المؤلفون: Jing Huo, Lin Feng, Yao Cheng, Yu-Lu Miao, Wen Liu, Miao-Miao Hou, Hui-Feng Zhang, Cai-Hong Yang, Yan Li, Ming-Sheng Zhang, Yan-Ying Fan

المصدر: Brain Research Bulletin, Vol 217, Iss , Pp 111072- (2024)

مصطلحات موضوعية: Traumatic brain injury, Delayed simvastatin treatment, ELOVL1, Therapeutic window, Brain tissue repair, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0361923024002065; https://doaj.org/toc/1873-2747

URL الوصول: https://doaj.org/article/45797c5fe69f43cb86832a16f9dbed2a

المؤلفون: Chloe Thomas, Dolores B. Njoku

المصدر: Frontiers in Medicine, Vol 11 (2024)

مصطلحات موضوعية: NAFLD, MAFLD, ELOVL1, PPARα, lipid, metabolism, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2024.1425528/full; https://doaj.org/toc/2296-858X

URL الوصول: https://doaj.org/article/73f05f117a7f4a7f8cf51824bc51d591

المؤلفون: Liang Qin, Cheng-ze Song, Fa-yang Yuan, Xue-fa Wang, Yang Yang, Yi-fei Ma, Zi-li Chen

المصدر: Heliyon, Vol 10, Iss 15, Pp e34961- (2024)

مصطلحات موضوعية: ELOVL1, HCC, PI3K-AKT-mTOR, Tumor promotion, Science (General), Q1-390, Social sciences (General), H1-99

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024109929; https://doaj.org/toc/2405-8440

URL الوصول: https://doaj.org/article/e985b5aea5b045e7ba788c8d0d8fd563

المؤلفون: Yu Zhang, Shujie Pang, Bo Sun, Minbo Zhang, Xiaoxiao Jiao, Linying Lai, Yiting Qian, Ning Yang, Wenzhuo Yang

المصدر: Frontiers in Oncology, Vol 12 (2022)

مصطلحات موضوعية: hepatocellular carcinoma, ELOVLs, ELOVL1, prognosis, immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.884066/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/745d2d791365428e85b1a6a047932371

المؤلفون: Jon H. Come (5395523), Timothy J. Senter (1309548), Michael P. Clark (1764619), John J. Court (1764601), Zachary Gale-Day (11663926), Wenxin Gu (1764613), Elaine Krueger (1720042), Jianglin Liang (1764637), Mark Morris (1834648), Suganthini Nanthakumar (2342815), Hardwin O’Dowd (1570984), Francois Maltais (2342827), Ganesh Iyer (2481568), John Andreassi (11663929), Christina Boucher (1562233), Tony Considine (11663932), Cameron S. Moody (1562266), William Taylor (373883), Arun K. Mohanty (11663935), Yulin Huang (447676), Harmon Zuccola (1816819), Joyce Coll (2884850), Kenneth C. Bonanno (2884844), Kevin J. Gagnon (1330194), Lu Gan (33435), Fan Lu (490738), Hong Gao (68166), Ananthisrinivas Chakilam (11663938), Juntyma Engtrakul (11663941), Bin Song (446187), Dan Crawford (8315991), Elisabeth Doyle (1900438), Tal Kramer (11663944), Bryan Vought (11663947), Jonathan Phillips (6332132), Raymond Kemper (11663950), Martin Sanders (11663953), Rebecca Swett (149249), Brinley Furey (11663956), Ray Winquist (11663959), Mark E. Bunnage (1290480), Katrina L. Jackson (2047516), Paul S. Charifson (1720039), Sanjay S. Magavi (11663962)

مصطلحات موضوعية: Biochemistry, Medicine, Neuroscience, Pharmacology, Chemical Sciences not elsewhere classified, cns precluded progression, central nervous system, 0 vlcfa synthesis, 0 vlcfa concentrations, treatment reduced c26, preclinical safety findings, selectively inhibits elovl1, ald patient fibroblasts, 27 , vivo <, reducing c26, findings require, elovl1 accumulation, elovl1 ), type levels, thiazole amides, relevant tissue, pyrazole amides, pathologies observed, highly potent, effective approach, ald )

Relation: https://figshare.com/articles/journal_contribution/Discovery_and_Optimization_of_Pyrazole_Amides_as_Inhibitors_of_ELOVL1/16958665

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00944.s001

المؤلفون: Zhixin Guo, Yanfeng Wang, Xue Feng, Chaogetu Bao, Qiburi He, Lili Bao, Huifang Hao, Zhigang Wang

