المؤلفون: Douglas A. Keller, Arianna Bassan, Alexander Amberg, Leigh Ann Burns Naas, Jon Chambers, Kevin Cross, Frances Hall, Gloria D. Jahnke, Amarjit Luniwal, Serena Manganelli, Jordi Mestres, Amy L. Mihalchik-Burhans, David Woolley, Raymond R. Tice

المصدر: Frontiers in Toxicology, Vol 5 (2023)

مصطلحات موضوعية: In silico toxicology protocol, mode of action, pregabalin, non-genotoxic carcinogen, oxidative stress, chronic inflammation, Toxicology. Poisons, RA1190-1270

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/ftox.2023.1234498/full; https://doaj.org/toc/2673-3080

URL الوصول: https://doaj.org/article/662e50fa83754807891531c6e030ecd7

المؤلفون: Bruce A. Corliss, Leon J. Delalio, T. C. Stevenson Keller, Alexander S. Keller, Douglas A. Keller, Bruce H. Corliss, Jody M. Beers, Shayn M. Peirce, Brant E. Isakson

المصدر: Frontiers in Physiology, Vol 10 (2019)

مصطلحات موضوعية: hemoglobin alpha, evolution, vasculature, iron flux, endothelial cells, Physiology, QP1-981

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphys.2019.01389/full; https://doaj.org/toc/1664-042X

URL الوصول: https://doaj.org/article/c29f96a691244be9b8e6b1c946d50eab

المؤلفون: Douglas A. Keller, Arianna Bassan, Alexander Amberg, Leigh Ann Burns Naas, Jon Chambers, Kevin Cross, Frances Hall, Gloria D. Jahnke, Amarjit Luniwal, Serena Manganelli, Jordi Mestres, Amy L. Mihalchik-Burhans, David Woolley, Raymond R. Tice

مصطلحات موضوعية: Pharmacology, Toxicology, Immunology, Toxicology (incl. Clinical Toxicology), Nanotoxicology, Health and Safety, In silico toxicology protocol, mode of action, pregabalin, non-genotoxic carcinogen, oxidative stress, chronic inflammation, cell proliferation

Relation: https://figshare.com/articles/dataset/Table1_In_silico_approaches_in_carcinogenicity_hazard_assessment_case_study_of_pregabalin_a_nongenotoxic_mouse_carcinogen_docx/24550123

الاتاحة: https://doi.org/10.3389/ftox.2023.1234498.s001
https://figshare.com/articles/dataset/Table1_In_silico_approaches_in_carcinogenicity_hazard_assessment_case_study_of_pregabalin_a_nongenotoxic_mouse_carcinogen_docx/24550123

المؤلفون: Jean-Charles Gautier, Myrtle Davis, Douglas A. Keller, Niresh Hariparsad, Jonathan A. Phillips, Radhakrishna Sura, Taraka Sai Pavan Grandhi, Terry R. Van Vleet

المصدر: Lab on a Chip. 20:468-476

مصطلحات موضوعية: 0301 basic medicine, Drug Industry, Drug Evaluation, Preclinical, Biomedical Engineering, Bioengineering, Kidney, Models, Biological, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Lab-On-A-Chip Devices, Humans, Safety testing, Pharmaceutical industry, ADME, urogenital system, business.industry, Human kidney, General Chemistry, Microfluidic Analytical Techniques, 030104 developmental biology, Pharmaceutical Preparations, Drug development, Risk analysis (engineering), 030220 oncology & carcinogenesis, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de840a616151794554b2a7cfe1beb0ca
https://doi.org/10.1039/c9lc00925f

المؤلفون: Lila Ramaiah, Douglas A. Keller, Michael Merz, David Brott, Silvia Lentini, Lucas Westcott‐Baker, Paul B. Watkins, Shashi K. Ramaiah, David L. Bourdet, Ann Marie Stanley, Rachel J. Church, Sharin E. Roth, Ajit Dash, Philip J. Sherratt, Mark I. Avigan, John Marcinak

