المؤلفون: Vera Kovaleva, Li-Ying Yu, Larisa Ivanova, Olesya Shpironok, Jinhan Nam, Ave Eesmaa, Esa-Pekka Kumpula, Sven Sakson, Urve Toots, Mart Ustav, Juha T. Huiskonen, Merja H. Voutilainen, Päivi Lindholm, Mati Karelson, Mart Saarma

المصدر: Cell Reports, Vol 42, Iss 2, Pp 112066- (2023)

مصطلحات موضوعية: CP: Neuroscience, CP: Molecular biology, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723000773; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/5219a8ab6680491fa637a30370d90b44

المؤلفون: Kovaleva, Vera, Yu, Li-Ying, Ivanova, Larisa, Shpironok, Olesya, Nam, Jinhan, Eesmaa, Ave, Kumpula, Esa-Pekka, Sakson, Sven, Toots, Urve, Ustav, Mart, Huiskonen, Juha T., Voutilainen, Merja H., Lindholm, Päivi, Karelson, Mati, Saarma, Mart

المساهمون: Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, Division of Pharmacology and Pharmacotherapy, Regenerative Neuroscience, Laboratory of Structural Biology, Molecular and Integrative Biosciences Research Programme, Helsinki Institute of Sustainability Science (HELSUS), Drug Research Program, Divisions of Faculty of Pharmacy, Mart Saarma / Principal Investigator

مصطلحات موضوعية: Neurosciences, Endoplasmic-reticulum stress, Unfolded protein response, Neurotrophic factor, Transmembrane protein, Kappa-b, Beta, Activation, Model, Proliferation, Homeostasis

وصف الملف: application/pdf

Relation: http://hdl.handle.net/10138/354614; 85149750137; 000931679000001

الاتاحة: http://hdl.handle.net/10138/354614

المؤلفون: Ave Eesmaa, Li-Ying Yu, Helka Göös, Tatiana Danilova, Kristofer Nõges, Emmi Pakarinen, Markku Varjosalo, Maria Lindahl, Päivi Lindholm, Mart Saarma

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 9489

مصطلحات موضوعية: CDNF, neurotrophic factor, ER stress, unfolded protein response, dopamine neurons, sympathetic neurons, apoptosis, protein–protein interactions, mechanism of action

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Neurobiology; https://dx.doi.org/10.3390/ijms23169489

الاتاحة: https://doi.org/10.3390/ijms23169489

المؤلفون: Garea-Rodríguez, Enrique, Eesmaa, Ave, Lindholm, Päivi K, Schlumbohm, Christina, König, Jessica, Meller, Birgit, Krieglstein, Kerstin, Helms, Gunther, Saarma, Mart, Fuchs, Eberhard

المصدر: PLoS ONE. 11(2):1-21

مصطلحات موضوعية: Medicin och hälsovetenskap, Medicinsk bioteknologi, Biomedicinsk laboratorievetenskap/teknologi, Medical and Health Sciences, Medical Biotechnology, Biomedical Laboratory Science/Technology, Medicinska och farmaceutiska grundvetenskaper, Farmakologi och toxikologi, Basic Medicine, Pharmacology and Toxicology, Naturvetenskap, Fysik, Annan fysik, Natural Sciences, Physical Sciences, Other Physics Topics

وصف الملف: electronic

URL الوصول: https://lup.lub.lu.se/record/8772474
https://portal.research.lu.se/files/4080792/8772498.PDF
http://dx.doi.org/10.1371/journal.pone.0149776

المؤلفون: Albert K, Raymundo DP, Panhelainen A, Eesmaa A, Shvachiy L, Araujo GR, Chmielarz P, Yan X, Singh A, Cordeiro Y, Palhano FL, Foguel D, Luk KC, Domanskyi A, Voutilainen MH, Huttunen HJ, Outeiro TF, Saarma M, Almeida MS, Airavaara M

المصدر: Molecular Therapy, 2021

وصف الملف: application/pdf

Relation: https://eprints.ncl.ac.uk/275504; https://eprints.ncl.ac.uk/fulltext.aspx?url=275504/EECCE016-F10E-40BD-9465-6F16D72396F1.pdf&pub_id=275504

الاتاحة: https://eprints.ncl.ac.uk/275504

المؤلفون: Albert, Katrina, Raymundo, Diana P., Panhelainen, Anne, Eesmaa, Ave, Shvachiy, Liana, Araujo, Gabriela R., Chmielarz, Piotr, Yan, Xu, Singh, Aastha, Cordeiro, Yraima, Palhano, Fernando L., Foguel, Debora, Luk, Kelvin C., Domanskyi, Andrii, Voutilainen, Merja H., Huttunen, Henri J., Outeiro, Tiago F., Saarma, Mart, Almeida, Marcius S., Airavaara, Mikko

