-
1Academic Journal
المؤلفون: Marjoleine F. Broekema, Maarten P.G. Massink, Cinzia Donato, Joep de Ligt, Joerg Schaarschmidt, Anouska Borgman, Marieke G. Schooneman, Diana Melchers, Martin N. Gerding, René Houtman, Alexandre M.J.J. Bonvin, Amit R. Majithia, Houshang Monajemi, Gijs W. van Haaften, Maarten R. Soeters, Eric Kalkhoven
المصدر: Molecular Metabolism, Vol 20, Iss , Pp 115-127 (2019)
مصطلحات موضوعية: Internal medicine, RC31-1245
وصف الملف: electronic resource
-
2
المؤلفون: Laura Van Moortel, Annick Verhee, René Houtman, Diana Melchers, Louis Delhaye, Jonathan Thommis, Kris Gevaert, Sven Eyckerman, Karolien De Bosscher
-
3
المؤلفون: Manav Korpal, Ping Zhu, Peter G. Smith, Markus Warmuth, Lihua Yu, Shihua Yao, Michael J. Wick, Suzanne Wardell, John Wang, Frédéric H. Vaillancourt, Michael Thomas, Vanitha Subramanian, Sasirekha Sivakumar, Amy Siu, Ricardo Ribas, Nathalie Rioux, Victoria Rimkunas, Dominic J. Reynolds, Sujatha Rajagopalan, Sudeep Prajapati, Sunil Pancholi, Morgan O'Shea, John Norris, Tuong-Vi Nguyen, Alyssa Moriarty, Diana Melchers, Lesley-Ann Martin, Crystal Mackenzie, Nicholas Larsen, Weidong G. Lai, Galina Kuznetsov, Pavan Kumar, Namita Kumar, Amy Kim, Craig Karr, Jaya J. Joshi, Sean Irwin, René Houtman, Andrew Hart, Ming-Hong Hao, Peter Fekkes, Sean Eckley, Subhasree Das, Benjamin Caleb, Silvia Buonamici, David M. Bolduc, Sergei Agoulnik, Kiran Aithal, Deepti Banka, Zhenhua J. Wu, Guo Zhu Zheng, Craig Furman, Xiaoling Puyang
-
4
المؤلفون: Manav Korpal, Ping Zhu, Peter G. Smith, Markus Warmuth, Lihua Yu, Shihua Yao, Michael J. Wick, Suzanne Wardell, John Wang, Frédéric H. Vaillancourt, Michael Thomas, Vanitha Subramanian, Sasirekha Sivakumar, Amy Siu, Ricardo Ribas, Nathalie Rioux, Victoria Rimkunas, Dominic J. Reynolds, Sujatha Rajagopalan, Sudeep Prajapati, Sunil Pancholi, Morgan O'Shea, John Norris, Tuong-Vi Nguyen, Alyssa Moriarty, Diana Melchers, Lesley-Ann Martin, Crystal Mackenzie, Nicholas Larsen, Weidong G. Lai, Galina Kuznetsov, Pavan Kumar, Namita Kumar, Amy Kim, Craig Karr, Jaya J. Joshi, Sean Irwin, René Houtman, Andrew Hart, Ming-Hong Hao, Peter Fekkes, Sean Eckley, Subhasree Das, Benjamin Caleb, Silvia Buonamici, David M. Bolduc, Sergei Agoulnik, Kiran Aithal, Deepti Banka, Zhenhua J. Wu, Guo Zhu Zheng, Craig Furman, Xiaoling Puyang
-
5
المؤلفون: Christine Helsen, Frank Claessens, Steven Joniau, Adriaan B. Houtsmuller, Lien Spans, Elien Smeets, Thomas Van den Broeck, Kam Y.J. Zhang, Diana Melchers, Rene Houtman, Bart Geverts, Arnout R.D. Voet, Martin E. van Royen, Stefan Prekovic
-
6
المؤلفون: Christine Helsen, Frank Claessens, Steven Joniau, Adriaan B. Houtsmuller, Lien Spans, Elien Smeets, Thomas Van den Broeck, Kam Y.J. Zhang, Diana Melchers, Rene Houtman, Bart Geverts, Arnout R.D. Voet, Martin E. van Royen, Stefan Prekovic
-
7
المؤلفون: Manav Korpal, Ping Zhu, Peter G. Smith, Markus Warmuth, Lihua Yu, Shihua Yao, Michael J. Wick, Suzanne Wardell, John Wang, Frédéric H. Vaillancourt, Michael Thomas, Vanitha Subramanian, Sasirekha Sivakumar, Amy Siu, Ricardo Ribas, Nathalie Rioux, Victoria Rimkunas, Dominic J. Reynolds, Sujatha Rajagopalan, Sudeep Prajapati, Sunil Pancholi, Morgan O'Shea, John Norris, Tuong-Vi Nguyen, Alyssa Moriarty, Diana Melchers, Lesley-Ann Martin, Crystal Mackenzie, Nicholas Larsen, Weidong G. Lai, Galina Kuznetsov, Pavan Kumar, Namita Kumar, Amy Kim, Craig Karr, Jaya J. Joshi, Sean Irwin, René Houtman, Andrew Hart, Ming-Hong Hao, Peter Fekkes, Sean Eckley, Subhasree Das, Benjamin Caleb, Silvia Buonamici, David M. Bolduc, Sergei Agoulnik, Kiran Aithal, Deepti Banka, Zhenhua J. Wu, Guo Zhu Zheng, Craig Furman, Xiaoling Puyang
