المؤلفون: Qinglong Meng (3567785), Carlos Ramírez-Palacios (9944570), Nikolas Capra (8448186), Mattijs E. Hooghwinkel (11271953), Sebastian Thallmair (1339593), Henriëtte J. Rozeboom (2885936), Andy-Mark W. H. Thunnissen (8448201), Hein J. Wijma (1773142), Siewert J. Marrink (135518), Dick B. Janssen (1566727)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Information Systems not elsewhere classified, substrate scope, Pj TA mutants, 86L, Transaminase, ω- TAs, 58G, 58M, amine, 417L, synthesis, amines, ketone, Pj TA-R 6, protein engineering strategy, variant, Pj TA-R 6 redesign, Pseudomonas jessenii

Relation: https://figshare.com/articles/journal_contribution/Computational_Redesign_of_an_Transaminase_from_Pseudomonas_jessenii_for_Asymmetric_Synthesis_of_Enantiopure_Bulky_Amines/15163742

الاتاحة: https://doi.org/10.1021/acscatal.1c02053.s001

المؤلفون: Carlos Ramírez-Palacios (9944570), Hein J. Wijma (1773142), Sebastian Thallmair (1339593), Siewert J. Marrink (135518), Dick B. Janssen (1566727)

مصطلحات موضوعية: Biophysics, Biochemistry, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, relevant conformational space, generated complexes containing, external aldimine intermediate, 62 compounds gathered, attack conformations observed, presented framework makes, limited substrate range, starting conformations, range predictions, vibrio fluvialis, transamination reaction, screen thousands, quantitatively predicted, natural substrates, industrial production, experimentally determined, enzyme variants, enzyme design, ee <, different substrates, computational protocol, computational prediction, chiral amines, catalytic selectivity

Relation: https://figshare.com/articles/journal_contribution/Computational_Prediction_of_Transaminase_Specificity_by_a_Combination_of_Docking_and_Molecular_Dynamics_Simulations/16821262

الاتاحة: https://doi.org/10.1021/acs.jcim.1c00617.s001

المؤلفون: Megan V. Doble (5897411), Lorenz Obrecht (10269982), Henk-Jan Joosten (4033187), Misun Lee (3076299), Henriette J. Rozeboom (1658674), Emma Branigan (1989781), James. H. Naismith (10269985), Dick B. Janssen (1566727), Amanda G. Jarvis (1604599), Paul C. J. Kamer (8728521)

مصطلحات موضوعية: Biophysics, Biochemistry, Biotechnology, Evolutionary Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Catalytic Activity Protein engineering, Thermostable variants, metalloenzyme, thermostability, 1- octene, protein scaffold, reaction temperatures, metal catalyst, 3 DM database, protein engineering, carrier protein 2 L, engineering Thermostability, Artificial Metalloenzymes, turnover number

Relation: https://figshare.com/articles/journal_contribution/Engineering_Thermostability_in_Artificial_Metalloenzymes_to_Increase_Catalytic_Activity/14179099

الاتاحة: https://doi.org/10.1021/acscatal.0c05413.s001