-
1
المؤلفون: Po Hu, Hongzheng Wang, Xiaoxuan Yu, Wenzhuo Sun, Hui Hui, Hui Li, Mengyuan Zhu, Zhanyu Wang, Jingyan Xu, Qinglong Guo, Yingjie Qing
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3178-3192 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: NPC, Niemann-Pick type disease C, Cathepsin D, ATG, autophagy related, NH4Cl, ammonium chloride, Lysosomal damage, Calcium in biology, Hematological malignancies, 0302 clinical medicine, RAB7A, RAS-related protein RAB-7a, K48, lysine 48, LC3, microtubule-associated protein 1 light chain 3, TFEB, transcription factor EB, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, RT-qPCR, real time quantitative PCR, Chemistry, LCD, lysosome-dependent cell death, CaN, calcineurin, P62/SQSTM1, sequestosome 1, Cell biology, TRPML1, transient receptor potential mucolipin 1, medicine.anatomical_structure, Cholesterol, 030220 oncology & carcinogenesis, shRNA, short hairpin RNA, Original Article, CsA, cyclosporine A, DAPI, 4′,6-diamidino-2-phenylindole dihydrochloride, Programmed cell death, AO, acridine orange, CTSD, cathepsin D, LW-218, PBS, phosphate-buffered saline, CTSB, cathepsin B, LMP, lysosome membrane permeabilization, EGTA, ethylene glycol-bis(2-aminoethyl ether)-N,N,N′,N′-tetraacetic acid, RM1-950, Lysosome-dependent cell death, 03 medical and health sciences, Dex, dexamethasone, ROS, reactive oxygen species, FBS, fetal bovine serum, Lysosome, NPC1, NPC intracellular cholesterol transporter 1, medicine, BAF A1, bafilomycin A1, 030304 developmental biology, Cathepsin, PBMCs, peripheral blood mononuclear cells, Lysosomal membrane permeabilization, K63, lysine 63, Cell growth, DCFH-DA, 2,7-dichlorodi-hydrofluorescein diacetate, Autophagy, BID, BH3-interacting domain death agonist, Lysophagy, OD, optical density, TFEB, CCK8, Cell Counting Kit, Therapeutics. Pharmacology, LAMPs, lysosomal-associated membrane proteins
-
2
المؤلفون: Jing Liu, Lasse Hyldgaard Klausen, Zhe Li, Ning Yan, Fanghao Chen, Yumei Zhang, Mingdong Dong, Wen Song, Yide He
المصدر: Bioactive Materials
Li, Z, He, Y, Klausen, L H, Yan, N, Liu, J, Chen, F, Song, W, Dong, M & Zhang, Y 2021, ' Growing vertical aligned mesoporous silica thin film on nanoporous substrate for enhanced degradation, drug delivery and bioactivity ', Bioactive Materials, vol. 6, no. 5, pp. 1452-1463 . https://doi.org/10.1016/j.bioactmat.2020.10.026
Bioactive Materials, Vol 6, Iss 5, Pp 1452-1463 (2021)مصطلحات موضوعية: RUNX2, runt-related transcription factor 2, Materials science, HAP, hydroxylapatite nanoparticles, 0206 medical engineering, Biomedical Engineering, DEX, dexamethasone, Nanotechnology, 02 engineering and technology, MSTF, mesoporous silica thin film, Article, Biomaterials, Titania nanotubes array, lcsh:TA401-492, Enhanced degradation, PT, polished titanium, Thin film, HMSTF, hybrid organic-inorganic MSTF, lcsh:QH301-705.5, Osteoblasts, Ti–OH, hydroxylated titanium, ALP, alkaline phosphatase, Nanoporous, Mesoporous silica, 021001 nanoscience & nanotechnology, 020601 biomedical engineering, TNN, titania nanonet, OCN, osteocalcin, Surface coating, Vertical aligned mesochannels, VMSTF, vertical aligned MSTF, lcsh:Biology (General), Permeability (electromagnetism), Drug delivery, PMSTF, parallel aligned MSTF, OPN, osteopontin, TNT, titania nanotube, lcsh:Materials of engineering and construction. Mechanics of materials, Mesoporous silica film, 0210 nano-technology, Mesoporous material, Biotechnology
-
3
المؤلفون: Zhonggao Gao, Wei Huang, Hongxia Duan, Yanhong Liu
