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المؤلفون: Marta Acchioni, Anna Lisa Remoli, Angela Battistini, Robert Clarke, Chiara Acchioni, Giulia Marsili, Roberto Orsatti, Edvige Perrotti, Marco Sgarbanti
المصدر: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 10, Pp 459-469 (2020)
Neoplasia (New York, N.Y.)مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Apoptosis, IκB kinase, medicine.disease_cause, environment and public health, IRFs, interferon regulatory factors, WB, western blot, 0302 clinical medicine, FOXO3a, forkhead box O 3a, NRU, neutral red uptake, Tumor Cells, Cultured, SDS, sodium dodecyl sulphate, skin and connective tissue diseases, Ub, ubiquitin, IRF-1, Chemistry, phosphorylation, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, WCE, whole cell extract, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, I-kappa B Kinase, Ni-NTA, nickel-nitrilotriacetic acid, HS, horse serum, protein stability, 030220 oncology & carcinogenesis, Phosphorylation, Female, Signal Transduction, Original article, CYLD, cylindromatosis, Breast Neoplasms, lcsh:RC254-282, CTR, control, 03 medical and health sciences, Breast cancer, breast cancer, CHX, cycloheximide, PBS, phosphate buffered saline, medicine, Humans, IFN, interferon, TBK-1, TANK Binding Kinase 1, TRAF2, tumor necrosis factor receptor-associated factor 2, Cell Proliferation, hEGF, human Epidermal Growth Factor, Innate immune system, Ubiquitin, Cell growth, Ubiquitination, ERα, estrogen receptor α, GST, glutathione S trasferase, medicine.disease, Stat-1, signal transducer and activator of transcription-1, enzymes and coenzymes (carbohydrates), 030104 developmental biology, Proteolysis, Cancer research, HDM2, human double minute 2 protein, IKK-ε, inhibitor of nuclear factor kappa-B kinase-ε, K48 polyubiquitination, FCS, fetal calf serum, Carcinogenesis, PCNA, Proliferating Cell Nuclear Antigen, IKK-ε, Interferon Regulatory Factor-1, Interferon regulatory factors
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المؤلفون: Anders Gunnarsson, Arjan Snijder, Christian Ottmann, Saleha Patel, Leonardo De Maria, Luc Brunsveld, Claire C. Munier, Carol MacKintosh, Karl Edman, Lisa Wissler, Perry Matthew, Marianna Longo
المساهمون: Chemical Biology, ICMS Core
المصدر: Journal of Biological Chemistry, 296:100551. American Society for Biochemistry and Molecular Biology Inc.
'Journal of Biological Chemistry ', vol: 296, pages: 100551-1-100551-15 (2021)
The Journal of Biological Chemistryمصطلحات موضوعية: Threonine, 0301 basic medicine, MINK1, misshapen-like kinase 1, Biochemistry, LBD, ligand-binding domain, Glucocorticoid receptor, MINK1, HATU, 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, glucocorticoid receptor, nuclear receptor, ROCK1, Phosphorylation, Kinase, Chemistry, TBST, tris-buffered saline with Polysorbate 20, DCM, dichloromethane, Cell biology, ROCK1, Rho-associated coiled-coil containing protein kinase 1, DMF, dimethylformamide, FP, fluorescence polarization, Protein Binding, Research Article, Transcriptional Activation, MINK1 kinase, TCEP, tris(2-carboxyethyl)phosphine, SPR, surface plasmon resonance, Protein Serine-Threonine Kinases, 03 medical and health sciences, Receptors, Glucocorticoid, PDB, Protein Data Bank, DIPEA, N,N-diisopropylethylamine, Humans, NTD, N-terminal domain, NMP, N-methyl-2-pyrrolidone, Protein kinase A, Molecular Biology, Transcription factor, GR, glucocorticoid receptor, 030102 biochemistry & molecular biology, 14-3-3 protein, ERα, estrogen receptor α, Cell Biology, KPSI, kilopounds per square inch, HEK293 Cells, protein–protein interaction, 030104 developmental biology, 14-3-3 Proteins, Gene Expression Regulation, Nuclear receptor, DBD, DNA-binding domain, Mutation, ERRγ, estrogen-related receptor γ, Co-IP, co-immunoprecipitation
وصف الملف: application/pdf
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المؤلفون: Zielinska, H. A., Holly, J. M.P., Bahl, A., Perks, C. M.
