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1
المؤلفون: Christian Harcken, Morrison B. Mac, Melissa Hill-Drzewi, Debbie Studwell, Diva Sze-Ming Chan, Donna Terenzzio, Heather Xia, Mita Patel, Yu Hui, Brian Linehan, Pingrong Liu, Lynne Canne Bannen, Raymond A. Kemper, Louise K. Modis, Dustin Smith, Lemieux Rene M, Miller Craig Andrew, Darren Disalvo, Raj Betageri, Jeremy I. Levin, Kimberly Fletcher, Daniel Kuzmich, Lori Patenaude, Stephanie M. Ng, Yong Wang, Eugene R. Hickey, Wei Xu, John Lord, Monica Patel, Can Mao, Horan Joshua Courtney, Tamara Denise Hopkins
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:466-471
مصطلحات موضوعية: 0301 basic medicine, Molecular charge, Clinical Biochemistry, Glutamic Acid, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, Thiadiazoles, Drug Discovery, Animals, Humans, Potency, Solubility, Molecular Biology, Oxadiazoles, S1p1 receptor, Chemistry, Organic Chemistry, Late stage, Brain, Hydrogen Bonding, Hep G2 Cells, Rats, Kinetics, Receptors, Lysosphingolipid, 030104 developmental biology, Molecular Medicine
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2
المؤلفون: Kenneth D. Rice, Neel Kumar Anand, Moon Hwan Kim, Jason Jevious Parks, Tsze H. Tsang, Donna T. Le, Larisa Dubenko, Erick Wang Co, Steven Charles Defina, Joerg Bussenius, Lynne Canne-Bannen, David J. Matthews, John M. Nuss, Stefan Engst, Simona Costanzo, Richard George Khoury, A. Douglas Laird, Diva Sze-Ming Chan, Wei Xu, Owen Joseph Bowles, Maurizio Franzini, Vasu Jammalamadaka, Ping Huang, Amy Lew Tsuhako, Yong Wang, David W. Markby, Baili Chen, Morrison B. Mac, Rhett Ronald Klein, Nicole Miller, Charles M. Blazey
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:2693-2697
مصطلحات موضوعية: Models, Molecular, Pyridines, Proto-Oncogene Proteins c-akt, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Mice, Phosphatidylinositol 3-Kinases, Enzyme activator, Dogs, In vivo, Microsomes, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Molecular Structure, Kinase, Chemistry, Akt/PKB signaling pathway, Organic Chemistry, Ribosomal Protein S6 Kinases, 70-kDa, Cancer, Haplorhini, medicine.disease, Enzyme Activation, Cancer research, Pyrazoles, Molecular Medicine
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3
المؤلفون: Louise K. Modis, Yong Wang, Stephanie M. Ng, Sulagna Sanyal, Brian Nicholas Cook, Lemieux Rene M, Melissa Hill-Drzewi, Younggi Choi, Wei Xu, Kristina Gueneva-Boucheva, Diva Sze-Ming Chan, Lori Patnaude, Edward Pack, Eugene R. Hickey, Michael B. Fisher, Can Mao, Horan Joshua Courtney, Lynne Canne Bannen, Steve Fogal, Morrison B. Mac, Shawn Anderson
المصدر: Bioorganicmedicinal chemistry letters. 24(20)
مصطلحات موضوعية: Agonist, Stereochemistry, medicine.drug_class, Metabolite, Sphingosine-1-phosphate receptor, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Pharmacology, Biochemistry, Piperazines, chemistry.chemical_compound, Structure-Activity Relationship, Oral administration, In vivo, Lymphopenia, Drug Discovery, medicine, Animals, Molecular Biology, Sphingosine-1-Phosphate Receptors, Oxadiazoles, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Prodrug, Phosphate, Rats, Receptors, Lysosphingolipid, chemistry, Rats, Inbred Lew, Molecular Medicine, Female, Lead compound
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4
المؤلفون: Kenneth D. Rice, Yong Wang, Lynne Canne Bannen, Morrison B. Mac, Vasu Jammalamadaka, Simona Costanzo, Maurizio Franzini, Erick Wang Co, Nicole Miller, Larisa Dubenko, Steven Charles Defina, Joerg Bussenius, Neel Kumar Anand, Douglas Laird, David J. Matthews, John M. Nuss, Jason Jevious Parks, Amy Lew Tsuhako, Rhett Ronald Klein, Donna T. Le, Tsze H. Tsang, Baili Chen, Charles M. Blazey, Moon Hwan Kim, David W. Markby, Richard George Khoury, Wei Xu, Diva Sze-Ming Chan, Owen Joseph Bowles, Stefan Engst, Ping Huang
المصدر: Bioorganicmedicinal chemistry letters. 22(6)
مصطلحات موضوعية: Male, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, Antineoplastic Agents, Pharmacology, Biochemistry, Pyrazolopyrimidine, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Pharmacokinetics, Cell Line, Tumor, Drug Discovery, Animals, Humans, Molecular Biology, Protein kinase B, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Chemistry, Kinase, Organic Chemistry, Ribosomal Protein S6 Kinases, 70-kDa, Xenograft Model Antitumor Assays, High-Throughput Screening Assays, Rats, Pyrimidines, Solubility, Ribosomal protein s6, Drug Design, Molecular Medicine, Pyrazoles, Lead compound, Signal Transduction