المؤلفون: Kaplan, Anat Levit, Confair, Danielle N, Kim, Kuglae, Barros-Álvarez, Ximena, Rodriguiz, Ramona M, Yang, Ying, Kweon, Oh Sang, Che, Tao, McCorvy, John D, Kamber, David N, Phelan, James P, Martins, Luan Carvalho, Pogorelov, Vladimir M, DiBerto, Jeffrey F, Slocum, Samuel T, Huang, Xi-Ping, Kumar, Jain Manish, Robertson, Michael J, Panova, Ouliana, Seven, Alpay B, Wetsel, Autumn Q, Wetsel, William C, Irwin, John J, Skiniotis, Georgios, Shoichet, Brian K, Roth, Bryan L, Ellman, Jonathan A

المصدر: Nature. 610(7932)

مصطلحات موضوعية: Theory Of Computation, Information and Computing Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Brain Disorders, Women's Health, 1.1 Normal biological development and functioning, Animals, Mice, Antidepressive Agents, Cryoelectron Microscopy, Fluoxetine, Hallucinogens, Ligands, Pyrrolidines, Receptor, Serotonin, 5-HT2A, Small Molecule Libraries, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/87f9q9sd
https://escholarship.org/content/qt87f9q9sd/qt87f9q9sd.pdf

المؤلفون: Cao, Can, Kang, Hye Jin, Singh, Isha, Chen, He, Zhang, Chengwei, Ye, Wenlei, Hayes, Byron W, Liu, Jing, Gumpper, Ryan H, Bender, Brian J, Slocum, Samuel T, Krumm, Brian E, Lansu, Katherine, McCorvy, John D, Kroeze, Wesley K, English, Justin G, DiBerto, Jeffrey F, Olsen, Reid HJ, Huang, Xi-Ping, Zhang, Shicheng, Liu, Yongfeng, Kim, Kuglae, Karpiak, Joel, Jan, Lily Y, Abraham, Soman N, Jin, Jian, Shoichet, Brian K, Fay, Jonathan F, Roth, Bryan L

المصدر: Nature. 600(7887)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Chemical Sciences, Chronic Pain, Pain Research, 2.1 Biological and endogenous factors, Generic health relevance, Cryoelectron Microscopy, Drug Inverse Agonism, GTP-Binding Protein alpha Subunits, Gi-Go, GTP-Binding Protein alpha Subunits, Gq-G11, Humans, Models, Molecular, Nerve Tissue Proteins, Pruritus, Receptors, G-Protein-Coupled, Receptors, Neuropeptide, General Science & Technology

URL الوصول: https://escholarship.org/uc/item/78f5d3k9

المؤلفون: Kim, Kuglae, Che, Tao, Panova, Ouliana, DiBerto, Jeffrey F, Lyu, Jiankun, Krumm, Brian E, Wacker, Daniel, Robertson, Michael J, Seven, Alpay B, Nichols, David E, Shoichet, Brian K, Skiniotis, Georgios, Roth, Bryan L

المصدر: Cell. 182(6)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Brain Disorders, Mental Health, Depression, Substance Misuse, Aetiology, 2.1 Biological and endogenous factors, Mental health, Animals, Cryoelectron Microscopy, Crystallography, X-Ray, GTP-Binding Protein alpha Subunits, Gq-G11, Gene Expression, HEK293 Cells, Hallucinogens, Humans, Ligands, Lysergic Acid Diethylamide, Methiothepin, Models, Chemical, Mutation, Protein Conformation, alpha-Helical, Receptor, Serotonin, 5-HT2A, Recombinant Proteins, Serotonin, Spodoptera, GPCR, LSD, psychedelic, sertotonin receptor, signal transduction, structural biology, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0wc7m3gg

المؤلفون: Yang, Yang, Kang, Hye Jin, Gao, Ruogu, Wang, Jingjing, Han, Gye Won, DiBerto, Jeffrey F., Wu, Lijie, Tong, Jiahui, Qu, Lu, Wu, Yiran, Pileski, Ryan, Li, Xuemei, Zhang, Xuejun Cai, Zhao, Suwen, Kenakin, Terry, Wang, Quan, Stevens, Raymond C., Peng, Wei, Roth, Bryan L., Rao, Zihe, Liu, Zhi-Jie

