt, Peter-Michael Blohm, Hans Matter, Detlev Schneider, Volker Brachvogel, Petra Lönze, Alexander Liesum, Elisabeth Defossa, Andrea Müller, Herman Schreuder, Peter Wildgoose, Fahad Al-Obeidi
المصدر: Journal of Medicinal Chemistry. 45:2749-2769
مصطلحات موضوعية: Models, Molecular, Quantitative structure–activity relationship, Indoles, Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, Molecular model, Stereochemistry, Factor Xa Inhibitor, Amidines, Quantitative Structure-Activity Relationship, Stereoisomerism, Crystallography, X-Ray, Drug Discovery, Hydrolase, medicine, Binding site, Binding Sites, biology, Chemistry, Amides, Docking (molecular), Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Factor Xa Inhibitors, Protein Binding
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7
المؤلفون: Norbert Krass, Dieter Isert, Rolf Horlein, Fischer Gerd, Theo Wollmann, Uwe Gerlach, Ulrich Stache, Elisabeth Defoßa, Rudolf Lattrell
المصدر: Liebigs Annalen. 1996:1743-1749
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Diastereomer, General Chemistry, Prodrug, Thioester, Oxime, Medicinal chemistry, chemistry.chemical_compound, chemistry, Yield (chemistry), Amine gas treating, Mercaptobenzothiazole, Physical and Theoretical Chemistry, Saponification
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8
المؤلفون: Stefan Bartoschek, Siegfried Stengelin, Christian Griesinger, K. Ulrich Wendt, Teresa Carlomagno, Viktoria Dietrich, Thomas Klabunde, Ingo Focken, Elisabeth Defossa
المصدر: Angewandte Chemie (International ed. in English). 49(8)
مصطلحات موضوعية: Drug, Quantitative structure–activity relationship, Magnetic Resonance Spectroscopy, Molecular Structure, Chemistry, Ligand, Stereochemistry, media_common.quotation_subject, Quantitative Structure-Activity Relationship, General Chemistry, Nuclear magnetic resonance spectroscopy, General Medicine, Ligands, Catalysis, Receptors, G-Protein-Coupled, Drug Design, Struktur aktivitats beziehungen, Molecule, Receptor, media_common, G protein-coupled receptor
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المؤلفون: Karl Dr. Schönafinger, Magda Kosmopoulou, Hans-Jörg Burger, Dieter Schmoll, Erich Von Roedern, Andreas W. Herling, K. Ulrich Wendt, Elisabeth Defossa, Edoardo Sarubbi, Nikos G. Oikonomakos, Volker Brachvogel, Dieter Kadereit, Thomas Klabunde
المصدر: Journal of Medicinal Chemistry 48:20(Oct2005):6178-6193
مصطلحات موضوعية: Models, Molecular, Allosteric regulation, InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL, Quantitative Structure-Activity Relationship, In Vitro Techniques, Crystallography, X-Ray, Chemical synthesis, Glycogen Phosphorylase, Liver Form, Glycogen phosphorylase, Drug Discovery, medicine, Animals, Humans, Urea, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), chemistry.chemical_classification, Binding Sites, biology, Chemistry, Biological activity, Adenosine Monophosphate, Rats, medicine.anatomical_structure, Enzyme, Biochemistry, Diabetes Mellitus, Type 2, Enzyme inhibitor, Hepatocyte, biology.protein, Hepatocytes, Molecular Medicine, Glycogen Phosphorylase, Muscle Form, Rabbits, Pharmacophore, Allosteric Site
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المؤلفون: Ioannis D. Kostas, Thomas Klabunde, Evangelia D. Chrysina, K. Ulrich Wendt, Magda Kosmopoulou, Nikos G. Oikonomakos, Demetres D. Leonidas, Elisabeth Defossa
المصدر: Protein Science 14:7(Jul2005):1760-1771
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Protein Conformation, Allosteric regulation, AMP binding, Crystallography, X-Ray, Biochemistry, Article, Glycogen Phosphorylase, Liver Form, Glycogen phosphorylase, Enzyme Stability, Transferase, Animals, Humans, Hypoglycemic Agents, Urea, Binding site, Enzyme Inhibitors, Glycogen synthase, Phosphorylase kinase, Molecular Biology, Binding Sites, biology, Molecular Structure, Chemistry, Activator (genetics), Muscles, Adenosine Monophosphate, Kinetics, biology.protein, Glycogen Phosphorylase, Muscle Form, Rabbits, Allosteric Site, Protein Binding
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