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1
المؤلفون: Peter King, Suso Platero, Matthew V. Lorenzi, Kelly Van De Ven, Caroline Paulussen, Liang Xie, Jennifer Yang, Jorge Vialard, Christopher Moy, Eleonora Jovcheva, Timothy Perera, David R. Newell, Jayaprakash Karkera, Sylvie Laquerre, Martin Page, Ron Gilissen, David C. Rees, Neil T. Thompson, George Ward, Desiree De Lange, Laurence Anne Mevellec, Patrick Angibaud, Matthew S Squires, Tinne Verhulst, Na Cheng, Eddy Jean Edgard Freyne, Christopher William Murray, Gordon Saxty
المصدر: Molecular Cancer Therapeutics. 16:1010-1020
مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Angiogenesis, Antineoplastic Agents, Biology, Fibroblast growth factor, Metastasis, Mice, 03 medical and health sciences, 0302 clinical medicine, Erdafitinib, Cell Line, Tumor, Quinoxalines, Drug Discovery, medicine, Animals, Humans, Molecular Targeted Therapy, Phosphorylation, Receptor, Protein Kinase Inhibitors, Cell Proliferation, Dose-Response Relationship, Drug, Kinase, medicine.disease, Receptors, Fibroblast Growth Factor, Xenograft Model Antitumor Assays, Cell biology, Disease Models, Animal, 030104 developmental biology, Oncology, Fibroblast growth factor receptor, 030220 oncology & carcinogenesis, Pyrazoles, Lysosomes, Tyrosine kinase, Protein Binding, Signal Transduction
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2
المؤلفون: Martyn Frederickson, Christopher W. Murray, Neil T. Thompson, Tim Perera, Anne Cleasby, Eddy Jean Edgard Freyne, Ruth Feltell, Jose Cosme, Lynsey Fazal, Christopher Charles Frederick Hamlett, Michael Reader, Rajdeep Benning, Alistair O'Brien, Peter King, Darcey Miller, Matthew Squires, Patrick Angibaud, Andrew Madin, Valerio Berdini, Emma Vickerstaffe, Gordon Saxty, Brent Graham, Charlotte Griffiths Jones, Andrew Pike, Edward J. Lewis, Michael A. Batey, Douglas D. Ross, Susanne S. Bethell, Sharna J. Rich, Lindsay A. Devine, Maria Grazia Carr, Abarna Thiru, Julie Irving, George Ward, John Lyons, David R. Newell
المصدر: Molecular Cancer Therapeutics. 10:1542-1552
مصطلحات موضوعية: Models, Molecular, musculoskeletal diseases, Gene isoform, Cancer Research, animal structures, Cell Survival, Drug Evaluation, Preclinical, Mice, Nude, Antineoplastic Agents, Fibroblast growth factor, Receptor tyrosine kinase, Mice, In vivo, Cell Line, Tumor, Neoplasms, medicine, Animals, Humans, Receptor, Protein Kinase Inhibitors, Cell Proliferation, Mice, Inbred BALB C, biology, Chemistry, Cancer, medicine.disease, Receptors, Fibroblast Growth Factor, Xenograft Model Antitumor Assays, Fibroblast Growth Factors, Treatment Outcome, Oncology, Cell culture, Fibroblast growth factor receptor, Drug Design, embryonic structures, Immunology, biology.protein, Cancer research, biological phenomena, cell phenomena, and immunity, Signal Transduction
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3
المؤلفون: Joaquín Pastor, Marcel Viellevoye, David Corens, Jan Heeres, Isabelle E.J.A. François, Marcel Borgers, Gerrit D. Dispersyn, Eddy Jean Edgard Freyne, Jannie Ausma, Lieven Meerpoel, Frederik Deroose, Erwin Coesemans, Sonia Martínez González, Klaartje Pellens, Bruno P. A. Cammue, Karin Thevissen, Els M.K. Meert
المصدر: ChemMedChem. 4:1714-1721
مصطلحات موضوعية: Antifungal, Antifungal Agents, Stereochemistry, medicine.drug_class, Endogeny, Piperazine-1-carboxamidine, Biochemistry, Piperazines, Structure-Activity Relationship, chemistry.chemical_compound, Candida albicans, Drug Discovery, Side chain, medicine, Phenyl group, General Pharmacology, Toxicology and Pharmaceutics, Mode of action, Pharmacology, chemistry.chemical_classification, Reactive oxygen species, biology, Organic Chemistry, biology.organism_classification, chemistry, Drug Design, Molecular Medicine, Reactive Oxygen Species