المصدر: Clinical Pharmacology and Therapeutics

مصطلحات موضوعية: medicine.medical_specialty, Reviews, Context (language use), Review, 030226 pharmacology & pharmacy, Specimen Handling, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Liver Function Tests, Informed consent, Medicine, Humans, Pharmacology (medical), Intensive care medicine, Pharmacology, Clinical Trials as Topic, Informed Consent, medicine.diagnostic_test, business.industry, Precision medicine, Biobank, Clinical trial, Biorepository, Phenotype, Drug development, 030220 oncology & carcinogenesis, Chemical and Drug Induced Liver Injury, business, Liver function tests, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75b21112abd059a7095cf1e95b7259e
http://europepmc.org/articles/PMC7006882

المؤلفون: Allison Laura Choy, Douglas A. Keller, Matthew F. Peters, Carmen Pin, Kyle L. Kolaja, Radhakrishna Sura, Lorna Ewart, Peggy Guzzie-Peck, Clay W Scott, Derek J. Leishman, Annie Moisan

المصدر: Lab on a chip. 20(7)

مصطلحات موضوعية: Cell type, Cell, Microfluidics, Biomedical Engineering, Bioengineering, Bioinformatics, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Intestinal mucosa, Organoid, Medicine, Humans, Microbiome, Intestinal Mucosa, 030304 developmental biology, 0303 health sciences, business.industry, In vitro toxicology, General Chemistry, Epithelium, Intestines, Organoids, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Stem cell, Caco-2 Cells, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e320538b399417dfcaef5a1cd406a78a
https://pubmed.ncbi.nlm.nih.gov/32129356

المؤلفون: Douglas A. Keller, Brian R. Berridge, Ananthsrinivas Chakilam, Yvonne Will, Monicah A. Otieno, Kristin M. Fabre, David B. Duignan, Yvonne P. Dragan, Lorna Ewart, Terry R. Van Vleet, Danilo A. Tagle, Claire G. Jeong, Jinping Gan, Peggy Guzzie-Peck, Jonathan A. Phillips, Jeetu Eswaraka, Sonia M. de Morais, David E. Watson, Radhakrishna Sura, William R Proctor

المصدر: Experimental Biology and Medicine. 242:1579-1585

مصطلحات موضوعية: 0301 basic medicine, Knowledge management, Drug Industry, business.industry, End user, Microfluidics, Liability, Drug Evaluation, Preclinical, Context (language use), General Biochemistry, Genetics and Molecular Biology, Biotechnology, 03 medical and health sciences, 030104 developmental biology, Resource (project management), Lab-On-A-Chip Devices, Paradigm shift, General partnership, Microchip Analytical Procedures, Commentary, Humans, business, Pace, Pharmaceutical industry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3128a14f0b4ce35a220ee4e7ecd5eeff
https://doi.org/10.1177/1535370217715441

المؤلفون: Monicah A. Otieno, Peggy Guzzie-Peck, Thomas W. Jones, Robert J Schulingkamp, Sherry J. Morgan, Ray Kemper, Douglas A. Keller, Jessica Couch

المصدر: Toxicologic Pathology. 45:372-380

مصطلحات موضوعية: 0301 basic medicine, Toxicology testing, medicine.medical_specialty, business.industry, Nonclinical safety, Survey result, Cell Biology, Disease, Pharmacology, Toxicology, Focus group, Opinion piece, Pathology and Forensic Medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Drug development, Family medicine, Medicine, business, Molecular Biology, 030217 neurology & neurosurgery, Pharmaceutical industry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f55e3d71fe05117175c74da158f90bcc
https://doi.org/10.1177/0192623317701004

المؤلفون: Adrian Roth, Douglas A. Keller, Philip Hewitt, Andreas Baudy, Terry R. Van Vleet, Radhakrishna Sura, Monicah A. Otieno, Jinping Gan, William R Proctor

المصدر: Lab on a chip. 20(2)

مصطلحات موضوعية: Drug Industry, Process (engineering), Computer science, Biomedical Engineering, Drug Evaluation, Preclinical, Bioengineering, Biochemistry, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Lab-On-A-Chip Devices, Animals, Humans, Animal testing, 030304 developmental biology, Pharmaceutical industry, 0303 health sciences, System development, business.industry, End user, General Chemistry, Drug development, Risk analysis (engineering), Safety risk, Liver, Pharmaceutical Preparations, 030220 oncology & carcinogenesis, Risk assessment, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad20b0de1b57f15d2012f4870b6fafb
https://pubmed.ncbi.nlm.nih.gov/31799979

