المؤلفون: Conrad E. Z. Chan (11014434), Shirley G. K. Seah (11014437), De Hoe Chye (11014440), Shane Massey (224366), Maricela Torres (11014443), Angeline P. C. Lim (11014446), Steven K. K. Wong (11014449), Jacklyn J. Y. Neo (11014452), Pui San Wong (11014455), Jie Hui Lim (11014458), Gary S. L. Loh (11014461), Dongling Wang (258597), Jerome D. Boyd-Kirkup (11014464), Siyu Guan (11014467), Dipti Thakkar (11014470), Guo Hui Teo (1521718), Kiren Purushotorman (11014473), Paul E. Hutchinson (6458183), Barnaby E. Young (10869381), Jenny G. Low (10499731), Paul A. MacAry (10534724), Hannes Hentze (6680750), Venkateshan S. Prativadibhayankara (11014476), Kantharaj Ethirajulu (2100358), Jason E. Comer (7908407), Chien-Te K. Tseng (492742), Alan D. T. Barrett (8980565), Piers J. Ingram (11014479), Trevor Brasel (502095), Brendon John Hanson (11014482)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Immunology, Cancer, Infectious Diseases, Virology, convalescent COVID -19 patient, anti-SARS-CoV -2 activities, SARS-CoV -2-infected hamsters, IFN, K 18-human ACE 2, attenuated pro-inflammatory responses, SARS-CoV -2 Spike protein, efficacy, Fc-null LALA variant, COVID -19. Importantly, Fc-mediated effector functions, SARS-CoV -2 neutralizing antibody, SC 31 treatment, SARS-CoV -2-neutralizing antibodies, SC 31

Relation: https://figshare.com/articles/journal_contribution/S1_File_-/14830476

الاتاحة: https://doi.org/10.1371/journal.pone.0253487.s005

المؤلفون: Conrad E. Z. Chan (11014434), Shirley G. K. Seah (11014437), De Hoe Chye (11014440), Shane Massey (224366), Maricela Torres (11014443), Angeline P. C. Lim (11014446), Steven K. K. Wong (11014449), Jacklyn J. Y. Neo (11014452), Pui San Wong (11014455), Jie Hui Lim (11014458), Gary S. L. Loh (11014461), Dongling Wang (258597), Jerome D. Boyd-Kirkup (11014464), Siyu Guan (11014467), Dipti Thakkar (11014470), Guo Hui Teo (1521718), Kiren Purushotorman (11014473), Paul E. Hutchinson (6458183), Barnaby E. Young (10869381), Jenny G. Low (10499731), Paul A. MacAry (10534724), Hannes Hentze (6680750), Venkateshan S. Prativadibhayankara (11014476), Kantharaj Ethirajulu (2100358), Jason E. Comer (7908407), Chien-Te K. Tseng (492742), Alan D. T. Barrett (8980565), Piers J. Ingram (11014479), Trevor Brasel (502095), Brendon John Hanson (11014482)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Immunology, Cancer, Infectious Diseases, Virology, convalescent COVID -19 patient, anti-SARS-CoV -2 activities, SARS-CoV -2-infected hamsters, IFN, K 18-human ACE 2, attenuated pro-inflammatory responses, SARS-CoV -2 Spike protein, efficacy, Fc-null LALA variant, COVID -19. Importantly, Fc-mediated effector functions, SARS-CoV -2 neutralizing antibody, SC 31 treatment, SARS-CoV -2-neutralizing antibodies, SC 31

Relation: https://figshare.com/articles/figure/Discovery_of_SC31_from_single_B_cells_/14830464

الاتاحة: https://doi.org/10.1371/journal.pone.0253487.s001

المؤلفون: Conrad E. Z. Chan (11014434), Shirley G. K. Seah (11014437), De Hoe Chye (11014440), Shane Massey (224366), Maricela Torres (11014443), Angeline P. C. Lim (11014446), Steven K. K. Wong (11014449), Jacklyn J. Y. Neo (11014452), Pui San Wong (11014455), Jie Hui Lim (11014458), Gary S. L. Loh (11014461), Dongling Wang (258597), Jerome D. Boyd-Kirkup (11014464), Siyu Guan (11014467), Dipti Thakkar (11014470), Guo Hui Teo (1521718), Kiren Purushotorman (11014473), Paul E. Hutchinson (6458183), Barnaby E. Young (10869381), Jenny G. Low (10499731), Paul A. MacAry (10534724), Hannes Hentze (6680750), Venkateshan S. Prativadibhayankara (11014476), Kantharaj Ethirajulu (2100358), Jason E. Comer (7908407), Chien-Te K. Tseng (492742), Alan D. T. Barrett (8980565), Piers J. Ingram (11014479), Trevor Brasel (502095), Brendon John Hanson (11014482)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Immunology, Cancer, Infectious Diseases, Virology, convalescent COVID -19 patient, anti-SARS-CoV -2 activities, SARS-CoV -2-infected hamsters, IFN, K 18-human ACE 2, attenuated pro-inflammatory responses, SARS-CoV -2 Spike protein, efficacy, Fc-null LALA variant, COVID -19. Importantly, Fc-mediated effector functions, SARS-CoV -2 neutralizing antibody, SC 31 treatment, SARS-CoV -2-neutralizing antibodies, SC 31