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4
المؤلفون: Peter ten Holte, Boudewijn Janssens, Sandrine Gaurrand, Janine Arts, Jacky van Gompel, Virginie Sophie Poncelet, Patrick Angibaud, Ann Marien, Hans De Winter, Bruno Roux, An Aerts, Verdonck Marc Gustaaf Celine, Jacky Van Dun, Luc Van Hijfte, Kristof Van Emelen, Isabelle Noëlle Constance Pilatte, Eddy Jean Edgard Freyne, Wim Floren, Michel Janicot, Sven Franciscus Anna Van Brandt, Jean-Michel Argoullon, Laurence Queguiner
المصدر: European Journal of Medicinal Chemistry. 40:597-606
مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Stereochemistry, medicine.drug_class, Hydroxamic Acids, Inhibitory Concentration 50, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Cell Proliferation, Pharmacology, Histone deacetylase 5, Hydroxamic acid, Molecular Structure, biology, HDAC11, Histone deacetylase 2, HDAC10, Organic Chemistry, Histone deacetylase inhibitor, General Medicine, Histone Deacetylase Inhibitors, Pyrimidines, chemistry, Biochemistry, Enzyme inhibitor, biology.protein, Female, Histone deacetylase, HeLa Cells
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5
المؤلفون: Gerda Smets, Laurence Mevellec, Michel Janicot, Pieter Van Remoortere, Bruno Roux, Yannick Aimé Eddy Ligny, Isabelle Noëlle Constance Pilatte, Jacky Van Dun, Wouters Walter Boudewijn Leopo, Xavier Bourdrez, Patrick Rene Angibaud, Geert Mannens, Marc Venet, David William End, Philippe Muller, Christophe Meyer, Patricia Lezouret, Siegrid Damsch, Eddy Jean Edgard Freyne, Virginie Sophie Poncelet
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:4365-4369
مصطلحات موضوعية: Farnesyl Protein Transferase, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Quinolones, Biochemistry, Chemical synthesis, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Farnesyltranstransferase, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Farnesyl-diphosphate farnesyltransferase, Alkyl and Aryl Transferases, Molecular Structure, biology, organic chemicals, Organic Chemistry, In vitro, Kinetics, Enzyme, chemistry, Enzyme inhibitor, Drug Design, Quinazolines, Quinolines, biology.protein, Molecular Medicine, Cell Division
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6
المؤلفون: Patrick Rene Angibaud, Eddy Jean Edgard Freyne, Christophe Meyer, Jacky Van Dun, Gerda Smets, Marc Venet, Isabelle Noëlle Constance Pilatte, Laurence Mevellec, Virginie Sophie Poncelet, Bruno Roux, Geert Mannens, Ashis K. Saha, David William End, Wouters Walter Boudewijn Leopo, Xavier Bourdrez, Patricia Lezouret
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:4361-4364
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Farnesyltransferase, Clinical Biochemistry, Molecular Conformation, Triazole, Administration, Oral, Pharmaceutical Science, Antineoplastic Agents, Quinolones, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Heterocyclic Compounds, Drug Discovery, Animals, Farnesyltranstransferase, Humans, Imidazole, Moiety, Enzyme Inhibitors, Molecular Biology, Alkyl and Aryl Transferases, biology, Organic Chemistry, Farnesyltransferase inhibitor, Triazoles, Kinetics, chemistry, Microsomes, Liver, biology.protein, Molecular Medicine, Cell Division
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7
المؤلفون: Isabelle Noëlle Constance Pilatte, Walter Wouters, Geert Mannens, Yannick Aimé Eddy Ligny, Marc Venet, Pieter Van Remoortere, David W. End, Philippe Muller, Ann Devine, Patrick Rene Angibaud, Gerda Smets, Jacky Van Dun, Xavier Bourdrez, Stacy Skrzat, Virginie Sophie Poncelet, Eddy Jean Edgard Freyne
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:1543-1547