المؤلفون: Fluoroacetate-mediated Toxicity, Fluorinated Ethanes, Douglas A. Keller, D. Christopher Roe, Paul H. Lieder

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://toxsci.oxfordjournals.org/content/30/2/213.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.318.7150; http://toxsci.oxfordjournals.org/content/30/2/213.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.318.7150
http://toxsci.oxfordjournals.org/content/30/2/213.full.pdf

المؤلفون: Thomas W. Jones, Timothy K. Hart, Maggie Liu, Michael W. Bolt, Donna Dambach, Vivek J. Kadambi, Douglas A. Keller, Thomas M. Monticello, David M. Potter

المصدر: Toxicology and applied pharmacology. 334

مصطلحات موضوعية: 0301 basic medicine, Databases, Factual, Drug Industry, Drug-Related Side Effects and Adverse Reactions, Concordance, Drug Evaluation, Preclinical, Context (language use), Toxicology, computer.software_genre, Risk Assessment, Translational Research, Biomedical, 03 medical and health sciences, Medicine, Animals, Humans, Animal testing, Adverse effect, Pharmacology, Database, business.industry, Clinical trial, 030104 developmental biology, Drug development, Toxicity, Models, Animal, Animal studies, business, computer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a10754d05264b32b6de539a9df6b09
https://pubmed.ncbi.nlm.nih.gov/28893587

المؤلفون: Sherry J, Morgan, Jessica, Couch, Peggy, Guzzie-Peck, Douglas A, Keller, Ray, Kemper, Monicah A, Otieno, Robert J, Schulingkamp, Thomas W, Jones

المصدر: Toxicologic pathology. 45(3)

مصطلحات موضوعية: Disease Models, Animal, Drug Industry, Surveys and Questionnaires, Drug Evaluation, Preclinical, Government Regulation, Animals, Decision Making, Organizational

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::bb33947cabcec10854013c397ee335c4
https://pubmed.ncbi.nlm.nih.gov/28351296

المؤلفون: Raymond R. Tice, Emmanuel Lemazurier, John C. Lipscomb, John R. Fowle, Kevin M. Crofton, Thomas B. Knudsen, Daland R. Juberg, Thomas Hartung, George P. Daston, Ronald N. Hines, Donna L. Mendrick, David E. Watson, Elaine M. Faustman, Alison H. Harrill, Suzanne Fitzpatrick, Miriam Sander, Richard A. Becker, Douglas A. Keller, Tina Bahadori, Nancy B. Beck

المصدر: Toxicological sciences : an official journal of the Society of Toxicology. 155(1)

مصطلحات موضوعية: 0301 basic medicine, Exposome, Computer science, Predictive toxicology, Forum: Future Tox III Commentary, 010501 environmental sciences, Regulatory policy, In Vitro Techniques, Toxicology, 01 natural sciences, Data science, Toolbox, 03 medical and health sciences, 030104 developmental biology, Environmental health, Toxicity Tests, Animals, Humans, Risk assessment, 0105 earth and related environmental sciences

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c4236e3a78690937c3ddb410ac9870
https://pubmed.ncbi.nlm.nih.gov/27780885

المؤلفون: Douglas A. Keller, Paul A. Andrews

المصدر: Reproductive toxicology (Elmsford, N.Y.). 66

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, business.industry, Toxicology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Animals, Laboratory, Toxicity Tests, medicine, Animals, Humans, Juvenile animal, Intensive care medicine, business, Child

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66419339a8c3bcd54513feb8651ca58d
https://pubmed.ncbi.nlm.nih.gov/27223405

المؤلفون: Richard J. Brennan, Karen L. Leach, Douglas A. Keller

المصدر: Antitargets and Drug Safety

مصطلحات موضوعية: business.industry, Kinase, Medicine, Pharmacology, business, Adverse effect

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::db8547c6cb876b4300f87a7081634398
https://doi.org/10.1002/9783527673643.ch16

المؤلفون: Archie E. Hamielec, Douglas M Keller, Leopold K. Kostanski

المصدر: Journal of Biochemical and Biophysical Methods. 58:159-186

مصطلحات موضوعية: Chromatography, Magnetic Resonance Spectroscopy, Light, Polymers, Calibration (statistics), Chemistry, Size-exclusion chromatography, Astrophysics::Instrumentation and Methods for Astrophysics, Biophysics, Analytical chemistry, Mass spectrometry, Biochemistry, Mass Spectrometry, Light scattering, Gel permeation chromatography, Calibration, Scattering, Radiation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0e14305ed3de74f131d26176a36ae4
https://doi.org/10.1016/j.jbbm.2003.10.001

