المؤلفون: Chen, Zhuo, Satake, Eiichiro, Pezzolesi, Marcus G., Dom, Zaipul I.Md, Stucki, Devorah, Kobayashi, Hiroki, Syreeni, Anna, Johnson, Adam T., Wu, Xiwei, Dahlström, Emma H., King, Jaxon B., Groop, Per-Henrik, Rich, Stephen S., Sandholm, Niina, Krolewski, Andrzej S., Natarajan, Rama

المساهمون: HUS Abdominal Center, CAMM - Research Program for Clinical and Molecular Metabolism, Nefrologian yksikkö, Research Programs Unit, Department of Medicine, Per Henrik Groop / Principal Investigator, Clinicum, Medicum

مصطلحات موضوعية: Biomedicine, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: Acknowledgments: We are grateful to F. Miao [City of hope (Coh)] for assistance with sample processing for dnamet and C. S. Jayasena (Coh) for assistance with the manuscript. research reported in this publication included work performed in the following Coh Cores/Shared resources: integrative Genomics and dna/rna synthesis (supported by the national Cancer institute grant P30Ca33572), and the Genomics Core at the University of S. California. We acknowledge l. J. Smyth, a. P. Maxwell, and a. J. McKnight for the laboratory analysis and initial quality control of the Finndiane eWaS data performed at Queen\u2019s University of Belfast. Funding: This study was supported in part by the following grants: nih grants r01dK065073 and r01dK081705 (r.n.); nih grant r01dK110350 (M.G.P. and r.n.); Wanek family project for the Cure of T1d at Coh (r.n. and Z.C.); a Pilot grant from the niddK-sponsored diabetes Complications Consortium (diacomp) (M.G.P. and Z.C.); nih grants r01dK041526, r01dK110350, r01dK126799, and r01dK131061 (a.S.K.); novo nordisk Foundation nnF14oC0013659 (ProTon) (a.S.K.); nih grant r01dK122586 (S.S.r.); helmsley Charitable Trust grant r-2204-05134 (S.S.r.); and Juvenile diabetes research Foundation grant 2-Sra-2022-1260-S-B (S.S.r.). The Finndiane study was supported by grants from Folkh\u00E4lsan research Foundation (P.-h.G.), Wilhelm and else Stockmann Foundation (P.-h.G.), \u201Cliv och h\u00E4lsa\u201DSociety (P.-h.G.), Sigrid Juselius Foundation (n.S. and P.-h.G.), helsinki University Central hospital research Funds TYh2023403 (P.-h.G.), novo nordisk Foundation nnF oC0013659 (P.-h.G.) and nnF23oC0082732 (n.S.), academy of Finland 316664 (P.-h.G.), and nih r01_ dK132299 (n.S. and P.-h.G.) and r01_dK105154 (P.-h.G.) for the Genetics of nephropathy an international effort (Genie) consortium. Author contributions: Z.C., a.S.K., and r.n. conceptualized the study. Z.C. obtained dnamet profiles of all the JKS participants and performed quality control, eWaS, and all the follow-up functional analyses. e.S. performed integrative analyses with circulating proteins and mirnas. d.S. and M.G.P. performed integrative analysis with genotyping profiles. e.S., Z.i.M.d., and h.K. collected phenotypic data of all the participants. X.W. assisted in data processing and analysis methods for the eWaS. a.S. performed validation analyses using Finndiane dnamet dataset. a.T.J., J.B.K., and M.G.P. obtained dnamet profiles of the samples collected at the second time point from a subset of the JKS cohort. The analysis results were investigated and interpreted by Z.C., e.S., r.n., a.S.K., S.S.r., Z.i.M.d., a.S., M.G.P., h.K., and d.S. and visualized by Z.C., e.S., M.G.P., r.n., and a.S.K. For Finndiane eWaS, a.S. and e.h.d. were responsible for data quality control, and n.S. and P.-h.G. were responsible for data and design. r.n., a.S.K., and M.G.P. provided resources for the study. The project was administrated by Z.C., a.S.K., and r.n. and supervised by r.n. and a.S.K. The manuscript was originally drafted by Z.C., a.S.K., and r.n., reviewed and edited by Z.C., r.n., e.S., a.S.K., Z.i.M.d., M.G.P., h.K., e.h.d., P.-h.G., n.S., a.S., X.W., and S.S.r. Competing interests: P.-h.G. has received investigator-initiated research grants from eli lilly and roche; is an advisory board member for abbVie, astellas, astraZeneca, Bayer, Boehringer ingelheim, Cebix, eli lilly, Janssen, Medscape, Merck Sharp & dohme, Mundipharma, nestl\u00E9, novartis, novo nordisk and Sanofi; and has received lecture fees from astraZeneca, Boehringer ingelheim, eli lilly, elo Water, Genzyme, Merck Sharp & dohme, Medscape, novartis, novo nordisk, PeerVoice, Sanofi, and Sciarc. all the other authors declare that they have no competing interests. Data and materials availability: all data associated with this study are present in the paper or the Supplementary Materials. de-identified data for participants in the JKS study can be made available upon request from the corresponding authors with a data transfer agreement.; Chen , Z , Satake , E , Pezzolesi , M G , Dom , Z I M , Stucki , D , Kobayashi , H , Syreeni , A , Johnson , A T , Wu , X , Dahlström , E H , King , J B , Groop , P-H , Rich , S S , Sandholm , N , Krolewski , A S & Natarajan , R 2024 , ' Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes ' , Science translational medicine , vol. 16 , no. 748 , adj3385 . https://doi.org/10.1126/scitranslmed.adj3385 , https://doi.org/10.1126/scitranslmed.adj3385; ORCID: /0000-0003-1857-2560/work/161250284; ORCID: /0000-0003-4322-6942/work/161251514; ORCID: /0000-0003-1271-8696/work/161252190; http://hdl.handle.net/10138/577249; 296c4184-9b7a-4445-bb91-c7378532dbb3; 85193967700; 001229107800005

الاتاحة: http://hdl.handle.net/10138/577249