مصطلحات موضوعية: Tertiary amine, Stereochemistry, Farnesyltransferase, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, In Vitro Techniques, Quinolones, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Farnesyltranstransferase, Humans, Moiety, Structure–activity relationship, Molecular Biology, Farnesyl-diphosphate farnesyltransferase, Alkyl and Aryl Transferases, biology, Bicyclic molecule, Chemistry, Organic Chemistry, Azepines, Xenograft Model Antitumor Assays, Microsomes, Liver, Quinazolines, biology.protein, Lactam, Molecular Medicine, Indicators and Reagents
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8
المؤلفون: Christopher Charles Frederick Hamlett, Christopher N. Johnson, Lieven Meerpoel, Rachel McMenamin, Pascal Bonnet, Ron Gilissen, Phillip J. Day, Laurence Mevellec, Joseph E. Coyle, Lijs Beke, Christophe Denis Adelinet, Sahil Patel, Steven Howard, Martyn Frederickson, Joannes T. M. Linders, David C. Rees, Valerio Berdini, Frederick Calo, Elisabeth Thérèse Jeanne Pasquier, Eddy Jean Edgard Freyne, Dirk Brehmer
مصطلحات موضوعية: Residue (chemistry), Kinase, Organic Chemistry, Drug Discovery, Transferase, Structure based, Chemical probe, Biology, Ligand (biochemistry), Biochemistry, Combinatorial chemistry, Cell biology, Maternal embryonic leucine zipper kinase
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9
المؤلفون: Lijs Beke, Joseph E. Coyle, Rachel McMenamin, Andrew Sharff, Dirk Brehmer, Francois Maria Sommen, Tongfei Wu, David C. Rees, Christopher N. Johnson, Lieven Meerpoel, Pascal Bonnet, Martyn Frederickson, Joannes T. M. Linders, Sahil Patel, Ron Gilissen, Phillip J. Day, Eddy Jean Edgard Freyne, Christopher Charles Frederick Hamlett, Steven Howard, Valerio Berdini
المصدر: ACS medicinal chemistry letters. 6(1)
مصطلحات موضوعية: Low affinity, Biochemistry, Fragment (computer graphics), Organic Chemistry, Drug Discovery, Transferase, Basic helix-loop-helix leucine zipper transcription factors, Chemical probe, Hinge region, Biology, Maternal embryonic leucine zipper kinase
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10
المؤلفون: W. Wouters, M. Venet, J. Van Wauwe, G. Sanz, Eddy Jean Edgard Freyne, A. Raeymaekers, R. De Coster
المصدر: Bioorganic & Medicinal Chemistry Letters. 8:267-272
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, medicine.drug_class, Clinical Biochemistry, Retinoic acid, Pharmaceutical Science, Antineoplastic Agents, Tretinoin, Pharmacology, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, In vivo, Drug Discovery, medicine, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Liarozole, Retinoid, Enzyme Inhibitors, Molecular Biology, Molecular Structure, biology, Chemistry, Organic Chemistry, Imidazoles, Cytochrome P450, Biological activity, Retinoic Acid 4-Hydroxylase, Rats, Enzyme inhibitor, biology.protein, Molecular Medicine, Dermatologic Agents
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11
المؤلفون: Gerard Charles Sanz, Eddy Jean Edgard Freyne, J. Van Wauwe, R. De Coster, A. Raeymaekers, W. Wouters, M. Venet
المصدر: ChemInform. 29
مصطلحات موضوعية: Blocking (radio), Chemistry, General Medicine, Pharmacology, Retinoic acid metabolism
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12
المؤلفون: Bruno Roux, Luc Van Hijfte, Jacky van Gompel, Claire Mackie, Sven Franciscus Anna Janssen Pharm. Van Brandt, Marc Noppe, Ann Marien, David Speybrouck, Lut Janssen, Marc Du Jardin, Wim Floren, Eddy Jean Edgard Freyne, Michel Janicot, Kristof Van Emelen, Jacky Van Dun, Ron Gilissen, Isabelle Noëlle Constance Pilatte, Virginie Sophie Poncelet, Patrick Angibaud, Verdonck Marc Gustaaf Celine, Peter ten Holte, Sandrine Gaurrand, Martin John Page, Jozef Peeters, Laurence Decrane, Janine Arts, Laurence Queguiner
المصدر: Bioorganicmedicinal chemistry letters. 20(1)
مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Mice, Nude, Antineoplastic Agents, Hydroxamic Acids, Biochemistry, Histone Deacetylases, Rats, Sprague-Dawley, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Structure–activity relationship, Animals, Cytotoxicity, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Hydroxamic acid, biology, Organic Chemistry, Histone deacetylase inhibitor, Xenograft Model Antitumor Assays, Rats, Histone Deacetylase Inhibitors, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Histone deacetylase
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13
المؤلفون: Wouters Walter Boudewijn Leopo, Alfons H. M. Raeymaekers, Ann Dillen, Jacky Van Dun, Marc Gaston Venet, Jozef H L Van Gelder, Roland De Coster, Eddy Jean Edgard Freyne, Marcel August Constant Janssen, M. D. W. G. Krekels, Gerard Charles Sanz
المصدر: The Journal of Steroid Biochemistry and Molecular Biology. 37:1049-1054
مصطلحات موضوعية: Male, medicine.medical_specialty, Gonadotropins, Equine, medicine.drug_class, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, In Vitro Techniques, Pharmacology, Steroid biosynthesis, Biochemistry, Gonadotropin-Releasing Hormone, Endocrinology, Adrenocorticotropic Hormone, Adrenal Cortex Hormones, In vivo, Internal medicine, Testis, medicine, Animals, Testosterone, Aromatase, Molecular Biology, Granulosa Cells, Aromatase inhibitor, Estradiol, biology, Aromatase Inhibitors, Chemistry, Ovary, Stereoisomerism, Cell Biology, Triazoles, Rats, Steroid hormone, Enzyme inhibitor, Steroid Hydroxylases, Vorozole, biology.protein, Molecular Medicine, Female, Steroids, medicine.drug
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14
المؤلفون: A. Raeymaekers, G. Vanden Bussche, Gerard Charles Sanz, E. Snoeck, R. De Coster, J. Bruynseels, W. Wouters, H. Vanden Bossche, M.-C. Coene, P. Van Rooy, G. Willemsens, Eddy Jean Edgard Freyne, P. A. J. Janssen
المصدر: The Prostate. 16:345-357
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, medicine.drug_class, Urology, medicine.medical_treatment, In Vitro Techniques, Steroid biosynthesis, Steroid, chemistry.chemical_compound, Adrenocorticotropic Hormone, Corticosterone, Internal medicine, medicine, Animals, Humans, Testosterone, Androstenedione, Aromatase, Aldosterone, Estradiol, biology, Imidazoles, Androgen Antagonists, Middle Aged, Androgen, Rats, Ketoconazole, Endocrinology, Oncology, chemistry, Microsome, biology.protein, Steroids, medicine.drug
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15
المؤلفون: and Alex De Groot, Yannick Ligney, Willy F. Cools, Jean Fernand Armand Lacrampe, Gustaaf M. Boeckx, Lieve Dillen, Fortin Jerome Michel Claude, David Corens, Jean Pierre Frans Van Wauwe, Eddy Jean Edgard Freyne, Jan Goossens, Werner C J Embrechts, Johan J. Willems, Frederik Deroose, Erwin Coesemans, Marc Willems
المصدر: Journal of medicinal chemistry. 48(6)
مصطلحات موضوعية: Adult, Carboxylic acid, medicine.medical_treatment, Pharmacology, In Vitro Techniques, Proinflammatory cytokine, In vivo, Drug Discovery, medicine, Animals, Chemokine CCL8, Humans, Chemokine CCL7, IC50, Lung, Chemokine CCL2, Whole blood, chemistry.chemical_classification, Sheep, Triazines, Interleukin-8, Interleukin, Esters, In vitro, Asthma, Bronchodilator Agents, Monocyte Chemoattractant Proteins, Thiazoles, Cytokine, Biochemistry, chemistry, Liver, Molecular Medicine, Cytokines, Interleukin-4, Interleukin-5
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16
المؤلفون: Didier de Chaffoy, Gustaaf Maria Boeckx, Gaston Stanislas Marcella Diels, Pedro Pardal Martínez, Davy Petrus Franciscus Maria Petit, Jean Pierre Frans Van Wauwe, Fred De Clerck, Marina Lucie Louise Cools, Anton Megens, José Manuel Alonso, Javier Fernández, Danielle Peeters, Adolfo Dı́az, Paul Stoppie, Laura Iturrino, Marijke Somers, F. Deroose, J. Ignacio Andres, Eddy Jean Edgard Freyne, Encarna Matesanz
