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المؤلفون: Guanting Li, Wenli Zang, Kexin Shi, Xinyu Zhou, Shuwen Fu, Yinglei Zhai
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 92-106 (2022)مصطلحات موضوعية: α-PD-L1, anti-PD-L1 monoclonal antibody, Carrier-free, IC50, half maximal inhibitory concentration, ITM, immunosuppressive tumor microenvironment, Drug resistance, Review, EPI, epirubicin, Medicine, Nanotechnology, ACT, adoptive cell transfer, ZHO, Z-Histidine-Obzl, DPDNAs, dual pure drug nano-assemblies, General Pharmacology, Toxicology and Pharmaceutics, PTT, photothermal therapy, media_common, DBNP, DOX-Ber nano-assemblies, PDNAs, pure drug nano-assemblies, FRET, Forster Resonance Energy Transfer, ATO, atovaquone, PD-1, PD receptor 1, TME, tumor microenvironment, RBC, red blood cell, Self-assembly, QSNAP, quantitative structure-nanoparticle assembly prediction, Anticancer drug, Pure drug, Cancer treatment, DBNP@CM, DBNP were cloaked with 4T1 cell membranes, Nanomedicine, PAI, photoacoustic imaging, PDT, photodynamic therapy, YSV, tripeptide tyroservatide, Drug delivery, CPT, camptothecin, DCs, dendritic cells, TNBC, triple negative breast, HMGB1, high-mobility group box 1, Drug, Carrier free, ATP, adenosine triphosphate, CTLs, cytotoxic T lymphocytes, media_common.quotation_subject, ICG, indocyanine green, PD-L1, PD receptor 1 ligand, Cancer therapy, ICD, immunogenic cell death, RM1-950, BV, Biliverdin, GEF, gefitinib, PPa, pheophorbide A, ABC, accelerated blood clearance, Ce6, chlorine e6, ROS, reactive oxygen species, NSCLC, non-small cell lung cancer, HCPT, hydroxycamptothecin, Combination therapy, NIR, near-infrared, TEM, transmission electron microscopy, EPR, enhanced permeability and retention, MTX, methotrexate, Nano-DDSs, nanoparticulate drug delivery systems, NPs, nanoparticles, Ber, berberine, Poly I:C, polyriboinosinic:polyribocytidylic acid, UA, ursolic acid, SPDNAs, single pure drug nano-assemblies, business.industry, MPDNAs, multiple pure drug nano-assemblies, ICB, immunologic checkpoint blockade, CI, combination index, TLR4, Toll-like receptor 4, TA, tannic acid, TTZ, trastuzumab, Top I & II, topoisomerase I & II, DOX, doxorubicin, PTX, paclitaxel, EGFR, epithelial growth factor receptor, MDS, molecular dynamics simulations, RNA, ribonucleic acid, dsRNA, double-stranded RNA, Therapeutics. Pharmacology, business, MRI, magnetic resonance imaging
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المصدر: Advanced Drug Delivery Reviews
مصطلحات موضوعية: ICAM1, Intercellular adhesion molecule–1, PLA, Poly(lactide), GEMM, Genetically modified mouse model, RAG, Rag-deficient, 02 engineering and technology, Metastasis, CCPM, Core-crosslinked block copolymer micelle, TME, Tumor microenvironment, TAM, Tumor-associated macrophages, Breast cancer, NIR, Near-infrared, Th2, Type 2 T helper, NK, Natural killer, AGM, Aminoglutethimide, Medicine, NF1, Neurofibromin 1, BRCA1, Breast cancer type 1 susceptibility protein, SPIO, Superparamagnetic iron oxide nanoparticle, 0303 health sciences, education.field_of_study, ERS1, Estrogen receptor gene, BRCA2, Breast cancer type 2 susceptibility protein, Organoids, CHEK2, Checkpoint kinase 2, Patient-derived xenografts, Nanomedicine, PTBPC, Poly(2‐((tert‐butoxycarbonyl)amino)‐3‐propyl carbonate, DOX, Doxorubicin, 0210 nano-technology, PDOX, Patient-derived organoid-derived xenograft, TNBC, Triple negative breast cancer, NOG, NOD/Shi-scid/γc−/− null, FITC, Fluorescein isothiocyanate, Antineoplastic Agents, 2D, Two-dimensional, MMDOX, Doxorubicin-loaded mixed micelles, Article, NOD-SCID, non-obese diabetic-severe combined immunodeficient, WHO, World Health Organization, FA, Folic acid, PyMT, Polyoma middle tumor-antigen, 03 medical and health