المؤلفون: Zhulin Tan, Xuan Ju, Hao Wu, Weitong Dong, Joyce C. Leung, Xiaowen Hou, Heewon Lee, Alice Granger, Joshua M. Paolillo, Susan V. DiMeo, Chengsheng Chen, Linglin Wu, Jon C. Lorenz, Max Sarvestani, Frederic Buono, Rogelio Frutos, Thomas G. Tampone, Xiaojun Huang, Gulin Zhang, Yuwen Wang, Earl Spinelli, Zhen Lei, Jinhua J. Song

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Biotechnology, Ecology, Sociology, Developmental Biology, Hematology, Space Science, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, scalable synthesis toward, scalable asymmetric synthesis, catalyzed epoxide opening, carbon quaternary stereocenter, 1 , requisite ketone, rapid manufacturing, part 2, overall yield, high chemical, heterocyclic core, five steps, final assembly, enantiomeric purities, enabling robust, 300 kg

Relation: https://figshare.com/articles/journal_contribution/Development_of_a_Scalable_Synthesis_toward_a_KRAS_G12C_Inhibitor_Building_Block_Bearing_an_All-Carbon_Quaternary_Stereocenter_Part_2_Asymmetric_Synthesis_via_Shi_Epoxidation/24947434

الاتاحة: https://doi.org/10.1021/acs.oprd.3c00363.s001
https://figshare.com/articles/journal_contribution/Development_of_a_Scalable_Synthesis_toward_a_KRAS_G12C_Inhibitor_Building_Block_Bearing_an_All-Carbon_Quaternary_Stereocenter_Part_2_Asymmetric_Synthesis_via_Shi_Epoxidation/24947434

المؤلفون: Earl Spinelli, Yin-Chao Tseng, Jonathan T. Reeves, Jinhua J. Song, Herbert Nar, Soojin Kim, John A. Smoliga, Nathan K. Yee, Varsolona Richard J, Zhibin Li, Chris H. Senanayake, Heewon Lee

المصدر: Organic Process Research & Development. 17:540-548

مصطلحات موضوعية: chemistry.chemical_classification, Active ingredient, Chemistry, Organic Chemistry, Free base, Salt (chemistry), Cocrystal, law.invention, Bioavailability, chemistry.chemical_compound, law, Organic chemistry, Molecule, Physical and Theoretical Chemistry, Crystallization, Phosphoric acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6efd6b7404046a2f46cd235d1ae2f313
https://doi.org/10.1021/op300239h

المؤلفون: Bikshandarkoil A. Narayanan, Bing-Shiou Yang, Wenjun Tang, Alexander Sienkiewicz, Max Sarvestani, Denis Byrne, Zhibin Li, Laurence J. Nummy, Earl Spinelli, Ashish Chitroda, Nathan K. Yee, Soojin Kim, Shengli Ma, Heewon Lee, Nelu Grinberg, Xudong Wei, Nitinchandra D. Patel, Chris H. Senanayake

المصدر: Organic Process Research & Development. 17:382-389

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Aryl, Reagent, Organic Chemistry, Halogenation, Organic chemistry, Regioselectivity, Pyridinium, Physical and Theoretical Chemistry, Guanidine, Carbonylation, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::953111085e2433d613ead94be7df06ff
https://doi.org/10.1021/op300331b

المؤلفون: Carl A. Busacca, Scot Campbell, XuWu Feng, Nelu Grinberg, Varsolona Richard J, Paul-James Jones, Xudong Wei, Nizar Haddad, Oliver Niemeier, Chris H. Senanayake, Wendelin Samstag, Heewon Lee, Juergen Schroeder, Jana Vitous, Vittorio Farina, Nina C. Gonnella, Thilo Berkenbusch, Earl Spinelli, John A. Smoliga, Jon C. Lorenz, Suresh R. Kapadia, Zhibin Li, Max Sarvestani, Anjan Saha

المصدر: Asian Journal of Organic Chemistry. 1:80-89

مصطلحات موضوعية: chemistry.chemical_classification, Dipeptide, Stereochemistry, Hepatitis C virus, Organic Chemistry, Peptide, Bond formation, medicine.disease_cause, Sulfone, chemistry.chemical_compound, chemistry, medicine, Nucleophilic substitution, Molecule, Saponification

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::707936b50f896303356fb30b8a615528
https://doi.org/10.1002/ajoc.201200014

