المؤلفون: Fiona Chapman, Luuk de Haan, Linda Gijzen, Wouter Strijker, Edgar Trelles Sticken, Sarah Jean Pour, Roman Wieczorek, Florian Haberstroh, Sandra Otte, Thomas Nahde, Liam Simms, Matthew Stevenson

المصدر: Frontiers in Toxicology, Vol 6 (2024)

مصطلحات موضوعية: cardiovascular disease, cigarette, co-culture, heated tobacco, electronic nicotine delivery system, Toxicology. Poisons, RA1190-1270

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/ftox.2024.1395670/full; https://doaj.org/toc/2673-3080

URL الوصول: https://doaj.org/article/0d419d3534074626a058c1b663677538

المؤلفون: Marjory Moreau, Liam Simms, Melvin E. Andersen, Edgar Trelles Sticken, Roman Wieczorek, Sarah Jean Pour, Fiona Chapman, Karin Roewer, Sandra Otte, Jeffrey Fisher, Matthew Stevenson

المصدر: Frontiers in Toxicology, Vol 6 (2024)

مصطلحات موضوعية: physiologically based pharmacokinetic (PBPK) modelling, respiratory toxicity, in vitro, aerosol, heated tobacco product (HTP), cigarette, Toxicology. Poisons, RA1190-1270

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/ftox.2024.1373325/full; https://doaj.org/toc/2673-3080

URL الوصول: https://doaj.org/article/06e7c45c8815464bb61eca7e8d431b5c

المؤلفون: Fiona Chapman, Sarah Jean Pour, Roman Wieczorek, Edgar Trelles Sticken, Jessica Budde, Karin Röwer, Sandra Otte, Elizabeth Mason, Lukasz Czekala, Thomas Nahde, Grant O’Connell, Liam Simms, Matthew Stevenson

المصدر: Frontiers in Toxicology, Vol 5 (2023)

مصطلحات موضوعية: in vitro, MucilAir™, heated tobacco, cigarette, tobacco harm reduction, repeat exposure, Toxicology. Poisons, RA1190-1270

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/ftox.2023.1076752/full; https://doaj.org/toc/2673-3080

URL الوصول: https://doaj.org/article/e61b781ed582475791e5e7e9411f68f8

المؤلفون: Liam Simms, Elizabeth Mason, Ellen L. Berg, Fan Yu, Kathryn Rudd, Lukasz Czekala, Edgar Trelles Sticken, Oleg Brinster, Roman Wieczorek, Matthew Stevenson, Tanvir Walele

المصدر: Current Research in Toxicology, Vol 2, Iss , Pp 309-321 (2021)

مصطلحات موضوعية: Next generation products, In vitro assays, Alternative methods, Panel, Toxicity signature, Phenotypic screening, Toxicology. Poisons, RA1190-1270

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666027X2100030X; https://doaj.org/toc/2666-027X

URL الوصول: https://doaj.org/article/06f36e7c18fa4832aef4f67611546bfb

المؤلفون: Lukasz Czekala, Roman Wieczorek, Liam Simms, Fan Yu, Jessica Budde, Edgar Trelles Sticken, Kathryn Rudd, Thomas Verron, Oleg Brinster, Matthew Stevenson, Tanvir Walele

المصدر: Current Research in Toxicology, Vol 2, Iss , Pp 99-115 (2021)

مصطلحات موضوعية: Cigarette, Electronic vapor product, Organotypic tissue model, Cilia, Immunohistochemistry, Pro-inflammatory markers, Toxicology. Poisons, RA1190-1270

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666027X21000098; https://doaj.org/toc/2666-027X

URL الوصول: https://doaj.org/article/cbd84fb8d9144c06af8e4733ebcfdf02

المؤلفون: Liam Simms, Kathryn Rudd, Jessica Palmer, Lukasz Czekala, Fan Yu, Fiona Chapman, Edgar Trelles Sticken, Roman Wieczorek, Lisa Maria Bode, Matthew Stevenson, Tanvir Walele

المصدر: Current Research in Toxicology, Vol 1, Iss , Pp 161-173 (2020)