sciences, HPMA, Hydroxypropyl methacrylamide, Drug Development, NMU, N-methyl-n-nitrosourea, Humans, SCID, Severe combined immunodeficient, education, WAP, Whey acidic protein, Immune status, MDR1, Multidrug resistance protein 1, PTEN, Phosphatase and tensin homolog, pDNA, Plasmid desoxyribonucleic acid, AuNR, Gold nanorod, medicine.disease, NP, Nanoparticle, VIP, Vasoactive intestinal peptide, Clinical trial, PLGA, poly(lactide-co-glycolide), Nanoparticles, HER2, Epidermal growth factor receptor 2, MMP, Metallopeptidases, Th1, Type 1 T helper, PGA, Poly-L-glutamic acid, Biomarkers, ROS, Reactive oxygen species, IHC, Immunohistochemistry, MMTV, Mouse mammary tumor virus, IO, Iron oxide, IONP, Iron oxide nanoparticle, Pharmaceutical Science, TP53, tumor protein p53, Bioinformatics, ATM, Ataxia-telangiectasia mutated, PALB2, Partner and localizer of BRCA2, Drug Delivery Systems, NSG, NOD scid gamma, uPAR, Urokinase plasminogen activator receptor, PDNA, Plasmid DNA, GSH, Glutathione, LTR, Long terminal repeat, Drug Carriers, EPR, Enhanced permeability and retention, PPTT, Plasmonic photothermal therapy, TPGS, D-α-tocopheryl polyethylene glycol 1000 succinate, DC, Dendritic cells, HIF1α, Hypoxia-inducible factor 1 alpha, MEF, Mouse embryonic fibroblasts, CAF, Cancer-associated fibroblasts, PR, Progesterone receptor, 021001 nanoscience & nanotechnology, Nanomedicines, Animal models, ER, Estrogen receptor, Nude, Athymic nude, DMBA, 7,12-dimethylbenzantracene, PEG, Polyethylene glycol, Female, MUC1, Mucin 1, QbD, Quality by design, 3D, Three-dimensional, PDX, Patient-derived xenograft, Population, Breast Neoplasms, Enhanced permeability and retention effect, Pre-clinical models, CSC, Cancer stem cells, ALOX5, Arachidonate 5-lipoxygenase, iPSC, induced pluripotent stem cells, ECM, Extracellular matrix, ComputingMethodologies_COMPUTERGRAPHICS, 030304 developmental biology, PI3KCA, Phosphatidylinositol 3-kinase, business.industry, SSMM, Sterically-stabilized mixed phospholipid nanomicelle, Cancer, FDA, Food and Drug Administration, PIMs, Porcine pulmonary intravascular macrophages, EGFR, Epithelial growth factor receptor, CDX, Cell-derived xenograft, STK11, Serine/Threonine Kinase 11, business
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المؤلفون: Tim Wallis, David C. Hancock, Aiman Alzetani, Anna Rattu, Rob M. Ewing, Ben G. Marshall, Yilu Zhou, Mark Jones, Franco Conforti, Julian Downward, Paul Skipp, Leanne Wickens, Donna E. Davies, Juanjuan Li, Sophie V. Fletcher, Fathima Maneesha Ibrahim, Luca Richeldi, Liudi Yao, Yihua Wang
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Male, NHLF, normal human lung fibroblast, ZEB1, zinc finger E-box-binding homeobox 1, Gene Expression, Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO, epithelial–mesenchymal transition, Biochemistry, GSVA, gene set variation analysis, Extracellular matrix, Idiopathic pulmonary fibrosis, Fibrosis, Cell Movement, Transforming Growth Factor beta, Pulmonary fibrosis, DEG, differentially expressed gene, ZEB1, Lung, Chemical Biology & High Throughput, CM, conditioned media, Chemistry, respiratory system, Cell biology, ECM, extracellular matrix, Extracellular Matrix, Crosstalk (biology), Tissue Plasminogen Activator, Female, EMT, epithelial–mesenchymal transition, Genetics & Genomics, Research Article, TGF-β, Model organisms, Epithelial-Mesenchymal Transition, FDR, false discovery rate, EGFR, Primary Cell Culture, 4-OHT, 4-hydroxytamoxifen, SPARC, secreted protein acidic and rich in cysteine, ERK, extracellular-regulated kinase, α-SMA, α-smooth muscle actin, Paracrine signalling, Signalling & Oncogenes, Growth factor receptor, TGF-β, transforming growth factor-β, GO, Gene Ontology, medicine, IPF, idiopathic pulmonary fibrosis, Humans, Epithelial–mesenchymal transition, Molecular Biology, IPFF, IPF fibroblast, pulmonary fibrosis, Zinc Finger E-box-Binding Homeobox 1, Epithelial Cells, SPARC, Cell Biology, Fibroblasts, Tumour Biology, medicine.disease, tPA, tissue plasminogen activator, Idiopathic Pulmonary Fibrosis, EGFR, epithelial growth factor receptor, ATII, alveolar epithelial type II, RAS