المؤلفون: Nelu Grinberg, Xudong Wei, Chris H. Senanayake, Nizar Haddad, Joe Johnson, Earl Spinelli, Suresh R. Kapadia, Heewon Lee, Carl A. Busacca, Max Sarvestani, Jon C. Lorenz, Xingzhong Zeng, Rich Varsolona, Anjan Saha, XuWu Feng

المصدر: The Journal of Organic Chemistry. 75:1155-1161

مصطلحات موضوعية: Models, Molecular, Vinyl Compounds, Stereochemistry, Strecker amino acid synthesis, Alkenes, Calorimetry, Aldehyde, Chemical synthesis, Catalysis, Side chain, Urea, Rhodium, Enzyme Inhibitors, chemistry.chemical_classification, Molecular Structure, Organic Chemistry, Asymmetric hydrogenation, Enantioselective synthesis, Stereoisomerism, Cathepsins, Claisen rearrangement, chemistry, Cyclization, Indicators and Reagents, Palladium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30af52e991d8b73166535a0efc21f2e
https://doi.org/10.1021/jo9022809

المؤلفون: Earl Spinelli, Mo Jiang, Zhibin Li, Chris H. Senanayake, Bing-Shiou Yang, Magnus C. Eriksson, Nathan K. Yee

المصدر: Organic Process Research & Development. 13:1307-1314

مصطلحات موضوعية: Active ingredient, chemistry.chemical_compound, chemistry, Drug candidate, Organic Chemistry, Organic chemistry, Free form, Physical and Theoretical Chemistry, Glutaric acid, Cocrystal, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ea19704dba03078496ed8dafd14c87e6
https://doi.org/10.1021/op900137j

المؤلفون: Lana Louise Smith-Keenan, Paul Kreye, Wendelin Samstag, Thomas Nicola, Victor Fuchs, XuWu Feng, Jinghua Xu, Jana Vitous, Earl Spinelli, Rogelio P. Frutos, Jonathan Tan, Eric Winter, Robert D. Simpson, Li Zhang, Fabrice Gallou, Michael D. Ridges, Nathan K. Yee, Vittorio Farina, Marvin Johnson, Xiao-Jun Wang, Nizar Haddad, Ioannis N. Houpis, Xudong Wei, Michael Brenner, Kai Donsbach, Yibo Xu

المصدر: The Journal of Organic Chemistry. 71:7133-7145

مصطلحات موضوعية: Macrocyclic Compounds, Molecular Structure, Scale (ratio), Chemistry, Stereochemistry, Organic Chemistry, Pilot scale, Hepacivirus, Metathesis, Antiviral Agents, Chemical synthesis, Protease inhibitor (biology), Thiazoles, Ring-closing metathesis, Cyclization, Hcv protease, Quinolines, medicine, Peptide bond, Protease Inhibitors, Carbamates, Chromatography, High Pressure Liquid, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff05409b6030e93939b82eb046705a1
https://doi.org/10.1021/jo060285j

المؤلفون: Shengli Ma, Elias I. Franses, Heewon Lee, Nelu Grinberg, Nathan K. Yee, Hung-Wei Tsui, Nien-Hwa Linda Wang, Carl A. Busacca, Ling Wu, Nina Gonella, Chris H. Senanayake, Keith R. Fandrick, Earl Spinelli

المصدر: Journal of chromatography. A. 1362

مصطلحات موضوعية: chemistry.chemical_classification, Heptane, Chromatography, Double bond, Allene, Circular Dichroism, Organic Chemistry, Enantioselective synthesis, Phenylcarbamates, Temperature, Stereoisomerism, General Medicine, Biochemistry, Analytical Chemistry, Alkadienes, chemistry.chemical_compound, chemistry, Phase (matter), Vibrational circular dichroism, Enantiomer, Enantiomeric excess, Cellulose

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad3171596cef3f9304d7f669f6a25a7
https://pubmed.ncbi.nlm.nih.gov/25193169