المصدر: Bioorganicmedicinal chemistry letters. 12(4)
مصطلحات موضوعية: Stereochemistry, Administration, Topical, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Humans, PDE4 Inhibitors, Enzyme Inhibitors, Ear Diseases, Molecular Biology, Rolipram, chemistry.chemical_classification, Inflammation, biology, Dose-Response Relationship, Drug, Chemistry, Organic Chemistry, Imidazoles, Combinatorial chemistry, In vitro, Cyclic Nucleotide Phosphodiesterases, Type 4, Rats, Disease Models, Animal, Enzyme, Enzyme inhibitor, 3',5'-Cyclic-AMP Phosphodiesterases, biology.protein, Molecular Medicine, Enantiomer, medicine.drug
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17
المؤلفون: Berthold Wroblowski, Norbert Esser, Matthew S Squires, Ron Gilissen, Neil Thompson, Lynsey Fazal, David R. Newell, Patrick Angibaud, George Ward, Laurence Anne Mevellec, Gordon Saxty, Tinne Verhulst, Timothy Perera, Eddy Jean Edgard Freyne, Peter King, Eleanora Jovcheva, Christopher William Murray, Jorge Vialard, Suso Platero, Olivier Querolle
المصدر: Cancer Research. 74:1738-1738
مصطلحات موضوعية: Cancer Research, Kinase, Fibroblast growth factor receptor 1, medicine.medical_treatment, Biology, Fibroblast growth factor, medicine.disease_cause, Targeted therapy, Oncology, Fibroblast growth factor receptor, Immunology, Cancer research, medicine, Kinase activity, Carcinogenesis, Tyrosine kinase
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18
المؤلفون: Sharna J. Rich, Jorge Vialard, Eleonora Jovcheva, Delphine Yvonne Raymonde Lardeau, David R. Newell, Virginie Poncelet, Helene Colombel, Anne Cleasby, Christopher William Murray, Christophe Denis Adelinet, Tinne Verhulst, Elisabeth Thérèse Jeanne Pasquier, Martin Page, Steve Mcclue, Matthew S Squires, Yannick Ligny, Jean Fernand Armand Lacrampe, Peter King, Yvan Simonnet, Timothy Perera, Laurence Mevellec, Patrick René Angibaud, Olivier Alexis Georges Querolle, Pilatte Isabelle Noelle Consta, Marc Willems, Gordon Saxty, Lieven Meerpoel, Werner Constant Johan Embrechts, Eddy Jean Edgard Freyne, Pascal Bonnet, Bruno Roux, Virginie Tronel, Rhalid Akkari, Valerio Berdini, Steven John Woodhead, Elodie Sement, Berthold Wroblowski, David C. Rees, Xavier Bourdrez, Imre Christian Francis Csoka, Marine Bourgeois, Ronaldus Arnodus Hendrika Joseph Gilissen, Alexandra Papanikos
المصدر: Cancer Research. 74:4748-4748
مصطلحات موضوعية: Cancer Research, Oncology, Fibroblast growth factor receptor, Drug discovery, Fibroblast growth factor receptor 1, Human gastric carcinoma, Biology, Kinase inhibition, Receptor, Fibroblast growth factor, Molecular biology
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19
المؤلفون: Tim Perera, Peter H. King, Deepika Lal, Nathaniel C. Doro, Eddy Jean Edgard Freyne, Eunice S. Wang
المصدر: Blood. 112:4026-4026
مصطلحات موضوعية: Chemotherapy, business.industry, Angiogenesis, medicine.medical_treatment, Immunology, Myeloid leukemia, Cell Biology, Hematology, Biochemistry, Chemotherapy regimen, medicine.anatomical_structure, medicine, Cancer research, Cytarabine, Doxorubicin, Bone marrow, Stem cell, business, medicine.drug
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20
المؤلفون: Wim Floren, Boudewijn Janssens, Michel Janicot, Peter King, Tim Perera, Eddy Jean Edgard Freyne, Matthias Versele, Tom Lavrijssen, Martin John Page
المصدر: European Journal of Cancer Supplements. 4:178
مصطلحات موضوعية: Cancer Research, Tyrosine-protein kinase CSK, biology, medicine.drug_class, Chemistry, Tyrosine-kinase inhibitor, Receptor tyrosine kinase, Oncology, ROR1, medicine, biology.protein, Cancer research, Bruton's tyrosine kinase, Tyrosine kinase, Platelet-derived growth factor receptor, Proto-oncogene tyrosine-protein kinase Src