وصف الملف: text
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المؤلفون: Lyugao Qin, Tomonori Kaneko, Xuguang Liu, Courtney Voss, Shawn S.-C. Li, Xuan Cao, Guoping Wang
المصدر: Paediatrics Publications
The Journal of Biological Chemistryمصطلحات موضوعية: PTEN, cell migration, DLC1, deleted in liver cancer 1, STAT3, signal transducer and activator of transcription 3, MAP Kinase Kinase 2, MAP Kinase Kinase 1, PI3K, Biochemistry, PDGF, platelet-derived growth factor, STAT3, GAP, GTPase-activating protein, Cell Movement, MEK1/2, mitogen-activated protein kinase kinase 1/2, Tensin, IL-6, interleukin-6, P-switch, phosphorylation switch, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, biology, phosphorylation, Chemistry, TME, tumor microenvironment, IP, immunoprecipitation, Cell migration, DLC1, Cell biology, ChIP, chromatin immunoprecipitation, ERK, WB, Western blot, VAV2, vav guanine nucleotide exchange factor 2, Intercellular Signaling Peptides and Proteins, GF, growth factor, RTK, receptor tyrosine kinase, Signal transduction, JAK, Janus kinase, Platelet-derived growth factor receptor, Signal Transduction, Research Article, STAT3 Transcription Factor, MAP Kinase Signaling System, TNS3, tensin-3, pPTEN, phosphorylated PTEN, Epithelial cell migration, GEF, guanine nucleotide exchange factor, Cell Line, Tumor, Humans, Protein kinase A, Molecular Biology, PI3K/AKT/mTOR pathway, IL-6, T-switch, transcriptional switch, Interleukin-6, Epithelial Cells, VAV2, Cell Biology, CTEN, C-terminal tension, PTEN, phosphatase and tensin homolog, ERK1/2, extracellular signal–regulated protein kinase 1/2, EGF, epithelial growth factor, EGFR, epithelial growth factor receptor, biology.protein, ABD, actin-binding domain, HGF, hepatocyte growth factor, qPCR, quantitative PCR, pTNS3, phosphorylated TNS3
وصف الملف: application/pdf
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المؤلفون: Ananya Pal, Reshma Taneja, Hsin Yao Chiu
المصدر: Redox Biology, Vol 25, Iss, Pp-(2019)
Redox Biologyمصطلحات موضوعية: Oncology, BIO, 6-bromoindirubin-3′-oxime, FGFR, Fibroblast Growth Factor Receptor, Biochemistry, MCU, Mitochondrial Calcium Uniporter, 0302 clinical medicine, LiCl, Lithium Chloride, Rhabdomyosarcoma, IGF-1R, Insulin-like Growth Factor1 Receptor, Homeostasis, GSI, Gama Secretase Inhibitor, Molecular Targeted Therapy, SOD, Superoxide Dismutase, lcsh:QH301-705.5, PAX3/7-FOXO1, Paired Box Protein 3/7-Forkhead Box Protein O1, TXN, Thioredoxin, Combination chemotherapy, MYF5, Myogenic Factor 5, ARMS, Alveolar Rhabdomyosarcoma, NICD, Notch Intracellular Domain, SHH, Sonic Hedgehog, AKT, Protein Kinase B, SFRP, Secreted Frizzled Related Proteins, PDGF, Platelet Derived Growth Factor, P38MAPK, P38 Mitogen Activated Protein Kinase, SUFU, Suppressor of Fused, BRAF, Proto-oncogene B-Raf and V-Raf Murine Sarcoma Viral Oncogene Homolog B, DDAH1, Dimethylarginine Dimethylaminohydrolase 1, MICU1, Mitochondrial Calcium Uptake 1, RHOA, Ras Homolog Gene Family Member A, lcsh:Medicine (General), TPA, 2-O-tetradecanoylphorbol-13-acetate, Redox homeostasis, medicine.medical_specialty, IGF, Insulin-like Growth Factor, PRC2, Polycomb Repressive Complex 2, Therapeutics, Article, LKB1, Threonine Kinase, PTCH, Patched, WHO, World Health Organization, 03 medical and health sciences, KMT1A, K-methyltransferase 1 A, CSC, Cancer Stem Cell, Humans, ALK, Anaplastic Lymphoma Kinase, DLL1, Delta