المؤلفون: Heewon Lee, Larry Nummy, Nathan K. Yee, Thomas Fachinger, Shengli Ma, Daniel R. Fandrick, Jonathan T. Reeves, Frank Roschangar, Denis Byrne, Max Sarvestani, Sherry Shen, Chris H. Senanayake, Bikshandarkoil A. Narayanan, Jinhua J. Song, Bo Qu, Phil DeCroos, Victor Fuchs, Nelu Grinberg, Zhibin Li, Burkhard Jäger, Ashish Chitroda, Jon C. Lorenz, Oliver Niemeier, Earl Spinelli, Soojin Kim, Nizar Haddad, Michael Brenner, Zhulin Tan, Xiufeng Sun, Varsolona Richard J, Sonia Rodriguez, Ajith Premasiri, Scot Campbell, Nina C. Gonnella

المصدر: The Journal of organic chemistry. 78(8)

مصطلحات موضوعية: Molecular Structure, Pyridines, Organic Chemistry, Enantioselective synthesis, Diastereomer, Stereoisomerism, Anisole, Medicinal chemistry, Cocrystal, Amides, chemistry.chemical_compound, chemistry, Yield (chemistry), Amide, Electrophile, Benzamides, Moiety, Organic chemistry, Pyrroles, Glucocorticoids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417034dc1c222b56e6e25fded0bb5608
https://pubmed.ncbi.nlm.nih.gov/23544738

المؤلفون: Earl Spinelli, Carl A. Busacca, Yong Dong

المصدر: Tetrahedron Letters. 37:2935-2938

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Organic Chemistry, Drug Discovery, Condensation, Cysteamine, One-Step, Amine gas treating, Enantiomeric excess, Biochemistry, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5e60a4ca50c3beff6bdcf6de4b9401d7
https://doi.org/10.1016/0040-4039(96)00451-0

المؤلفون: Carl A. Busacca, Yong Dong, Earl Spinelli

المصدر: ChemInform. 27

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Condensation, Amine gas treating, Cysteamine, One-Step, General Medicine, Enantiomeric excess, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ec63732c7c595dedd11d14cbd7726b47
https://doi.org/10.1002/chin.199633143

المؤلفون: Scot J. Campbell, Keith McKellop, Yong Dong, Jon C. Lorenz, Fenghe Qiu, Regina C. So, Carl A. Busacca, Danja Grossbach, Ji-Young Kim, Magnus C. Eriksson, Paul-James Jones, Lana Smith, Robert D. Simpson, Robert E Harris, Jana Vitous, Earl Spinelli, Erin M O'Brien, Chiara Zavattaro

المصدر: The Journal of organic chemistry. 69(16)

مصطلحات موضوعية: Intramolecular reaction, Stereochemistry, Chemistry, Ligand, Intramolecular force, Heck reaction, Organic Chemistry, Chiral ligand, Electronic effect, Enantioselective synthesis, Combinatorial chemistry, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6396be8891b49970e971ccbc3bddbe
https://pubmed.ncbi.nlm.nih.gov/15287760

المؤلفون: Carl A. Busacca, Earl Spinelli, Erin M O'Brien, Danja Grossbach, Regina C. So

المصدر: Organic letters. 5(4)

مصطلحات موضوعية: Chemistry, Ligand, Phosphines, Organic Chemistry, Enantioselective synthesis, Imidazoles, Stereoisomerism, Electrons, Photochemistry, Ligands, Biochemistry, Catalysis, chemistry.chemical_compound, Heck reaction, Electronic effect, Physical and Theoretical Chemistry, Selectivity, Phosphine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a41745c984640e69fe31dc11cae30c8
https://pubmed.ncbi.nlm.nih.gov/12583778

المؤلفون: Danja Grossbach, Earl Spinelli, Carl A. Busacca

المصدر: ChemInform. 31

مصطلحات موضوعية: Tert butyl, chemistry.chemical_compound, Chemistry, Yield (chemistry), Ethylenediamine, General Medicine, Medicinal chemistry, Sequence (medicine)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d39386642b908c5551593f21a54d2944
https://doi.org/10.1002/chin.200039062

المؤلفون: Danja Grossbach, Lana Smith, Mike Ridges, Carl A. Busacca, Scot Campbell, Earl Spinelli, Yong Dong

المصدر: The Journal of organic chemistry. 65(15)

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Camphordiamine, Chemistry, Stereochemistry, Organic Chemistry, Stereoselectivity, Antineoplastic Agents, Stereoisomerism, Diamines, Mass Spectrometry, Camphor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de9564bc6cebfa57a417c7051b214f1
https://pubmed.ncbi.nlm.nih.gov/10959889