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1
المؤلفون: Donald J. Graham, Elizabeth Martin, Ming-Tain Lai, Peter Sklar, Meizhen Feng, Winnie Ngo, Carey Hwang, Sushma Kumar, Daria J. Hazuda, Ernest Asante-Appiah
المصدر: Journal of Acquired Immune Deficiency Syndromes (1999)
مصطلحات موضوعية: Oncology, NNRTI, Cyclopropanes, medicine.medical_specialty, Efavirenz, Anti-HIV Agents, Pyridones, replication capacity, HIV Infections, Drug resistance, In Vitro Techniques, resistance, chemistry.chemical_compound, Clinical Trials, Phase II as Topic, In vivo, Doravirine, Internal medicine, Drug Resistance, Viral, doravirine, Medicine, Humans, Pharmacology (medical), Reverse-transcriptase inhibitor, business.industry, Rilpivirine, virus diseases, clinical trial, Clinical Science, Triazoles, Reverse transcriptase, Benzoxazines, Clinical trial, Infectious Diseases, chemistry, Clinical Trials, Phase III as Topic, Alkynes, HIV-1, business, medicine.drug
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2Academic Journal
المؤلفون: Steven W. Ludmerer, Donald J. Graham, Evelyn Boots, Edward M. Murray, Amy Simcoe, Eric J. Markel, Jay A, Osvaldo A. Flores, David B. Olsen, Daria J. Hazuda, Robert L. Lafemina, Jay A. Grobler
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.326.886; http://aac.asm.org/content/49/5/2059.full.pdf
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3
المؤلفون: Anne Taylor, Charles J. Mcintyre, Christine Fandozzi, Carolyn McHale, Jillian DiMuzio, Steven Harper, Steven S. Carroll, Vincenzo Summa, Jeff Fritzen, Aileen Soriano, Marco Ferrara, Joseph J. Romano, David B. Olsen, Kevin Nguyen, Steven W. Ludmerer, Nigel J. Liverton, Robert Chase, Stuart Black, John W. Butcher, Kevin F. Gilbert, Qian Huang, Michael T. Rudd, Adam Gates, Paul J. Coleman, Marcello DiFilippo, Mark Stahlhut, Kimberly J. Bush, John Swestock, Nicole Trainor, Christine Burlein, Stephanie McClain, John A. McCauley, M. Katharine Holloway, Donald J. Graham
المساهمون: Rudd, Mt, Butcher, Jw, Nguyen, Kt, Mcintyre, Cj, Romano, Jj, Gilbert, Kf, Bush, Kj, Liverton, Nj, Holloway, Mk, Harper, S, Ferrara, M, Difilippo, M, Summa, V, Swestock, J, Fritzen, J, Carroll, S, Burlein, C, Dimuzio, Jm, Gates, A, Graham, Qian Huang, Dj, Mcclain, S, Mchale, C, Stahlhut, Mw, Black, S, Chase, R, Soriano, A, Fandozzi, C, Taylor, A, Trainor, N, Olsen, Db, Coleman, Pj, Ludmerer, Sw, Mccauley, Ja
المصدر: ChemMedChem. 10:727-735
مصطلحات موضوعية: Models, Molecular, Macrocyclic Compounds, medicine.medical_treatment, Mutant, Hepacivirus, Viral Nonstructural Proteins, Biology, Crystallography, X-Ray, Antiviral Agents, Biochemistry, Virus, Drug Discovery, Genotype, medicine, Hepatitis C Virus NS3/4A Protease Inhibitors, Animals, Humans, Potency, Sulfones, General Pharmacology, Toxicology and Pharmaceutics, Quinazolinones, Pharmacology, NS3, Protease, Organic Chemistry, Hepatitis C, medicine.disease, Rats, Mutation, Molecular Medicine
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4
المؤلفون: Niloufar Mobashery, Julie Strizki, Carolyn McHale, Jacqueline D. Reeves, Amber A. Rivera, Richard J. O. Barnard, Amy L. Himmelberger, Mark J. DiNubile, David C. Nickle, Donald J. Graham, Peggy Hwang, William Newhard, Daria J. Hazuda, Carol A. Cheney