-
8
المؤلفون: Suzanne G. Mays, Emma H. D’Agostino, Autumn R. Flynn, Xiangsheng Huang, Guohui Wang, Xu Liu, Elizabeth J. Millings, C. Denise Okafor, Anamika Patel, Michael L. Cato, Jeffery L. Cornelison, Diana Melchers, René Houtman, David D. Moore, John W. Calvert, Nathan T. Jui, Eric A. Ortlund
المصدر: Cell chemical biology. 29(7)
مصطلحات موضوعية: Pharmacology, Mice, Clinical Biochemistry, Drug Discovery, Molecular Medicine, Animals, Receptors, Cytoplasmic and Nuclear, Colitis, Ligands, Molecular Biology, Biochemistry, Phospholipids
-
9
المؤلفون: Teresa A. Martin, Yin Li, Christopher G. Mayne, Laurel A. Coons, René Houtman, Kathryn E. Carlson, Diana Melchers, John A. Katzenellenbogen, J. Tyler Ramsey, Tanner B. Jefferson, Kenneth S. Korach
المصدر: Sci Signal
مصطلحات موضوعية: Estrogen insensitivity syndrome, Mutant, Allosteric regulation, Drug Resistance, Mutation, Missense, Estrogen receptor, Peptide binding, Molecular Dynamics Simulation, Ligands, Biochemistry, Article, Nuclear Receptor Coactivator 3, 03 medical and health sciences, Nuclear Receptor Coactivator 1, 0302 clinical medicine, Protein Domains, Coactivator, medicine, Humans, Receptor, Molecular Biology, 030304 developmental biology, 0303 health sciences, Binding Sites, Chemistry, Estrogen Receptor alpha, Estrogens, Hep G2 Cells, Cell Biology, medicine.disease, Cell biology, Kinetics, HEK293 Cells, Gene Expression Regulation, 030220 oncology & carcinogenesis, Corepressor, Protein Binding
-
10
المؤلفون: René Houtman, Jeffery L. Cornelison, Emma H. D’Agostino, Diana Melchers, Michael L. Cato, Eric A. Ortlund, Suzanne G. Mays, Alyssa M. Johnson, Nathan T. Jui, Anamika Patel
المصدر: Bioorg Med Chem Lett
مصطلحات موضوعية: Agonist, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Substituent, Pharmaceutical Science, Receptors, Cytoplasmic and Nuclear, Biochemistry, 01 natural sciences, Article, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Drug Development, Drug Discovery, medicine, Humans, Metabolic disease, Molecular Biology, 030304 developmental biology, 0303 health sciences, Aniline Compounds, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Liver receptor homolog-1, Organic Chemistry, Lipid metabolism, Photochemical Processes, 0104 chemical sciences, 3. Good health, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Nuclear receptor, chemistry, Molecular Medicine, Target gene, Oxidation-Reduction, Conjugate
-
11
المؤلفون: Sean Eckley, Markus Warmuth, Ping Zhu, Deepti Banka, Zhenhua J. Wu, Nicholas A. Larsen, Sudeep Prajapati, Ricardo Ribas, Ming-Hong Hao, Pavan Kumar, Pete Smith, Michael J. Wick, Kiran Aithal, Crystal Mackenzie, John D. Norris, Sasirekha Sivakumar, V. Subramanian, Tuong-Vi Nguyen, Lihua Yu, Sean Irwin, Andrew Hart, Craig Furman, Alyssa Moriarty, Amy Kim, Benjamin Caleb, O'shea Morgan Welzel, Craig Karr, Sunil Pancholi, Frédéric H. Vaillancourt, Silvia Buonamici, Manav Korpal, Namita Kumar, Weidong G. Lai, Diana Melchers, Peter Fekkes, René Houtman, Lesley-Ann Martin, Xiaoling Puyang, Victoria Rimkunas, Michael Thomas, Amy Siu, Reynolds Dominic, Sujatha Rajagopalan, Suzanne E. Wardell, John Wang, Jaya Julie Joshi, Zheng Guo Zhu, David M. Bolduc, Nathalie Rioux, Subhasree Das, Sergei Agoulnik, Shihua Yao, Galina Kuznetsov
