المؤلفون: Spiwoková, Petra, Horn, Martin, Fanfrlík, Jindřich, Jílková, Adéla, Fajtová, Pavla, Leontovyč, Adrian, Houštecká, Radka, Bieliková, Lucia, Brynda, Jiří, Chanová, Marta, Mertlíková-Kaiserová, Helena, Caro-Diaz, Eduardo, Almaliti, Jehad, El-Sakkary, Nelly, Gerwick, William, Caffrey, Conor, Mareš, Michael

المصدر: ACS Infectious Diseases. 10(6)

مصطلحات موضوعية: Schistosoma mansoni, acrylamide inhibitor, cathepsin B, cysteine protease, drug target, parasite, Cathepsin B, Animals, Schistosoma mansoni, Crystallography, X-Ray, Schistosomicides, Protein Binding, Models, Molecular

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/29t9q2g4
https://escholarship.org/content/qt29t9q2g4/qt29t9q2g4.pdf

المؤلفون: Monti, Ludovica, Cornec, Anne-Sophie, Oukoloff, Killian, Kovalevich, Jane, Prijs, Kristen, Alle, Thibault, Brunden, Kurt R, Smith, Amos B, El-Sakkary, Nelly, Liu, Lawrence J, Syed, Ali, Skinner, Danielle E, Ballatore, Carlo, Caffrey, Conor R

المصدر: ACS Infectious Diseases. 7(5)

مصطلحات موضوعية: Rare Diseases, Neurosciences, Orphan Drug, Vector-Borne Diseases, Infectious Diseases, Digestive Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Infection, Good Health and Well Being, Animals, Humans, Microtubules, Paralysis, Schistosoma mansoni, Structure-Activity Relationship, Schistosomiasis, parasite, drug discovery, tubulin, phenylpyrimidines, structure-activity relationship, structure−activity relationship, Medical Microbiology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0jc824t0

المؤلفون: Probst, Alexandra, Häberli, Cécile, Siegel, Dionicio, Huang, Jianbo, Vigneron, Seth, Ta, Anh P, Skinner, Danielle E, El-Sakkary, Nelly, Momper, Jeremiah D, Gangoiti, Jon, Dong, Yuxiang, Vennerstrom, Jonathan L, Charman, Susan A, Caffrey, Conor R, Keiser, Jennifer

المصدر: Journal of Antimicrobial Chemotherapy. 75(10)

مصطلحات موضوعية: Rare Diseases, Vector-Borne Diseases, Infectious Diseases, Digestive Diseases, Infection, Good Health and Well Being, Acridines, Animals, Cricetinae, Hydrazones, Mice, Schistosoma mansoni, Schistosomiasis mansoni, Schistosomicides, Microbiology, Medical Microbiology, Pharmacology and Pharmaceutical Sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9zf2j4g6

المؤلفون: El-Sakkary, Nelly

Thesis Advisors: Paula Ribeiro (Supervisor)

مصطلحات موضوعية: Parasitology

Relation: Pid: 146792

الاتاحة: https://escholarship.mcgill.ca/concern/theses/bg257h47d

المؤلفون: Bibo-Verdugo, Betsaida, Wang, Steven C, Almaliti, Jehad, Ta, Anh P, Jiang, Zhenze, Wong, Derek A, Lietz, Christopher B, Suzuki, Brian M, El-Sakkary, Nelly, Hook, Vivian, Salvesen, Guy S, Gerwick, William H, Caffrey, Conor R, O’Donoghue, Anthony J

المصدر: ACS Infectious Diseases. 5(10)

مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Rare Diseases, Infectious Diseases, Vector-Borne Diseases, Digestive Diseases, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Good Health and Well Being, Animals, Antineoplastic Agents, Bortezomib, Caspases, Cysteine Proteinase Inhibitors, Drug Delivery Systems, Hep G2 Cells, Humans, Leupeptins, Oligopeptides, Proteasome Endopeptidase Complex, Proteasome Inhibitors, Schistosoma mansoni, proteasome, Schistosoma, schistosomiasis, bortezomib, catfilzomib, carmaphycin, MG132, carfilzomib, Medical microbiology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/15g414tw

المؤلفون: Probst, Alexandra, Nguyen, Thi, El-Sakkary, Nelly, Skinner, Danielle, Suzuki, Brian, Buckner, Frederick, Gelb, Michael, Caffrey, Conor, Debnath, Anjan

