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المؤلفون: Matthew E. Cramp, Mohamed I.F. Shariff, Munirah Alsaleh, Thomas A Barbera, Yi-Liang Shen, Puangrat Yongvanit, Simon D. Taylor-Robinson, Elaine Holmes, Shaun Greer, Mary M.E. Crossey, Larry K. Koomson, Stephen D. Ryder, Paiboon Sithithaworn, Watcharin Loilome, Abigail Zabron, Christopher A. Wadsworth, Kathryn Nash, Martin Prince, Zoe Leftley, Narong Khuntikeo, Helen L. Reeves, I. Jane Cox, Roger Williams
المساهمون: AMMF, Wellcome Trust, Imperial Health Charity, Imperial College Trust, Royal College of Physicians
المصدر: J Clin Exp Hepatol
مصطلحات موضوعية: HILIC, hydrophilic interaction liquid chromatography, Cirrhosis, VIP, variable importance in projection, MDR3, multidrug-resistant protein 3, Gastroenterology, PC, phosphatidylcholine, Liver disease, 0302 clinical medicine, Primary biliary cirrhosis, PHOSPHATIDYLCHOLINE, ABC, ATP-binding cassette, Hepatobiliary disease, HPO, hydrogen peroxide, MAGNETIC-RESONANCE-SPECTROSCOPY, LYSOPHOSPHATIDYLCHOLINE, metabolomics, LC-MS, liquid chromatography–mass spectroscopy, 3. Good health, 030220 oncology & carcinogenesis, CRP, C-reactive protein, Biomarker (medicine), Original Article, 030211 gastroenterology & hepatology, cholangiocarcinoma, Life Sciences & Biomedicine, medicine.medical_specialty, CCA, cholangiocarcinoma, PE, phosphatidylethanolamine, 03 medical and health sciences, Metabolomics, diagnostic biomarkers, Cholestasis, Internal medicine, medicine, Metabolome, NMR, nuclear magnetic resonance, UPLC, Ultraperformance liquid chromatography, metabolic finger print, PRIMARY BILIARY-CIRRHOSIS, PCA, principal component analysis, Science & Technology, Gastroenterology & Hepatology, MS, mass spectroscopy, Hepatology, MUTATIONS, business.industry, GC–MS, gas chromatography–mass spectroscopy, medicine.disease, OPLS, orthogonal projections to latent structures, PSC, primary sclerosing cholangitis, OPLS-DA, orthogonal projections to latent structures discriminant analysis, mass spectroscopy, DDA, data-dependent acquisition, BILE, ESI, electrospray ionisation, PBC, primary biliary cirrhosis, HCC, hepatocellular carcinoma, business
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المساهمون: 10213503 - Van der Westhuizen, Francois Hendrikus, 12253936 - Venter, Gerda, 10066136 - Erasmus, Elardus, 23491639 - Van der Berg, Carien L.
المصدر: Data in Brief
Data in Brief, Vol 29, Iss, Pp-(2020)مصطلحات موضوعية: medicine.drug_class, E1, Estrone, Metabolite, E3, Estriol, Urine, Fractionation, lcsh:Computer applications to medicine. Medical informatics, ESI, Electrospray ionisation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, MS/MS, Tandem mass spectrometry, Biochemistry, Genetics and Molecular Biology, E2, Estradiol, medicine, Solid phase extraction, SPE, Solid phase extraction, LC-MS/MS, lcsh:Science (General), M, Methyl conjugation, 030304 developmental biology, MS, Mass spectrometry, G, Glucuronide conjugation, 0303 health sciences, Multidisciplinary, Chromatography, Estrogen metabolism, S, Sulphate conjugation, Elution, Chemistry, LC, Liquid chromatography, OH, Hydroxy, MeOH, Methanol, Metabolic pathway, v/v, Volume/volume ratio, Estrogen, lcsh:R858-859.7, Glucuronide, 030217 neurology & neurosurgery, lcsh:Q1-390, Method optimisation
وصف الملف: application/pdf
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المؤلفون: Griffiths, William J., Hearn, Thomas, Crick, Peter J., Abdel-Khalik, Jonas, Dickson, Alison, Yutuc, Eylan, Wang, Yuqin
المصدر: Chemistry and Physics of Lipids