مصطلحات موضوعية: E-cigarettes, Developmental toxicity, Cigarettes, Nicotine, Human induced pluripotent stem cells, In vitro reproduction assay, Toxicology. Poisons, RA1190-1270

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666027X20300189; https://doaj.org/toc/2666-027X

URL الوصول: https://doaj.org/article/3200b0658b504f1eadcc15761e4dd5e9

المؤلفون: Liam Simms, Fan Yu, Jessica Palmer, Kathryn Rudd, Edgar Trelles Sticken, Roman Wieczorek, Fiona Chapman, Lukasz Czekala, Matthew Stevenson, Grant O’Connell

المصدر: Frontiers in Toxicology, Vol 4 (2022)

مصطلحات موضوعية: cigarette, NGP, nicotine, cardiotoxicity, hiPSC-CM, in vitro, Toxicology. Poisons, RA1190-1270

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/ftox.2022.747508/full; https://doaj.org/toc/2673-3080

URL الوصول: https://doaj.org/article/aac91d20500244e2a23128728628312c

المؤلفون: David Thorne, Jason Adamson, Edgar Trelles Sticken, Roman Wieczorek, Holger Behrsing, Sandro Steiner, Shoaib Majeed, Stefan Frentzel, Shinkichi Ishikawa, Shigeaki Ito, Liam Simms, Kei Yoshino, Julia Hoeng, Marianna Gaca

المصدر: Toxicology Research and Application, Vol 5 (2021)

مصطلحات موضوعية: Toxicology. Poisons, RA1190-1270

Relation: https://doi.org/10.1177/2397847321992752; https://doaj.org/toc/2397-8473; https://doaj.org/article/4f050252956f42fb9c78086460bc3c1a

الاتاحة: https://doi.org/10.1177/2397847321992752
https://doaj.org/article/4f050252956f42fb9c78086460bc3c1a

المؤلفون: Fiona Chapman, Luuk de Haan, Linda Gijzen, Wouter Strijker, Edgar Trelles Sticken, Sarah Jean Pour, Roman Wieczorek, Florian Haberstroh, Sandra Otte, Thomas Nahde, Liam Simms, Matthew Stevenson

مصطلحات موضوعية: Pharmacology, Toxicology, Immunology, Toxicology (incl. Clinical Toxicology), Nanotoxicology, Health and Safety, cardiovascular disease, cigarette, co-culture, heated tobacco, electronic nicotine delivery system

Relation: https://figshare.com/articles/figure/Image1_Optimisation_of_an_in_vitro_human_cardiovascular_model_on-a-chip_for_toxicological_assessment_of_nicotine_delivery_products_jpg/26028019

الاتاحة: https://doi.org/10.3389/ftox.2024.1395670.s001
https://figshare.com/articles/figure/Image1_Optimisation_of_an_in_vitro_human_cardiovascular_model_on-a-chip_for_toxicological_assessment_of_nicotine_delivery_products_jpg/26028019

المؤلفون: Marjory Moreau, Liam Simms, Melvin E. Andersen, Edgar Trelles Sticken, Roman Wieczorek, Sarah Jean Pour, Fiona Chapman, Karin Roewer, Sandra Otte, Jeffrey Fisher, Matthew Stevenson

مصطلحات موضوعية: Pharmacology, Toxicology, Immunology, Toxicology (incl. Clinical Toxicology), Nanotoxicology, Health and Safety, physiologically based pharmacokinetic (PBPK) modelling, respiratory toxicity, in vitro, aerosol, heated tobacco product (HTP), cigarette, multiple-path particle dosimetry

Relation: https://figshare.com/articles/dataset/DataSheet1_Use_of_quantitative_in_vitro_to_in_vivo_extrapolation_QIVIVE_for_the_assessment_of_non-combustible_next-generation_product_aerosols_docx/25584330

الاتاحة: https://doi.org/10.3389/ftox.2024.1373325.s001
https://figshare.com/articles/dataset/DataSheet1_Use_of_quantitative_in_vitro_to_in_vivo_extrapolation_QIVIVE_for_the_assessment_of_non-combustible_next-generation_product_aerosols_docx/25584330