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 55-70 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: CQ, chloroquine, MSNs, mesoporous silica nanoparticles, Review, Drug resistance, HNSCC, head and neck squamous cell carcinoma, Metastasis, 0302 clinical medicine, MDR, multidrug resistance, CL-siSOX2, cationic lipoplex of SOX2 small interfering RNA, Medicine, ABC, ATP binding cassette, IONP, iron oxide nanoparticle, General Pharmacology, Toxicology and Pharmaceutics, Sali-ABA, 4-(aminomethyl) benzaldehyde-modified Sali, NF-κB, nuclear factor-kappa B, TNBC, triple negative breast cancer, 0303 health sciences, MNP, micellar nanoparticle, Cancer stem cells, Molecular level, BM-MSCs-derived Exos, bone marrow mesenchymal stem cells-derived exosomes, iTEP, immune-tolerant, elastin-like polypeptide, ECM, extracellular matrix, Drug delivery systems, DCLK1, doublecortin-like kinase 1, EpCAM, epithelial cell adhesion molecule, cRGD, cyclic Arg-Gly-Asp, PDT, photodynamic therapy, AFN, apoferritin, 030220 oncology & carcinogenesis, Cancer treatment, Cellular level, CMP, carbonate-mannose modified PEI, Drug delivery, uPAR, urokinase plasminogen activator receptor, Stem cell, GEMP, gemcitabine monophosphate, LNCs, lipid nanocapsules, EMT, epithelial–mesenchymal transition, mAbs, monoclonal antibodies, CSCs, cancer stem cells, Nav, navitoclax, PEG-PLA, poly(ethylene glycol)-b-poly(d,l-lactide), Cancer therapy, DQA-PEG2000-DSPE, dequlinium and carboxyl polyethylene glycol-distearoylphosphatidylethanolamine, GLUT1, glucose ligand to the glucose transporter 1, PEG-PCD, poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol), Dex, dexamethasone, 03 medical and health sciences, Cancer stem cell, Niche, SSCs, somatic stem cells, Targeting strategies, MB, methylene blue, 030304 developmental biology, business.industry, DLE, drug loading efficiency, lcsh:RM1-950, HH, Hedgehog, PU-PEI, polyurethane-short branch-polyethylenimine, Biomarker, Glu, glucose, medicine.disease, DOX, doxorubicin, SLNs, solid lipid nanoparticles, DDSs, drug delivery systems, Biomarker (cell), EPND, nanodiamond-Epirubicin drug complex, PTX, paclitaxel, PLGA, poly(ethylene glycol)-poly(d,l-lactide-co-glycolide), ALDH, aldehyde dehydrogenase, PBAEs, poly(β-aminoester), lcsh:Therapeutics. Pharmacology, mPEG-b-PCC-g-GEM-g-DC-g-CAT, poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylenecarbonate-graft-dodecanol-graft-cationic ligands), LAC, lung adenocarcinoma, TPZ, tirapazamine, PEG-b-PLA, poly(ethylene glycol)-block-poly(d,l-lactide), Cancer cell, ncRNA, non-coding RNAs, Cancer research, HCC, hepatocellular carcinoma, business, HIF1α, hypoxia-inducible factor 1-alpha, MAPK, mitogen-activated protein kinase, CAFs, cancer-associated fibroblasts
-
4
المؤلفون: Zhirong Zhang, Xianyan Qin, Tao Gong, Xu Zhou, Yingying Xu, Yao Fu
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 835-847 (2021)مصطلحات موضوعية: DiD, 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindodicarbocyanineperchlorate, Cy5.5-NHS, cyanine 5.5-N-hydroxysuccinimide, iNOS, nitric oxide synthase, Pharmacology, CLT, celastrol, Micelle, chemistry.chemical_compound, IL-1β, interleukin 1β, 0302 clinical medicine, Fibrosis, Renal fibrosis, Controlled release, Anti-TGFβ antibody, RIF, renal interstitial fibrosis, General Pharmacology, Toxicology and Pharmaceutics, RSR, real-time swelling ratio, HA, hyaluronic acid, TNF-α, tumor necrosis factor α, 0303 health sciences, Kidney, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labelling, Celastrol, NHS, N-hydroxysuccinimide, ECM, extracellular matrix,
