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1HPW-RX40 prevents human platelet activation by attenuating cell surface protein disulfide isomerases
المؤلفون: Jia-Hau Lee, I-Hua Chen, Po-Hsiung Kung, Ying-Ting Lin, Pei-Wen Hsieh, Chin-Chung Wu
المصدر: Redox Biology
Redox Biology, Vol 13, Iss C, Pp 266-277 (2017)مصطلحات موضوعية: 0301 basic medicine, Male, Conformational change, PDI, protein disulfide isomerase, Anti-thrombotic agents, EGSH, eosin-coupled glutathione, Clinical Biochemistry, Di-E-GSSG, dieosin glutathione disulfide, Plasma protein binding, Biochemistry, ERp57, endoplasmic reticulum protein 57, Mice, GRP78, 78 kDa glucose-regulated protein, Nitrostyrene, ERp5, endoplasmic reticulum protein 5, Platelet, Enzyme Inhibitors, Protein disulfide-isomerase, lcsh:QH301-705.5, ERp72, endoplasmic reticulum protein 72, lcsh:R5-920, biology, Chemistry, GSSG, oxidized glutathione, Molecular Docking Simulation, lcsh:Medicine (General), Research Paper, Protein Binding, inorganic chemicals, Platelets, Blood Platelets, Integrin, HPW-RX40, Protein Disulfide-Isomerases, CHOP, CCAAT-enhancer-binding protein homologous protein, Styrenes, ER, endoplasmic reticulum, 03 medical and health sciences, PBS, phosphate buffered saline, TG, Thapsigargin, Cell Line, Tumor, PAO, phenylarsine oxide, Animals, Humans, Platelet activation, Viability assay, SDS-PAGE, polyacrylamide gel electrophoresis, TMX, transmembrane thioredoxin-related protein, Binding Sites, Endoplasmic reticulum, Organic Chemistry, U46619, 9,11-dideoxy-9,11-methanoepoxy PGF2α, Protein disulfide isomerase, Platelet Activation, nervous system diseases, body regions, Chlorobenzoates, Mice, Inbred C57BL, 030104 developmental biology, GPIIb/IIIa, glycoprotein IIb/IIIa, lcsh:Biology (General), DTT, dithiothreitol, Biophysics, biology.protein, DiOC6(3), 3,3′-dihexyloxacarbocyanine iodide, MNS, 3,4-methylenedioxy-nitrostyrene
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المؤلفون: Alexandre C. Pereira, Francisco R.M. Laurindo, Daniel Martins-de-Souza, Percíllia V.S. Oliveira, Victor Debbas, Sheila Garcia-Rosa, Ana Iochabel Soares Moretti, Ana Teresa Azevedo Sachetto, Tiphany Coralie De Bessa, Nathalia Tenguan Silva, Marcelo L. Santoro
المصدر: Redox Biology, Vol 22, Iss, Pp-(2019)
Redox Biologyمصطلحات موضوعية: Male, Proteomics, GSSG, glutathione disulfide, Platelet Aggregation, Proteome, PDI, protein disulfide isomerase, Cellular differentiation, Endothelial cells, Clinical Biochemistry, Gene Expression, Biochemistry, ERp57, endoplasmic reticulum protein 57, Gene expression, Protein disulfide-isomerase, lcsh:QH301-705.5, Cells, Cultured, ERp72, endoplasmic reticulum protein 72, lcsh:R5-920, biology, HRG, histidine-rich glycoprotein, Chemistry, ELISA, enzyme-linked immunosorbent assay, Phenotype, Blood proteins, Healthy Volunteers, Cell biology, Plasma proteome, Female, PRP, Platelet-rich plasma, lcsh:Medicine (General), Oxidation-Reduction, Research Paper, Adult, inorganic chemicals, Cell Survival, Protein Disulfide-Isomerases, Context (language use), Enzyme-Linked Immunosorbent Assay, ER, endoplasmic reticulum, CM, conditioned medium, FBS, fetal bovine serum, HUVEC, human umbilical vein endothelial cell line, Humans, EC, endothelial cell, Organic Chemistry, Reproducibility of Results, TMB, tetramethylbenzidine, Protein disulfide isomerase, Plasma protein signatures, Thiol proteins, nervous system diseases, Fibronectin, body regions, lcsh:Biology (General), biology.protein, MPB, 3-(N-maleimido-propionyl) biocytin, Biomarkers, GSNO, S-nitrosoglutathione, pecPDI, peri/epicellular PDI