المؤلفون: Fan Yu, Kathryn Rudd, Sarah Jean Pour, Edgar Trelles Sticken, Ole Dethloff, Roman Wieczorek, Thomas Nahde, Liam Simms, Fiona Chapman, Lukasz Czekala, Matthew Stevenson, Grant O'Connell

المصدر: Applied In Vitro Toxicology. 8:24-35

مصطلحات موضوعية: Medical Laboratory Technology, Health, Toxicology and Mutagenesis, Toxicology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a882e13ee9739b7131f01aea250c39bf
https://doi.org/10.1089/aivt.2021.0020

المؤلفون: Roman Wieczorek, Edgar Trelles Sticken, Sarah Jean Pour, Fiona Chapman, Karin Röwer, Sandra Otte, Matthew Stevenson, Liam Simms

المصدر: Journal of Applied Toxicology.

مصطلحات موضوعية: Toxicology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::676657d0a427f6aecd69ccbb0dd6d515
https://doi.org/10.1002/jat.4442

المؤلفون: Fiona Chapman, Sarah Jean Pour, Roman Wieczorek, Edgar Trelles Sticken, Jessica Budde, Karin Röwer, Sandra Otte, Elizabeth Mason, Lukasz Czekala, Thomas Nahde, Grant O’Connell, Liam Simms, Matthew Stevenson

مصطلحات موضوعية: Pharmacology, Toxicology, Immunology, Toxicology (incl. Clinical Toxicology), Nanotoxicology, Health and Safety, in vitro, MucilAir™, heated tobacco, cigarette, tobacco harm reduction, repeat exposure

Relation: https://figshare.com/articles/dataset/DataSheet1_Twenty-eight_day_repeated_exposure_of_human_3D_bronchial_epithelial_model_to_heated_tobacco_aerosols_indicates_decreased_toxicological_responses_compared_to_cigarette_smoke_docx/22109882

الاتاحة: https://doi.org/10.3389/ftox.2023.1076752.s001
https://figshare.com/articles/dataset/DataSheet1_Twenty-eight_day_repeated_exposure_of_human_3D_bronchial_epithelial_model_to_heated_tobacco_aerosols_indicates_decreased_toxicological_responses_compared_to_cigarette_smoke_docx/22109882

المؤلفون: Giel Hendriks, Roman Wieczorek, Jutta Pani, Liam Simms, Edgar Trelles Sticken, Lukasz Czekala, Remco Derr, Kathryn Rudd, Lisa Maria Bode, Fiona Chapman, Nynke Moelijker, Inger Brandsma, Tanvir Walele, Matthew Stevenson

المصدر: Mutagenesis

مصطلحات موضوعية: AcademicSubjects/SCI01140, Glycerol, Nicotine, DNA damage, Health, Toxicology and Mutagenesis, Electronic Nicotine Delivery Systems, Pharmacology, Toxicology, medicine.disease_cause, Risk Assessment, Cigarette Smoking, Mice, 03 medical and health sciences, Clastogen, 0302 clinical medicine, Smoke, Tobacco, Genetics, medicine, Animals, Humans, Genetics (clinical), 030304 developmental biology, Aerosols, 0303 health sciences, AcademicSubjects/MED00305, Mutagenicity Tests, Chemistry, Smoking, Mouse Embryonic Stem Cells, Aneugens, Propylene Glycol, In vitro, Mice, Inbred C57BL, Oxidative Stress, 030220 oncology & carcinogenesis, Toxicity, Original Manuscripts, Aneugen, Micronucleus, Oxidative stress, DNA Damage, Mutagens, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b5a25f353d6fbbec338ce3d9e9a3c3
https://doi.org/10.1093/mutage/geaa033

المؤلفون: Edgar Trelles-Sticken, Ole Dethloff, Liam Simms, Francesca Buchanan, Kathryn Rudd, Tanvir Walele, Grant O’Connell, Roman Wieczorek, Jutta Pani, Lukasz Czekala, Matthew Stevenson