المساهمون: Regenerative Neuroscience, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, Divisions of Faculty of Pharmacy, Helsinki One Health (HOH), Neuroscience Center, Biosciences, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Henri Juhani Huttunen / Principal Investigator, Mart Saarma / Principal Investigator

مصطلحات موضوعية: UNFOLDED PROTEIN RESPONSE, TO-NEURON TRANSMISSION, LEWY BODY, PARKINSONS-DISEASE, BRAIN PATHOLOGY, FACTOR CDNF, FIBRILS, OLIGOMERS, SECRETION, TOXICITY, Neurosciences, Pharmacy

وصف الملف: application/pdf

Relation: K.A. was supported by the Finnish Parkinson's Foundation, the Finnish Cultural Foundation, and the Ella and Georg Ehrnrooth Foundation. D.P.R. was supported by the National Council for Scientific and Technological Development (CNPq), Fundacao de Amparo a Pesquisa do Rio de Janeiro (FAPERJ), and Deutscher Akademischer Austauschdienst (DAAD). A.P. was funded by the Jane and Aatos Erkko Foundation. M.H.V. was funded by the Jane and Aatos Erkko Foundation, the Finnish Parkinson Foundation, and the Academy of Finland (grants 126744, 309708, and 314233). A.D. was funded by the Academy of Finland (grants 293392 and 319195) and the Paivikki and Sakari Sohlberg Foundation. H.J.H. has received funding from the Academy of Finland (grant 296409). T.F.O. is supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy (grant EXC 2067/1390729940). M.S., A.E., and A.S. were funded by the Jane and Aatos Erkko Foundation and the Academy of Finland (grant 1310891). M.A. was supported by the Academy of Finland (grants 256398, 250275, and 309489), Instrumentarium Science Foundation, and Sigrid Juselius Foundation. M.S.A. is supported by Capes-Print, CNPq, and FAPERJ. M.A. & M.S. were supported by The Michael J. Fox Foundation for Parkinson's Research.; Albert , K , Raymundo , D P , Panhelainen , A , Eesmaa , A , Shvachiy , L , Araujo , G R , Chmielarz , P , Yan , X , Singh , A , Cordeiro , Y , Palhano , F L , Foguel , D , Luk , K C , Domanskyi , A , Voutilainen , M H , Huttunen , H J , Outeiro , T F , Saarma , M , Almeida , M S & Airavaara , M 2021 , ' Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo ' , Molecular therapy , vol. 29 , no. 9 , pp. 2821-2840 . https://doi.org/10.1016/j.ymthe.2021.04.035; ORCID: /0000-0002-9867-4438/work/100256278; ORCID: /0000-0002-2026-1609/work/100257019; ORCID: /0000-0001-5543-7160/work/100258884; ORCID: /0000-0003-1802-3625/work/150691363; http://hdl.handle.net/10138/334463; b51a571d-5d7e-4943-a90a-8332a77e0e91; 000692597100005

الاتاحة: http://hdl.handle.net/10138/334463

المؤلفون: Eesmaa, Ave, Yu, Li-Ying, Göös, Helka, Nõges, Kristofer, Kovaleva, Vera, Hellman, Maarit, Zimmermann, Richard, Jung, Martin, Permi, Perttu, Varjosalo, Markku, Lindholm, Paivi, Saarma, Mart

المساهمون: Institute of Biotechnology, Molecular Systems Biology, Biosciences, Mart Saarma / Principal Investigator

مصطلحات موضوعية: ENDOPLASMIC-RETICULUM STRESS, NEUROTROPHIC FACTOR MANF, ER-STRESS, COMPREHENSIVE RESOURCE, BIP, BINDING, ATF6, ATP, DISSOCIATION, IRE1-ALPHA, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: This work was funded by Jane and Aatos Erkko Foundation, Academy of Finland (grant 1310891) and European Union H2020 project "TreatER" (No 732386).; Eesmaa , A , Yu , L-Y , Göös , H , Nõges , K , Kovaleva , V , Hellman , M , Zimmermann , R , Jung , M , Permi , P , Varjosalo , M , Lindholm , P & Saarma , M 2021 , ' The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor ' , Journal of Biological Chemistry , vol. 296 , 100295 . https://doi.org/10.1016/j.jbc.2021.100295; ORCID: /0000-0003-3022-5035/work/101724452; ORCID: /0000-0002-1340-9732/work/101725040; ORCID: /0000-0002-6175-4872/work/101725797; ORCID: /0000-0001-5543-7160/work/101727176; http://hdl.handle.net/10138/335440; ea4b6708-8220-4b58-a2ba-ea4c8c740cf5; 000672866400269