المصدر: Cancer Discovery. 8:1176-1193
مصطلحات موضوعية: 0301 basic medicine, Fulvestrant, Cell growth, business.industry, Estrogen receptor, Cancer, medicine.disease, Estrogen Receptor Antagonists, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Breast cancer, Oncology, In vivo, 030220 oncology & carcinogenesis, Cancer research, medicine, business, Estrogen receptor alpha, medicine.drug
-
12
المؤلفون: René Houtman, Dirk Pijnenburg, Marjoleine F. Broekema, Danielle A.A. Hollman, Eric Kalkhoven, Henk-Jan van den Ham, Diana Melchers, Arjen Koppen, Rob Ruijtenbeek, Saskia W.C. van Mil
المساهمون: Virology
المصدر: Endocrinology, 159(6), 2397-2407. Endocrine Society
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Protein domain, Receptors, Cytoplasmic and Nuclear, Computational biology, Plasma protein binding, Biology, Interactome, 03 medical and health sciences, Endocrinology, Protein Domains, Internal medicine, Protein Interaction Mapping, medicine, Animals, Cluster Analysis, Humans, Databases, Protein, Transcription factor, Peptide sequence, Phylogeny, Regulation of gene expression, Gene Expression Profiling, High-Throughput Screening Assays, Gene expression profiling, 030104 developmental biology, Nuclear receptor, Drug Design, Co-Repressor Proteins, Protein Binding, Transcription Factors
-
13
المؤلفون: Diana Melchers, Jochem Louisse, Ivonne M.C.M. Rietjens, René Houtman, John P. Groten, Ignacio Miro Estruch, Laura H.J. de Haan
المصدر: Journal of Receptors and Signal Transduction, 38(2), 112-121
Journal of Receptors and Signal Transduction 38 (2018) 2مصطلحات موضوعية: 0301 basic medicine, proliferation, Retinoic acid, Estrogen receptor, Tretinoin, Toxicology, Biochemistry, crosstalk, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, breast cancer, Genes, Reporter, coregulator, medicine, Humans, Receptor, Luciferases, Molecular Biology, neoplasms, Toxicologie, Cell Proliferation, VLAG, ERα, Cell Nucleus, Cell growth, organic chemicals, Estrogens, Cell Biology, Subcellular localization, biological factors, Cell biology, Gene Expression Regulation, Neoplastic, 030104 developmental biology, chemistry, Receptors, Estrogen, 030220 oncology & carcinogenesis, MCF-7 Cells, Signal transduction, Estrogen receptor alpha, RAR, medicine.drug, Protein Binding, Signal Transduction
وصف الملف: application/octet-stream; application/pdf
-
14Academic Journal
المؤلفون: Ying Wu, Peggy De Kievit, Lars Vahlkamp, Dirk Pijnenburg, Maarten Smit, Martijn Dankers, Diana Melchers, Martijn Stax, Piet J. Boender, Colin Ingham, Niek Bastiaensen, Rik De Wijn, Dirk Van Alewijk, Henk Van Damme, Anton K. Raap, Alan B. Chan, Rinie Van Beuningen
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.6801; http://nar.oxfordjournals.org/content/32/15/e123.full.pdf
-
15
المؤلفون: Ignacio Miro Estruch, Laura H.J. de Haan, Diana Melchers, John P. Groten, Jochem Louisse, Ivonne M.C.M. Rietjens, René Houtman
المصدر: Biochimica et Biophysica Acta. Proteins & Proteomics 1865 (2017) 9