Relation: https://figshare.com/articles/figure/Determination_of_SC31_binding_to_spike_variants_/14830467

الاتاحة: https://doi.org/10.1371/journal.pone.0253487.s002

المؤلفون: Conrad E. Z. Chan (11014434), Shirley G. K. Seah (11014437), De Hoe Chye (11014440), Shane Massey (224366), Maricela Torres (11014443), Angeline P. C. Lim (11014446), Steven K. K. Wong (11014449), Jacklyn J. Y. Neo (11014452), Pui San Wong (11014455), Jie Hui Lim (11014458), Gary S. L. Loh (11014461), Dongling Wang (258597), Jerome D. Boyd-Kirkup (11014464), Siyu Guan (11014467), Dipti Thakkar (11014470), Guo Hui Teo (1521718), Kiren Purushotorman (11014473), Paul E. Hutchinson (6458183), Barnaby E. Young (10869381), Jenny G. Low (10499731), Paul A. MacAry (10534724), Hannes Hentze (6680750), Venkateshan S. Prativadibhayankara (11014476), Kantharaj Ethirajulu (2100358), Jason E. Comer (7908407), Chien-Te K. Tseng (492742), Alan D. T. Barrett (8980565), Piers J. Ingram (11014479), Trevor Brasel (502095), Brendon John Hanson (11014482)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Immunology, Cancer, Infectious Diseases, Virology, convalescent COVID -19 patient, anti-SARS-CoV -2 activities, SARS-CoV -2-infected hamsters, IFN, K 18-human ACE 2, attenuated pro-inflammatory responses, SARS-CoV -2 Spike protein, efficacy, Fc-null LALA variant, COVID -19. Importantly, Fc-mediated effector functions, SARS-CoV -2 neutralizing antibody, SC 31 treatment, SARS-CoV -2-neutralizing antibodies, SC 31

Relation: https://figshare.com/articles/figure/Establishment_of_K-18_human_ACE2_transgenic_mouse_SARS-CoV-2_infection_model_/14830470

الاتاحة: https://doi.org/10.1371/journal.pone.0253487.s003

المؤلفون: Conrad E. Z. Chan (11014434), Shirley G. K. Seah (11014437), De Hoe Chye (11014440), Shane Massey (224366), Maricela Torres (11014443), Angeline P. C. Lim (11014446), Steven K. K. Wong (11014449), Jacklyn J. Y. Neo (11014452), Pui San Wong (11014455), Jie Hui Lim (11014458), Gary S. L. Loh (11014461), Dongling Wang (258597), Jerome D. Boyd-Kirkup (11014464), Siyu Guan (11014467), Dipti Thakkar (11014470), Guo Hui Teo (1521718), Kiren Purushotorman (11014473), Paul E. Hutchinson (6458183), Barnaby E. Young (10869381), Jenny G. Low (10499731), Paul A. MacAry (10534724), Hannes Hentze (6680750), Venkateshan S. Prativadibhayankara (11014476), Kantharaj Ethirajulu (2100358), Jason E. Comer (7908407), Chien-Te K. Tseng (492742), Alan D. T. Barrett (8980565), Piers J. Ingram (11014479), Trevor Brasel (502095), Brendon John Hanson (11014482)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Immunology, Cancer, Infectious Diseases, Virology, convalescent COVID -19 patient, anti-SARS-CoV -2 activities, SARS-CoV -2-infected hamsters, IFN, K 18-human ACE 2, attenuated pro-inflammatory responses, SARS-CoV -2 Spike protein, efficacy, Fc-null LALA variant, COVID -19. Importantly, Fc-mediated effector functions, SARS-CoV -2 neutralizing antibody, SC 31 treatment, SARS-CoV -2-neutralizing antibodies, SC 31

Relation: https://figshare.com/articles/figure/SC31_reduces_viral_load_in_tissues_following_SARS-CoV-2_challenge_in_Indian_Rhesus_Macaques_/14830473