المؤلفون: Jay I. Goodman, Richard D. Storer, Peter Kasper, Douglas A. Keller, Abigail Jacobs, Ronald J. Gerson, Gerald G. Long, John E. French, Tohru Inoue, Amy L. Lavin, James S. MacDonald, Bruce McCullough, Frank D. Sistare, Jan Willem van der Laan

المصدر: Toxicological Sciences. 77:188-194

مصطلحات موضوعية: Genetically modified mouse, Protocol (science), Research program, Risk analysis (engineering), business.industry, Carcinogenicity testing, Data interpretation, Experimental work, Toxicology, business, Risk assessment, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f1d01af48b5a8bb8b6dbe956d70f54f7
https://doi.org/10.1093/toxsci/kfh037

المؤلفون: Paul B. Watkins, David L. Eaton, Thomas B. Knudsen, Maurice Whelan, Suzanne Compton Fitzpatrick, Donna L. Mendrick, Nancy G. Doerrer, Douglas A. Keller, Edward W. Carney, Miriam Sander, Raymond R. Tice, Kenneth L. Hastings

المصدر: Toxicological sciences : an official journal of the Society of Toxicology. 143(2)

مصطلحات موضوعية: Societies, Scientific, In Vitro Techniques, Forum: Predictive Toxicology in Future Tox II, In silico, Context (language use), Research needs, Computational biology, Predictive toxicology, Biology, Congresses as Topic, Bioinformatics, Toxicology, United States, Regulatory toxicology, Predictive Value of Tests, Adverse Outcome Pathway, Computer Simulation, Risk assessment

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41562d31d932f4df951491865e9d06e9
https://pubmed.ncbi.nlm.nih.gov/25628403

المؤلفون: Peter P. Fu, R. Michael Mcclain, John E. Sagartz, James A. Popp, Dan Casciano, James S. MacDonald, Douglas A. Keller

المصدر: Toxicologic Pathology. 29:128-137

مصطلحات موضوعية: Male, Pathology, medicine.medical_specialty, Maximum Tolerated Dose, Carcinogenicity Tests, Administration, Oral, Mice, Inbred Strains, Mutagen, Pharmacology, Animal Testing Alternatives, Toxicology, medicine.disease_cause, Sensitivity and Specificity, Pathology and Forensic Medicine, Mice, Oral administration, medicine, Animals, Humans, Mode of action, Molecular Biology, Carcinogen, business.industry, Reproducibility of Results, Neoplasms, Experimental, Cell Biology, Disease Models, Animal, Animals, Newborn, Phenacetin, Toxicity, Carcinogens, Female, Phenobarbital, business, Genotoxicity, Mutagens, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af15976547d304539a5af26ff8b1191
https://doi.org/10.1080/019262301753178537

المؤلفون: Christopher Bevan, Anthony S. Panepinto, Karin S. Bentley, Douglas A. Keller

المصدر: Drug and Chemical Toxicology. 24:273-285

مصطلحات موضوعية: Male, medicine.medical_specialty, Erythrocytes, Cyclophosphamide, Health, Toxicology and Mutagenesis, Bone Marrow Cells, Mice, Inbred Strains, Air Pollutants, Occupational, Toxicology, medicine.disease_cause, Rats, Sprague-Dawley, Mice, chemistry.chemical_compound, Cyclohexanes, Internal medicine, Administration, Inhalation, Cyclohexenes, Butadienes, medicine, Animals, 4-Vinylcyclohexene, Pharmacology, Inhalation Exposure, Micronucleus Tests, Chemical Health and Safety, Dose-Response Relationship, Drug, Inhalation, Chemistry, Public Health, Environmental and Occupational Health, General Medicine, Rats, Endocrinology, medicine.anatomical_structure, Toxicity, Immunology, Micronucleus test, Female, Bone marrow, Micronucleus, Genotoxicity, Mutagens, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193dac5a0eabf5ec5f61bb80321ef336
https://doi.org/10.1081/dct-100103724