G", the loss modulus, IL-6, interleukin 6, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Drug delivery, “Plum‒pudding” structure, Original Article, FITC, fluorescein isothiocyanate, medicine.symptom, HASH, thiolated hyaluronic acid, Inflammation, DEX, dexamethasone, α-SMA, α-smooth muscle actin, 03 medical and health sciences, medicine, SEM, scanning electron microscopy, TEM, transmission electron microscopy, UUO, unilateral ureteral obstruction, EDCI, carbodiimide hydrochloride, 030304 developmental biology, ESR, equilibrium swelling ratio, business.industry, lcsh:RM1-950, TGF-β1, transforming growth factor β1, PDI, polydispersity index, medicine.disease, Hydrogel, Localized therapy, lcsh:Therapeutics. Pharmacology, chemistry, G', storage modulus, bis-F127-MA, bis-F127-methacrylate, BSA, bovine serum albumin, MOD, mean optical density, business, SD, standard deviation, DAPI, 4′,6-diamidino-2-phenylindole -
5
المؤلفون: Wen Li, Hiroshi Kurihara, Chang Yan, Zhuo Luo, Rong-Rong He, Yi-Fang Li, Robert Dallmann, Xue Li
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 3, Pp 383-398 (2020)مصطلحات موضوعية: TRKA, tropomyosin receptor kinase A, CTCF, CCCTC-binding factor, GREs, GR response elements, viruses, Cell, GRs, glucocorticoid receptors, SGKs, serum and glucocorticoid-regulated protein kinases, Stimulation, Review, PTMs, post-translational modifications, Herpes simplex virus type 1, medicine.disease_cause, 0302 clinical medicine, NK cells, natural killer cells, REST, RE1-silencing transcription factor, H3K9, histone H3 on lysines 9, sncRNAs, small non-coding RNAs, HSV-1, herpes simplex virus type 1, General Pharmacology, Toxicology and Pharmaceutics, ICP, infected cell polypeptide, MOI, multiplicity of infection, 0303 health sciences, PDK1, pyruvate dehydrogenase lipoamide kinase isozyme 1, TRIM14, tripartite motif-containing 14, PRRs, pattern-recognition receptors, OCT-1, octamer binding protein 1, Reactivation, HSV-1, RANKL, receptor activator of NF-κB ligands, T3, thyroid hormone, humanities, medicine.anatomical_structure, 4E-BP, eIF4E-binding protein, CPE, cytopathic effect, 030220 oncology & carcinogenesis, Latency, HPK, herpetic simplex keratitis, AD, Alzheimer's disease, DCs, dendritic cells, TCM, traditional Chinese medicine, TRM, tissue resident memory T cells, Recurrent infections, HPT axis, hypothalamic–pituitary–thyroid axis, LAT, latency-associated transcripts, SIRT1, sirtuin 1, AMPK, AMP-dependent kinase, NGF, nerve growth factor, TK, thymidine kinase, DEX, dexamethasone, HPA axis, hypothalamo–pituitary–adrenal axis, mTOR, mammalian target of rapamycin, MAVS, mitochondrial antiviral-signaling protein, ORFs, open reading frames, Biology, Stress, CNS, central nervous system, Inhibitory postsynaptic potential, AKT, protein kinase B, HCF-1, host cell factor 1, Virus, 03 medical and health sciences, ROS, reactive oxygen species, CORT, corticosterone, PRC1, protein regulator of cytokinesis 1, PAMPs, pathogen-associated molecular patterns, medicine, Latency (engineering), 030304 developmental biology, Balance (ability), PML, promyelocytic leukemia protein, IRF3, interferon regulatory factor 3, lcsh:RM1-950, ND10, nuclear domains 10, LSD1, lysine-specific demethylase 1, CTL, cytotoxic T lymphocyte, HDACs, histone deacetylases, LRF, Luman/CREB3 recruitment factor, CoREST, REST corepressor 1, lcsh:Therapeutics. Pharmacology, cGAS, cyclic GMP-AMP synthase, Herpes simplex virus, TG, trigeminal ganglia, Susceptibility, PI3K, phosphoinositide 3-kinases, DAMPs, damage-associated molecular patterns, Immunology, PNS, peripheral nervous system, BCL-2, B-cell lymphoma 2, KLF15, Krüppel-like transcription factor 15
