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1Academic Journal
المؤلفون: Alessio Vittorio Colombo, Rebecca Katie Sadler, Gemma Llovera, Vikramjeet Singh, Stefan Roth, Steffanie Heindl, Laura Sebastian Monasor, Aswin Verhoeven, Finn Peters, Samira Parhizkar, Frits Kamp, Mercedes Gomez de Aguero, Andrew J MacPherson, Edith Winkler, Jochen Herms, Corinne Benakis, Martin Dichgans, Harald Steiner, Martin Giera, Christian Haass, Sabina Tahirovic, Arthur Liesz
المصدر: eLife, Vol 10 (2021)
مصطلحات موضوعية: alzheimer's disease, microbiome, microglia, neuroinflammation, amyloid, metabolites, Medicine, Science, Biology (General), QH301-705.5
وصف الملف: electronic resource
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2Academic Journal
المؤلفون: Harald Steiner, Edith Winkler, Mark S. Shearman, Ron Prywes, Christian Haass
المصدر: Neurobiology of Disease, Vol 8, Iss 4, Pp 717-722 (2001)
مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
وصف الملف: electronic resource
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3
المؤلفون: Harald Steiner, Frits Kamp, Finn Peters, Edith Winkler, Andrew J. Macpherson, Christian Haass, Arthur Liesz, Alessio Colombo, Aswin Verhoeven, Sabina Tahirovic, Vikramjeet Singh, Corinne Benakis, Martin Dichgans, Mercedes Gomez de Agüero, Steffanie Heindl, Jochen Herms, Rebecca Sadler, Martin Giera, Laura Sebastian Monasor, Samira Parhizkar, Stefan Roth, Gemma Llovera
مصطلحات موضوعية: medicine.anatomical_structure, Microglia, Chemistry, Biophysics, medicine, Deposition (chemistry)
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4
المؤلفون: Franz Bracher, Frits Kamp, Julia Junker, Edith Winkler, Christoph Müller, Harald Steiner
المصدر: The journal of steroid biochemistry and molecular biology 211, 105880-(2021). doi:10.1016/j.jsbmb.2021.105880
مصطلحات موضوعية: 0301 basic medicine, Male, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, Endogeny, Biochemistry, Gas Chromatography-Mass Spectrometry, Steroid, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Endocrinology, medicine, Animals, Derivatization, Molecular Biology, Chromatography, metabolism [Sulfates], Sulfates, Chemistry, Selected reaction monitoring, metabolism [Steroids], Brain, Cell Biology, methods [Gas Chromatography-Mass Spectrometry], Sterol, analysis [Sulfates], Mice, Inbred C57BL, 030104 developmental biology, Liver, metabolism [Brain], 030220 oncology & carcinogenesis, ddc:540, Molecular Medicine, Steroids, Female, Gas chromatography–mass spectrometry, Quantitative analysis (chemistry), analysis [Steroids], Homogenization (biology), metabolism [Liver]
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5
المؤلفون: Rebecca Sadler, Martin Giera, Martin Dichgans, Mercedes Gomez de Agüero, Jochen Herms, Stefan Roth, Christian Haass, Edith Winkler, Alessio Colombo, Finn Peters, Frits Kamp, Andrew J. Macpherson, Laura Sebastian Monasor, Arthur Liesz, Samira Parhizkar, Sabina Tahirovic, Steffanie Heindl, Gemma Llovera, Aswin Verhoeven, Vikramjeet Singh, Corinne Benakis, Harald Steiner
مصطلحات موضوعية: Apolipoprotein E, medicine.medical_specialty, Endocrinology, Downregulation and upregulation, Chemistry, Internal medicine, digestive, oral, and skin physiology, Plasma concentration, medicine, digestive system, Aβ deposition, Gut microbiome
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6
المؤلفون: Rico J. E. Derks, Frederick Campbell, Edgar Dawkins, Edith Winkler, Li Kong, Frits Kamp, Harald Steiner, Alexander Kros, Martin Giera