الاتاحة: http://hdl.handle.net/10138/335440

المؤلفون: Yagi, Takuya, Asada, Rie, Kanekura, Kohsuke, Eesmaa, Ave, Lindahl, Maria, Saarma, Mart, Urano, Fumihiko

المساهمون: Institute of Biotechnology

مصطلحات موضوعية: ENDOPLASMIC-RETICULUM STRESS, UNFOLDED PROTEIN RESPONSE, THIOREDOXIN-INTERACTING PROTEIN, NEUROTROPHIC FACTOR, KEY REGULATORS, CELL-DEATH, BETA-CELLS, ER, IDENTIFICATION, INSULIN, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: This work was partly supported by the grants from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) (DK112921), the National Center for Advancing Translational Sciences (NCATS) of the NIH (TR002065), and philanthropic supports from the Unravel Wolfram Syndrome Fund, the Silberman Fund, the Stowe Fund, the Snow Foundation, the Eye Hope Foundation, the Ellie White Foundation for the Rare Genetic Disorders, and the Feiock Fund to F. U. Research reported in this publication was also supported by the Washington University Institute of Clinical and Translational Sciences grant UL1TR002345 from NCATS of the NIH and Washington University Diabetes Research Center grant P30DK020579 from the NIDDK of the NIH. The content is solely the responsibility of the authors and does not necessarily represent the official view of the NIH. T.Y. was partly supported by fellowships from the Japan Society for the Promotion of Science, the Uehara Memorial Foundation, and the Kanae Foundation. We thank Dr. Karl-Heinz Smalla (Leibniz Institute for Neurobiology) for providing Np55-EGFP and Np65-EGFP.; Yagi , T , Asada , R , Kanekura , K , Eesmaa , A , Lindahl , M , Saarma , M & Urano , F 2020 , ' Neuroplastin Modulates Anti-inflammatory Effects of MANF ' , iScience , vol. 23 , no. 12 , 101810 . https://doi.org/10.1016/j.isci.2020.101810; ORCID: /0000-0002-5674-8830/work/89115189; ORCID: /0000-0001-5543-7160/work/89117943; http://hdl.handle.net/10138/326450; 19bd0ea2-d348-4827-b59b-20977d3ba2d7; 000600670000056

الاتاحة: http://hdl.handle.net/10138/326450

المؤلفون: Takuya Yagi, Rie Asada, Kohsuke Kanekura, Ave Eesmaa, Maria Lindahl, Mart Saarma, Fumihiko Urano

المصدر: iScience, Vol 23, Iss 12, Pp 101810- (2020)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Cell Biology, Science

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004220310075; https://doaj.org/toc/2589-0042

URL الوصول: https://doaj.org/article/45fd4ed484f446d8996fccda110cb797

المؤلفون: Eesmaa, Heiki

المساهمون: Karton, Inga, juhendaja, Tartu Ülikool. Sotsiaalteaduste valdkond, Tartu Ülikool. Psühholoogia instituut

مصطلحات موضوعية: motiveeriv intervjueerimine, standardpatsient, simulatsioon, arstitudeng, MITI kodeerimissüsteem, motivational interviewing, standardized patient, simulation, medical student, pre and post training assessment, Motivational Interviewing Treatment Integrity, üliõpilastööd

وصف الملف: application/pdf

Relation: https://hdl.handle.net/10062/95288

الاتاحة: https://hdl.handle.net/10062/95288

المؤلفون: Eesmaa, Ave, Yu, Li-Ying, Göös, Helka, Danilova, Tatiana, Nõges, Kristofer, Pakarinen, Emmi, Varjosalo, Markku, Lindahl, Maria, Lindholm, Päivi, Saarma, Mart

وصف الملف: application/pdf

Relation: Eesmaa, A.; Yu, L.-Y.; Göös, H.; Danilova, T.; Nõges, K.; Pakarinen, E.; Varjosalo, M.; Lindahl, M.; Lindholm, P.; Saarma, M. CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival. Int. J. Mol. Sci. 2022, 23, 9489.; http://hdl.handle.net/10138/349434