مصطلحات موضوعية: 7-OC, 7-oxocholesterol, MSn, MS with multistage fragmentation, HSD, hydroxysteroid dehydrogenase, 3β,7α-diHCA(25R), 3β,7α-dihydroxycholest-5-en-(25R)26-oic acid, Molecular Conformation, 7α-HC, 7α-hydroxycholesterol, 3β,7β-diHCA(25S), 3β,7β-dihydroxycholest-5-en-(25S)26-oic acid, Mass Spectrometry, 3β,7α-diHCA(25S), 3β,7α-dihydroxycholest-5-en-(25S)26-oic acid, 25-HC, 25-hydroxycholesterol, CTX, cerebrotendinous xanthomatosis, LIT, linear ion trap, 7αH,3O-CA(25S), 7α-hydroxy-3-oxocholest-4-en-(25S)26-oic acid, LC, liquid chromatography, Stereoisomerism, Oxysterols, 7αH,3O-Δ4-BA, 7α-hydroxy-3-oxochol-4-enoic acid, EADSA, enzyme-assisted derivatisation for steroid analysis, CYP, cytochrome P450, NPC, Niemann Pick type C, 7αH,3O-CA(25R), 7α-hydroxy-3-oxocholest-4-en-(25R)26-oic acid, GC, gas chromatography, Oxidoreductases, 3β,7β-diHCA(25R), 3β,7β-dihydroxycholest-5-en-(25R)26-oic acid, AMACR, alphamethylacyl-CoA racemase, Hydroxycholesterol, Article, 24R-HC, 24R-hydroxycholesterol, Cholestenoic acid, Epimer, 3β,7α-diH-Δ5-BA, 3β,7α-dihydroxychol-5-enoic acid, ACOX2, acyl-coenzyme A oxidase 2, Humans, ComputingMethodologies_COMPUTERGRAPHICS, Sterol, SRM, standard reference material, (25R)26-HC, (25R)26-hydroxycholesterol, Cholestenes, 7β-HC, 7β-hydroxycholesterol, Cholic Acids, RIC, reconstructed ion chromatogram, 7α-HCO, 7α-hydroxycholest-4-en-3-one, MS, mass spectrometry, ESI, electrospray ionisation, SLOS, Smith-Lemli-Opitz syndrome, 24S-HC, 24S-hydroxycholesterol, 3β,7β-diH-Δ 5-BA, 3β,7β-dihydroxychol-5-enoic acid, GP, Girard P reagent, Derivatisation, MRM, multiple reaction monitoring, Chromatography, Liquid
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المؤلفون: Mark J W, McPhail, Debbie L, Shawcross, Matthew R, Lewis, Iona, Coltart, Elizabeth J, Want, Charalambos G, Antoniades, Kiril, Veselkov, Evangelos, Triantafyllou, Vishal, Patel, Oltin, Pop, Maria, Gomez-Romero, Michael, Kyriakides, Rabiya, Zia, Robin D, Abeles, Mary M E, Crossey, Wayel, Jassem, John, O'Grady, Nigel, Heaton, Georg, Auzinger, William, Bernal, Alberto, Quaglia, Muireann, Coen, Jeremy K, Nicholson, Julia A, Wendon, Elaine, Holmes, Simon D, Taylor-Robinson
المصدر: Journal of Hepatology
مصطلحات موضوعية: Liver Cirrhosis, Male, Time Factors, OPLS, orthogonal projection least squares, Biopsy, INR, international normalised ratio, CV-ANOVA, cross-validated analysis of variance, UKELD, United Kingdom end-stage liver disease, PCA, principal components analysis, Metabolic profiling, CLIF-SOFA, chronic liver failure sequential organ failure assessment, Cell Death, PLSDA, partial least squares discriminant analysis, STOCSY, statistical correlation spectroscopy, Outcome prediction, Middle Aged, ACLF, acute on chronic liver failure, Immunohistochemistry, Survival Rate, CPS, Child-Pugh Score, Liver, Metabonomics, MHE, minimal hepatic encephalopathy, Cytokines, Female, Research Article, Adult, TOF, time-of-flight, GC-MS, gas chromatography mass spectrometry, MELD, model for end-stage liver disease, UPLC, ultra-performance liquid chromatography, Young Adult, ALF, acute liver failure, Acute on chronic liver failure, Humans, Metabolomics, NMR, nuclear magnetic resonance, ComputingMethodologies_COMPUTERGRAPHICS, Aged, Retrospective Studies, LPC, lysophosphatidylcholine, Hepatology, United Kingdom, CPMG, Carr-Purcell-Meiboom-Gill, MS, mass spectrometry, ESI, electrospray ionisation, Personalised medicine, Biomarkers, Follow-Up Studies, PC, phosphocholine
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المؤلفون: Strzelecka, Dominika, Holman, Stephen W., Eyers, Claire E.