المصدر: Asian-Australasian Journal of Animal Sciences, Vol 29, Iss 11, Pp 1646-1652 (2016)

مصطلحات موضوعية: Bovine Mammary Epithelial Cells [BMECs], Mammalian Target of Rapamycin Complex 1 [mTORC1], Elongation of Very-long-chain Fatty Acids 1 [ELOVL1], DHA, Animal culture, SF1-1100, Animal biochemistry, QP501-801

وصف الملف: electronic resource

Relation: http://www.ajas.info/upload/pdf/ajas-29-11-1646.pdf; https://doaj.org/toc/1011-2367; https://doaj.org/toc/1976-5517

URL الوصول: https://doaj.org/article/3549c3c6014b4b87b6422b520f628041

المؤلفون: Nesli-Ece Sen, Aleksandar Arsovic, David Meierhofer, Susanne Brodesser, Carola Oberschmidt, Júlia Canet-Pons, Zeynep-Ece Kaya, Melanie-Vanessa Halbach, Suzana Gispert, Konrad Sandhoff, Georg Auburger

المصدر: International Journal of Molecular Sciences; Volume 20; Issue 23; Pages: 5854

مصطلحات موضوعية: olivo-ponto-cerebellar atrophy (OPCA), amyotrophic lateral sclerosis (ALS), leukodystrophy, ceramide synthase (CERS2/CERS1), serine palmitoyltransferase 2 ( Sptlc2 ), neutral sphingomyelinase ( Smpd3 ), neutral ceramidase ( Asah2 ), fatty acid elongase ( Elovl1 / 4 / 5 ), SCA34, SCA38, acid sphingomyelinase (ASMase, Smpd1 )

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms20235854

الاتاحة: https://doi.org/10.3390/ijms20235854

المؤلفون: Fan, LY, Saavedra Garcia, P, Lam, EW

المساهمون: Medical Research Council (MRC), Imperial College Trust

المصدر: 610 ; 606

مصطلحات موضوعية: ACAA2, Acetyl-CoA acetyltransferase 2, ACACA, Acetyl-CoA carboxylase, ACAD8, Acyl-CoA dehydrogenase family member 8, ACADM, Acyl-CoA dehydrogenase C4 to C12 straight chain, ACOX, Acyl-CoA oxidase, ACSL3/4, Acyl-CoA synthetase long-chain family member 3/4, ACSS, Acyl-CoA synthetase short-chain family member, CPT2, Carnitine palmitoyltransferase II, Caenorhabditis elegans, DAF-16, DAG, Diacylglycerol, DGAT, Diacylglycerol O-acyltransferase, ECHS1, Short-chain enoyl-CoA hydratase 1, ELOVL1, Elongation of very long chain fatty acids protein 1, FA, fatty acid, FADS2, Fatty acid desaturase 2

Relation: Data in Brief; http://hdl.handle.net/10044/1/45105; https://dx.doi.org/10.1016/j.dib.2017.02.055; MR/N012097/1; WSCC_P66361

الاتاحة: http://hdl.handle.net/10044/1/45105
https://doi.org/10.1016/j.dib.2017.02.055

المؤلفون: Akçakaya, Nihan Hande, Yararbaş, Kanay, Süsgün, Seda, İşeri, Sibel Aylin Uğur, Kihara, Akio, Takahashi, Taiko, Mercan, Sevcan, Sassa, Takayuki, Akçapınar, Günseli Bayram

المساهمون: SÜSGÜN, Seda

مصطلحات موضوعية: Takahashi T., Mercan S., Sassa T., Akçapınar G. B., Yararbaş K., Süsgün S., İşeri S. A. U., Kihara A., Akçakaya N. H., Hypomyelinating spastic dyskinesia and ichthyosis caused by a homozygous splice site mutation leading to exon skipping in ELOVL1.-, Brain & development

Time: 2022

Relation: http://hdl.handle.net/20.500.12645/30511

الاتاحة: https://hdl.handle.net/20.500.12645/30511
https://doi.org/10.1016/j.braindev.2022.03.003

المؤلفون: Yu Zhang, Shujie Pang, Bo Sun, Minbo Zhang, Xiaoxiao Jiao, Linying Lai, Yiting Qian, Ning Yang, Wenzhuo Yang

مصطلحات موضوعية: Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, hepatocellular carcinoma, ELOVLs, ELOVL1, prognosis, immunotherapy