المصدر: Applied In Vitro Toxicology. 6:11-41

مصطلحات موضوعية: Chemistry, Health, Toxicology and Mutagenesis, food and beverages, Toxicology, medicine.disease_cause, In vitro, law.invention, Aerosol, Nicotine, Medical Laboratory Technology, Point of delivery, law, medicine, Cigarette smoke, Food science, Electronic cigarette, Chemical composition, Genotoxicity, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c8c1ebe9c548d1efac858f38c808a640
https://doi.org/10.1089/aivt.2019.0015

المؤلفون: Fiona Chapman, Edgar Trelles Sticken, Roman Wieczorek, Sarah Jean Pour, Ole Dethloff, Jessica Budde, Kathryn Rudd, Elizabeth Mason, Lukasz Czekala, Fan Yu, Liam Simms, Thomas Nahde, Grant O'Connell, Matthew Stevenson

المصدر: Toxicology in Vitro. 86:105510

مصطلحات موضوعية: Nicotine, Smoke, Tobacco, Tobacco Products, General Medicine, Electronic Nicotine Delivery Systems, Toxicology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43181ad4653bcba69146ffb4891c19f
https://doi.org/10.1016/j.tiv.2022.105510

المؤلفون: Paul Walker, Edgar Trelles-Sticken, Lukasz Czekala, Tanvir Walele, Matthew Stevenson, Liam Simms

المصدر: Toxicology in Vitro. 58:86-96

مصطلحات موضوعية: Glycerol, 0301 basic medicine, Nicotine, Cell Survival, Electronic Nicotine Delivery Systems, Toxicology, medicine.disease_cause, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Adenosine Triphosphate, 0302 clinical medicine, Smoke, medicine, Humans, Cigarette smoke, Food science, Viability assay, Membrane Potential, Mitochondrial, Tobacco harm reduction, Chemistry, Cell Cycle, NF-kappa B, Epithelial Cells, Biological activity, Tobacco Products, General Medicine, Glutathione, Propylene Glycol, High-Throughput Screening Assays, 030104 developmental biology, 030220 oncology & carcinogenesis, High-content screening, Reactive Oxygen Species, Menthol, Oxidative stress, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ea7ab0b6137ef8adb9bf5dd092984a
https://doi.org/10.1016/j.tiv.2019.03.018

المؤلفون: Jessica Budde, Oleg Brinster, Fan Yu, Lukasz Czekala, Roman Wieczorek, Matthew Stevenson, Kathryn Rudd, Thomas Verron, Tanvir Walele, Edgar Trelles Sticken, Liam Simms

المصدر: Current Research in Toxicology
Current Research in Toxicology, Vol 2, Iss, Pp 99-115 (2021)

مصطلحات موضوعية: THR, Tobacco Harm Reduction, MIE, Molecular Initiating Event, Health, Toxicology and Mutagenesis, DPBS, Dulbecco's phosphate-buffered saline containing Ca2+ and Mg2+, EVP, Electronic Vapor Product, AOP, Adverse Outcome Pathway, Pharmacology, Toxicology, Applied Microbiology and Biotechnology, MWP, Multi-Well Plate, TNF-α, Tumor Necrosis Factor Alpha, RA1190-1270, Cigarette smoke, 3D, Three Dimensional, Respiratory system, Cigarette, Tobacco harm reduction, ANOVA, Analysis of Variance, FOX-J1, Forkhead Box J1 protein, H&E, Hematoxylin and Eosin, Immunohistochemistry, NKT, Natural Killer T Cells, medicine.anatomical_structure, CAA, Cilia Active Area, IIVS, Institute for In Vitro Sciences, TEER, Transepithelial Electrical Resistance, IL-8, Interleukin-8, PBS, Phosphate Buffered Saline, Organotypic tissue model, CBF, Cilia Beat Frequency, ALI, Air-Liquid Interface, PMN, polymorphonuclear, KERs, Key Event Relationships, Article, MMP-1, Matrix Metalloproteinase-1, MMP-3, Matrix Metalloproteinase-3, medicine, IL-13, Interleukin 13, Cilia, IL-6, Interleukin-6, MUC5AC, Mucin 5AC Protein, ComputingMethodologies_COMPUTERGRAPHICS, Smoke, Lung, LDH, Lactate Dehydrogenase, business.industry, COPD, Chronic Obstructive Pulmonary Disease, CYP450, Cytochrome P450, TPM, Total Particulate Matter, Human airway, 3R4F, Scientific Reference Tobacco Cigarette (University of Kentucky), Aerosol, SAEIVS, Smoke Aerosol Exposure In Vitro System, Pro-inflammatory markers, Electronic vapor product, Toxicology. Poisons, Respiratory epithelium, ISO, International Organization for Standardization, EGFR, Epidermal Growth Factor Receptor, business, 2D, Two Dimensional, KEs, Key Events, MMP-9, Matrix Metalloproteinase-9, IL-1β, Interleukin 1 Beta

