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1
المؤلفون: Mark J. Evans, Paige Erin Mahaney, Jay E. Wrobel, Matthew L. Crawley, Ray Unwalla, Kim Callain Younghee, John F. Mehlmann, Joseph T. Lundquist, Douglas C. Harnish
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:5289-5292
مصطلحات موضوعية: Models, Molecular, Agonist, Molecular model, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Receptors, Cytoplasmic and Nuclear, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Structure–activity relationship, Pyrroles, Molecular Biology, Pyrrole, Chemistry, Organic Chemistry, Azepines, Nuclear receptor, Molecular Medicine, Farnesoid X receptor, Protein Binding
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2
المؤلفون: Janet E. Paulsen, Zhijian Lu, Grace Yan, Jocelyn Sanford, Heather H. Shih, Adam Reid Root, Khetemenee Lam, Douglas C Harnish, Richard Zollner, Wei Cao, Lioudmila Tchistiakova, Mostafa Ait-Zahra, Valerie Calabro, Rita Agostinelli, Stephane Olland, Davinder Gill, Angela Robak
المصدر: FEBS Journal. 276:4909-4920
مصطلحات موضوعية: endocrine system diseases, integumentary system, Chemistry, Chinese hamster ovary cell, media_common.quotation_subject, food and beverages, Cell Biology, Biochemistry, Fusion protein, law.invention, Protein structure, law, Recombinant DNA, lipids (amino acids, peptides, and proteins), Binding site, Scavenger receptor, Internalization, Receptor, Molecular Biology, media_common
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3
المؤلفون: Lisa Borges-Marcucci, Christine Huard, KehDih Lai, George P. Vlasuk, Douglas C. Harnish, Stephen J. Gardell, Mark J. Evans, Paige E. Mahaney, Julie A. Krueger, Shuguang Wang, Robert V. Martinez
المصدر: American Journal of Physiology-Gastrointestinal and Liver Physiology. 296:G543-G552
مصطلحات موضوعية: Male, Agonist, medicine.medical_specialty, Very low-density lipoprotein, Indoles, Physiology, medicine.drug_class, Receptors, Cytoplasmic and Nuclear, Mice, Transgenic, Fructose, Kidney, Rats, Sprague-Dawley, Mice, chemistry.chemical_compound, High-density lipoprotein, Hyperinsulinism, Physiology (medical), Internal medicine, medicine, Animals, Humans, Liver X receptor, Cells, Cultured, Triglycerides, Dyslipidemias, Apolipoprotein A-I, Hepatology, Bile acid, Cholesterol, Gastroenterology, Azepines, Mice, Mutant Strains, Rats, DNA-Binding Proteins, Mice, Inbred C57BL, Disease Models, Animal, Endocrinology, Receptors, LDL, Nuclear receptor, chemistry, Hyperglycemia, Receptors, Leptin, Female, Farnesoid X receptor, Transcription Factors
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4
المؤلفون: Robert John Steffan, Eugene John Trybulski, Douglas C. Harnish, Fei Ye, Paige E. Mahaney, Joseph P. Sabatucci, Michael Byron Webb, Christopher C. Chadwick
المصدر: Bioorganic & Medicinal Chemistry. 14:3455-3466
مصطلحات موضوعية: Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Estrogen receptor, Nuclear factor κb, Ligands, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Mediator, Quinoxalines, Drug Discovery, Humans, Molecular Biology, Cells, Cultured, Molecular Structure, Ligand, Chemistry, Organic Chemistry, NF-kappa B, Biological activity, NF-κB, In vitro, Receptors, Estrogen, Molecular Medicine, Signal Transduction
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5
المؤلفون: Christopher C. Chadwick, Mary-Margaret O’Donnell, Eugene John Trybulski, Douglas C. Harnish, Mark A. Ashwell, Moore William Jay, Joseph P. Sabatucci
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:854-858
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Estrogen receptor, Inflammation, Ligands, Biochemistry, Cell Line, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Structure–activity relationship, Receptor, Molecular Biology, Transcription factor, Estrogen receptor beta, Transcriptional activity, Sulfonamides, Molecular Structure, Ligand, Chemistry, Organic Chemistry, Sulfonamide (medicine), NF-kappa B, General Medicine, Mice, Inbred C57BL, Receptors, Estrogen, Molecular Medicine, Estrogen-related receptor gamma, medicine.symptom, medicine.drug
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6