المصدر: Cancer Letters
Zielinska, H A, Holly, J M P, Bahl, A & Perks, C M 2018, ' Inhibition of FASN and ERα signalling during hyperglycaemia-induced matrix-specific EMT promotes breast cancer cell invasion via a caveolin-1-dependent mechanism ', Cancer Letters, vol. 419, pp. 187-202 . https://doi.org/10.1016/j.canlet.2018.01.028مصطلحات موضوعية: EMT, Epithelial to mesenchymal transition, MMP, Matrix metalloproteinase, Epithelial-Mesenchymal Transition, GLUT, Glucose transporter, Caveolin 1, TCA, tricarboxylic acid, Breast Neoplasms, Article, ns, not significant, Breast cancer, ECM, Extracellular matrix, FASN, Fatty acid synthase, PHGDH, Phosphoglycerate dehydrogenase, MCT, Monocarboxylate transporter, Cell Movement, Cell Line, Tumor, TGFβ, Transforming growth factor β, Hyperglycaemia, Humans, Neoplasm Invasiveness, G6PD, Glucose-6-phosphate dehydrogenase, Fibronectin, ERα, Estrogen receptor α, GFPT1, Glutamine–fructose-6 phosphateransaminase 1, Cell Proliferation, NS, Non-silencing, Epithelial to mesenchymal transition, LDH, Lactate dehydrogenase, Estrogen Receptor alpha, OXPHOS, Oxidative phosphorylation, MET, Mesenchymal to epithelial transition, Extracellular Matrix, Fatty Acid Synthase, Type I, Glucose, TALDO1, Transaldolase 1, Hyperglycemia, TKT, Transketolase, MCF-7 Cells, Female, RNA Interference, ICEP, Warburg effect, PARP, Poly(ADP-ribose) polymerase, Signal Transduction
وصف الملف: application/pdf
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المؤلفون: Hiroki Yamagata, Kotaro Mizuta, Tsugumi Fujita, Eiichi Kumamoto
المصدر: Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 10, Iss C, Pp 145-151 (2017)مصطلحات موضوعية: 0301 basic medicine, endocrine system, medicine.medical_specialty, medicine.drug_class, Local anesthetic, 4-OHT, 4-hydroxytamoxifen, Biophysics, Estrogen receptor, Sciatic nerve, DMSO, dimethyl sulfoxide, Inhibitory postsynaptic potential, Biochemistry, lcsh:Biochemistry, 03 medical and health sciences, Bisphenol A, Nerve conduction inhibition, 0302 clinical medicine, IC50, half-maximal inhibitory concentration, Internal medicine, medicine, lcsh:QD415-436, TTX, tetrodotoxin, lcsh:QH301-705.5, IC50, urogenital system, Chemistry, Neurotoxicity, Antagonist, ERα, estrogen receptor α, medicine.disease, LA, local anesthetic, DRG, dorsal root ganglion, BPA, bisphenol A, ERβ, estrogen receptor β, 17β-Estradiol, nH, Hill coefficient, 030104 developmental biology, Endocrinology, lcsh:Biology (General), Endocrine disruptor, Estrogen, ERRγ, estrogen-related receptor γ, Frog, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery, Research Article, CAP, compound action potential
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المؤلفون: Stephanie K. Meyer, Tarek M. Abdelghany, Anna Kjerstine Rosenmai, Ibrahim Ibrahim, Jeremy M. Palmer, Lucy Bates, Lynsay I. Blake, Peter G. Blain, Katie Morse, Martin P. Cooke, Philip M. E. Probert, Alistair C. Leitch, Matthew C. Wright, Noha F. Abdelkader, Michael Dunn, Agneta Oskarsson, Colin H Wilson, David Jones, Rodrigo Figueiredo
المصدر: Food and chemical toxicology, 2020, Vol.136, pp.111069 [Peer Reviewed Journal]
Food and Chemical Toxicologyمصطلحات موضوعية: Ionic Liquids, Autoimmunity, PPARα, peroxisome proliferator activated receptor alpha, Pharmacology and Toxicology, PBC, Toxicology, Article, Cell Line, Xenobiotics, PBC, primary biliary cholangitis, also previously known as primary biliary cirrhosis, 03 medical and health sciences, chemistry.chemical_compound, 0404 agricultural biotechnology, 11. Sustainability, Animals, Humans, Autoimmune liver disease, Volatile solvents, M8OI, 1 octyl 3 methylimidazolium, PDC-E2, pyruvate dehydrogenase complex E2 component, 030304 developmental biology, 0303 health sciences, ALP, alkaline phosphatase, Chemistry, 1-octyl-3-methylimidazolium, Imidazoles, ERα, estrogen receptor α, 04 agricultural and veterinary sciences, General Medicine, Contamination, 040401 food science, C8[mim], Experimental animal, Liver, GGT, γ-glutamyltransferase, 13. Climate action, AhR, aryl hydrocarbon receptor, Environmental chemistry, AMA, anti-mitochondrial antibody, Toxicity, Ionic liquid, AR, androgen receptor, Food Science