المصدر: Biochimica et biophysica acta / Biomembranes 1862(5), 183200 (2020). doi:10.1016/j.bbamem.2020.183200
BBA-Biomembranes, 1862(5). ELSEVIERمصطلحات موضوعية: Lipid Bilayers, gamma-Secretase, Biochemistry, Micelle, Polyethylene Glycols, Fatty Acids, Monounsaturated, chemistry.chemical_compound, chemistry [Fatty Acids, Monounsaturated], 0302 clinical medicine, Lipid bilayer, Micelles, 0303 health sciences, biology, Chemistry, Fatty Acids, metabolism [Membrane Lipids], Alzheimer's disease, Photochemical Processes, Membrane, chemistry [Polyethylene Glycols], chemistry [Fatty Acids], Intramembrane protease, Biophysics, chemistry [Lipid Bilayers], metabolism [Membranes], chemistry [Cell Membrane], Nervonic acid, metabolism [Cell Membrane], Light activation, Membrane Lipids, 03 medical and health sciences, Alzheimer Disease, ddc:570, Amphiphile, Lipidomics, isolation & purification [Lipid Bilayers], Humans, 030304 developmental biology, Membranes, Cell Membrane, Membrane Proteins, Cell Biology, Very long chain fatty acids, metabolism [Amyloid Precursor Protein Secretases], Cell membranes, Membrane protein, biology.protein, Amyloid Precursor Protein Secretases, 030217 neurology & neurosurgery, metabolism [Membrane Proteins]
وصف الملف: application/pdf
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7
المؤلفون: Shu-Gui Huang, Martin Bienengraeber, Doerthe Druhmann, Karim S. Echtay, Peter Mayinger, Simone Heimpel, Frits Kamp, Edith Winkler, Karina Frischmuth
المصدر: Archives of biochemistry and biophysics. 657
مصطلحات موضوعية: 0301 basic medicine, Biophysics, Mitochondrion, Fatty Acids, Nonesterified, Biochemistry, 03 medical and health sciences, Adenosine Triphosphate, Adipose Tissue, Brown, Brown adipose tissue, medicine, Uncoupling protein, Animals, Humans, Inner mitochondrial membrane, Molecular Biology, Binding Sites, ATP synthase, biology, Chemistry, Drug discovery, Thermogenesis, Cell biology, 030104 developmental biology, medicine.anatomical_structure, biology.protein, Mitochondrial Uncoupling Proteins, Flux (metabolism), Protein Binding
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8
المؤلفون: Frits Kamp, Edith Winkler, Loren M. LaPointe, Holger A. Scheidt, Daniel Huster, James M. Hutchison, Gabriele Basset, Hannes Heinel, Harald Steiner, Charles R. Sanders
المصدر: ACS chemical neuroscience 9(7), 1702-1713 (2018). doi:10.1021/acschemneuro.8b00068
مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein E, Protein Conformation, alpha-Helical, Physiology, antagonists & inhibitors [Amyloid Precursor Protein Secretases], Biochemistry, chemistry.chemical_compound, Amyloid beta-Protein Precursor, 0302 clinical medicine, metabolism [Amyloid beta-Protein Precursor], Amyloid precursor protein, Receptor, Notch1, Bexarotene, Liposome, biology, Molecular Structure, Chemistry, General Medicine, chemistry [Bexarotene], Transmembrane domain, Cholesterol, Neuroprotective Agents, pharmacology [Bexarotene], chemistry [Neuroprotective Agents], ddc:540, Phosphatidylcholines, medicine.drug, Cognitive Neuroscience, Static Electricity, Phospholipid, Article, 03 medical and health sciences, Downregulation and upregulation, Protein Domains, medicine, Humans, chemistry [Phosphatidylcholines], 1-palmitoyl-2-oleoylphosphatidylcholine, pharmacology [Neuroprotective Agents], Cell Biology, metabolism [Cholesterol], In vitro, metabolism [Amyloid Precursor Protein Secretases], 030104 developmental biology, metabolism [Receptor, Notch1], HEK293 Cells, Liposomes, biology.protein, Biophysics, Amyloid Precursor Protein Secretases, 030217 neurology & neurosurgery, metabolism [Liposomes]