الاتاحة: http://hdl.handle.net/10138/349434

المؤلفون: Eesmaa, Hele

المساهمون: Nõmper, Ants, juhendaja, Sein, Karin, juhendaja, Tartu Ülikool. Sotsiaalteaduste valdkond, Tartu Ülikool. Õigusteaduskond, Tartu Ülikool

مصطلحات موضوعية: enesemääramisõigus, ravisoostumus, asendusotsustaja, võrguväljaanded, tulevikujuhised, meditsiiniõigus, ravist keeldumine, elu pikendamine, patsiendi elulõpu tahteavaldus, surma edasilükkamine, meditsiinieetika, tahteavaldus, patsiendi õigused, autonoomia, magistritööd, otsusevõimetus, põhiõigused

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______1018::dd78de16dca81b0c65b6463e59cd8d7b
http://hdl.handle.net/10062/82451

المؤلفون: Mätlik, K., Yu, Li-ying, Eesmaa, A., Hellman, M., Lindholm, P., Peränen, J., Galli, E., Anttila, J., Saarma, M., Permi, Perttu, Airavaara, M., Arumäe, U.

مصطلحات موضوعية: prosurvival proteins, mesencephalic astrocyte-derived neurotrophic factor

وصف الملف: application/pdf

Relation: Cell Death and Disease; 12; CONVID_25529377

الاتاحة: http://urn.fi/URN:NBN:fi:jyu-201604202254

المؤلفون: Mätlik, K, Yu, Li-ying, Eesmaa, A, Hellman, M, Lindholm, P, Peränen, J, Galli, E, Anttila, J, Saarma, M, Permi, P, Airavaara, M, Arumäe, U

المصدر: Cell Death & Disease ; volume 6, issue 12, page e2032-e2032 ; ISSN 2041-4889

الاتاحة: http://dx.doi.org/10.1038/cddis.2015.371
https://www.nature.com/articles/cddis2015371.pdf
https://www.nature.com/articles/cddis2015371

المؤلفون: Vera Kovaleva, Richard Zimmermann, Mart Saarma, Maarit Hellman, Li-Ying Yu, Helka Göös, Päivi Lindholm, Perttu Permi, Ave Eesmaa, Kristofer Nõges, Martin Jung, Markku Varjosalo

المساهمون: Institute of Biotechnology, Molecular Systems Biology, Biosciences, Mart Saarma / Principal Investigator

المصدر: Journal of Biological Chemistry
The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, BiFC, bimolecular fluorescence complementation, MST, microscale thermophoresis, PDIA1, protein disulfide isomerase family A member 1, Apoptosis, NEUROTROPHIC FACTOR MANF, Endoplasmic Reticulum, Biochemistry, protein-protein interaction, Mice, Bimolecular fluorescence complementation, UPR, unfolded protein response, ENDOPLASMIC-RETICULUM STRESS, Mesencephalon, Neurotrophic factors, Insulin-Secreting Cells, Protein Interaction Mapping, BINDING, COMPREHENSIVE RESOURCE, ATF6, unfolded protein response (UPR), PDIA6, protein disulfide isomerase family A member 6, PPIs, protein-protein interactions, Endoplasmic Reticulum Chaperone BiP, Heat-Shock Proteins, NPTN, neuroplastin, biology, Chemistry, apoptosis, unfolded protein response, dopamine neurons, 3. Good health, Cell biology, GDNF, glial cell line–derived neurotrophic factor, IRE1-ALPHA, SBD, substrate-binding domain, endoplasmic reticulum stress, MANF, mesencephalic astrocyte-derived neurotrophic factor, Tm, tunicamycin, neuroprotection, Research Article, Protein Binding, Signal Transduction, GRP78, Protein Disulfide-Isomerase Family, Cell Survival, TH, tyrosine hydroxylase, Primary Cell Culture, SCG, superior cervical ganglion, Protein Disulfide-Isomerases, IRE1, inositol-requiring enzyme 1, ER-STRESS, ER, endoplasmic reticulum, 03 medical and health sciences, ohjelmoitunut solukuolema, C-MANF, C-terminal domain of MANF, CSPs, chemical shift perturbations, Animals, Humans, HSP70 Heat-Shock Proteins, Nerve Growth Factors, NBD, nucleotide-binding domain, NMR, nuclear magnetic resonance, Molecular Biology, 030102 biochemistry & molecular biology, BIP, Dopaminergic Neurons, Gene Expression Profiling, Binding protein, neuronal cell death, DISSOCIATION, Cell Biology, NEI, nucleotide exchange inhibitor, Embryo, Mammalian, adenosiinitrifosfaatti, ATP, hermosolut, mesencephalic astrocyte-derived neurotrophic factor, protein–protein interaction, PERK, protein kinase RNA-like ER kinase, HEK293 Cells, 030104 developmental biology, Gene Expression Regulation, Chaperone (protein), Tg, thapsigargin, biology.protein, Unfolded protein response, AP-MS, affinity purification mass spectrometry, 1182 Biochemistry, cell and molecular biology, GFP-SH, SH-tagged GFP, endoplasmic reticulum stress (ER stress), DA, dopamine, mesencephalic astrocyte-derived neurotrophic factor (MANF), proteiinit, Neuroplastin

