المؤلفون: Rudd, Michael T., Manley, Peter J., Hanney, Barbara, Meng, Zhaoyang, Shu, Youheng, de Leon, Pablo, Frie, Jessica L., Han, Yongxin, Wai, Jenny Miu-Chun, Yang, Zhi-Qiang, Perkins, James J., Hurzy, Danielle M., Manikowski, Jesse J., Zhu, Hong, Bungard, Christopher J., Converso, Antonella, Meissner, Robert S., Cosden, Mali L., Hayashi, Ikuo, Ma, Lei, O’Brien, Julie, Uebele, Victor N., Schachter, Joel B., Bhandari, Neetesh, Ward, Gwendolyn J., Fillgrove, Kerry L., Lu, Bing, Liang, Yuexia, Dubost, David C., Puri, Vanita, Eddins, Donnie M., Vardigan, Joshua D., Drolet, Robert E., Kern, Jonathan T., Uslaner, Jason M.

المساهمون: Merck Sharp and Dohme

المصدر: ACS Medicinal Chemistry Letters ; volume 14, issue 8, page 1088-1094 ; ISSN 1948-5875 1948-5875

الاتاحة: http://dx.doi.org/10.1021/acsmedchemlett.3c00210
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00210

المؤلفون: Jay A. Grobler, Abbas Walji, Paul J. Coleman, Min Xu, Timothy J. Hartingh, Natasa Pajkovic, John T. Sisko, David A. Powell, John M. Sanders, Michael D. Miller, Mark Embrey, Rada Vanessa L, Keith P. Moore, Daniel J. Klein, Nguyen Natalie, Izzat T. Raheem, Dubost David C, Guillaume Barbe, Louis-Charles Campeau, Daria J. Hazuda, John S. Wai, Thomas G. Steele, John D. Schreier, Jamie M. McCabe Dunn

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2038-2046

مصطلحات موضوعية: 0301 basic medicine, Pyridones, Clinical Biochemistry, Human immunodeficiency virus (HIV), Pharmaceutical Science, Integrase inhibitor, HIV Infections, HIV Integrase, Pharmacology, medicine.disease_cause, 01 natural sciences, Biochemistry, Strand transfer, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, HIV Integrase Inhibitors, Molecular Biology, biology, Organic Chemistry, Raltegravir, 0104 chemical sciences, Integrase, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, chemistry, HIV-1, Aminal, biology.protein, Molecular Medicine, Lead compound, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3afda9a20f9b604f336f17e0d16627b
https://doi.org/10.1016/j.bmcl.2017.02.039

المؤلفون: Dubost, David C., Kaufman, Michael J., Jahansouz, Hossain, Brenner, Gerald S.

المصدر: Drug Development and Industrial Pharmacy ; volume 22, issue 9-10, page 873-880 ; ISSN 0363-9045 1520-5762

الاتاحة: http://dx.doi.org/10.3109/03639049609065917
http://www.tandfonline.com/doi/pdf/10.3109/03639049609065917

المؤلفون: Bungard, Christopher J., Williams, Peter D., Ballard, Jeanine E., Bennett, David J., Beaulieu, Christian, Bahnck-Teets, Carolyn, Carroll, Steve S., Chang, Ronald K., Dubost, David C., Fay, John F., Diamond, Tracy L., Greshock, Thomas J., Hao, Li, Holloway, M. Katharine, Felock, Peter J., Gesell, Jennifer J., Su, Hua-Poo, Manikowski, Jesse J., McKay, Daniel J., Miller, Mike, Min, Xu, Molinaro, Carmela, Moradei, Oscar M., Nantermet, Philippe G., Nadeau, Christian, Sanchez, Rosa I., Satyanarayana, Tummanapalli Albany Molecular Research Singapore Research Center, 61 Science Park Road #05-01, The Galen Singapore Science Park II, Singapore 117525, Shipe, William D. Merck Research Lab., West Point, PA, Singh, Sanjay K. Albany Molecular Research Singapore Research Center, Truong, Vouy Linh Merck Frosst Centre for Therapeutic Research, Quebec, Vijayasaradhi, Sivalenka Albany Molecular Research Singapore Research Center, Wiscount, Catherine M. Merck Research Lab., West Point, PA, Vacca, Joseph P. Merck Frosst Centre for Therapeutic Research, Quebec, Crane, Sheldon N. Merck Frosst Centre for Therapeutic Research, Quebec, McCauley, John A. Merck Research Lab., West Point, PA

مصطلحات موضوعية: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY, 60 APPLIED LIFE SCIENCES

وصف الملف: application/pdf

Relation: http://www.osti.gov/servlets/purl/1404956; https://www.osti.gov/biblio/1404956; https://doi.org/10.1021/acsmedchemlett.6b00135

الاتاحة: http://www.osti.gov/servlets/purl/1404956
https://www.osti.gov/biblio/1404956
https://doi.org/10.1021/acsmedchemlett.6b00135

المؤلفون: Li Hao, Carolyn Bahnck-Teets, Catherine M. Wiscount, Daniel J. McKay, Carmela Molinaro, Ronald K. Chang, S S Carroll, Sivalenka Vijayasaradhi, Philippe G. Nantermet, Sanjay Kumar Singh, Christopher J. Bungard, Dubost David C, David Jonathan Bennett, Thomas J. Greshock, Hua-Poo Su, Rosa I. Sanchez, Vouy Linh Truong, Xu Min, John F. Fay, Jeanine E. Ballard, John A. McCauley, Christian Beaulieu, M. Katharine Holloway, Joseph P. Vacca, Michael W. Miller, Tummanapalli Satyanarayana, Sheldon Crane, William D. Shipe, Jesse J. Manikowski, Peter D. Williams, Christian Nadeau, Jennifer J. Gesell, Tracy L. Diamond, Peter J. Felock, Oscar Miguel Moradei

مصطلحات موضوعية: Hydrolase inhibitor, chemistry.chemical_classification, Protease, 010405 organic chemistry, Chemistry, Stereochemistry, medicine.medical_treatment, Organic Chemistry, Human immunodeficiency virus (HIV), 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Biochemistry, 0104 chemical sciences, chemistry.chemical_compound, Aspartate binding, Enzyme, Morpholine, Drug Discovery, medicine, Potency, HIV Protease Inhibitor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f685aed82b9b428b5b9e7330d8f427
https://europepmc.org/articles/PMC4948015/

المؤلفون: Michael J. Bogusky, Zimmerman Jeffrey A, Arthur B. Coddington, Dubost David C, Steven M. Pitzenberger, Michael J. Kaufman

المصدر: Pharmaceutical Research. 13:1811-1814

مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Organic Chemistry, Solid-state, Pharmaceutical Science, Excipient, Peptide, Nuclear magnetic resonance spectroscopy, Combinatorial chemistry, Cyclic peptide, Reaction product, Freeze-drying, chemistry, medicine, Molecular Medicine, Degradation (geology), Organic chemistry, Pharmacology (medical), Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::68811213a149cb0367955f047b1cba18
https://doi.org/10.1023/a:1016024923002

المؤلفون: Dubost, David C., Kaufman, Michael J., Zimmerman, Jeffrey A., Bogusky, Michael J., Coddington, Arthur B., Pitzenberger, Steven M.

المصدر: Pharmaceutical Research; December 1996, Vol. 13 Issue: 12 p1811-1814, 4p