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9
المؤلفون: Harald Steiner, Edith Winkler, Dieter Langosch, Ayse Julius
المصدر: Biochemistry 54(40), 6149-6152 (2015). doi:10.1021/acs.biochem.5b00986
مصطلحات موضوعية: metabolism [Amyloid beta-Peptides], Biochemistry, Amyloid beta-Protein Precursor, Alzheimer Disease, metabolism [Amyloid beta-Protein Precursor], Amyloid precursor protein, Humans, Cysteine, APH-1, chemistry [Amyloid beta-Protein Precursor], Integral membrane protein, Amyloid beta-Peptides, biology, Chemistry, analysis [Cysteine], P3 peptide, metabolism [Amyloid Precursor Protein Secretases], metabolism [Cysteine], Biochemistry of Alzheimer's disease, Transmembrane domain, Alpha secretase, ddc:540, biology.protein, Biophysics, chemistry [Amyloid beta-Peptides], Amyloid Precursor Protein Secretases, Protein Multimerization, Amyloid precursor protein secretase, metabolism [Alzheimer Disease]
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10
المؤلفون: Harald Steiner, Elisabeth Kremmer, Regina Fluhrer, David B. Teplow, Edith Winkler, Gudula Grammer, Lucas Martin, Margaret M. Condron, Bärbel Klier, Christian Haass, Akio Fukumori, Martina Haug-Kröper
المصدر: J. Biol. Chem. 283, 30121-30128 (2008)
Fluhrer, R; Fukumori, A; Martin, L; Grammer, G; Haug-Kröper, M; Klier, B; et al.(2008). Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. Journal of Biological Chemistry, 283(44), 30121-30128. doi: 10.1074/jbc.M806092200. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2ht7q8wh
The Journal of biological chemistry, vol 283, iss 44مصطلحات موضوعية: Signal peptide, Protein Structure, Biochemistry & Molecular Biology, Proteases, Amino Acid Motifs, Molecular Sequence Data, Mutant, Biology, Medical and Health Sciences, Models, Biological, Biochemistry, Catalysis, Presenilin, Cell Line, Models, Alzheimer Disease, mental disorders, Aspartic Acid Endopeptidases, Humans, Missense mutation, Amino Acid Sequence, ddc:610, Molecular Biology, Peptide sequence, Amyloid beta-Peptides, Enzyme Catalysis and Regulation, Tumor Necrosis Factor-alpha, Temperature, Cell Biology, Biological Sciences, Biological, Protein Structure, Tertiary, Chemical Sciences, Mutation, Peptides, Signal peptide peptidase, Tertiary, Intracellular
وصف الملف: application/pdf
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11Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process
المؤلفون: Regina Fluhrer, Edith Winkler, Johannes Trambauer, Frits Kamp, Amelie Ebke, Harald Steiner
المصدر: Biophysical journal 108(5), 1229-1237 (2015). doi:10.1016/j.bpj.2014.12.045
مصطلحات موضوعية: Cell signaling, Proteases, medicine.medical_treatment, Kinetics, Biophysics, Biology, chemistry [Intracellular Membranes], Cleavage (embryo), Amyloid beta-Protein Precursor, ddc:570, medicine, Humans, Enzyme kinetics, ddc:610, chemistry [Amyloid beta-Protein Precursor], Protease, Intracellular Membranes, metabolism [Amyloid Precursor Protein Secretases], Turnover number, Cell biology, Proteostasis, HEK293 Cells, Proteolysis, Amyloid Precursor Protein Secretases, Proteins and Nucleic Acids
وصف الملف: application/pdf
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12