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba67fdc3a02685b761410ce5bf3b080
https://pubmed.ncbi.nlm.nih.gov/34345855

المؤلفون: Fan Yu, Roman Wieczorek, Edgar Trelles Sticken, Matthew Stevenson, Kathryn Rudd, Lukasz Czekala, Fiona Chapman, Lisa Maria Bode, Liam Simms, Tanvir Walele, Jessica Palmer

المصدر: Current Research in Toxicology
Current Research in Toxicology, Vol 1, Iss, Pp 161-173 (2020)

مصطلحات موضوعية: Health, Toxicology and Mutagenesis, OECD, Organisation for Economic Co-operation and Development, Developmental toxicity, HTP, heated tobacco product, Pharmacology, Toxicology, Applied Microbiology and Biotechnology, Nicotine, EVP, electronic vapour product, chemistry.chemical_compound, HPLC-DAD, high-performance liquid chromatography with a diode-array detector, Induced pluripotent stem cell, Cytotoxicity, CDC, Centers for Disease Control and Prevention, ISO, International Organization for Standardisation, Human induced pluripotent stem cells, Q-TOF, Quadrupole Time-of-Flight, EPA, United States Environmental Protection Agency, bPBS, bubbled phosphate buffered saline, E-cigarettes, TT21C, toxicity testing in the 21st century, iPS cells, induced pluripotent stem cells, COT, United Kingdom Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment, medicine.drug, DART, developmental and reproductive toxicity, NICE, National Institute for Health and Care Excellence, NHS, United Kingdom National Health Service, FDR, false discovery rate, ECVAM, European Center for the Validation of Alternative Methods, nAChRs, nicotinic acetylcholine receptors, Article, ROS, reactive oxygen species, PBS, phosphate buffered saline, lcsh:RA1190-1270, medicine, devTOXqP, devTOX quickPredict, Viability assay, HYB, hybrid product, o/c, ornithine/cystine ratio, e-cigarettes, electronic cigarettes, lcsh:Toxicology. Poisons, ComputingMethodologies_COMPUTERGRAPHICS, Smoke, LOQ, limit of quantification, PG/VG, propylene glycol/vegetable glycerine, Cigarettes, TP, cell viability toxicity potential concentration, CV, coefficient of variation, UPLC-HRMS, ultra-high performance liquid chromatography coupled high resolution mass spectrometry, DNPH, 2,4-dinitrophenylhydrazine, Embryonic stem cell, In vitro reproduction assay, POD, point of difference, chemistry, HPHCs, Harmful and Potentially Harmful Constituents, ISTD, internal standard, dTP, developmental toxicity potential concentration, ODC, ornithine decarboxylase, ND, No effect was detected within the exposure range tested, ATRA, All-trans-retinoic acid, dTT, developmental toxicity threshold, LC-MS/MS, liquid chromatography with tandem mass spectrometry, Toxicant

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876534347cf918727bc854bd8c355cad
https://pubmed.ncbi.nlm.nih.gov/34345845

المؤلفون: Edgar Trelles-sticken, Michael E. Dresser, Harry Scherthan

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/39/11/J_Cell_Biol_2000_Oct_2_151(1)_95-106.tar.gz

وصف الملف: application/zip

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.285.2256

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.285.2256