مصطلحات موضوعية: Entamoeba histolytica, Schistosoma mansoni, chemotherapy, farnesyltransferase, lonafarnib, metronidazole, statin, tipifarnib, Amebiasis, Animals, Biomphalaria, Cell Survival, Disease Models, Animal, Drug Evaluation, Preclinical, Drug Synergism, Drug Therapy, Entamoeba histolytica, Farnesyltranstransferase, Female, Metronidazole, Piperidines, Pyridines, Quinolones, Schistosoma mansoni, Trypanosoma brucei brucei, Trypanosoma cruzi

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4qr742hc
https://escholarship.org/content/qt4qr742hc/qt4qr742hc.pdf

المؤلفون: Long, Thavy, Rojo-Arreola, Liliana, Shi, Da, El-Sakkary, Nelly, Jarnagin, Kurt, Rock, Fernando, Meewan, Maliwan, Rascón, Alberto A, Lin, Lin, Cunningham, Katherine A, Lemieux, George A, Podust, Larissa, Abagyan, Ruben, Ashrafi, Kaveh, McKerrow, James H, Caffrey, Conor R

المصدر: PLoS neglected tropical diseases. 11(7)

مصطلحات موضوعية: Animals, Animals, Genetically Modified, Caenorhabditis elegans, Schistosoma mansoni, Anthelmintics, Cloning, Molecular, Catalytic Domain, Locomotion, Cyclic Nucleotide Phosphodiesterases, Type 4, Phosphodiesterase 4 Inhibitors, Orphan Drug, Biotechnology, Rare Diseases, Infectious Diseases, Genetics, Vector-Borne Diseases, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Tropical Medicine, Biological Sciences, Medical and Health Sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/37t2q5gm

المؤلفون: Yeh, Yi-Ting, Skinner, Danielle E., Criado-Hidalgo, Ernesto, Chen, Natalie Shee, Garcia-De Herreros, Antoni, El-Sakkary, Nelly, Liu, Lawrence, Zhang, Shun, Kandasamy, Adithan, Chien, Shu, Lasheras, Juan C., del Álamo, Juan C., Caffrey, Conor R.

المساهمون: Hsieh, Michael H., Bill and Melinda Gates Foundation, National Institute of General Medical Sciences, National Science Foundation, Fundación Bancaria ”la Caixa”, “la Caixa” Foundation, American Heart Association, National Institute of Allergy and Infectious Diseases

المصدر: PLOS Pathogens ; volume 18, issue 3, page e1010309 ; ISSN 1553-7374

الاتاحة: http://dx.doi.org/10.1371/journal.ppat.1010309
https://dx.plos.org/10.1371/journal.ppat.1010309

المؤلفون: Badoco, Fernanda R., Paula, Lucas A.L., Orenha, Renato P., Mendes, Tiago M.F., Squarisi, Iara S., El-Sakkary, Nelly, Loiola, Messias C., Katz, Naftale, Tavares, Denise C., Sairre, Mirela I., Parreira, Renato Luis T., Janku Cabral, Fernanda, Alegretti, Silmara M., Caffrey, Conor R., Magalhães, Lizandra G.

المصدر: Chemico-Biological Interactions ; volume 368, page 110191 ; ISSN 0009-2797

الاتاحة: http://dx.doi.org/10.1016/j.cbi.2022.110191
https://api.elsevier.com/content/article/PII:S0009279722003969?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0009279722003969?httpAccept=text/plain

المؤلفون: Mathavan, Indran, Liu, Lawrence J., Robinson, Sean W., El-Sakkary, Nelly, Elatico, Adam Jo J., Gomez, Darwin, Nellas, Ricky, Owens, Raymond J., Zuercher, William, Navratilova, Iva, Caffrey, Conor R., Beis, Konstantinos

المساهمون: Medical Research Council, National Institute of Allergy and Infectious Diseases

المصدر: ACS Medicinal Chemistry Letters ; volume 13, issue 11, page 1715-1722 ; ISSN 1948-5875 1948-5875

الاتاحة: http://dx.doi.org/10.1021/acsmedchemlett.2c00248
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00248

المؤلفون: Padalino, Gilda, El-Sakkary, Nelly, Liu, Lawrence J., Liu, Chenxi, Harte, Danielle S.G., Barnes, Rachel E., Sayers, Edward, Forde-Thomas, Josephine, Whiteland, Helen, Bassetto, Marcella, Ferla, Salvatore, Johnson, George, Jones, Arwyn T., Caffrey, Conor R., Chalmers, Iain, Brancale, Andrea, Hoffmann, Karl F.