-
6
المؤلفون: Stanislav Micuda, Jana Nekvindová, Alzbeta Horvatova, Jan Dušek, Lucie Hyrsova, Petr Pavek, Tomas Smutny, Sabine Gerbal-Chaloin
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 136-152 (2020)مصطلحات موضوعية: Original article, DMEs, drug metabolizing enzymes, ER, estrogen receptor, DEX, dexamethasone, LBD, ligand binding domain, DMSO, dimethyl sulfoxide, digestive system, PCN, pregnenolone 16α-carbonitrile, 03 medical and health sciences, Glucocorticoid, 0302 clinical medicine, Glucocorticoid receptor, Downregulation and upregulation, CYP3A4, cytochrome P450 3A4, Cytochrome P450 3A4, 3′-UTR, 3′-untranslated region, miRNA, microRNA, Gene expression, microRNA, Rif, rifampicin, General Pharmacology, Toxicology and Pharmaceutics, GRα, glucocorticoid receptor α, 030304 developmental biology, Gluc, Gaussia luciferase, PPARα, peroxisome proliferator-activated receptor α, 0303 health sciences, Pregnane X receptor, Expression vector, CYP3A4, Chemistry, Three prime untranslated region, PXR, pregnane X receptor, lcsh:RM1-950, MicroRNA, NR, nuclear receptor, digestive system diseases, Cell biology, lcsh:Therapeutics. Pharmacology, RXRα, retinoid X receptor α, PB, phenobarbital, 030220 oncology & carcinogenesis, MRE, miRNA-response element, CAR, constitutive androstane receptor, SEAP, secreted alkaline phosphatase, PHHs, primary human hepatocytes, Regulation
-
7
المؤلفون: Marc K. Hellerstein, Szu-Chi Liao, Taiyi Kuo, Rebecca A. Lee, Mohamad Dandan, Sneha Damal Villivalam, Tzu-Chieh Chen, Jen-Chywan Wang, Sona Kang, Damian E. Costello, Hussein Mohammed, Mahalakshmi Shankaran, Maggie Chang
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Male, protein synthesis, medicine.medical_treatment, Muscle Fibers, Skeletal, White adipose tissue, AcH4, acetylated histone H4, Biochemistry, Medical and Health Sciences, Mice, Glucocorticoid receptor, GRE, glucocorticoid response element, insulin resistance, polycyclic compounds, glucocorticoid receptor, Insulin, 2.1 Biological and endogenous factors, pAkt, phosphorylated Akt, Aetiology, Pik3r1, Mice, Knockout, Chemistry, Diabetes, Skeletal, AcH3, acetylated histone H3, Biological Sciences, Muscle atrophy, ChIP, chromatin immunoprecipitation, Class Ia Phosphatidylinositol 3-Kinase, Muscular Atrophy, medicine.anatomical_structure, striated muscle, Muscle, medicine.symptom, Glucocorticoid, hormones, hormone substitutes, and hormone antagonists, PI3K, phosphoinositide 3-kinase, medicine.drug, Research Article, Signal Transduction, medicine.medical_specialty, Biochemistry & Molecular Biology, Pik3r1, phosphoinositide-3-kinase regulatory subunit 1, Knockout, DEX, dexamethasone, Muscle Fibers, GA, gastrocnemius, Striated, 03 medical and health sciences, Insulin resistance, Internal medicine, medicine, Animals, skeletal muscle, Molecular Biology, Protein kinase B, Glucocorticoids, Metabolic and endocrine, GR, glucocorticoid receptor, 030102 biochemistry & molecular biology, Animal, Skeletal muscle, Cell Biology, medicine.disease, Muscle, Striated, PTEN, phosphatase and tensin homolog, Disease Models, Animal, 030104 developmental biology, Endocrinology, Glucose, Musculoskeletal, Disease Models, Chemical Sciences, Proto-Oncogene Proteins c-akt
وصف الملف: application/pdf
-
8
المؤلفون: Patrick Couvreur, Romain Brusini, Mariana Varna
المساهمون: Institut Galien Paris-Saclay (IGPS), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
المصدر: Advanced Drug Delivery Reviews