المؤلفون: Marcus Kostka, Gabriele Basset, Edith Winkler, Christian Haass, Stefan Prokop, Aya Yamasaki, Dieter Edbauer, Harald Steiner
المصدر: Journal of Biological Chemistry. 277:39062-39065
مصطلحات موضوعية: DNA, Complementary, Nicastrin, Down-Regulation, Biochemistry, Presenilin, Cell Line, Epitopes, Mice, RNA interference, PEN-2, Endopeptidases, Presenilin-2, Presenilin-1, Animals, Aspartic Acid Endopeptidases, Humans, APH-1, Molecular Biology, Mice, Knockout, Membrane Glycoproteins, biology, Membrane Proteins, Active site, RNA, Cell Biology, Precipitin Tests, Protein Structure, Tertiary, Cell biology, Gamma-secretase complex, biology.protein, Electrophoresis, Polyacrylamide Gel, Amyloid Precursor Protein Secretases, Protein Binding
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13
المؤلفون: Edith Winkler, Martin Klingenberg, Karim S. Echtay
المصدر: Biochemical Society Transactions. 29:806-811
مصطلحات موضوعية: Ubiquinone, Saccharomyces cerevisiae, medicine.disease_cause, Models, Biological, Biochemistry, Ion Channels, Inclusion bodies, Cofactor, Mitochondrial Proteins, Adenosine Triphosphate, Escherichia coli, medicine, Uncoupling protein, Uncoupling Protein 1, UCP3, biology, Vesicle, Membrane Proteins, Biological Transport, Mitochondria, Coenzyme Q – cytochrome c reductase, biology.protein, Heterologous expression, Protons, Carrier Proteins
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14
المؤلفون: Ron Prywes, Edith Winkler, Christian Haass, Harald Steiner, Mark S. Shearman
المصدر: Neurobiology of Disease, Vol 8, Iss 4, Pp 717-722 (2001)
مصطلحات موضوعية: Cell signaling, Proteolysis, Plaque, Amyloid, Biology, Cleavage (embryo), Kidney, Transfection, Presenilin, Cell Line, lcsh:RC321-571, Amyloid beta-Protein Precursor, Endopeptidases, Presenilin-2, medicine, Presenilin-1, Aspartic Acid Endopeptidases, Humans, Protease Inhibitors, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, medicine.diagnostic_test, Receptors, Notch, ATF6, Membrane Proteins, Dipeptides, Transmembrane protein, Cell biology, Activating Transcription Factor 6, DNA-Binding Proteins, Transmembrane domain, Neurology, Biochemistry, Mutagenesis, Unfolded protein response, Carbamates, Amyloid Precursor Protein Secretases, Transcription Factors
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15
المصدر: Biochemical and Biophysical Research Communications. 282:334-340
مصطلحات موضوعية: Expression vector, Saccharomyces cerevisiae, Biophysics, Cell Biology, Biology, Mitochondrion, biology.organism_classification, Biochemistry, Ion Channels, Yeast, Inclusion bodies, Mitochondria, Mitochondrial Proteins, Uncoupling Protein 3, Uncoupling protein, Electrophoresis, Polyacrylamide Gel, Carrier Proteins, Inner mitochondrial membrane, Molecular Biology, Subcellular Fractions, UCP3
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16
المؤلفون: Edith Winkler, Karim S. Echtay, Martin Klingenberg
المصدر: Nature. 408:609-613
مصطلحات موضوعية: Protein Conformation, Ubiquinone, Coenzyme A, Oxidative phosphorylation, Ion Channels, Cofactor, Mitochondrial Proteins, Structure-Activity Relationship, chemistry.chemical_compound, Cricetinae, Escherichia coli, Animals, Uncoupling protein, Uncoupling Protein 1, Inclusion Bodies, Multidisciplinary, biology, Membrane Proteins, Biological Transport, Membrane transport, Mitochondrial carrier, Recombinant Proteins, Thermogenin, Mitochondria, chemistry, Biochemistry, Coenzyme Q – cytochrome c reductase, biology.protein, Cattle, Protons, Carrier Proteins