Relation: https://figshare.com/articles/figure/Image_1_ELOVLs_Predict_Distinct_Prognosis_Value_and_Immunotherapy_Efficacy_In_Patients_With_Hepatocellular_Carcinoma_tif/20316180

الاتاحة: https://doi.org/10.3389/fonc.2022.884066.s001
https://figshare.com/articles/figure/Image_1_ELOVLs_Predict_Distinct_Prognosis_Value_and_Immunotherapy_Efficacy_In_Patients_With_Hepatocellular_Carcinoma_tif/20316180

المؤلفون: Taiko Takahashi, Sevcan Mercan, Takayuki Sassa, Günseli Bayram Akçapınar, Kanay Yararbaş, Seda Süsgün, Sibel Aylin Uğur İşeri, Akio Kihara, Nihan Hande Akçakaya

المساهمون: SÜSGÜN, Seda

المصدر: Braindevelopment. 44(6)

مصطلحات موضوعية: Sulfonamides, Dyskinesias, Fatty Acid Elongases, Cerebral Palsy, Fatty Acids, Imidazoles, Ichthyosis, General Medicine, Exons, Thiophenes, Takahashi T., Mercan S., Sassa T., Akçapınar G. B. , Yararbaş K., Süsgün S., İşeri S. A. U. , Kihara A., Akçakaya N. H. , -Hypomyelinating spastic dyskinesia and ichthyosis caused by a homozygous splice site mutation leading to exon skipping in ELOVL1.-, Brain & development, 2022, Ceramides, Pedigree, Developmental Neuroscience, Muscle Spasticity, Tandem Mass Spectrometry, Pediatrics, Perinatology and Child Health, Mutation, Humans, Neurology (clinical), Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a8c811962bf5bdd5f4087a4eb3949e
https://pubmed.ncbi.nlm.nih.gov/35379526

المؤلفون: Richard A. Anderson, Katrin Ottersbach, Hélène Jakobczyk, Foteini Fotopoulou, Rishi S. Kotecha, Camille Malouf, Andrew J. Finch, Vasiliki Symeonidou, Salem Bashanfer

المصدر: Cell Reports
Symeonidou, V, Jakobczyk, H, Bashanfer, S, Malouf, C, Fotopoulou, F, Kotecha, R S, Anderson, R A, Finch, A J & Ottersbach, K 2021, ' Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements. ', Cell Reports, vol. 37, no. 4 . https://doi.org/10.1016/j.celrep.2021.109900

مصطلحات موضوعية: MLL-AF4, Adult, Male, infant leukemia, Mice, Transgenic, Disease, acute lymphoblastic leukemia, Biology, Bioinformatics, PLK1, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Mice, Fetus, hemic and lymphatic diseases, Report, ELOVL1, Cell Line, Tumor, Animals, Humans, Progenitor cell, Gene, Fatty acid metabolism, Fatty Acids, Infant, Newborn, RNA, B-ALL, onco-fetal signature, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Hematopoietic Stem Cells, Haematopoiesis, chemistry, Female

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025f38cdcc64cc9ffaaa0290715a11e7
http://europepmc.org/articles/PMC8567312

المؤلفون: Weipeng Wang, Qiburi He, Zhixin Guo, Limin Yang, Lili Bao, Wenlei Bao, Xu Zheng, Yanfeng Wang, Zhigang Wang

المصدر: International Journal of Molecular Sciences; Volume 16; Issue 7; Pages: 16440-16453

مصطلحات موضوعية: cashmere goat, ELOVL1, expression pattern

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Biochemistry; https://dx.doi.org/10.3390/ijms160716440

الاتاحة: https://doi.org/10.3390/ijms160716440

المؤلفون: Chen, Lixian, Wu, Nan, Kennedy, Lindsey, Francis, Heather, Ceci, Ludovica, Zhou, Tianhao, Samala, Niharika, Kyritsi, Konstantina, Wu, Chaodong, Sybenga, Amelia, Ekser, Burcin, Dar, Wasim, Atkins, Constance, Meadows, Vik, Glaser, Shannon, Alpini, Gianfranco

المساهمون: Surgery, School of Medicine

المصدر: Author

مصطلحات موضوعية: angiogenesis, ductular reaction, ELOVL1, hepatic steatosis, miR-125b

وصف الملف: application/pdf

Relation: Hepatology; Chen, L., Wu, N., Kennedy, L., Francis, H., Ceci, L., Zhou, T., Samala, N., Kyritsi, K., Wu, C., Sybenga, A., Ekser, B., Dar, W., Atkins, C., Meadows, V., Glaser, S., & Alpini, G. (2021). Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes. Hepatology, 74(4), 1845-1863. https://doi.org/10.1002/hep.31871; https://hdl.handle.net/1805/26876

الاتاحة: https://hdl.handle.net/1805/26876

المؤلفون: Klemp, Henry Gerd

المساهمون: Fischer, André Prof. Dr., Nave, Klaus-Armin Prof. Dr.