وصف الملف: application/pdf

Relation: https://orca.cardiff.ac.uk/id/eprint/144330/3/Anti-schistosomal%20activities%20of%20quinoxaline-containing%20compounds-%20from%20hit%20identification%20to%20lead%20optimisation.pdf; Padalino, Gilda https://orca.cardiff.ac.uk/view/cardiffauthors/A27145397.html, El-Sakkary, Nelly, Liu, Lawrence J., Liu, Chenxi, Harte, Danielle S.G., Barnes, Rachel E., Sayers, Edward https://orca.cardiff.ac.uk/view/cardiffauthors/A1147882.html orcid:0000-0002-2621-1119 orcid:0000-0002-2621-1119, Forde-Thomas, Josephine, Whiteland, Helen, Bassetto, Marcella https://orca.cardiff.ac.uk/view/cardiffauthors/A152466O.html, Ferla, Salvatore, Johnson, George, Jones, Arwyn T. https://orca.cardiff.ac.uk/view/cardiffauthors/A009296R.html orcid:0000-0003-2781-8905 orcid:0000-0003-2781-8905, Caffrey, Conor R., Chalmers, Iain, Brancale, Andrea https://orca.cardiff.ac.uk/view/cardiffauthors/A040319Q.html orcid:0000-0002-9728-3419 orcid:0000-0002-9728-3419 and Hoffmann, Karl F. 2021. Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. European Journal of Medicinal Chemistry 226 , 113823. 10.1016/j.ejmech.2021.113823 https://doi.org/10.1016/j.ejmech.2021.113823 file https://orca.cardiff.ac.uk/id/eprint/144330/3/Anti-schistosomal%20activities%20of%20quinoxaline-containing%20compounds-%20from%20hit%20identification%20to%20lead%20optimisation.pdf

الاتاحة: https://orca.cardiff.ac.uk/id/eprint/144330/
https://doi.org/10.1016/j.ejmech.2021.113823
https://orca.cardiff.ac.uk/id/eprint/144330/3/Anti-schistosomal%20activities%20of%20quinoxaline-containing%20compounds-%20from%20hit%20identification%20to%20lead%20optimisation.pdf

المؤلفون: Zorn, Kimberley M., Sun, Shengxi, McConnon, Cecelia L., Ma, Kelley, Chen, Eric K., Foil, Daniel H., Lane, Thomas R., Liu, Lawrence J., El-Sakkary, Nelly, Skinner, Danielle E., Ekins, Sean, Caffrey, Conor R.

المساهمون: National Institute of Allergy and Infectious Diseases, Bill and Melinda Gates Foundation, National Institute of General Medical Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development

المصدر: ACS Infectious Diseases ; volume 7, issue 2, page 406-420 ; ISSN 2373-8227 2373-8227

الاتاحة: http://dx.doi.org/10.1021/acsinfecdis.0c00754
http://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.0c00754
https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.0c00754

المؤلفون: Buskes, Melissa J., Clements, Monica, Bachovchin, Kelly A., Jalani, Hitesh B., Leonard, Allison, Bag, Seema, Klug, Dana M., Singh, Baljinder, Campbell, Robert F., Sciotti, Richard J., El-Sakkary, Nelly, Caffrey, Conor R., Pollastri, Michael P., Ferrins, Lori

المساهمون: National Institute of Allergy and Infectious Diseases, Bill and Melinda Gates Foundation, South African Agency for Science and Technology Advancement

المصدر: ACS Medicinal Chemistry Letters ; volume 11, issue 3, page 258-265 ; ISSN 1948-5875 1948-5875

الاتاحة: http://dx.doi.org/10.1021/acsmedchemlett.9b00455
http://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00455
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00455

المؤلفون: El-Sakkary, Nelly, Chen, Steven, Arkin, Michelle R., Caffrey, Conor R., Ribeiro, Paula

مصطلحات موضوعية: RESEARCH ARTICLE

وصف الملف: text/html

Relation: http://dmm.biologists.org/cgi/content/short/11/7/dmm033563; http://dx.doi.org/10.1242/dmm.033563

الاتاحة: http://dmm.biologists.org/cgi/content/short/11/7/dmm033563
https://doi.org/10.1242/dmm.033563

المؤلفون: Klug, Dana M., Mavrogiannaki, Eftychia M., Forbes, Katherine C., Silva, Lisseth, Díaz-González, Rosario, Pérez-Moreno, Guiomar, Ceballos-Pérez, Gloria, García-Hernández, Raquel, Bosch-Navarrete, Cristina, Cordon-Obras, Carlos, Gómez-Liñán, Claudia, Saura, Andreu, Momper, Jeremiah D., Martínez-Martínez, María S., Manzano, Miguel, Syed, Ali Asgher, El-Sakkary, Nelly, Caffrey, Conor R., Gamarro, Francisco, Ruiz-Pérez, Luis Miguel, González Pacanowska, Dolores, Ferrins, L, Navarro, Miquel, Pollastri, M.P.

