المؤلفون: Jacob Schimetz, Pranav Shah, Charles Keese, Chris Dehnert, Michael Detweiler, Sam Michael, Catherine Toniatti-Yanulavich, Xin Xu, Elias C. Padilha

المصدر: SLAS Technology, Vol 29, Iss 1, Pp 100116- (2024)

مصطلحات موضوعية: Transtepithelial electrical resistance (TEER), Caco-2, MDCK, Membrane biology, Automation, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2472630323000651; https://doaj.org/toc/2472-6303

URL الوصول: https://doaj.org/article/a609b454386141629841489eac1b65f4

المؤلفون: Rintaro Kato, Wenyu Zeng, Vishal B. Siramshetty, Jordan Williams, Md Kabir, Natalie Hagen, Elias C. Padilha, Amy Q. Wang, Ewy A. Mathé, Xin Xu, Pranav Shah

المصدر: Frontiers in Pharmacology, Vol 14 (2023)

مصطلحات موضوعية: parallel artificial membrane permeability assay (PAMPA), blood-brain barrier (BBB), drug discovery, quantitative structure-activity relationship (QSAR), computational drug design, ADME, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1291246/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/f2af9b80c1964c48b71ae481314f0507

المؤلفون: Mengbi Yang, Amy Q. Wang, Elias C. Padilha, Pranav Shah, Natalie R. Hagen, China Ryu, Khalida Shamim, Wenwei Huang, Xin Xu

المصدر: Frontiers in Pharmacology, Vol 14 (2023)

مصطلحات موضوعية: niclosamide, prodrug, PBPK modeling, cross-species prediction, tissue distribution, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1099425/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/7f49f978d6434fb4a382907efaad474b

المؤلفون: Elias C. Padilha, Mengbi Yang, Pranav Shah, Amy Q. Wang, Jianmin Duan, Joshua K. Park, Charles N. Zawatsky, May Christine V. Malicdan, George Kunos, Malliga R. Iyer, Geneviève Gaucher, François Ravenelle, Resat Cinar, Xin Xu

المصدر: Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115178- (2023)

مصطلحات موضوعية: PBPK modeling, PK scaling, In vivo chiral conversion, Hermansky-Pudlak syndrome, Pulmonary Fibrosis, ADME, Therapeutics. Pharmacology, RM1-950

Relation: http://www.sciencedirect.com/science/article/pii/S0753332223009691; https://doaj.org/toc/0753-3322; https://doaj.org/article/1588916561494097bd24648713f8ed8a

الاتاحة: https://doi.org/10.1016/j.biopha.2023.115178
https://doaj.org/article/1588916561494097bd24648713f8ed8a

المؤلفون: Amy Q. Wang, Natalie R. Hagen, Elias C. Padilha, Mengbi Yang, Pranav Shah, Catherine Z. Chen, Wenwei Huang, Pramod Terse, Philip Sanderson, Wei Zheng, Xin Xu

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: GS-441524, SARS-CoV-2, pharmacokinetics, oral bioavailability, UPLC-MS/MS, nucleoside transporters, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.918083/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/96df82be203a4011897c62432885afde

المؤلفون: Md Kabir, Elias C. Padilha, Pranav Shah, Ruili Huang, Srilatha Sakamuru, Eric Gonzalez, Lin Ye, Xin Hu, Mark J. Henderson, Menghang Xia, Xin Xu

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: cytochrome P450, CYP3A7, CYP3A4, drug metabolism, qHTS data analysis, neonates, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.899536/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/f9d354218d0943e386f9679ca6dac038

المؤلفون: Tuan Xu, Md Kabir, Srilatha Sakamuru, Pranav Shah, Elias C. Padilha, Deborah K. Ngan, Menghang Xia, Xin Xu, Anton Simeonov, Ruili Huang

المصدر: Journal of Chemical Information and Modeling. 63:846-855

مصطلحات موضوعية: General Chemical Engineering, General Chemistry, Library and Information Sciences, Computer Science Applications

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::28b9bc5154894ff26e8a9a015ae2b586
https://doi.org/10.1021/acs.jcim.2c01516

المؤلفون: Elias C. Padilha, Jianyao Wang, Ed Kerns, Arthur Lee, Wenwei Huang, Jian-kang Jiang, John McKew, Abdul Mutlib, Rosangela G. Peccinini, Paul B. Yu, Philip Sanderson, Xin Xu

المصدر: Frontiers in Pharmacology, Vol 10 (2019)

مصطلحات موضوعية: metabolite identification, fibrodysplasia ossificans progressiva, structure optimization, aldehyde oxidase, reactive metabolite, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2019.00234/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/be16eb237d3c4520a0bdf5769ab1d489