Advanced Drug Delivery Reviews, Elsevier, 2020, 157, pp.161-178. ⟨10.1016/j.addr.2020.07.010⟩مصطلحات موضوعية: [SDV]Life Sciences [q-bio], Anti-Inflammatory Agents, Pharmaceutical Science, 02 engineering and technology, Disease, Dex, Dexamethasone, Pathogenesis, TCR, T cell receptors, bFGF, basic fibroblast growth factor, Drug Delivery Systems, DC, dendritic cells, ATP, Adenosine Triphosphate, HA, Hyaluronic Acid, LMWH, Low Molecular Weight Heparin, NPs, Nanoparticles, pDNA, plasmid DeoxyriboNucleic Acid, Tissue homeostasis, COVID-19, coronavirus disease 2019, EAE, experimental autoimmune encephalomyelitis, NIPAM, N-Isopropyl acrylamide, ICAM, Inter-Cellular Adhesion Molecule, 0303 health sciences, VEGF, Vascular Endothelial Growth Factor, RA, Rheumatoid arthritis, PRR, Pattern-Recognition Receptor, VCAM, Vascular Cell Adhesion Molecule, 021001 nanoscience & nanotechnology, Clinical application, ROS, Radical Oxygen Species, 3. Good health, IBD, Inflammatory Bowel Diseases, PEG, Polyethylene Glycol, Nanomedicine, TLR, Toll-Like Receptor, APCs, antigen-presenting cells, medicine.symptom, 0210 nano-technology, 5-ASA, 5-AminoSalicylic Acid (also called Mesalazine), 2019-20 coronavirus outbreak, PSL, PhosphatidylSerine-containing Liposome, MPO, Myeloperoxidase, PEI, Polyethyleneimine, Inflammation, TNF-α, Tumor Necrosis Factor alpha, Article, NF-κB, Nuclear Factor-kappa B, Permeability, PLGA, Poly(Lactic-co-Glycolic Acid), 03 medical and health sciences, Immune system, medicine, Animals, Humans, HIF, Hypoxia-Inducible transcription Factor, LXR, Liver X Receptor, 030304 developmental biology, NSAID, Non-Steroidal Anti-inflammatory Drug, IL-10, Interleukin 10, business.industry, Active principle, Endothelial Cells, AMPS, 2-Acrylamido-2-MethylPropane-Sulfonic acid, EPR, Enhanced Permeability and Retention, FDA, Food and Drug Administration, MAPK, Mitogen Activated Protein Kinase, Biomimetic nanoparticles, LPS, LipoPolySaccharide, Pre-clinical assessment, MPSS, MethylPrednisolone Sodium Succinate, Cancer research, Nanoparticles, ELVIS, Extravasation through Leaky Vasculature and subsequent Inflammatory cell-mediated Sequestration, business, IFN-γ, Interferon gamma
-
9
المؤلفون: Angel Tsz-Yau Wan, Wai-Yee Chan, Heung Man Lee, Juliana C.N. Chan, Zhangting Wang, Alice P.S. Kong, Kai-Kei Miu, Hoi-Hung Cheung, Gang Lu, Xueyan Zhang
المصدر: JHEP Reports
JHEP Reports, Vol 2, Iss 6, Pp 100179-(2020)مصطلحات موضوعية: Hepatic steatosis, HFD, high-fat diet, HFrD, high-fructose drink, OGTT, oral glucose tolerance test, FASN, fatty acid synthase, Glucocorticoid receptor, Diabetes mellitus, AAV, adeno-associated virus, DM, diabetes mellitus, DEG, differentially expressed gene, miRNA, microRNA, Immunology and Allergy, NR3C1, nuclear receptor subfamily 3, group C, member 1, biology, Fatty liver, Gastroenterology, VAT, visceral adipose tissue, MicroRNA, CPT, carnitine palmitoyl transferase, Fatty acid synthase, HOMA-IR, homeostatic model assessment of insulin resistance, Lipogenesis, shRNA, short hairpin RNA, Research Article, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, DEX, dexamethasone, DNL, de novo lipogenesis, Transcription repressor, Insulin resistance, Internal medicine, 3′-UTR, 3′-untranslated region, Internal Medicine, medicine, lcsh:RC799-869, TAG, triacylglyceride/triglyceride, Hepatology, business.industry, FA, fatty acid, OA, oleic acid, High carbohydrate consumption, SCD1, stearoyl-CoA desaturase-1, T2DM, type 2 diabetes mellitus, medicine.disease, NT, non-targeting, Endocrinology, Nuclear receptor, biology.protein, lcsh:Diseases of the digestive system. Gastroenterology, GCR, glucocorticoid receptor, Steatosis, business, FAO, fatty acid oxidation