مصطلحات موضوعية: Rare diseases, Rare disorders, Metabolomics, LC-MS, Mass spectrometry, Zellwegers disease, Peroxisomes, ELOVL1, neurometabolic, Biologie (PPN619462639)

Time: 610

Relation: http://creativecommons.org/licenses/by-nc-nd/4.0/; http://hdl.handle.net/21.11130/00-1735-0000-0008-5943-9; http://dx.doi.org/10.53846/goediss-8875; urn:nbn:de:gbv:7-21.11130/00-1735-0000-0008-5943-9-8

الاتاحة: http://hdl.handle.net/21.11130/00-1735-0000-0008-5943-9
https://doi.org/10.53846/goediss-8875
https://nbn-resolving.org/urn:nbn:de:gbv:7-21.11130/00-1735-0000-0008-5943-9-8

المؤلفون: Lili Bao, Chaogetu Bao, Zhixin Guo, Zhigang Wang, Yanfeng Wang, Huifang Hao, Qiburi He, Xue Feng

المصدر: Asian-Australasian Journal of Animal Sciences
Asian-Australasian Journal of Animal Sciences, Vol 29, Iss 11, Pp 1646-1652 (2016)

مصطلحات موضوعية: 0301 basic medicine, Elongation of Very-long-chain Fatty Acids 1 [ELOVL1], lcsh:Animal biochemistry, mTORC1, Mammalian Target of Rapamycin Complex 1 [mTORC1], Article, 03 medical and health sciences, chemistry.chemical_compound, Bovine Mammary Epithelial Cells [BMECs], 0302 clinical medicine, Biosynthesis, Lipid biosynthesis, Gene expression, lcsh:QP501-801, lcsh:SF1-1100, Messenger RNA, Cell growth, Metabolism, DHA, 030104 developmental biology, Biochemistry, chemistry, Docosahexaenoic acid, 030220 oncology & carcinogenesis, Animal Science and Zoology, lipids (amino acids, peptides, and proteins), lcsh:Animal culture, Food Science

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6b7ba6ca0d7890d1c1b23945c382e1
http://europepmc.org/articles/PMC5088386

المؤلفون: Yanfeng Wang, Limin Yang, Zhixin Guo, Xu Zheng, Qiburi He, Wenlei Bao, Weipeng Wang, Zhigang Wang, Lili Bao

المصدر: International Journal of Molecular Sciences
Volume 16
Issue 7
Pages 16440-16453
International Journal of Molecular Sciences, Vol 16, Iss 7, Pp 16440-16453 (2015)

مصطلحات موضوعية: Male, Fatty Acid Elongases, Molecular Sequence Data, Down-Regulation, mTORC1, Biology, Mechanistic Target of Rapamycin Complex 1, cashmere goat, Catalysis, Article, Inorganic Chemistry, lcsh:Chemistry, chemistry.chemical_compound, Acetyltransferases, Complementary DNA, ELOVL1, Gene expression, Cashmere goat, Animals, Amino Acid Sequence, RNA, Messenger, Physical and Theoretical Chemistry, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, Fatty acid synthesis, Cells, Cultured, chemistry.chemical_classification, Messenger RNA, Base Sequence, Goats, TOR Serine-Threonine Kinases, Organic Chemistry, Fatty Acids, General Medicine, Fibroblasts, Computer Science Applications, Amino acid, Biochemistry, chemistry, lcsh:Biology (General), lcsh:QD1-999, Organ Specificity, expression pattern, Multiprotein Complexes, Female, biological phenomena, cell phenomena, and immunity

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f8311ded30ce458b1ceba022507fe3
http://europepmc.org/articles/PMC4519958

المؤلفون: Lavender Yuen-Nam Fan, Paula Saavedra-García, Eric Wing-Fai Lam

المصدر: Data in Brief
Data in Brief, Vol 11, Iss C, Pp 606-610 (2017)

