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1Academic Journal
المؤلفون: Morteza Salarzaei, Ralf L. O. van de Laar, Patricia C. Ewing-Graham, Shiva Najjary, Edith van Esch, Heleen J. van Beekhuizen, Dana A. M. Mustafa
المصدر: International Journal of Molecular Sciences, Vol 25, Iss 11, p 6205 (2024)
مصطلحات موضوعية: cervical cancer, targeted gene expression profiling, squamous cell carcinoma, adenocarcinoma, immune cells, Biology (General), QH301-705.5, Chemistry, QD1-999
Relation: https://www.mdpi.com/1422-0067/25/11/6205; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/bc73d63dcd45487d8cf93c81893fbdb6
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المؤلفون: Edith Van Esch, Ziena Abdulrahman, Natasja Hendriks, Arnold Jan Kruse, Antonios Somarakis, Anna Sande, Heleen Van Beekhuizen, Jurgen Piek, Noel De Miranda, Loes Kooreman, Brigitte Slangen, Sjoerd Van Der Burg, Peggy De Vos Van Steenwijk
المصدر: E-Posters.
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المؤلفون: Edith van Esch, Johan Bulten, Leon F.A.G. Massuger, Michelle van der Linden, Joanne A. de Hullu, Sophieke C.H.A. van der Steen, Tjalling Bosse, E.J. Dreef, Mariëtte I.E. van Poelgeest
المصدر: Gynecologic Oncology, 151, 3, pp. 453-459
Gynecologic Oncology, 151, 453-459
Gynecologic Oncology, 151(3), 453-459مصطلحات موضوعية: 0301 basic medicine, Stromal cell, CD14, Imiquimod, chemical and pharmacologic phenomena, Immune infiltrate, 03 medical and health sciences, 0302 clinical medicine, Immune system, Lymphocytes, Tumor-Infiltrating, Stroma, medicine, Tumor Microenvironment, Humans, Aged, CD20, Aged, 80 and over, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], biology, Vulvar Neoplasms, business.industry, Obstetrics and Gynecology, FOXP3, Middle Aged, biochemical phenomena, metabolism, and nutrition, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], Vulvar Paget disease, 030104 developmental biology, Paget Disease, Extramammary, Treatment Outcome, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Oncology, 030220 oncology & carcinogenesis, Immunology, biology.protein, bacteria, Female, business, CD8, medicine.drug
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4Report
المؤلفون: ZonMw: The Netherlands Organisation for Health Research and Development, Stichting Olijf: Dutch patient association for women with gynaecological cancer, Leids Universitair Medisch Centrum: Department of Medical Oncology and Department of Pathology, Maastricht Universitair Medisch Centrum: Department of Gynaecology and Department of Pathology, Erasmus Medisch Centrum: Department of Gynaecology, Radboud Medisch Centrum: Department of Gynaecology
المساهمون: Edith van Esch, Principal Investigator, gynaecologist
المصدر: Predicting Response In Cervical Intraepithelial Neoplasia to Topical Imiquimod Treatment
de Witte CJ, van de Sande AJ, van Beekhuizen HJ, Koeneman MM, Kruse AJ, Gerestein CG. Imiquimod in cervical, vaginal and vulvar intraepithelial neoplasia: a review. Gynecol Oncol. 2015 Nov;139(2):377-84. doi: 10.1016/j.ygyno.2015.08.018. Epub 2015 Aug 31.
Loopik DL, van Drongelen J, Bekkers RLM, Voorham QJM, Melchers WJG, Massuger LFAG, van Kemenade FJ, Siebers AG. Cervical intraepithelial neoplasia and the risk of spontaneous preterm birth: A Dutch population-based cohort study with 45,259 pregnancy outcomes. PLoS Med. 2021 Jun 4;18(6):e1003665. doi: 10.1371/journal.pmed.1003665. eCollection 2021 Jun.
Hendriks N, Koeneman MM, van de Sande AJM, Penders CGJ, Piek JMJ, Kooreman LFS, van Kuijk SMJ, Hoosemans L, Sep SJS, de Vos Van Steenwijk PJ, van Beekhuizen HJ, Slangen BFM, Nijman HW, Kruitwagen RFPM, Kruse AJ. Topical Imiquimod Treatment of High-grade Cervical Intraepithelial Neoplasia (TOPIC-3): A Nonrandomized Multicenter Study. J Immunother. 2022 Apr 1;45(3):180-186. doi: 10.1097/CJI.0000000000000414.
Abdulrahman Z, de Miranda N, van Esch EMG, de Vos van Steenwijk PJ, Nijman HW, J P Welters M, van Poelgeest MIE, van der Burg SH. Pre-existing inflammatory immune microenvironment predicts the clinical response of vulvar high-grade squamous intraepithelial lesions to therapeutic HPV16 vaccination. J Immunother Cancer. 2020 Mar;8(1):e000563. doi: 10.1136/jitc-2020-000563. Erratum In: J Immunother Cancer. 2020 May;8(1):e000563corr1. doi: 10.1136/jitc-2020-000563corr1.
Abdulrahman Z, de Miranda NFCC, Hellebrekers BWJ, de Vos van Steenwijk PJ, van Esch EMG, van der Burg SH, van Poelgeest MIE. A pre-existing coordinated inflammatory microenvironment is associated with complete response of vulvar high-grade squamous intraepithelial lesions to different forms of immunotherapy. Int J Cancer. 2020 Nov 15;147(10):2914-2923. doi: 10.1002/ijc.33168. Epub 2020 Jul 3.
Galon J, Bruni D. Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. Nat Rev Drug Discov. 2019 Mar;18(3):197-218. doi: 10.1038/s41573-018-0007-y.
Muntinga CLP, de Vos van Steenwijk PJ, Bekkers RLM, van Esch EMG. Importance of the Immune Microenvironment in the Spontaneous Regression of Cervical Squamous Intraepithelial Lesions (cSIL) and Implications for Immunotherapy. J Clin Med. 2022 Mar 5;11(5):1432. doi: 10.3390/jcm11051432.
Mitra A, MacIntyre DA, Lee YS, Smith A, Marchesi JR, Lehne B, Bhatia R, Lyons D, Paraskevaidis E, Li JV, Holmes E, Nicholson JK, Bennett PR, Kyrgiou M. Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity. Sci Rep. 2015 Nov 17;5:16865. doi: 10.1038/srep16865.
Ovestad IT, Gudlaugsson E, Skaland I, Malpica A, Kruse AJ, Janssen EA, Baak JP. Local immune response in the microenvironment of CIN2-3 with and without spontaneous regression. Mod Pathol. 2010 Sep;23(9):1231-40. doi: 10.1038/modpathol.2010.109. Epub 2010 May 28.
Loopik DL, Bentley HA, Eijgenraam MN, IntHout J, Bekkers RLM, Bentley JR. The Natural History of Cervical Intraepithelial Neoplasia Grades 1, 2, and 3: A Systematic Review and Meta-analysis. J Low Genit Tract Dis. 2021 Jul 1;25(3):221-231. doi: 10.1097/LGT.0000000000000604.
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