المصدر: Nature Communications ; volume 14, issue 1 ; ISSN 2041-1723

الاتاحة: http://dx.doi.org/10.1038/s41467-023-37177-6
https://www.nature.com/articles/s41467-023-37177-6.pdf
https://www.nature.com/articles/s41467-023-37177-6

المؤلفون: Wang, Yue, Zhuang, Youwen, DiBerto, Jeffrey F., Zhou, X. Edward, Schmitz, Gavin P., Yuan, Qingning, Jain, Manish K., Liu, Weiyi, Melcher, Karsten, Jiang, Yi, Roth, Bryan L., Xu, H. Eric

المساهمون: Ministry of Science and Technology of the People's Republic of China, Science and Technology Commission of Shanghai Municipality, National Institutes of Health, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, National Institute of Mental Health, Chinese Academy of Sciences, National Natural Science Foundation of China

المصدر: Cell ; volume 186, issue 2, page 413-427.e17 ; ISSN 0092-8674

الاتاحة: http://dx.doi.org/10.1016/j.cell.2022.12.026
https://api.elsevier.com/content/article/PII:S0092867422015458?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0092867422015458?httpAccept=text/plain

المؤلفون: Salas-Estrada, Leslie, Provasi, Davide, Qiu, Xing, Kaniskan, Husnu Ümit, Huang, Xi-Ping, DiBerto, Jeffrey F., Lamim Ribeiro, João Marcelo, Jin, Jian, Roth, Bryan L., Filizola, Marta

المساهمون: National Institute on Drug Abuse

المصدر: Journal of Chemical Information and Modeling ; volume 63, issue 16, page 5056-5065 ; ISSN 1549-9596 1549-960X

الاتاحة: https://doi.org/10.1021/acs.jcim.3c00651
https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.3c00651

المؤلفون: DiBerto, Jeffrey F., Smart, Katie, Olsen, Reid H.J., Roth, Bryan L.

المصدر: STAR Protocols ; volume 3, issue 2, page 101259 ; ISSN 2666-1667

الاتاحة: http://dx.doi.org/10.1016/j.xpro.2022.101259
https://api.elsevier.com/content/article/PII:S2666166722001393?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2666166722001393?httpAccept=text/plain

المؤلفون: Zhong, Xiaofang, Li, Qiongyu, Polacco, Benjamin J, Patil, Trupti, Marley, Aaron, Foussard, Helene, Khare, Prachi, Vartak, Rasika, Xu, Jiewei, DiBerto, Jeffrey F, Roth, Bryan L, Eckhardt, Manon, von Zastrow, Mark, Krogan, Nevan J, Hüttenhain, Ruth

المصدر: Molecular Systems Biology; Aug2024, Vol. 20 Issue 8, p952-971, 20p

المؤلفون: Kang, Hye Jin, Krumm, Brian E., Tassou, Adrien, Geron, Matan, DiBerto, Jeffrey F., Kapolka, Nicholas J., Gumpper, Ryan H., Sakamoto, Kensuke, Dewran Kocak, D., Olsen, Reid H.J., Huang, Xi-Ping, Zhang, Shicheng, Huang, Karen L., Zaidi, Saheem A., Nguyen, MyV.T., Jo, Min Jeong, Katritch, Vsevolod, Fay, Jonathan F., Scherrer, Grégory, Roth, Bryan L.

المساهمون: National Institute of Diabetes and Digestive and Kidney Diseases

المصدر: Cell ; ISSN 0092-8674

الاتاحة: https://doi.org/10.1016/j.cell.2024.11.001
https://api.elsevier.com/content/article/PII:S0092867424012753?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0092867424012753?httpAccept=text/plain

المؤلفون: Slocum, Samuel T., DiBerto, Jeffrey F., Roth, Bryan L.