-
10
المؤلفون: Karsten Mäder, Y.A. Brito Barrera, E. Lehner, Christian Wölk, Matthias Menzel, Christian E.H. Schmelzer, Thomas Groth, Gerd Hause
المساهمون: Publica
المصدر: Materials Today Bio, Vol 7, Iss, Pp 100071-(2020)
Materials Today Bioمصطلحات موضوعية: AFM, Atomic force microscopy, DOPE, dioleoylphosphatidylethanolamine, Biomedical Engineering, LbL, Layer-by-Layer technique, osteogenic differentiation, Bioengineering, cationic lipids, DMEM, Dulbecco’s modified Eagle’s medium, CS, chondroitin sulfate, Dex, Dexamethasone, Biomaterials, chemistry.chemical_compound, ECM, Extracellular matrix, Full Length Article, DLS, Dynamic light scattering, Col I, Collagen I, SEM, Scanning electron microscopy, Cationic liposome, PEM, Polyelectrolyte multilayer, Chondroitin sulfate, Bone regeneration, Molecular Biology, lcsh:QH301-705.5, chondroitin sulfate, OO4, (N-{6-amino-1-[N-(9Z) -octadec9-enylamino] -1-oxohexan-(2S) -2-yl} -N’- {2- [N, N-bis(2-aminoethyl) amino] ethyl} -2-hexadecylpropandiamide), Liposome, lcsh:R5-920, collagen I, TEM, Transmission electron microscopy, Chemistry, PEI, Polyethylenimine, GAG, Glycosaminoglycan, Cell Biology, Transfection, PBS, Phosphate-buffered saline, polyelectrolyte multilayer system, Polyelectrolyte, CLSM, Confocal Laser Scanning Microscopy, WCA, Water contact angle, internalization, Dextran, lcsh:Biology (General), Drug delivery, Biophysics, C2C12 myoblasts, lcsh:Medicine (General), SPR, Surface plasmon resonance, Biotechnology
-
11
المؤلفون: Min Kyung Khang, Liping Tang, Shuxin Li, Jun Zhou, Cynthia M. Co
المصدر: Bioactive Materials
Bioactive Materials, Vol 5, Iss 4, Pp 1102-1112 (2020)مصطلحات موضوعية: medicine.drug_class, 0206 medical engineering, Biomedical Engineering, Inflammation, 02 engineering and technology, Inflammatory responses, BMC, biotinylated micelle, Anti-inflammatory, Article, Dexamethasone, Biomaterials, Dex, Dexamethasone, Neutravidin/biotin system, In vivo, medicine, lcsh:TA401-492, lcsh:QH301-705.5, Pretargeting, biology, BFMC, biotinylated- and folate-conjugated micelle, Chemistry, Macrophages, NeutrAvidin, 021001 nanoscience & nanotechnology, 020601 biomedical engineering, lcsh:Biology (General), Folate receptor, Biotinylation, FMC, folate-conjugated micelle, Drug delivery, biology.protein, Cancer research, Polymeric micelles, lcsh:Materials of engineering and construction. Mechanics of materials, medicine.symptom, 0210 nano-technology, Biotechnology
-
12Different regulation of lipogenesis in sebocytes and subcutaneous preadipocytes in hamsters in vitro
المؤلفون: Toshikazu Koiwai, Fusatoshi Shibata, Noriko Akimoto, Takashi Sato
المصدر: Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 22, Iss, Pp-(2020)مصطلحات موضوعية: 0301 basic medicine, Preadipocytes, medicine.medical_specialty, medicine.medical_treatment, Biophysics, Adipose tissue, Biochemistry, DMEM/F12, Dulbecco's modified Eagle's medium/Ham's F12 medium, lcsh:Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Dex, dexamethasone, 0302 clinical medicine, FBS, fetal bovine serum, Lipid droplet, Adipocyte, Internal medicine, Sebocytes, medicine, lcsh:QD415-436, PG, prostaglandin, IGF-1, insulin-like growth factor 1, lcsh:QH301-705.5, Triacyglycerol, IBMX, 3-isobutyl-1-methyl-xanthine, Insulin, Growth factor, Lipogenesis, Lipid-droplet formation, PPAR, peroxisome proliferation-activating receptor, TG, triacylglycerol, 030104 developmental biology, Endocrinology, chemistry, lcsh:Biology (General), 030220 oncology & carcinogenesis, Perilipin, 5α-DHT, 5α-dihydrotestosterone, 1,25(OH)2D3, 1α,25-dihydroxyvitamin D3, Differentiation Inducer, Research Article