وصف الملف: application/pdf
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المصدر: Matrix Biology Plus, Vol 6, Iss, Pp 100038-(2020)
Matrix Biology Plusمصطلحات موضوعية: HA, hyaluronan, Computer science, Biochemistry, miR, microRNA, tPA, tissue-type plasminogen activator, Matrix (mathematics), Human disease, TGFβ, transforming growth factor β, PG, proteoglycans, lcsh:QH301-705.5, Cancer, Cognitive science, Complex matrix, MET, mesenchymal-epithelial transition, uPA, urokinase-type plasminogen activator, LEKTI, lympho-epithelial Kazal-type inhibitor, EMILIN2, elastin microfibril interfacer 2, VEGF, vascular endothelial growth factor, Phenotype, Reciprocity (evolution), ECM, extracellular matrix, UVR, ultraviolet radiation, ERβ, estrogen receptor β, PLL, poly-l-lysine, SLRP, small leucine rich proteoglycans, Research strategies, MMP, matrix metalloproteinases, SSR, solar-simulated radiation, ADAM, a disintegrin and metalloproteinases, Proteoglycans, AGE, advanced glycation end products, Collagen, Methodologies, RTK, receptor tyrosine kinase, EMT, epithelial-mesenchymal transition, HAS2-AS1, HAS2 antisense 1, LOX, lysyl oxidases, Histology, EMILIN1, elastin microfibril interfacer 1, LTBP, latent TGFβ-binding proteins, Biophysics, Original research, Article, IR-A, insulin receptor A, OB, osteoblast, ROS, reactive oxygen species, IBC, inflammatory breast cancer, Genetics, IGF-IR, insulin growth factor I receptor, HAS2, hyaluronan synthase 2, PARs, protease activated receptors, Molecular Biology, EGF, epidermal growth factor, HMGA2, high-mobility group AT-Hook 2, HB-EGF, heparin binding EGF, MAGP, microfibril-associated glycoproteins, ERα, estrogen receptor α, Cell Biology, Human body, EGFR, epidermal growth factor receptor, OI, osteogenesis imperfecta, lcsh:Biology (General), TNT, tunneling nanotubes, GBM, glioblastoma, Angiogenesis, DDR1, discoidin domain receptor 1
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المؤلفون: Xiaolei Li, Weidong Han, Xiaobing Fu
المصدر: Mutation Research. Reviews in Mutation Research
مصطلحات موضوعية: Models, Molecular, Poly Adenosine Diphosphate Ribose, Transcription, Genetic, Health, Toxicology and Mutagenesis, Apoptosis, ADPR, ADP-ribose, Conserved sequence, Macro domain, Drug Delivery Systems, Protein structure, DT, diphtheria toxin, MSCI, meiotic sex chromosome inactivation, SFV, Semliki Forest Virus, STS, staurosporine, Macro, IAPs, inhibitors of apoptosis, BER, base excision repair, KS, Kabuki syndrome, Conserved Sequence, Genetics, TNF, tumor necrosis factor, PARG, PAR glycohydrolase, PARylation, poly(ADP-ribosyl)ation, ITC, isothermal titration calorimetry, CoaSt6, Collaborator of Stat6, Biological function, mARTs, mono-ADP-ribosyltransferases, PTMs, posttranslational modifications, RNAP II, RNA polymerase II, EMT, epithelial–mesenchymal transition, Protein family, SSBR, single-strand break repair, BCL2, B cell lymphoma 2, OAADPR, O-acetyl-ADP-ribose, Sequence alignment, Computational biology, APLF, aprataxin PNK-like factor, Biology, Article, Chromatin remodeling, Structure-Activity Relationship, NF-κB, nuclear factor-kappaB, Disease association, CHIP, chromatin immunoprecipitation, Animals, Humans, PARPs, PAR polymerases, Genetic Predisposition to Disease, CBP, CREB-binding protein, TRF1, telomeric repeat binding factor-1, Macro domain family, STAT6, signal transducer and activator of transcription-6, 3D, three-dimensional, ERα, estrogen receptor α, bAREs, bacterial-produce ADP-ribosylating exotoxins, DSBs, DNA double-stranded breaks, PARBMs, PAR binding motifs, Protein Structure, Tertiary, stomatognathic diseases, ETA, exotoxin A, Posttranslational modifications, CHFR, checkpoint protein with FHA and RING domain, AR, androgen receptor, PAR, poly(ADP-ribose), PBZ, PAR binding zinc finger, Carrier Proteins, Sequence Alignment, Structural feature, Function (biology), DNA Damage