وصف الملف: application/pdf; fulltext

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313ba32ad4a5ccd78db57615fd60c668
http://urn.fi/URN:NBN:fi:jyu-202102221722

المؤلفون: Li-Ying Yu, Mart Saarma, Päivi Lindholm, Merja H. Voutilainen, Mati Karelson, Vera Kovaleva, Juha T. Huiskonen, Larisa Ivanova, Ave Eesmaa, Jinhan Nam, Esa-Pekka Kumpula

مصطلحات موضوعية: 0303 health sciences, Chemistry, ATF6, Endoplasmic reticulum, Neurodegeneration, medicine.disease, Transmembrane protein, Cell biology, 03 medical and health sciences, 0302 clinical medicine, Neurotrophic factors, Unfolded protein response, medicine, Phosphorylation, Receptor, 030217 neurology & neurosurgery, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::74c5121ba0f7ed4b4469a61f87c5b3c0
https://doi.org/10.1101/2020.09.22.307744

المؤلفون: Rie Asada, Kohsuke Kanekura, Ave Eesmaa, Mart Saarma, Maria Lindahl, Fumihiko Urano, Takuya Yagi

المساهمون: Institute of Biotechnology

المصدر: iScience
iScience, Vol 23, Iss 12, Pp 101810-(2020)

مصطلحات موضوعية: 0301 basic medicine, Programmed cell death, Inflammation, 02 engineering and technology, Biology, Biochemistry, Article, 03 medical and health sciences, BETA-CELLS, ENDOPLASMIC-RETICULUM STRESS, Neurotrophic factors, Cell surface receptor, Glial cell line-derived neurotrophic factor, medicine, Secretion, lcsh:Science, Receptor, Molecular Biology, THIOREDOXIN-INTERACTING PROTEIN, KEY REGULATORS, Multidisciplinary, IDENTIFICATION, Chemistry, UNFOLDED PROTEIN RESPONSE, Endoplasmic reticulum, Neurodegeneration, Cell Biology, 021001 nanoscience & nanotechnology, medicine.disease, INSULIN, 3. Good health, Cell biology, 030104 developmental biology, CELL-DEATH, ER, biology.protein, Unfolded protein response, 1182 Biochemistry, cell and molecular biology, lcsh:Q, medicine.symptom, Signal transduction, 0210 nano-technology, Neuroplastin, NEUROTROPHIC FACTOR

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf3ce9fffcc30900960f4ef0f3a52d18
https://pubmed.ncbi.nlm.nih.gov/33299977

المؤلفون: Mari Sepp, Kaja Kannike, Ave Eesmaa, Mari Urb, Tõnis Timmusk

المصدر: PLoS ONE, Vol 6, Iss 7, p e22138 (2011)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21789225/pdf/?tool=EBI; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/1564e7c68906478d959b38a687e3a376

المؤلفون: Eesmaa, Mari

المساهمون: Ivask, Signe, juhendaja, Tartu Ülikool. Sotsiaalteaduste valdkond, Tartu Ülikool. Ühiskonnateaduste instituut

مصطلحات موضوعية: bakalaureusetööd

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______1018::1aa6df73e84087887d2b610f6b9f9718
http://hdl.handle.net/10062/67709

المؤلفون: Eesmaa, Gregor

المساهمون: Krips, Kristjan, juhendaja, Tartu Ülikool. Loodus- ja täppisteaduste valdkond, Tartu Ülikool. Arvutiteaduse instituut

مصطلحات موضوعية: authorization, claims, efficiency, privacy, Merkle tree, cryptographic hash tree, bakalaureusetööd, informaatika, infotehnoloogia, informatics, infotechnology

وصف الملف: application/pdf

Relation: https://hdl.handle.net/10062/93971

الاتاحة: https://hdl.handle.net/10062/93971