المؤلفون: Mengbi Yang, Amy Q. Wang, Elias C. Padilha, Pranav Shah, Natalie R. Hagen, China Ryu, Khalida Shamim, Wenwei Huang, Xin Xu

مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, niclosamide, prodrug, PBPK modeling, cross-species prediction, tissue distribution

Relation: https://figshare.com/articles/dataset/Table1_Use_of_physiological_based_pharmacokinetic_modeling_for_cross-species_prediction_of_pharmacokinetic_and_tissue_distribution_profiles_of_a_novel_niclosamide_prodrug_DOCX/22585663

الاتاحة: https://doi.org/10.3389/fphar.2023.1099425.s001
https://figshare.com/articles/dataset/Table1_Use_of_physiological_based_pharmacokinetic_modeling_for_cross-species_prediction_of_pharmacokinetic_and_tissue_distribution_profiles_of_a_novel_niclosamide_prodrug_DOCX/22585663

المؤلفون: Amy Q, Wang, Natalie R, Hagen, Elias C, Padilha, Mengbi, Yang, Pranav, Shah, Catherine Z, Chen, Wenwei, Huang, Pramod, Terse, Philip, Sanderson, Wei, Zheng, Xin, Xu

المصدر: Frontiers in pharmacology. 13

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::1a1306a393ba725bfc19e8cef40f3df3
https://pubmed.ncbi.nlm.nih.gov/36052127

المؤلفون: Md Kabir, Elias C. Padilha, Pranav Shah, Ruili Huang, Srilatha Sakamuru, Eric Gonzalez, Lin Ye, Xin Hu, Mark J. Henderson, Menghang Xia, Xin Xu

مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, cytochrome P450, CYP3A7, CYP3A4, drug metabolism, qHTS data analysis, neonates, substrates, inhibitors

Relation: https://figshare.com/articles/dataset/DataSheet1_Identification_of_Selective_CYP3A7_and_CYP3A4_Substrates_and_Inhibitors_Using_a_High-Throughput_Screening_Platform_xlsx/20206760

الاتاحة: https://doi.org/10.3389/fphar.2022.899536.s001
https://figshare.com/articles/dataset/DataSheet1_Identification_of_Selective_CYP3A7_and_CYP3A4_Substrates_and_Inhibitors_Using_a_High-Throughput_Screening_Platform_xlsx/20206760

المؤلفون: Douglas R. Davies, Gloria A. Benavides, Xin Hu, Jeffrey P. Norenberg, Somnath Jana, Ganesha Rai, Pavan Muttil, Larry A. Sklar, Katherine Pohida, Daniel J. Urban, Kabir, David M. Dranow, Andrew J. Flint, Leonard M. Neckers, Giuseppe L. Squadrito, David J. Maloney, William J. Moore, Victor M. Darley-Usmar, Elias C. Padilha, Ajit Jadhav, Matthew D. Hall, Kyle R. Brimacombe, Dorian M. Cheff, Anton Simeonov, Nitesh K. Kunda, Plamen P. Christov, Pranav Shah, Tamara Anderson, Dingyin Tao, Hu Zhu, Murali Cherukuri, Yuhong Fang, Shyh-Ming Yang, Gary A. Sulikowski, Gordon M. Stott, Donna F. Kusewitt, Tobie D. Lee, Chi V. Dang, Alex G. Waterson, Mark J. Henderson, Bryan T. Mott, Kwangho Kim, Michelle S. Johnson, Helen J. Hathaway, Nobu Oshima

المصدر: J Med Chem

مصطلحات موضوعية: Pyrazole, 01 natural sciences, Article, Cell activity, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, Lactate dehydrogenase, Drug Discovery, Animals, Humans, Glycolysis, Enzyme Inhibitors, 030304 developmental biology, 0303 health sciences, L-Lactate Dehydrogenase, Xenograft Model Antitumor Assays, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Biochemistry, chemistry, Molecular Medicine, Pyrazoles, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b11cff4db96920574f1004df1f63c0
https://pubmed.ncbi.nlm.nih.gov/32902275

المؤلفون: Gregory J. Tawa, Richard Stone, Amy Wang, Gurmit Grewal, Ashish Thakur, Suiyang Liu, Xin Xu, Carina Danchik, Elias C. Padilha, Pranav Shah, Anton Simeonov, Surender Kharbanda, Kabir, Garrett Dunn, Mark J. Henderson