الاتاحة: https://doi.org/10.1371/journal.pone.0253487.s004

المؤلفون: Conrad E. Z. Chan (11014434), Shirley G. K. Seah (11014437), De Hoe Chye (11014440), Shane Massey (224366), Maricela Torres (11014443), Angeline P. C. Lim (11014446), Steven K. K. Wong (11014449), Jacklyn J. Y. Neo (11014452), Pui San Wong (11014455), Jie Hui Lim (11014458), Gary S. L. Loh (11014461), Dongling Wang (258597), Jerome D. Boyd-Kirkup (11014464), Siyu Guan (11014467), Dipti Thakkar (11014470), Guo Hui Teo (1521718), Kiren Purushotorman (11014473), Paul E. Hutchinson (6458183), Barnaby E. Young (10869381), Jenny G. Low (10499731), Paul A. MacAry (10534724), Hannes Hentze (6680750), Venkateshan S. Prativadibhayankara (11014476), Kantharaj Ethirajulu (2100358), Jason E. Comer (7908407), Chien-Te K. Tseng (492742), Alan D. T. Barrett (8980565), Piers J. Ingram (11014479), Trevor Brasel (502095), Brendon John Hanson (11014482)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Immunology, Cancer, Infectious Diseases, Virology, convalescent COVID -19 patient, anti-SARS-CoV -2 activities, SARS-CoV -2-infected hamsters, IFN, K 18-human ACE 2, attenuated pro-inflammatory responses, SARS-CoV -2 Spike protein, efficacy, Fc-null LALA variant, COVID -19. Importantly, Fc-mediated effector functions, SARS-CoV -2 neutralizing antibody, SC 31 treatment, SARS-CoV -2-neutralizing antibodies, SC 31

Relation: https://figshare.com/articles/figure/Dose-and_time-dependent_therapeutic_benefit_of_SC31_/14830491

الاتاحة: https://doi.org/10.1371/journal.pone.0253487.g004

المؤلفون: Conrad E. Z. Chan (11014434), Shirley G. K. Seah (11014437), De Hoe Chye (11014440), Shane Massey (224366), Maricela Torres (11014443), Angeline P. C. Lim (11014446), Steven K. K. Wong (11014449), Jacklyn J. Y. Neo (11014452), Pui San Wong (11014455), Jie Hui Lim (11014458), Gary S. L. Loh (11014461), Dongling Wang (258597), Jerome D. Boyd-Kirkup (11014464), Siyu Guan (11014467), Dipti Thakkar (11014470), Guo Hui Teo (1521718), Kiren Purushotorman (11014473), Paul E. Hutchinson (6458183), Barnaby E. Young (10869381), Jenny G. Low (10499731), Paul A. MacAry (10534724), Hannes Hentze (6680750), Venkateshan S. Prativadibhayankara (11014476), Kantharaj Ethirajulu (2100358), Jason E. Comer (7908407), Chien-Te K. Tseng (492742), Alan D. T. Barrett (8980565), Piers J. Ingram (11014479), Trevor Brasel (502095), Brendon John Hanson (11014482)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Immunology, Cancer, Infectious Diseases, Virology, convalescent COVID -19 patient, anti-SARS-CoV -2 activities, SARS-CoV -2-infected hamsters, IFN, K 18-human ACE 2, attenuated pro-inflammatory responses, SARS-CoV -2 Spike protein, efficacy, Fc-null LALA variant, COVID -19. Importantly, Fc-mediated effector functions, SARS-CoV -2 neutralizing antibody, SC 31 treatment, SARS-CoV -2-neutralizing antibodies, SC 31

Relation: https://figshare.com/articles/figure/SC31_binds_SARS-CoV-2_SP_and_neutralizes_virus_through_inhibition_of_binding_to_ACE2_/14830479

الاتاحة: https://doi.org/10.1371/journal.pone.0253487.g001

المؤلفون: Conrad E. Z. Chan (11014434), Shirley G. K. Seah (11014437), De Hoe Chye (11014440), Shane Massey (224366), Maricela Torres (11014443), Angeline P. C. Lim (11014446), Steven K. K. Wong (11014449), Jacklyn J. Y. Neo (11014452), Pui San Wong (11014455), Jie Hui Lim (11014458), Gary S. L. Loh (11014461), Dongling Wang (258597), Jerome D. Boyd-Kirkup (11014464), Siyu Guan (11014467), Dipti Thakkar (11014470), Guo Hui Teo (1521718), Kiren Purushotorman (11014473), Paul E. Hutchinson (6458183), Barnaby E. Young (10869381), Jenny G. Low (10499731), Paul A. MacAry (10534724), Hannes Hentze (6680750), Venkateshan S. Prativadibhayankara (11014476), Kantharaj Ethirajulu (2100358), Jason E. Comer (7908407), Chien-Te K. Tseng (492742), Alan D. T. Barrett (8980565), Piers J. Ingram (11014479), Trevor Brasel (502095), Brendon John Hanson (11014482)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Immunology, Cancer, Infectious Diseases, Virology, convalescent COVID -19 patient, anti-SARS-CoV -2 activities, SARS-CoV -2-infected hamsters, IFN, K 18-human ACE 2, attenuated pro-inflammatory responses, SARS-CoV -2 Spike protein, efficacy, Fc-null LALA variant, COVID -19. Importantly, Fc-mediated effector functions, SARS-CoV -2 neutralizing antibody, SC 31 treatment, SARS-CoV -2-neutralizing antibodies, SC 31