المصدر: Virology. 443:278-284
مصطلحات موضوعية: Cyclopropanes, Male, Indoles, Vaniprevir, Hepacivirus, Isoindoles, medicine.disease_cause, Gastroenterology, Polyethylene Glycols, chemistry.chemical_compound, Genotype, Treatment Failure, Sulfonamides, education.field_of_study, Hepatitis C-genotype 1, Hepatitis C, Middle Aged, Treatment Outcome, RNA, Viral, Drug Therapy, Combination, Female, Adult, medicine.medical_specialty, Adolescent, Proline, Lactams, Macrocyclic, Hepatitis C virus, Population, Viremia, Biology, Antiviral Agents, Treatment experienced, Young Adult, Double-Blind Method, Leucine, Virology, Internal medicine, Drug Resistance, Viral, Ribavirin, medicine, Humans, Dosing, education, Resistance-associated variants, Aged, Genetic Variation, Hepatitis C, Chronic, medicine.disease, Amino Acid Substitution, chemistry, Peptide Hydrolases
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7619ea624eb71d616e98034d1959625
https://doi.org/10.1016/j .virol.2013.05.013 -
5
المؤلفون: John A. McCauley, Kevin Nguyen, Anne Taylor, Joseph J. Romano, Steven S. Carroll, Nicole Trainor, Qian Huang, Stephanie McClain, M. Katharine Holloway, Joseph P. Vacca, Jillian DiMuzio, Christine Burlein, Christine Fandozzi, Carolyn McHale, Vincenzo Summa, Michael Rowley, John W. Butcher, Nigel J. Liverton, Charles J. Mcintyre, Adam Gates, Bang-Lin Wan, Michael T. Rudd, Donald J. Graham, Steven Harper, David B. Olsen, Terry A. Lyle, Kevin F. Gilbert, Mark Stahlhut, Kimberly J. Bush, Steven W. Ludmerer
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:7207-7213
مصطلحات موضوعية: Macrocyclic Compounds, Genotype, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Mutant, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Ring (chemistry), Biochemistry, Structure-Activity Relationship, Genotype 1b, Catalytic Domain, Drug Discovery, medicine, Animals, Potency, Protease Inhibitors, Molecular Biology, Binding Sites, Protease, Chemistry, Organic Chemistry, Intracellular Signaling Peptides and Proteins, Rats, Molecular Docking Simulation, Kinetics, Liver, Cyclization, Rat liver, Mutation, Molecular Medicine, Carrier Proteins, Linker, Half-Life
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6
المؤلفون: John Swestock, Christine Fandozzi, John A. McCauley, Nicole Trainor, Bang-Lin Wan, M. Katharine Holloway, Donald J. Graham, Charles J. Mcintyre, Nigel J. Liverton, Joseph J. Romano, Michael T. Rudd, John W. Butcher, Steven S. Carroll, Mark Stahlhut, Kevin F. Gilbert, Jillian DiMuzio, David B. Olsen, Steven W. Ludmerer, Kimberly J. Bush, Kevin Nguyen, Joseph P. Vacca
المصدر: ACS Medicinal Chemistry Letters. 2:207-212
مصطلحات موضوعية: chemistry.chemical_classification, Protease, Chemistry, Hepatitis C virus, medicine.medical_treatment, Organic Chemistry, Hepatitis C, medicine.disease, medicine.disease_cause, Biochemistry, Amino acid, Enzyme, Plasma exposure, Drug Discovery, medicine, Potency, Dosing
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7
المؤلفون: Nicole Trainor, Christine Fandozzi, Kevin F. Gilbert, Joseph J. Romano, Bang-Lin Wan, Shi-Shan Mao, John Swestock, John A. McCauley, M. Katharine Holloway, David B. Olsen, Nigel J. Liverton, Kimberly J. Bush, Donald J. Graham, Mark Stahlhut, Steven S. Carroll, John W. Butcher, Steven W. Ludmerer, Michael T. Rudd, Jillian DiMuzio, Kevin Nguyen, Joseph P. Vacca, Charles J. Mcintyre