المصدر: J Med Chem

مصطلحات موضوعية: Thermal shift assay, Drug Evaluation, Preclinical, Hydroxamic Acids, 01 natural sciences, Article, 03 medical and health sciences, Mice, Phosphatidylinositol 3-Kinases, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Cytotoxicity, IC50, 030304 developmental biology, Phosphoinositide-3 Kinase Inhibitors, Quinazolinones, chemistry.chemical_classification, 0303 health sciences, Mice, Inbred BALB C, Chemistry, In vitro, 0104 chemical sciences, Protein Structure, Tertiary, Rats, Histone Deacetylase Inhibitors, 010404 medicinal & biomolecular chemistry, Enzyme, HEK293 Cells, Biochemistry, Cell culture, Drug Design, Molecular Medicine, Female, Pharmacophore

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9ffbdc8bfa071c84860ca39d9c7e49
https://europepmc.org/articles/PMC7238858/

المؤلفون: Marc Singleton, Kelly A. Rice, Kylie M. Konrath, Samarjit Patnaik, Dandan Li, Amy Wang, Udo Rudloff, Elias C. Padilha, Juan J. Marugan, Xin Xu, Pranav Shah, Emma Hughes

المصدر: Cancer Chemother Pharmacol

مصطلحات موضوعية: 0301 basic medicine, Male, Cancer Research, Swine, Drug Evaluation, Preclinical, Administration, Oral, Pharmacology, Toxicology, Article, Excretion, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, 0302 clinical medicine, Dogs, Pharmacokinetics, Cytochrome P-450 Enzyme System, Species Specificity, In vivo, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Pharmacology (medical), Drug Interactions, Pyrroles, Tissue Distribution, Biotransformation, ADME, Volume of distribution, CYP3A4, Chemistry, Haplorhini, Bioavailability, Rats, Mice, Inbred C57BL, 030104 developmental biology, Pyrimidines, Oncology, 030220 oncology & carcinogenesis, Microsomes, Liver, Swine, Miniature, Female, Drug metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82bcbf45d67dea8dba324f3a8464f63a
https://pubmed.ncbi.nlm.nih.gov/32185484

المؤلفون: Ganesha Rai, Elias C. Padilha, Xin Xu, Pranav Shah

المصدر: J Pharm Biomed Anal

مصطلحات موضوعية: Metabolite, Clinical Biochemistry, Aminopyridines, Pharmaceutical Science, 01 natural sciences, Article, Analytical Chemistry, Mice, chemistry.chemical_compound, Drug Discovery, Animals, Aldehyde oxidase, Spectroscopy, chemistry.chemical_classification, Sulfonamides, Reactive oxygen species, NADPH oxidase, biology, 010405 organic chemistry, Superoxide, 010401 analytical chemistry, NADPH Oxidases, Metabolism, Rats, 0104 chemical sciences, Cytosol, Enzyme, Pharmaceutical Preparations, chemistry, Biochemistry, biology.protein, Reactive Oxygen Species

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37fc552130924e8aa479b21061aa422e
https://doi.org/10.1016/j.jpba.2021.114102

المؤلفون: Elias C, Padilha, Jianyao, Wang, Ed, Kerns, Arthur, Lee, Wenwei, Huang, Jian-Kang, Jiang, John, McKew, Abdul, Mutlib, Rosangela G, Peccinini, Paul B, Yu, Philip, Sanderson, Xin, Xu

المصدر: Frontiers in Pharmacology

مصطلحات موضوعية: Pharmacology, reactive metabolite, metabolite identification, fibrodysplasia ossificans progressiva, structure optimization, Original Research, aldehyde oxidase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::c6f1687efd66744e2b0dc58ad5c10312
https://pubmed.ncbi.nlm.nih.gov/31068801

المؤلفون: Elias C. Padilha, Jianyao Wang, Ed Kerns, Arthur Lee, Wenwei Huang, Jian-kang Jiang, John McKew, Abdul Mutlib, Rosangela G. Peccinini, Paul B. Yu, Philip Sanderson, Xin Xu

مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, metabolite identification, fibrodysplasia ossificans progressiva, structure optimization, aldehyde oxidase, reactive metabolite

Relation: https://figshare.com/articles/dataset/Table_1_Application_of_in_vitro_Drug_Metabolism_Studies_in_Chemical_Structure_Optimization_for_the_Treatment_of_Fibrodysplasia_Ossificans_Progressiva_FOP_DOCX/8033351

الاتاحة: https://doi.org/10.3389/fphar.2019.00234.s001
https://figshare.com/articles/dataset/Table_1_Application_of_in_vitro_Drug_Metabolism_Studies_in_Chemical_Structure_Optimization_for_the_Treatment_of_Fibrodysplasia_Ossificans_Progressiva_FOP_DOCX/8033351