Like 1, Adverse effect, BCOR, BCL6 Corepressor, HEY1, Hairy and Enhancer of Split Related with YRPW Motif Protein 1, ATP2A3, ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+, medicine.disease, MYOD1, Myoblast Determination Protein, RBPJ, Recombining Binding Protein Suppressor of Hairless, Clinical trial, 030104 developmental biology, HAT, Histone Acetyltransferase, JAG1, Jagged 1, IC, Intracellular, TSA, Trichostatin A, 030217 neurology & neurosurgery, 2-ME, Methoxyestradiol, 0301 basic medicine, VANGL2, Van Gogh-like 2, Clinical Biochemistry, Drug resistance, SMO, Smoothened, Epigenesis, Genetic, VAC, Vincristine, Actinomycin D and Cyclophosphamide, Metastasis, NOSIP, Nitric Oxide Synthase Interacting Protein, COX7A1, Cytochrome c Oxidase Polypeptide 7A1, GLRX, Glutaredoxin, PI3K, Phosphatidylinositol-3-Kinase, TPC, Tumour Propagating Cells, DNMT, DNA Methyltransferase, LRP, Low Density Lipoprotein Receptor Related Protein, GSK3, Glycogen Kinase synthase, GLI, Glioma Associated Oncogene, lcsh:R5-920, VEGF, Vascular Endothelial Growth Factor, EMT, Epithelial to Mesenchymal Transition, FDA, US Food and Drug Administration, Soft tissue sarcoma, CK1α, Caesin Kinase 1 α, PCP, Planar Cell Polarity, HHIP, Hedgehog Interacting Protein, TCF/LEF, Transcription factor/Lymphoid Enhancer Binding Factor 1, SFK, YES/SRC family tyrosine kinase, HIF-1 α, Hypoxia Inducible Factor 1 α, CDK, Cyclin Dependent Kinase, ERK1/2, Extracellular Signal Regulated Kinase ½, JNK, Janus Kinase 1, EGFR, Epithelial Growth Factor Receptor, ICN1, Intracellular Notch Domain 1, Oxidation-Reduction, BRD, BET-containing Proteins, IHH, Indian Hedgehog Protein, Transcription, SP, Specificity Transcription Factor, BET, Bromodomain and extra-terminal, MST1, Macrophage Stimulating 1, TXNDC12, Thioredoxin Domain-containing Protein 12, MEK, Mitogen Activated Protein Kinase, Signalling, EZH2, Enhancer of Zeste Homolog 2, mTOR, (PI3K)-AKT-mammalian target of rapamycin, HES1, Hairy and Enhancer of Split-1, NOS1, Nitric Oxide Synthase 1, Internal medicine, RASSF4, Ras Association domain family member 4, medicine, ERMS, Embryonal Rhabdomyosarcoma, PTK2, Protein Tyrosine Kinase 2, Epigenetics, S6K1, S6 Kinase 1, DZNep, Deazaneplanocin A, MOB1, Mps One Binder Kinase Activator-like 1, SAHA, Suberoylanilide Hydroxamic Acid, DHH, Desert Hedgehog Protein, 5-aza-dc, 5-aza-2′-deoxycytidine, business.industry, GTP, Guanosine-5′-triphosphate, Organic Chemistry, YAP, Yes Associated Protein 1, PPP, Picropodophyllin, PDX, Patient Derived Xenograft, SETD2, SET Domain Containing 2, Oxidative Stress, lcsh:Biology (General), PcG, Polycomb group, AP1, Activator Protein 1, MEF2C, Myocyte Enhancer Factor 2C, SOX2, Sex determining Region Y-box 2, business, ROS, Reactive Oxygen Species
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المصدر: Respiratory Medicine Case Reports
Respiratory Medicine Case Reports, Vol 31, Iss, Pp 101247-(2020)مصطلحات موضوعية: COPD, chronic obstructive airways disease, Pulmonary and Respiratory Medicine, medicine.medical_specialty, TM, Tracheomalacia, Case Report, TBM, tracheobronchomalacia, CT, computerised tomography, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Roflumilast, lcsh:RC705-779, Tracheobronchomalacia, business.industry, Standard treatment, lcsh:Diseases of the respiratory system, FEV1, forced expiratory volume in 1 second, respiratory system, medicine.disease, Obstructive lung disease, EGFR, Epithelial growth factor receptor, respiratory tract diseases, Cough, 030228 respiratory system, Lung disease, 030220 oncology & carcinogenesis, Mycoplasma pneumonia, Immunology of roflumilast, Sputum, EDAC, excessive dynamic airway collapse, medicine.symptom, business, Airway, PEFR, peak expiratory flow rate, medicine.drug