المصدر: Journal of Neurochemistry ; volume 162, issue 1, page 24-38 ; ISSN 0022-3042 1471-4159

الاتاحة: http://dx.doi.org/10.1111/jnc.15540
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jnc.15540
https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jnc.15540

المؤلفون: Levine, Olivia B., Skelly, Mary Jane, Miller, John D., Rivera-Irizarry, Jean K., Rowson, Sydney A., DiBerto, Jeffrey F., Rinker, Jennifer A., Thiele, Todd E., Kash, Thomas L., Pleil, Kristen E.

المساهمون: U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse, U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism, Brain and Behavior Research Foundation NARSAD Young Investigator Award, Stephen and Anna Maria Kellen Foundation Junior Faculty Award

المصدر: Nature Communications ; volume 12, issue 1 ; ISSN 2041-1723

الاتاحة: http://dx.doi.org/10.1038/s41467-021-25368-y
https://www.nature.com/articles/s41467-021-25368-y.pdf
https://www.nature.com/articles/s41467-021-25368-y

المؤلفون: DiBerto, Jeffrey F., Roth, Bryan L.

المساهمون: NIH

المصدر: Neuron ; volume 109, issue 16, page 2499-2501 ; ISSN 0896-6273

الاتاحة: http://dx.doi.org/10.1016/j.neuron.2021.07.017
https://api.elsevier.com/content/article/PII:S0896627321005389?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0896627321005389?httpAccept=text/plain

المؤلفون: Chakraborty, Soumen, DiBerto, Jeffrey F., Faouzi, Abdelfattah, Bernhard, Sarah M., Gutridge, Anna M., Ramsey, Steven, Zhou, Yuchen, Provasi, Davide, Nuthikattu, Nitin, Jilakara, Rahul, Nelson, Melissa N. F., Asher, Wesley B., Eans, Shainnel O., Wilson, Lisa L., Chintala, Satyanarayana M., Filizola, Marta, van Rijn, Richard M., Margolis, Elyssa B., Roth, Bryan L., McLaughlin, Jay P., Che, Tao, Sames, Dalibor, Javitch, Jonathan A., Majumdar, Susruta

المساهمون: University of California, San Francisco, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, Hope for Depression Research Foundation

المصدر: Journal of Medicinal Chemistry ; volume 64, issue 18, page 13873-13892 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.1c01273
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01273

المؤلفون: Che, Tao, English, Justin, Krumm, Brian E., Kim, Kuglae, Pardon, Els, Olsen, Reid H. J., Wang, Sheng, Zhang, Shicheng, Diberto, Jeffrey F., Sciaky, Noah, Carroll, F. Ivy, Steyaert, Jan, Wacker, Daniel, Roth, Bryan L.

المصدر: Nature Communications ; volume 11, issue 1 ; ISSN 2041-1723

الاتاحة: http://dx.doi.org/10.1038/s41467-020-14889-7
https://www.nature.com/articles/s41467-020-14889-7.pdf
https://www.nature.com/articles/s41467-020-14889-7

المؤلفون: Hardaway, J. Andrew, Halladay, Lindsay R., Mazzone, Christopher M., Pati, Dipanwita, Bloodgood, Daniel W., Kim, Michelle, Jensen, Jennifer, DiBerto, Jeffrey F., Boyt, Kristen M., Shiddapur, Ami, Erfani, Ava, Hon, Olivia J., Neira, Sofia, Stanhope, Christina M., Sugam, Jonathan A., Saddoris, Michael P., Tipton, Greg, McElligott, Zoe, Jhou, Thomas C., Stuber, Garret D., Bruchas, Michael R., Bulik, Cynthia M., Holmes, Andrew, Kash, Thomas L.