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17
المصدر: Biochemistry. 39:3311-3317
مصطلحات موضوعية: Stereochemistry, Glutamine, Glutamic Acid, Saccharomyces cerevisiae, Guanosine triphosphate, Biochemistry, Ion Channels, Electron Transport, Mitochondrial Proteins, chemistry.chemical_compound, Adipose Tissue, Brown, Chlorides, Cricetinae, Animals, Nucleotide, Binding site, Site-directed mutagenesis, Uncoupling Protein 1, chemistry.chemical_classification, Aspartic Acid, Binding Sites, Uncoupling Agents, Mutagenesis, Membrane Proteins, Electron transport chain, Mitochondria, Cytosol, Amino Acid Substitution, chemistry, Mutagenesis, Site-Directed, Nucleoside triphosphate, Guanosine Triphosphate, Asparagine, Protons, Carrier Proteins
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18
المؤلفون: Martin Klingenberg, Martin Bienengräber, Edith Winkler, Karina Frischmuth, Tom Caskey, Karim S. Echtay, Qingyun Liu
المصدر: FEBS Letters. 450:8-12
مصطلحات موضوعية: GTP', Proteolipids, Biophysics, Biology, Mitochondrion, Guanosine Diphosphate, Biochemistry, Ion Channels, ATP/ADP regulation, Mitochondrial Proteins, Chlorides, Structural Biology, Cricetinae, Uncoupling protein, Brown adipose tissue, Escherichia coli, Genetics, medicine, Animals, Humans, Uncoupling Protein 3, Nucleotide, Molecular Biology, Uncoupling Protein 1, UCP3, Inclusion Bodies, chemistry.chemical_classification, Nucleotides, Membrane Proteins, Skeletal muscle, Biological Transport, Cell Biology, medicine.anatomical_structure, Adipose Tissue, chemistry, Guanosine Triphosphate, Chloride transport, Carrier Proteins, Thermogenesis
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19
المصدر: Journal of Biological Chemistry. 273:24368-24374
مصطلحات موضوعية: Models, Molecular, Purine, GTP', viruses, Biology, Guanosine Diphosphate, Biochemistry, Ion Channels, Protein Structure, Secondary, Substrate Specificity, Mitochondrial Proteins, chemistry.chemical_compound, Adipose Tissue, Brown, Cricetinae, Diethyl Pyrocarbonate, Animals, Point Mutation, Histidine, Nucleotide, Cloning, Molecular, Binding site, Molecular Biology, Uncoupling Protein 1, chemistry.chemical_classification, Binding Sites, Wild type, Membrane Proteins, Cell Biology, Hydrogen-Ion Concentration, Recombinant Proteins, Mitochondria, Kinetics, Amino Acid Substitution, chemistry, Mutagenesis, Site-Directed, Nucleoside triphosphate, Guanosine Triphosphate, Protons, Carrier Proteins, Nucleoside
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20
المؤلفون: Edith Winkler, Elmar Wachter, Martin Klingenberg
المصدر: Biochemistry. 36:148-155
مصطلحات موضوعية: Indoles, GTP', Stereochemistry, Molecular Sequence Data, Peptide, Borohydrides, Biochemistry, Ion Channels, Mitochondrial Proteins, chemistry.chemical_compound, Adipose Tissue, Brown, Cricetinae, Animals, Uncoupling protein, Trypsin, Nucleotide, Amino Acid Sequence, Cyanogen Bromide, Uncoupling Protein 1, chemistry.chemical_classification, Edman degradation, Nucleotides, Lauric Acids, Membrane Proteins, Isoxazoles, Hydrogen-Ion Concentration, Peptide Fragments, Transmembrane domain, chemistry, Nucleoside triphosphate, Electrophoresis, Polyacrylamide Gel, Guanosine Triphosphate, Protons, Carrier Proteins, Sequence Analysis, Nucleoside
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