المصدر: Journal of Medicinal Chemistry. 53:2443-2463
مصطلحات موضوعية: Cyclopropanes, Indoles, Macrocyclic Compounds, Serine Proteinase Inhibitors, Pan troglodytes, Proline, Metabolic Clearance Rate, Lactams, Macrocyclic, Hepatitis C virus, medicine.medical_treatment, Vaniprevir, Drug Evaluation, Preclinical, Hepacivirus, Isoindoles, Viral Nonstructural Proteins, medicine.disease_cause, Inhibitory Concentration 50, Structure-Activity Relationship, Viral Proteins, chemistry.chemical_compound, Dogs, Leucine, Drug Discovery, Genotype, medicine, Animals, Potency, chemistry.chemical_classification, Sulfonamides, NS3, Protease, Molecular Structure, Intracellular Signaling Peptides and Proteins, Macaca mulatta, Virology, Rats, Enzyme, Liver, Models, Chemical, Biochemistry, chemistry, Area Under Curve, Molecular Medicine, Carrier Proteins, Linker
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8
المؤلفون: Christine Fandozzi, John A. McCauley, M. Katharine Holloway, Donald J. Graham, Jillian DiMuzio, David B. Olsen, Joseph P. Vacca, Charles J. Mcintyre, Nigel J. Liverton, Mark Stahlhut, Michael T. Rudd, Steven S. Carroll, Steven W. Ludmerer, Daria J. Hazuda
المصدر: Antimicrobial Agents and Chemotherapy. 54:305-311
مصطلحات موضوعية: Cyclopropanes, Proteases, Indoles, Genotype, Pan troglodytes, Proline, Lactams, Macrocyclic, medicine.medical_treatment, Hepatitis C virus, Vaniprevir, Hepacivirus, Interferon alpha-2, Isoindoles, Viral Nonstructural Proteins, Biology, medicine.disease_cause, Antiviral Agents, Cell Line, Substrate Specificity, chemistry.chemical_compound, Dogs, Blood serum, Leucine, medicine, Animals, Humans, Potency, Protease Inhibitors, Pharmacology (medical), Pharmacology, Sulfonamides, NS3, Protease, Interferon-alpha, Hepatitis C, medicine.disease, Macaca mulatta, Virology, Recombinant Proteins, Rats, Infectious Diseases, chemistry, Area Under Curve, Replicon, Half-Life
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9
المؤلفون: Sergio Altamura, Giacomo Paonessa, Andrea Carfi, Marco Mattu, Linda Bartholomew, Giovanni Migliaccio, Antonella Cellucci, Raffaele De Francesco, Donald J. Graham, Steven W. Ludmerer, Gaetano Barbato, Edwin H. Rydberg
المصدر: Journal of Molecular Biology. 390:1048-1059
مصطلحات موضوعية: Models, Molecular, Genotype, Hepatitis C virus, Mutant, Hepacivirus, Viral Nonstructural Proteins, Biology, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Protein Structure, Secondary, chemistry.chemical_compound, Structural Biology, Drug Resistance, Viral, medicine, Replicon, Binding site, Molecular Biology, NS5B, Polymerase, chemistry.chemical_classification, Binding Sites, Indoleacetic Acids, Nucleosides, DNA-Directed RNA Polymerases, Molecular biology, Kinetics, Enzyme, Amino Acid Substitution, Biochemistry, chemistry, Structural Homology, Protein, biology.protein, Mutant Proteins
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10
المؤلفون: Donald J. Graham, Steven W. Ludmerer, David B. Olsen, Nanyan Rena Zhang, Kenneth A. Koeplinger, Malcolm MacCoss, Daria J. Hazuda, Mary-Ellen Davies, Larry Handt, Steven S. Carroll
المصدر: Antimicrobial Agents and Chemotherapy. 53:926-934