المصدر: International Journal of Mass Spectrometry
INTERNATIONAL JOURNAL OF MASS SPECTROMETRYمصطلحات موضوعية: Proteomics, MS/MS, tandem mass spectrometry, LC, liquid chromatography, MSE, mass spectrometry with elevated energy (a form of data-independent tandem mass spectrometry), SWATH, sequential window acquisition of all theoretical fragment ion spectra, DIA, data-independent acquisition, DMSO, dimethyl sulfoxide, Condensed Matter Physics, HDMSE, ion mobility-assisted MSE, LC–MS, Article, cpc, copies per cell, MS, mass spectrometry, Q-ToF, quadrupole-time-of-flight, Quantification, Peptide, ESI, electrospray ionisation, Label-free, Physical and Theoretical Chemistry, DMSO, Instrumentation, Spectroscopy, ComputingMethodologies_COMPUTERGRAPHICS
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المؤلفون: Kendall, Alexandra, Kiezel-Tsugunova, Magdalena, Brownbridge, Luke, Harwood, John L., Nicolaou, Anna
المصدر: Biochimica et Biophysica Acta
Kendall, A, Kiezel-Tsugunova, M, Brownbridge, L, Harwood, J L & Nicolaou, A 2017, ' Lipid functions in skin: differential effects of n-3 polyunsaturated fatty acids on cutaneous ceramides, in a human skin organ culture model ', Biochimica et Biophysica Acta-Biomembranes, vol. 10 . https://doi.org/10.1016/j.bbamem.2017.03.016مصطلحات موضوعية: P, phytosphingosine, MS/MS, tandem mass spectrometry, Spectrometry, Mass, Electrospray Ionization, Docosahexaenoic Acids, PUFA, polyunsaturated fatty acid(s), Biophysics, DHA, docosahexaenoic acid, AA, arachidonic acid, CER[AS], alpha-hydroxy fatty acid/sphingosine base ceramide, CER[NDS], non-hydroxy fatty acid/dihydrosphingosine base ceramide, Ceramides, Biochemistry, C1P, ceramide-1-phosphate, Article, UPLC, ultraperformance liquid chromatography, Organ Culture Techniques, Fatty Acids, Omega-3, Omega-3 fatty acids, CER[AH], alpha-hydroxy fatty acid/6-hydroxy-sphingosine base ceramide, CER[AP], alpha-hydroxy fatty acid/phytosphingosine base ceramide, Humans, CB, cannabinoid receptor, S, sphingosine, CER[NP], non-hydroxy fatty acid/phytosphingosine base ceramide, DS1P, dihydrosphingosine-1-phosphate, DS, dihydrosphingosine, S1P, sphingosine-1-phosphate, Skin, LA, linoleic acid, H, 6-hydroxysphingosine, Mass spectrometry, integumentary system, CER[NH], non-hydroxy fatty acid/6-hydroxy-sphingosine base ceramide, Cell Biology, CER[EOS], ester-linked omega-hydroxy fatty acid/sphingosine base ceramide, EPA, eicosapentaenoic acid, CER[EOH], ester-linked omega-hydroxy fatty acid/6-hydroxy-sphingosine base ceramide, CER[EODS], ester-linked omega-hydroxy fatty acid/dihydrosphingosine base ceramide, CER[EOP], ester-linked omega-hydroxy fatty acid/phytosphingosine base ceramide, MS, mass spectrometry, Eicosapentaenoic Acid, n-3PUFA, omega-3 polyunsaturated fatty acid, Lipidomics, CER[NS], non-hydroxy fatty acid/sphingosine base ceramide, ESI, electrospray ionisation, lipids (amino acids, peptides, and proteins), CER[ADS], alpha-hydroxy fatty acid/dihydrosphingosine base ceramide
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المؤلفون: Crick, Peter J., Aponte, Jennifer, Bentley, T. William, Matthews, Ian, Wang, Yuqin, Griffiths, William J.
المصدر: Biochemical and Biophysical Research Communications
مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, ER, estrogen receptor, MSn, MS with multistage fragmentation, Liquid chromatography, Biophysics, GP, Girard P, Biochemistry, Article, EADSA, enzyme-assisted derivatisation for sterol (or steroid) analysis, Humans, Molecular Biology, ROR, retinoic acid related orphan receptor, Chromatography, High Pressure Liquid, ComputingMethodologies_COMPUTERGRAPHICS, API, atmospheric pressure ionisation, LIT, linear ion trap, Mass spectrometry, LC, liquid chromatography, Cholesterol Oxidase, 3β-HCA, 3β-hydroxycholest-5-en-(25R)-26-oic acid, Cell Biology, EBI2, Epstein–Barr virus induced gene 2, RIC, reconstructed ion chromatogram, Hydroxycholesterols, 4-DMAP, 4-dimethylaminopyridine, Girard P reagent, Betaine, Sterols, MS, mass spectrometry or mass spectrum, ESI, electrospray ionisation, lipids (amino acids, peptides, and proteins), Indicators and Reagents, LXR, liver X receptor, GC, gas chromatography, Derivatisation, MRM, multiple reaction monitoring
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المؤلفون: Meljon, Anna, Wang, Yuqin, Griffiths, William J.