Biochimica et Biophysica Acta. Proteins & Proteomics, 1865(9), 1195-1206مصطلحات موضوعية: 0301 basic medicine, Agonist, Tetrahydronaphthalenes, medicine.drug_class, Receptors, Retinoic Acid, Amino Acid Motifs, Biophysics, Protein Array Analysis, Subtype, Retinoic acid receptor beta, Tretinoin, Thiophenes, Biology, Response Elements, Toxicology, Biochemistry, Benzoates, Analytical Chemistry, 03 medical and health sciences, Retinoids, Structure-Activity Relationship, Protein Domains, medicine, Ligand binding domain (LBD), Chromans, Receptor, Molecular Biology, Transcription factor, Toxicologie, VLAG, Anthracenes, Binding Sites, Ligand binding assay, Retinoic Acid Receptor alpha, Antagonist, Retinoic acid receptor gamma, Coregulator, Recombinant Proteins, Cell biology, Retinoic acid receptor, 030104 developmental biology, Retinoic acid receptor alpha, embryonic structures, RAR, Protein Binding
وصف الملف: application/pdf; application/octet-stream
-
16
المؤلفون: Frank Claessens, Elien Smeets, Thomas Van den Broeck, Adriaan B. Houtsmuller, Lien Spans, Kam Y. J. Zhang, Arnout Voet, Martin E. van Royen, Christine Helsen, Stefan Prekovic, Diana Melchers, Bart Geverts, Steven Joniau, René Houtman
المساهمون: Pathology
المصدر: Molecular Cancer Therapeutics, 15(7), 1702-1712. American Association for Cancer Research Inc.
مصطلحات موضوعية: Models, Molecular, Transcriptional Activation, 0301 basic medicine, Agonist, Cancer Research, medicine.medical_specialty, medicine.drug_class, Mutant, Molecular Conformation, Antineoplastic Agents, Biology, Ligands, medicine.disease_cause, Partial agonist, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Internal medicine, Nitriles, Phenylthiohydantoin, LNCaP, medicine, Cluster Analysis, Humans, Enzalutamide, Codon, Receptor, Mutation, Gene Expression Profiling, Androgen Antagonists, Gene Expression Regulation, Neoplastic, Androgen receptor, 030104 developmental biology, Endocrinology, Amino Acid Substitution, Oncology, chemistry, Drug Resistance, Neoplasm, Receptors, Androgen, Benzamides, Cancer research, prostate cancer androgen receptor enzalutamide resistance, Protein Binding
وصف الملف: Print-Electronic
-
17
المؤلفون: Myles Brown, Diana Melchers, Jonas de Tribolet-Hardy, Christine Fritz, René Houtman, Lei Gu, Laura Cato, Andrea Corsinotti, Ulrich Wagner, Jean-Philippe Theurillat, Christian D. Fankhauser, Tiannan Guo, Patrick Tschopp, Ruedi Aebersold, Anna C. Groner, Qing Zhong, Hana Janouskova, Levi A. Garraway, Andrew C.B. Cato, Tiziano Bernasocchi, Cédric Poyet, Peter J. Wild
المساهمون: University of Zurich, Theurillat, Jean-Philippe
المصدر: Cancer Cell. 29:846-858
مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, 610 Medicine & health, SPOP, Biology, urologic and male genital diseases, TRIM24, 1307 Cell Biology, 03 medical and health sciences, Prostate cancer, 10049 Institute of Pathology and Molecular Pathology, medicine, Animals, Humans, 1306 Cancer Research, Nuclear protein, Cell Proliferation, Regulation of gene expression, Nuclear Proteins, Prostatic Neoplasms, Cell Biology, Gene signature, medicine.disease, 3. Good health, Bromodomain, Gene Expression Regulation, Neoplastic, Repressor Proteins, Androgen receptor, 10062 Urological Clinic, Prostatic Neoplasms, Castration-Resistant, 030104 developmental biology, Oncology, Receptors, Androgen, Disease Progression, Cancer research, 2730 Oncology, Carrier Proteins, Neoplasm Transplantation, Signal Transduction
وصف الملف: Groner_CancerCell_2016.pdf - application/pdf
-
18
المؤلفون: Diana Melchers, Brian R. Walker, Ruth Morgan, Natalie Z.M. Homer, René Houtman, Katharina Beck, Onno C. Meijer, Patrick W. F. Hadoke, Alex Odermatt, Mark Nixon, John Keen
المصدر: Endocrine Abstracts.