مصطلحات موضوعية: Time Factors, Pan troglodytes, Hepacivirus, Hepatitis C virus, medicine.disease_cause, Antiviral Agents, Drug Administration Schedule, Tubercidin, Virus, Inhibitory Concentration 50, chemistry.chemical_compound, medicine, Animals, Pharmacology (medical), Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, biology, Ribavirin, Nucleosides, Hepatitis C, Viral Load, biology.organism_classification, medicine.disease, Virology, Infectious Diseases, chemistry, Area Under Curve, RNA, Viral, Viral disease, Viral load
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11Academic Journal
المؤلفون: Summa V, Steven W Ludmerer, John A McCauley, Christine Fandozzi, Christine Burlein, Giuliano Claudio, Paul J Coleman, Jillian M DiMuzio, Marco Ferrara, Marcello Di Filippo, Adam T Gates, Donald J Graham, Steven Harper, Daria J Hazuda, Qian Huang, Carolyn McHale, Edith Monteagudo, Vincenzo Pucci, Michael Rowley, Michael T Rudd, Aileen Soriano, Mark W Stahlhut, Joseph P Vacca, David B Olsen, Nigel J Liverton, Steven S Carroll
المساهمون: Summa, V, Steven, W Ludmerer, John, A McCauley, Christine, Fandozzi, Christine, Burlein, Giuliano, Claudio, Paul, J Coleman, Jillian, M DiMuzio, Marco, Ferrara, Marcello Di, Filippo, Adam, T Gate, Donald, J Graham, Steven, Harper, Daria, J Hazuda, Qian, Huang, Carolyn, Mchale, Edith, Monteagudo, Vincenzo, Pucci, Michael, Rowley, Michael, T Rudd, Aileen, Soriano, Mark, W Stahlhut, Joseph, P Vacca, David, B Olsen, Nigel, J Liverton, Steven, S Carroll
Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000306826300016; volume:56; issue:8; firstpage:4161; lastpage:4167; numberofpages:7; journal:ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; http://hdl.handle.net/11588/771084; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84864387126
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12
المؤلفون: David B. Olsen, Donald J. Graham, Steven W. Ludmerer, Daria J. Hazuda, Mark Stahlhut, Osvaldo A. Flores, Robert L. Lafemina
المصدر: Antiviral Research. 69:24-30
مصطلحات موضوعية: Models, Molecular, Adenosine, Ribonucleoside Diphosphate Reductase, viruses, Hepatitis C virus, Hepacivirus, Viral Nonstructural Proteins, Virus Replication, medicine.disease_cause, Cell Line, chemistry.chemical_compound, Species Specificity, Virology, Genotype, medicine, Humans, Replicon, NS5B, Polymerase, Pharmacology, Genetics, NS3, biology, virus diseases, Nucleoside inhibitor, biochemical phenomena, metabolism, and nutrition, RNA-Dependent RNA Polymerase, Nucleotidyltransferase, digestive system diseases, chemistry, biology.protein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302d4ffe74b5248914139ee22cca1601
https://doi.org/10.1016/j .antiviral.2005.08.005 -
13
المؤلفون: Vincenzo Summa, Steven W. Ludmerer, John A. McCauley, Christine Fandozzi, Christine Burlein, Giuliano Claudio, Paul J. Coleman, Jillian M. DiMuzio, Marco Ferrara, Marcello Di Filippo, Adam T. Gates, Donald J. Graham, Steven Harper, Daria J. Hazuda, Qian Huang, Carolyn McHale, Edith Monteagudo, Vincenzo Pucci, Michael Rowley, Michael T. Rudd, Aileen Soriano, Mark W. Stahlhut, Joseph P. Vacca, David B. Olsen, Nigel J. Liverton, Steven S. Carroll