المصدر: Biochemical and Biophysical Research Communications
Meljon, A, Wang, Y & Griffiths, W J 2014, ' Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse ', Biochemical and Biophysical Research Communications, vol. 446, no. 3, pp. 768-774 . https://doi.org/10.1016/j.bbrc.2014.01.153مصطلحات موضوعية: Lxr, liver x receptor, Biophysics, MSn, mass spectrometry with multistage fragmentation, Biochemistry, Article, Mice, Oxysterol, RP, reversed phase, polycyclic compounds, Cholesterol 24-Hydroxylase, Brain/metabolism, Animals, Hydroxycholesterols/metabolism, FT, Fourier transform, Molecular Biology, SCAP, SREBP cleavage-activating protein, 24S,25-Epoxycholesterol, ComputingMethodologies_COMPUTERGRAPHICS, Mice, Knockout, LC, liquid chromatography, Brain, INSIG, insulin induced gene, Cell Biology, Steroid Hydroxylases/genetics, SREBP, sterol regulatory-element binding protein, RIC, reconstructed ion chromatogram, Hydroxycholesterols, Cyp, cytochrome P450, Cholesterol, Cyp46a1, SPE, solid phase extraction, MS, mass spectrometry or mass spectrum, 24S-Hydroxycholesterol, 24R-Hydroxycholesterol, Steroid Hydroxylases, ESI, electrospray ionisation, lipids (amino acids, peptides, and proteins), Female, Cholesterol/analogs & derivatives, wt, wild type, GP, Girard P reagent, MRM, multiple reaction monitoring, TLR, Toll-like receptor
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المؤلفون: Wang, Yuchen, Karu, Kersti, Meljon, Anna, Turton, John, Yau, Joyce L., Seckl, Jonathan R., Wang, Yuqin, Griffiths, William J.
المصدر: Wang, Y, Karu, K, Meljon, A, Turton, J, Yau, J L, Seckl, J R, Wang, Y & Griffiths, W J 2014, ' 24S,25-Epoxycholesterol in mouse and rat brain ', Biochemical and Biophysical Research Communications, vol. 449, no. 2, pp. 229–234 . https://doi.org/10.1016/j.bbrc.2014.05.012
Biochemical and Biophysical Research Communicationsمصطلحات موضوعية: Male, RICs, reconstructed ion chromatogram, APCI, atmospheric pressure chemical ionisation, MSn, mass spectrometry with multistage fragmentation, Biochemistry, 25-epoxide, Rats, Sprague-Dawley, Mice, 24S-hydroxycholesterol, 3β,7α-Dihydroxycholest-5-en-24S,25-epoxide, HMG-CoA, 3-hydroxy-3-methyl-glutaryl-CoA, LIT, linear ion-trap, Ctx, cortex, Insig, insulin-induced gene, Mice, Knockout, LC, liquid chromatography, DDA, data dependent analysis, Brain, BBB, blood brain barrier, Sterols, Cholesterol, CYP or Cyp, cytochrome P450, 3β,7α-Dihydroxycholest-5-en-24S, SREBP-2, sterol regulatory element-binding protein-2, Female, wt, wild type, GC, gas chromatography, Metabolic Networks and Pathways, Spectrometry, Mass, Electrospray Ionization, LXRs or Lxrs, liver X receptors, Cytochrome P450 Family 7, Biophysics, Mevalonic Acid, GP, Girard P, CNS, central nervous system, Models, Biological, Article, ER, endoplasmic reticulum, Mice, Congenic, Cytochrome P450 7b1, Animals, SCAP, SREBP-cleavage activating protein, Molecular Biology, 24S,25-Epoxycholesterol, ComputingMethodologies_COMPUTERGRAPHICS, API, atmospheric pressure ionisation, Cell Biology, Rats, Mice, Inbred C57BL, MS, mass spectrometry or mass spectrum, Steroid Hydroxylases, ESI, electrospray ionisation, Vm, ventral midbrain, MRM, multiple reaction monitoring
وصف الملف: application/pdf