المساهمون: Instituto Nacional de Alergias y Enfermedades Infecciosas, Ministerio de Economía, Industria y Competitividad (España), National Science Foundation for K.F., Subdireccion General de Redes ́ y Centros de Investigacion Cooperativa (RICET

Relation: Publisher's version; http://dx.doi.org/10.1021/acs.jmedchem.1c00674; Sí; Journal of Medicinal Chemistry 64: 9404- 9430 (2021); http://hdl.handle.net/10261/359703

الاتاحة: http://hdl.handle.net/10261/359703
https://doi.org/10.1021/acs.jmedchem.1c00674

المؤلفون: Instituto Nacional de Alergias y Enfermedades Infecciosas, Ministerio de Economía, Industria y Competitividad (España), National Science Foundation for K.F., Subdireccion General de Redes ́ y Centros de Investigacion Cooperativa (RICET, Klug, Dana M., Mavrogiannaki, Eftychia M., Forbes, Katherine C., Silva, Lisseth, Díaz-González, Rosario, Pérez-Moreno, Guiomar, Ceballos-Pérez, Gloria, García-Hernández, Raquel, Bosch-Navarrete, Cristina, Cordon-Obras, Carlos, Gómez-Liñán, Claudia, Saura, Andreu, Momper, Jeremiah D., Martínez-Martínez, María S., Manzano, Miguel, Syed, Ali Asgher, El-Sakkary, Nelly, Caffrey, Conor R., Gamarro, Francisco, Ruiz-Pérez, Luis Miguel, González Pacanowska, Dolores, Ferrins, L, Navarro, Miquel, Pollastri, M.P.

مصطلحات الفهرس: artículo

URL: http://hdl.handle.net/10261/359703
Publisher's version
http://dx.doi.org/10.1021/acs.jmedchem.1c00674
Sí

المؤلفون: El-Shehabi, Fouad, Taman, Amira, Moali, Lorena S., El-Sakkary, Nelly, Ribeiro, Paula

المساهمون: Aksoy, Serap

المصدر: PLoS Neglected Tropical Diseases ; volume 6, issue 2, page e1523 ; ISSN 1935-2735

الاتاحة: http://dx.doi.org/10.1371/journal.pntd.0001523
http://dx.plos.org/10.1371/journal.pntd.0001523

المؤلفون: Monti, Ludovica, Cornec, Anne-Sophie, Oukoloff, Killian, Kovalevich, Jane, Prijs, Kristen, Alle, Thibault, Brunden, Kurt R., Smith, Amos B., El-Sakkary, Nelly, Liu, Lawrence J., Syed, Ali, Skinner, Danielle E., Ballatore, Carlo, Caffrey, Conor R.

المساهمون: National Institute of Allergy and Infectious Diseases

المصدر: ACS Infectious Diseases ; volume 7, issue 5, page 1089-1103 ; ISSN 2373-8227 2373-8227

الاتاحة: http://dx.doi.org/10.1021/acsinfecdis.0c00508
https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.0c00508

المؤلفون: Zorn, Kimberley M, Chen, Eric K, Mcconnon, Cecelia L, Shengxi Sun, El-Sakkary, Nelly, Wang, Steven C, Clark, Alex, Caffrey, Conor R, Ekins, Sean

الاتاحة: https://dx.doi.org/10.13140/rg.2.2.20256.43527
http://rgdoi.net/10.13140/RG.2.2.20256.43527

المؤلفون: Ribeiro, Paula, Gupta, Vandana, El-Sakkary, Nelly

المصدر: Invertebrate Neuroscience ; volume 12, issue 1, page 13-28 ; ISSN 1354-2516 1439-1104

الاتاحة: http://dx.doi.org/10.1007/s10158-012-0132-y
http://link.springer.com/content/pdf/10.1007/s10158-012-0132-y.pdf
http://link.springer.com/article/10.1007/s10158-012-0132-y/fulltext.html
http://link.springer.com/content/pdf/10.1007/s10158-012-0132-y