مصطلحات موضوعية: FADS2, Fatty acid desaturase 2, ACSL3/4, Acyl-CoA synthetase long-chain family member 3/4, TAG, triacylglycerol, DAF-16, ACACA, Acetyl-CoA carboxylase, MLYCD, Malonyl-CoA decarboxylase, lcsh:Computer applications to medicine. Medical informatics, FASN, Fatty acid synthase, DAG, Diacylglycerol, DGAT, Diacylglycerol O-acyltransferase, PUFA, polyunsaturated fatty acid, ACAA2, Acetyl-CoA acetyltransferase 2, CPT2, Carnitine palmitoyltransferase II, lcsh:Science (General), Caenorhabditis elegans, HADHA, Hydroxyacyl-CoA dehydrogenase/3-Ketoacyl-CoA thiolase/Enoyl-CoA hydratase, alpha subunit, Data Article, VLCFA, Very long chain fatty acid, SCD1/5, Stearoyl-CoA desaturase 1/5, FOX, Forkhead box, FA, fatty acid, PNPLA, patatin like phospholipase domain containing, ELOVL1, Elongation of very long chain fatty acids protein 1, FOXO3, FOXM1, ACAD8, Acyl-CoA dehydrogenase family member 8, ACSS, Acyl-CoA synthetase short-chain family member, MOGAT1/2, Monoacylglycerol O-acyltransferase 1/2, ACADM, Acyl-CoA dehydrogenase C4 to C12 straight chain, LCFA, Long chain fatty acid, ACOX, Acyl-CoA oxidase, Lipid metabolism, ECHS1, Short-chain enoyl-CoA hydratase 1, HADH, Hydroxyacyl-coenzyme A dehydrogenase, lcsh:R858-859.7, FATP4, Fatty acid transport protein 4, TCA, Tricarboxylic acid, lcsh:Q1-390

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::657e1963501772ba0ba77ac0aa563b87
https://pubmed.ncbi.nlm.nih.gov/28349111

المؤلفون: Johannes Berger, Stephan Kemp, Patrick Aubourg

المصدر: Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease; Vol 1822

مصطلحات موضوعية: endocrine system, congenital, hereditary, and neonatal diseases and abnormalities, endocrine system diseases, Disease, Peroxisome, Biology, ATP Binding Cassette Transporter, Subfamily D, Member 1, 03 medical and health sciences, VLCFA, 0302 clinical medicine, Pregnancy, Prenatal Diagnosis, ELOVL1, medicine, Animals, Humans, Adrenoleukodystrophy, Gene, Molecular Biology, 030304 developmental biology, Genetics, 0303 health sciences, Fatty Acids, Leukodystrophy, ABCD1, Brain, nutritional and metabolic diseases, Heterozygote advantage, medicine.disease, Phenotype, 3. Good health, ALDP, Mutation, Molecular Medicine, ATP-Binding Cassette Transporters, Female, 030217 neurology & neurosurgery, Biogenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9573b8dfd568e294f80fa5c4695eebca

المؤلفون: Michael J. Boyd (1764598), Philip N. Collier (1562239), Michael P. Clark (1764619), Hongbo Deng (1764592), Sarathy Kesavan (1950592), Steven M. Ronkin (11798628), Nathan Waal (1720030), Jian Wang (5901), Jingrong Cao (1577356), Pan Li (335711), Jon Come (1562230), Ioana Davies (1764610), John P. Duffy (1764631), John E. Cochran (2160814), John J. Court (1764601), Kishan Chandupatla (2863559), Katrina L. Jackson (2047516), Francois Maltais (2342827), Hardwin O’Dowd (1570984), Christina Boucher (1562233), Tony Considine (11663932), William P. Taylor (1764604), Hong Gao (68166), Ananthisrinivas Chakilam (11663938), Juntyma Engtrakul (11663941), Dan Crawford (8315991), Elizabeth Doyle (11798631), Jonathan Phillips (6332132), Raymond Kemper (11663950), Rebecca Swett (149249), James Empfield (11798634), Mark E. Bunnage (1290480), Paul S. Charifson (1720039), Sanjay Shivayogi Magavi (11798637)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, throughput radiometric screen, favorable pharmacokinetics culminating, exploring therapeutic approaches, central nervous system, 0 lysophosphatidyl choline, ald patient fibroblasts, 22 , 0 vlcfa synthesis, potent elovl1 inhibitor, selective inhibitor, highly potent, useful tool, type levels, reducing c26, reduced c26, near wild, murine model, may serve, lpc ), ko mice, based compounds, ald )

Relation: https://figshare.com/articles/dataset/Discovery_of_Novel_Orally_Bioavailable_Pyrimidine_Ether-Based_Inhibitors_of_ELOVL1/17131737

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00948.s001