المؤلفون: Robert John Steffan, Lydia Mosyak, Richard C. Winneker, Susan Chippari, Lisa Borges-Marcucci, Amy Eckert, William Jay Moore, Zhang Xu, Edward Martin Matelan, Christopher C. Chadwick, Mark A. Ashwell, William Ronald Solvibile, Steven J. Adelman, Thomas Kenney, Eugene John Trybulski, Douglas C. Harnish
المصدر: Current Topics in Medicinal Chemistry. 6:103-111
مصطلحات موضوعية: Chemokine, Estrogen receptor, Inflammation, Pharmacology, Ligands, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Estrogen receptor beta, chemistry.chemical_classification, Molecular Structure, biology, Chemistry, Ligand, Cell adhesion molecule, Anti-Inflammatory Agents, Non-Steroidal, General Medicine, Enzyme, Receptors, Estrogen, Drug development, Chronic Disease, biology.protein, Pyrazoles, medicine.symptom
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7
المؤلفون: Mark J. Evans, Lisa Borges-Marcucci, Pu Qin, Douglas C. Harnish
المصدر: American Journal of Physiology-Gastrointestinal and Liver Physiology. 289:G267-G273
مصطلحات موضوعية: Male, Physiology, medicine.drug_class, Ratón, Liver cytology, Gene Expression, Receptors, Cytoplasmic and Nuclear, Inflammation, Biology, Response Elements, Mice, Physiology (medical), medicine, Animals, Humans, Promoter Regions, Genetic, Receptor, Cells, Cultured, Hepatology, Bile acid, Tumor Necrosis Factor-alpha, Gastroenterology, Cholic Acids, Isoxazoles, Intercellular Adhesion Molecule-1, Cell biology, DNA-Binding Proteins, Mice, Inbred C57BL, medicine.anatomical_structure, Liver, Biochemistry, Hepatocyte, Hepatocytes, medicine.symptom, Signal transduction, Intracellular, Signal Transduction, Transcription Factors
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8
المؤلفون: Leo M. Albert, Yelena Leathurby, Lili Wang, Max Follettie, Lisa Borges-Marcucci, Robert John Steffan, James C. Keith, Christopher C. Chadwick, Douglas C. Harnish
المصدر: Arthritis Research & Therapy
مصطلحات موضوعية: Male, Transcriptional Activation, medicine.medical_specialty, Immunology, Estrogen receptor, Arthritis, Inflammation, Ligands, Animals, Genetically Modified, Arthritis, Rheumatoid, Rheumatology, Internal medicine, Gene expression, medicine, Immunology and Allergy, Animals, Humans, business.industry, Acute-phase protein, NF-kappa B, NFKB1, medicine.disease, Rats, Disease Models, Animal, Endocrinology, Receptors, Estrogen, Rats, Inbred Lew, Cancer research, Pyrazoles, Tumor necrosis factor alpha, Female, medicine.symptom, Signal transduction, business, Research Article, Signal Transduction
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9
المؤلفون: Mark J. Evans, Douglas C. Harnish, KehDih Lai
المصدر: Journal of Biological Chemistry. 278:36418-36429
مصطلحات موضوعية: Male, Time Factors, Receptors, Cytoplasmic and Nuclear, Estrogen receptor, Biochemistry, Rats, Sprague-Dawley, Mice, Cholesterol 7-alpha-Hydroxylase, Promoter Regions, Genetic, Mice, Knockout, Orphan receptor, Estradiol, Reverse Transcriptase Polymerase Chain Reaction, hemic and immune systems, Cell biology, DNA-Binding Proteins, Liver, Receptors, Estrogen, embryonic structures, Small heterodimer partner, biological phenomena, cell phenomena, and immunity, Dimerization, Plasmids, Protein Binding, animal structures, Molecular Sequence Data, chemical and pharmacologic phenomena, Biology, Transfection, Cholesterol 7 alpha-hydroxylase, Cell Line, Phenols, Animals, Humans, Steroid 12-alpha-Hydroxylase, RNA, Messenger, Molecular Biology, Transcription factor, Hormone response element, Binding Sites, Base Sequence, Dose-Response Relationship, Drug, Estrogen Receptor alpha, Cell Biology, Protein Structure, Tertiary, Rats, Gene Expression Regulation, Nuclear receptor, Mutation, Cancer research, Pyrazoles, RNA, Farnesoid X receptor, Gene Deletion, Transcription Factors
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10
المؤلفون: Mark J. Evans, Steven J. Adelman, Amy Eckert, Douglas C. Harnish, KehDih Lai
المصدر: Circulation Research. 89:823-830