المساهمون: National Institute on Alcohol Abuse and Alcoholism, Swedish Research Council, Cancer Center Core, North Carolina Biotechnology Center

المصدر: Neuron ; volume 102, issue 5, page 1037-1052.e7 ; ISSN 0896-6273

الاتاحة: http://dx.doi.org/10.1016/j.neuron.2019.03.037
https://api.elsevier.com/content/article/PII:S0896627319303265?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0896627319303265?httpAccept=text/plain

المؤلفون: Krumm, Brian E., DiBerto, Jeffrey F., Olsen, Reid H. J., Kang, Hye Jin, Slocum, Samuel T., Zhang, Shicheng, Strachan, Ryan T., Huang, Xi-Ping, Slosky, Lauren M., Pinkerton, Anthony B., Barak, Lawrence S., Caron, Marc G., Kenakin, Terry, Fay, Jonathan F., Roth, Bryan L.

المساهمون: National Institute of Diabetes and Digestive and Kidney Diseases

المصدر: Biochemistry ; volume 62, issue 7, page 1233-1248 ; ISSN 0006-2960 1520-4995

الاتاحة: http://dx.doi.org/10.1021/acs.biochem.3c00029
https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.3c00029

المؤلفون: Hewitt, Natalie, Ma, Ning, Arang, Nadia, Martin, Sarah A., Prakash, Ajit, DiBerto, Jeffrey F., Knight, Kevin M., Ghosh, Soumadwip, Olsen, Reid H. J., Roth, Bryan L., Gutkind, J. Silvio, Vaidehi, Nagarajan, Campbell, Sharon L., Dohlman, Henrik G.

المصدر: Science Signaling ; volume 16, issue 772 ; ISSN 1945-0877 1937-9145

الاتاحة: http://dx.doi.org/10.1126/scisignal.abq7842
https://www.science.org/doi/pdf/10.1126/scisignal.abq7842

المؤلفون: Salas-Estrada, Leslie, Provasi, Davide, Qui, Xing, Kaniskan, Husnu Ümit, Huang, Xi-Ping, DiBerto, Jeffrey F., Lamim Ribeiro, João Marcelo, Jin, Jian, Roth, Bryan L., Filizola, Marta

مصطلحات موضوعية: artificial intelligence, generative deep models, drug design, 𝜅-opioid receptor, opioid use disorders, GPCRs

Relation: https://doi.org/10.5281/zenodo.7877933; https://doi.org/10.5281/zenodo.7877934; oai:zenodo.org:7877934

الاتاحة: https://doi.org/10.5281/zenodo.7877934

المؤلفون: DiBerto, Jeffrey F., Olsen, Reid H. J., Roth, Bryan L.

المصدر: Bioluminescence ; Methods in Molecular Biology ; page 185-195 ; ISSN 1064-3745 1940-6029 ; ISBN 9781071624722 9781071624739

الاتاحة: http://dx.doi.org/10.1007/978-1-0716-2473-9_13
https://link.springer.com/content/pdf/10.1007/978-1-0716-2473-9_13

المؤلفون: Thompson, Karen J., Khajehali, Elham, Bradley, Sophie J., Navarrete, Jovana S., Huang, Xi Ping, Slocum, Samuel, Jin, Jian, Liu, Jing, Xiong, Yan, Olson, Reid H.J., Diberto, Jeffrey F., Boyt, Kristen M., Pina, Melanie M., Pati, Dipanwita, Molloy, Colin, Bundgaard, Christoffer, Sexton, Patrick M., Kash, Thomas L., Krashes, Michael J., Christopoulos, Arthur, Roth, Bryan L., Tobin, Andrew B.

مصطلحات موضوعية: QH301 Biology

وصف الملف: text

Relation: http://eprints.gla.ac.uk/177465/13/177465.pdf; Thompson, K. J. et al. (2018) DREADD agonist 21 is an effective agonist for muscarinic-based DREADDs in vitro and in vivo. ACS Pharmacology and Translational Science , 1(1), pp. 61-72. (doi:10.1021/acsptsci.8b00012 ) (PMID:30868140) (PMCID:PMC6407913)

الاتاحة: http://eprints.gla.ac.uk/177465/
http://eprints.gla.ac.uk/177465/13/177465.pdf