المساهمون: Summa, V, Steven, W Ludmerer, John, A McCauley, Christine, Fandozzi, Christine, Burlein, Giuliano, Claudio, Paul, J Coleman, Jillian, M DiMuzio, Marco, Ferrara, Marcello Di, Filippo, Adam, T Gate, Donald, J Graham, Steven, Harper, Daria, J Hazuda, Qian, Huang, Carolyn, Mchale, Edith, Monteagudo, Vincenzo, Pucci, Michael, Rowley, Michael, T Rudd, Aileen, Soriano, Mark, W Stahlhut, Joseph, P Vacca, David, B Olsen, Nigel, J Liverton, Steven, S Carroll
مصطلحات موضوعية: Cyclopropanes, Elbasvir, Genotype, Pan troglodytes, Hepatitis C virus, Hepacivirus, Biology, Viral Nonstructural Proteins, medicine.disease_cause, Antiviral Agents, Telaprevir, chemistry.chemical_compound, Dogs, Interferon, Pegylated interferon, Boceprevir, Quinoxalines, Drug Resistance, Viral, medicine, Animals, Protease inhibitor (pharmacology), Protease Inhibitors, Pharmacology (medical), Author Correction, Pharmacology, Sulfonamides, Hepatitis C, Chronic, Viral Load, Virology, Amides, Rats, Infectious Diseases, chemistry, Liver, Carbamates, Viral load, medicine.drug
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14
المؤلفون: Donald J. Graham, Malathi Shivaprakash, Kalpana K Bakshi, Rand R. Rhodes, David W. Haas, Jon H. Condra, Joshua Chen, Alfred Saah, Mark J. DiNubile, Daniel J. Holder, Robert M. Danovich
المصدر: The Journal of Infectious Diseases. 187:1157-1162
مصطلحات موضوعية: Adult, Cyclopropanes, Male, medicine.medical_specialty, Efavirenz, Anti-HIV Agents, viruses, Organophosphonates, HIV Infections, Indinavir, Gastroenterology, Virus, chemistry.chemical_compound, immune system diseases, Internal medicine, Drug Resistance, Viral, Oxazines, medicine, Adefovir, Humans, Immunology and Allergy, Treatment Failure, Sida, Nelfinavir, biology, business.industry, Adenine, Proteolytic enzymes, HIV, virus diseases, HIV Protease Inhibitors, Middle Aged, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Virology, Benzoxazines, Infectious Diseases, chemistry, Alkynes, Female, Viral disease, business, medicine.drug
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15
المؤلفون: Christine Fandozzi, David B. Olsen, Amin A. Nomeir, Bin Hu, Donald J. Graham, Joseph A. Kozlowski, Hao Wu, Wei Chang, Steven W. Ludmerer, Peter T. Meinke, Richard Soll, Bin Zhong, Craig A. Coburn, John A. Mccauley, Stacia Kargman, Qian Huang, Rong Liu, Joseph P. Vacca, Dahai Wang
المصدر: ChemMedChem. 8(12)
مصطلحات موضوعية: Elbasvir, Indoles, Pan troglodytes, viruses, Drug Evaluation, Preclinical, Hepacivirus, Pharmacology, Biology, Viral Nonstructural Proteins, Biochemistry, Antiviral Agents, Structure-Activity Relationship, Dogs, Drug Discovery, Genotype, Potency, Animals, General Pharmacology, Toxicology and Pharmaceutics, Enzyme Inhibitors, NS5A, Benzofurans, Organic Chemistry, Imidazoles, virus diseases, Virology, digestive system diseases, Viral Breakthrough, Rats, Regimen, Grazoprevir, Mutation, Molecular Medicine, Viral load, Half-Life, Protein Binding
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16
المؤلفون: Stephanie Curry, John A. Howe, Maria J. Frontera, Richard J. O. Barnard, Donald J. Graham, Robert Chase, Frederick C. Lahser, E. Hughes, Anita Y. M. Howe, Patricia McMonagle, Marcelo Silva, Samir Gupta, M. Treitel
المصدر: Journal of hepatology. 59(1)