مصطلحات موضوعية: Transcriptional Activation, medicine.medical_specialty, Physiology, medicine.drug_class, Ovariectomy, Recombinant Fusion Proteins, Estrogen receptor, Genistein, Coronary Artery Disease, Biology, Ethinyl Estradiol, Transfection, Cell Line, Proinflammatory cytokine, Mice, chemistry.chemical_compound, Estradiol Congeners, Genes, Reporter, In vivo, Internal medicine, Gene expression, medicine, Animals, RNA, Messenger, Enzyme Inhibitors, Transcription factor, Oligonucleotide Array Sequence Analysis, Inflammation, Regulation of gene expression, Dose-Response Relationship, Drug, Estrogen Replacement Therapy, NF-kappa B, Mice, Inbred C57BL, Disease Models, Animal, Endocrinology, Gene Expression Regulation, Liver, Receptors, Estrogen, chemistry, Estrogen, Diet, Atherogenic, Female, Cardiology and Cardiovascular Medicine
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11
المؤلفون: Marshall S. Scicchitano, C. Richard Lyttle, Sotirios K. Karathanasis, Steven J. Adelman, Douglas C. Harnish
المصدر: Endocrinology. 141:3403-3411
مصطلحات موضوعية: Electrophoresis, medicine.medical_specialty, Blotting, Western, Genetic Vectors, Estrogen receptor, Biology, Transfection, Adenoviridae, Cell Line, Estrogen-related receptor alpha, Endocrinology, Internal medicine, medicine, Humans, Luciferases, Estrogen receptor beta, Nuclear receptor co-repressor 1, PELP-1, Anticholesteremic Agents, NF-kappa B, Nuclear Proteins, Estrogens, Receptor Cross-Talk, CREB-Binding Protein, Histone Deacetylase Inhibitors, Nuclear receptor coactivator 1, Receptors, Estrogen, Trans-Activators, Cancer research, Estrogen-related receptor gamma, Estrogen receptor alpha, hormones, hormone substitutes, and hormone antagonists, Interleukin-1, Plasmids
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12
المؤلفون: Sotirios K. Karathanasis, Rahmesh A. Bhat, Mark J. Evans, Douglas C. Harnish, Marshall S. Scicchitano
المصدر: Journal of Biological Chemistry. 273:9270-9278
مصطلحات موضوعية: Carcinoma, Hepatocellular, Transcription, Genetic, Recombinant Fusion Proteins, Estrogen receptor, Biology, Transfection, Biochemistry, Transcription (biology), Coactivator, Tumor Cells, Cultured, Humans, RNA, Messenger, Luciferases, Promoter Regions, Genetic, Enhancer, Molecular Biology, Psychological repression, Transcription factor, Adaptor Proteins, Signal Transducing, Binding Sites, Apolipoprotein A-I, Estradiol, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Liver Neoplasms, Nuclear Proteins, Promoter, Cell Biology, DNA-binding domain, Phosphoproteins, Molecular biology, Nuclear Receptor Interacting Protein 1, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Kinetics, Enhancer Elements, Genetic, Hepatocyte Nuclear Factor 4, Receptors, Estrogen, Hepatocyte Nuclear Factor 3-beta, Transcription Factors
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13
المؤلفون: Heather H. Shih, Douglas C. Harnish, Paula Miller
المصدر: Pharmaceutical Sciences Encyclopedia
مصطلحات موضوعية: Food and drug administration, Protein therapeutics, business.industry, Medicine, Computational biology, Pharmacology, business
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14
المؤلفون: Russell Widom, Edward J. Kilbourne, Douglas C. Harnish, Sohail Malik, Sotirios K. Karathanasis
المصدر: Journal of Biological Chemistry. 270:7004-7010
مصطلحات موضوعية: Transcription, Genetic, Sp1 Transcription Factor, Molecular Sequence Data, Response element, Enhancer RNAs, Biology, Biochemistry, Immediate early protein, Immediate-Early Proteins, Humans, Binding site, Enhancer, Molecular Biology, Transcription factor, Early Growth Response Protein 1, Regulation of gene expression, Apolipoprotein A-I, Base Sequence, Cell Biology, Molecular biology, DNA-Binding Proteins, body regions, Enhancer Elements, Genetic, Gene Expression Regulation, Nuclear receptor, hormones, hormone substitutes, and hormone antagonists, Transcription Factors
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15
المؤلفون: S. K. Karathanasis, Douglas C. Harnish, Sohail Malik
المصدر: Journal of Biological Chemistry. 269:28220-28226
مصطلحات موضوعية: Cooperative binding, Cell Biology, Biology, digestive system, Biochemistry, Molecular biology, Transactivation, Nuclear receptor, Transcription (biology), embryonic structures, Gene expression, lipids (amino acids, peptides, and proteins), Enhancer, Molecular Biology, Gene, Transcription factor