Relation: https://figshare.com/articles/figure/SC31_requires_Fc_effector_functions_for_optimal_therapeutic_benefit_/14830488

الاتاحة: https://doi.org/10.1371/journal.pone.0253487.g003

المؤلفون: Conrad E. Z. Chan (11014434), Shirley G. K. Seah (11014437), De Hoe Chye (11014440), Shane Massey (224366), Maricela Torres (11014443), Angeline P. C. Lim (11014446), Steven K. K. Wong (11014449), Jacklyn J. Y. Neo (11014452), Pui San Wong (11014455), Jie Hui Lim (11014458), Gary S. L. Loh (11014461), Dongling Wang (258597), Jerome D. Boyd-Kirkup (11014464), Siyu Guan (11014467), Dipti Thakkar (11014470), Guo Hui Teo (1521718), Kiren Purushotorman (11014473), Paul E. Hutchinson (6458183), Barnaby E. Young (10869381), Jenny G. Low (10499731), Paul A. MacAry (10534724), Hannes Hentze (6680750), Venkateshan S. Prativadibhayankara (11014476), Kantharaj Ethirajulu (2100358), Jason E. Comer (7908407), Chien-Te K. Tseng (492742), Alan D. T. Barrett (8980565), Piers J. Ingram (11014479), Trevor Brasel (502095), Brendon John Hanson (11014482)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Immunology, Cancer, Infectious Diseases, Virology, convalescent COVID -19 patient, anti-SARS-CoV -2 activities, SARS-CoV -2-infected hamsters, IFN, K 18-human ACE 2, attenuated pro-inflammatory responses, SARS-CoV -2 Spike protein, efficacy, Fc-null LALA variant, COVID -19. Importantly, Fc-mediated effector functions, SARS-CoV -2 neutralizing antibody, SC 31 treatment, SARS-CoV -2-neutralizing antibodies, SC 31

Relation: https://figshare.com/articles/figure/SC31_induces_ADCC_/14830482

الاتاحة: https://doi.org/10.1371/journal.pone.0253487.g002

المؤلفون: Conrad E. Z. Chan (11014434), Shirley G. K. Seah (11014437), De Hoe Chye (11014440), Shane Massey (224366), Maricela Torres (11014443), Angeline P. C. Lim (11014446), Steven K. K. Wong (11014449), Jacklyn J. Y. Neo (11014452), Pui San Wong (11014455), Jie Hui Lim (11014458), Gary S. L. Loh (11014461), Dongling Wang (258597), Jerome D. Boyd-Kirkup (11014464), Siyu Guan (11014467), Dipti Thakkar (11014470), Guo Hui Teo (1521718), Kiren Purushotorman (11014473), Paul E. Hutchinson (6458183), Barnaby E. Young (10869381), Jenny G. Low (10499731), Paul A. MacAry (10534724), Hannes Hentze (6680750), Venkateshan S. Prativadibhayankara (11014476), Kantharaj Ethirajulu (2100358), Jason E. Comer (7908407), Chien-Te K. Tseng (492742), Alan D. T. Barrett (8980565), Piers J. Ingram (11014479), Trevor Brasel (502095), Brendon John Hanson (11014482)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Immunology, Cancer, Infectious Diseases, Virology, convalescent COVID -19 patient, anti-SARS-CoV -2 activities, SARS-CoV -2-infected hamsters, IFN, K 18-human ACE 2, attenuated pro-inflammatory responses, SARS-CoV -2 Spike protein, efficacy, Fc-null LALA variant, COVID -19. Importantly, Fc-mediated effector functions, SARS-CoV -2 neutralizing antibody, SC 31 treatment, SARS-CoV -2-neutralizing antibodies, SC 31

Relation: https://figshare.com/articles/figure/SC31_minimizes_disease_after_SARS-CoV-2_challenge_in_Golden_Syrian_hamsters_and_Indian_Rhesus_Macaques_/14830494

الاتاحة: https://doi.org/10.1371/journal.pone.0253487.g005