مصطلحات موضوعية: Adult, Male, Genotype, Proline, Hepatitis C virus, Hepacivirus, Pharmacology, Viral Nonstructural Proteins, medicine.disease_cause, Antiviral Agents, Telaprevir, chemistry.chemical_compound, Boceprevir, Medicine, Potency, Humans, Protease inhibitor (pharmacology), Protease Inhibitors, Replicon, NS3, Hepatology, business.industry, virus diseases, Hepatitis C, Hepatitis C, Chronic, Middle Aged, Viral Load, medicine.disease, Virology, digestive system diseases, Kinetics, chemistry, RNA, Viral, Female, business, Oligopeptides, medicine.drug
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17
المؤلفون: Jon H. Condra, Y. Li, Mark W. Stahlhut, Leah Gotlib, Donald J. Graham, J. Fu, David B. Olsen
المصدر: Protein Expression and Purification. 5:614-621
مصطلحات موضوعية: Lysis, Protein subunit, Molecular Sequence Data, Size-exclusion chromatography, Biology, medicine.disease_cause, Cell Line, Escherichia coli, medicine, Humans, Cloning, Molecular, chemistry.chemical_classification, Gel electrophoresis, Chromatography, Base Sequence, Isoelectric focusing, RNA-Directed DNA Polymerase, HIV Reverse Transcriptase, Amino acid, Enzyme, chemistry, Biochemistry, HIV-1, Mutagenesis, Site-Directed, Quinazolines, Reverse Transcriptase Inhibitors, Biotechnology
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18
المؤلفون: Jules A. Shafer, A M Stern, C D Bennett, L Gotlib, Jon H. Condra, David B. Olsen, S S Carroll, Lawrence C. Kuo, Donald J. Graham
المصدر: Journal of Biological Chemistry. 268:276-281
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Protein primary structure, Nucleic acid sequence, RNA, Cell Biology, Biology, Biochemistry, Reverse transcriptase, Enzyme, chemistry, Structure–activity relationship, Nucleotide, Primer (molecular biology), Molecular Biology
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19
المؤلفون: David B. Olsen, Nanyan Rena Zhang, Nigel J. Liverton, Malcolm MacCoss, Larry Handt, Mary-Ellen Davies, Steven S. Carroll, Kenneth A. Koeplinger, Daria J. Hazuda, Steven W. Ludmerer, Donald J. Graham
المصدر: Antimicrobial agents and chemotherapy. 55(2)
مصطلحات موضوعية: Cyclopropanes, Indoles, Pan troglodytes, Proline, Hepacivirus, Hepatitis C virus, Lactams, Macrocyclic, Isoindoles, Viral Nonstructural Proteins, medicine.disease_cause, Antiviral Agents, Tubercidin, Drug Administration Schedule, Leucine, medicine, Sustained viral response, Animals, Pharmacology (medical), Protease inhibitor (pharmacology), Protease Inhibitors, Pharmacology, Sulfonamides, biology, Nucleoside analogue, Dose-Response Relationship, Drug, Hepatitis C, Chronic, Viral Load, biology.organism_classification, Virology, Infectious Diseases, Treatment Outcome, Immunology, Drug Therapy, Combination, Viral load, Direct acting, medicine.drug
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20
المؤلفون: Jill A. Wolfgang, V V Sardana, William J. Long, Donald J. Graham, Emilio A. Emini, Donald W. Lineberger, Jon H. Condra, A J Schlabach, Leah Gotlib
المصدر: Journal of Biological Chemistry. 267:17526-17530
مصطلحات موضوعية: chemistry.chemical_classification, biology, Functional analysis, Stereochemistry, Mutant, Cell Biology, Biochemistry, Reverse transcriptase, Virus, Amino acid, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Binding site, Molecular Biology