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16
المؤلفون: Michael Gyda, D. M. Kochhar, Dianne Robert Soprano, Kenneth J. Soprano, Roshantha A.S. Chandraratna, Heng Jiang, Douglas C. Harnish
المصدر: Teratology. 50:38-43
مصطلحات موضوعية: Embryology, medicine.medical_specialty, Ectromelia, Receptors, Retinoic Acid, medicine.drug_class, Health, Toxicology and Mutagenesis, Retinoic acid, Tretinoin, Biology, Toxicology, Benzoates, Mice, Retinoids, chemistry.chemical_compound, Isomerism, Internal medicine, Gene expression, medicine, Animals, RNA, Messenger, Retinoid, Mice, Inbred ICR, Messenger RNA, Embryogenesis, Abnormalities, Drug-Induced, Embryo, Retinoic acid receptor, Endocrinology, Mechanism of action, chemistry, embryonic structures, Fatty Acids, Unsaturated, Female, medicine.symptom, Developmental Biology
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17
المؤلفون: Michael A. Satre, Heng Jiang, Douglas C. Harnish, D. M. Kochhar, Michael Gyda, Kenneth E. Ugen, Lan X. Chen, Dianne Robert Soprano, Kenneth J. Soprano
المصدر: Mechanisms of Development. 45:243-253
مصطلحات موضوعية: Male, Embryology, medicine.medical_specialty, Receptors, Retinoic Acid, medicine.drug_class, Ratón, Retinoic acid, Tretinoin, Biology, Mice, chemistry.chemical_compound, Fetus, Internal medicine, Morphogenesis, medicine, Animals, RNA, Messenger, Retinoid, Chromatography, High Pressure Liquid, Mice, Inbred ICR, Messenger RNA, Embryogenesis, Teratology, Retinoic acid receptor, Teratogens, Endocrinology, chemistry, embryonic structures, Female, Developmental Biology
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18
المؤلفون: Matthew L. Crawley, Kim Callain Younghee, Paige Erin Mahaney, John F. Mehlmann, Mark J. Evans, Ray Unwalla, Jay E. Wrobel, Joseph T. Lundquist, Douglas C. Harnish
المصدر: ChemInform. 41
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Molecular model, Stereochemistry, Aqueous solubility, Farnesoid X receptor, General Medicine, Crystal structure, Ligand binding domain, In vitro, Pyrrole
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19
المؤلفون: Kristin M. Phipps, Lisa Borges-Marcucci, KehDih Lai, Douglas C. Harnish, Matthew L. Crawley, Vikram S. Patel, Irene Feingold, Rayomand J. Unwalla, John F. Mehlmann, Wah-Tung Hum, Paige Erin Mahaney, Thomas Joseph Commons, Julius E Eta, Jay E. Wrobel, Weixin Xu, Daniel M. Green, Kim Callain Younghee, Mark J. Evans, Joseph T. Lundquist
المصدر: Journal of medicinal chemistry. 53(4)
مصطلحات موضوعية: Agonist, Male, Models, Molecular, medicine.medical_specialty, Very low-density lipoprotein, Indoles, medicine.drug_class, Biological Availability, Receptors, Cytoplasmic and Nuclear, Cell Line, Rats, Sprague-Dawley, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Internal medicine, Drug Discovery, medicine, Animals, Humans, Receptor, Triglycerides, Hypolipidemic Agents, Mice, Knockout, Triglyceride, Cholesterol, Azepines, Cholesterol, LDL, Macaca mulatta, Rats, Endocrinology, chemistry, Nuclear receptor, Receptors, LDL, Solubility, LDL receptor, Microsomes, Liver, Molecular Medicine, Farnesoid X receptor, Female
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20
المؤلفون: Christine Huard, Mark D Mattaliano, Wei Cao, Andrew A. Hill, Heather H. Shih, Janet E. Paulsen, Wenyan Zhong, Robert V. Martinez, Douglas C Harnish
المصدر: American journal of physiology. Cell physiology. 296(6)
مصطلحات موضوعية: Transcription, Genetic, Physiology, Biology, Cell Line, Epidermal growth factor, Transduction, Genetic, Gene expression, Transcriptional regulation, Cell Adhesion, Cluster Analysis, Humans, Scavenger receptor, Aorta, Oligonucleotide Array Sequence Analysis, Regulation of gene expression, Inflammation, Gene Expression Profiling, Oxidative Stress Pathway, Endothelial Cells, Cell Biology, Scavenger Receptors, Class E, Molecular biology, Endothelial stem cell, Lipoproteins, LDL, Gene Expression Regulation, lipids (amino acids, peptides, and proteins), Signal transduction, Signal Transduction, Transcription Factors