مصطلحات موضوعية: Agonist, medicine.medical_specialty, Chemistry, medicine.drug_class, Partial agonist, Mineralocorticoid receptor, Glucocorticoid receptor, Endocrinology, Internal medicine, medicine, Enzyme-linked receptor, Inverse agonist, Beta (finance), Endogenous agonist
-
19
المؤلفون: Andreas Stomby, Johan Björkegren, Ruth Andrew, Brian R. Walker, Roland H Stimson, Ariella Cohain, Rita Upreti, Patrick W. F. Hadoke, Natalie Z.M. Homer, Tom Michoel, Eric E. Schadt, Arno Ruusalepp, Katharina Beck, Anna Anderson, René Houtman, Tommy Olsson, Mark Nixon, Christopher J. Kenyon, John Keen, Alex Odermatt, Onno C. Meijer, Diana Melchers, Ruth Morgan, Andrew A Crawford
المصدر: Scientific Reports
Morgan, R A, Beck, K R, Nixon, M, Homer, N Z M, Crawford, A A, Melchers, D, Houtman, R, Meijer, O C, Stomby, A, Anderson, A J, Upreti, R, Stimson, R H, Olsson, T, Michoel, T, Cohain, A, Ruusalepp, A, Schadt, E E, Björkegren, J L M, Andrew, R, Kenyon, C J, Hadoke, P W F, Odermatt, A, Keen, J A & Walker, B R 2017, ' Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity ', Scientific Reports, vol. 7, no. 1, 10633 . https://doi.org/10.1038/s41598-017-10410-1
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Morgan, R A, Beck, K R, Nixon, M, Homer, N Z M, Crawford, A A, Melchers, D, Houtman, R, Meijer, O C, Stomby, A, Anderson, A J, Upreti, R, Stimson, R H, Olsson, T, Michoel, T, Cohain, A, Ruusalepp, A, Schadt, E E, Björkegren, J L M, Andrew, R, Kenyon, C J, Hadoke, P W F, Odermatt, A, Keen, J A & Walker, B R 2017, ' Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity ', Scientific Reports, vol. 7, 10633 . https://doi.org/10.1038/s41598-017-10410-1
Scientific Reports, 7مصطلحات موضوعية: 0301 basic medicine, Male, Models, Molecular, Carbonyl Reductase, Hydrocortisone, Hydroxycorticosteroids, Molecular Conformation, Adipose tissue, lcsh:Medicine, Gene Expression, Pharmacology, Mice, 0302 clinical medicine, Glucocorticoid receptor, Medicine, Carbonyl Reductase (NADPH), lcsh:Science, chemistry.chemical_classification, Multidisciplinary, Farmakologi och toxikologi, 3. Good health, Phenotype, Liver, Female, Endogenous agonist, Protein Binding, medicine.medical_specialty, CBR1, 030209 endocrinology & metabolism, Pharmacology and Toxicology, Article, 03 medical and health sciences, Structure-Activity Relationship, Receptors, Glucocorticoid, Internal medicine, Journal Article, Animals, Humans, Horses, Obesity, Glucocorticoids, Genetic Association Studies, business.industry, lcsh:R, Genetic Variation, Metabolism, Disease Models, Animal, 030104 developmental biology, Enzyme, Endocrinology, chemistry, lcsh:Q, business, Energy Metabolism, Drug metabolism
وصف الملف: application/pdf
-
20
المؤلفون: Si Wang, Antwan G.H. Ederveen, Johannes H.J. van den Berg, Ivonne M.C.M. Rietjens, Laura H.J. de Haan, John P. Groten, Diana Melchers, Nynke M. Evers, René Houtman
المصدر: Journal of Steroid Biochemistry and Molecular Biology 143 (2014)
Journal of Steroid Biochemistry and Molecular Biology, 143, 376-385مصطلحات موضوعية: Selective Estrogen Receptor Modulators, breast-cancer-cells, Agonist, medicine.medical_specialty, (er)alpha, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Blotting, Western, Clinical Biochemistry, Estrogen receptor, Breast Neoplasms, Biology, Toxicology, Biochemistry, Endocrinology, Internal medicine, expression, Coactivator, Tumor Cells, Cultured, medicine, Estrogen Receptor beta, Humans, genes, Receptor, Molecular Biology, Toxicologie, VLAG, Cell Proliferation, phytoestrogens, mechanisms, Reporter gene, ligands, Cell growth, Estrogen Receptor alpha, Estrogens, antagonist, Cell Biology, coactivator, Cell biology, Nuclear receptor, Molecular Medicine, Female, transcription, Estrogen receptor alpha
وصف الملف: application/pdf; application/octet-stream
Full Text Finder