-
13Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights
المؤلفون: Vijaya Rajendran, Kumar Janakiraman, Subramanian Natesan, Ruckmani Kandasamy, Venkateshwaran Krishnaswami
المصدر: Materials Today. Communications
مصطلحات موضوعية: 0301 basic medicine, Pir-SLN, piroxicam solid lipid nanoparticles, C-SLN, curcumin loaded solid lipid nanoparticles, COX- 1, cyclooxygenase - 1, HUVEC, human umbilical vein cells, ACF-SLN, aceclofenac loaded solid lipid nanoparticles, RA, rheumatoid arthritis, PCL-PEG, poly (ethylene glycol)-block-poly (ε-caprolactone), 02 engineering and technology, AIA, antigen-induced arthritis, AST, aspartate aminotransferase, VIP, vasoactive intestinal peptide, Pharmacology, VCAM-1, vascular cell adhesion molecule-1, FA, folic acid, LX-NMs, larnoxicam loaded nanomicelles, DMARD, disease modifying antirheumatic drugs, GC, glucocorticoid, TAC-LCNCs, tacrolimus loaded lipidic core nanocapsules, Materials Chemistry, TNF-α, tumour necrosis factor, General Materials Science, P-SLN, piperine loaded solid lipid nanoparticle, RGD, arginine-glycine aspartic acid, NSAIDs, non steroidal anti-inflammatory drugs, media_common, HEKcells, human embryonic kidney cells, DEX-PMs, dexamethasone-loaded polymeric micelles, HA- AuNP/TCZ, hyaluronate gold nanoparticle/Tocilizumab, ALP, alkaline phosphate, CLSM, confocal laser scanning microscopy, 021001 nanoscience & nanotechnology, VEGF, vascular endothelial growth factor, mRNA, messenger RNA, MTX-LCNCs, methotrexate-loaded lipidic core nanocapsules, RNAi, RNA interference, IND-NMs, indomethacin loaded polymeric micelles, Mechanics of Materials, Rheumatoid arthritis, shRNA, short hairpin RNA, HSA-NCs, human serum albumin nanocapsules, medicine.symptom, TAC-HSA-NPs, tacrolimus human serum albumin nanoparticle, 0210 nano-technology, LDE, lipidic nanoemulsion, Drug, Materials science, media_common.quotation_subject, SLN, solid lipid nanoparticles, A-SLN, actarit loaded solid lipid nanoparticles, Inflammation, DEX, dexamethasone, Nanocapsules, Article, 03 medical and health sciences, FR-β, folate receptor-beta, ALT, alanine aminotransferase, Solid lipid nanoparticle, medicine, Effective treatment, PSA-PCL-CyA-NMs, polysialic acid- polycaprolactone cyclosporine A nanomicelles, ComputingMethodologies_COMPUTERGRAPHICS, CEL-TS-LN, celecoxib loaded tristearin based lipidic nanoparticles, CHNP, chitosan nanoparticle, medicine.disease, PCL, polycaprolactone, Ig, immunoglobulin, PSA, polysialic acid, Bioavailability, IL, interleukin, CFA, complete freund’s adjuvant, Regimen, 030104 developmental biology, siRNA, small interfering RNA, Nanoformulation, Ind-NCs, indomethacin-loaded nanocapsules, Nanoparticles, COX- 2, cyclooxygenase - 2
-
14
المؤلفون: János Szlávik, Botond Lakatos, Edina Szabó, István Vályi-Nagy, Balint Gergely Szabo, Ilona Bobek
المصدر: Journal De Mycologie Medicale
مصطلحات موضوعية: VAP, ventilator-associated pneumonia, Male, ISA, isavuconazole, ISHAM, International Society for Human and Animal Mycology, ARDS, COVID-19, coronavirus disease-19, MP, methylprednisolone, HI, Horowitz index (PaO2/FiO2), L-AMB, liposomal amphotericin-B, IDSA, Infectious Disease Society of America, VOR, voriconazole, CHF, chronic heart failure, Cytokine storm, Candida parapsilosis, Aspergillosis, iv., intravenously, chemistry.chemical_compound, Invasive fungal infection, EUCAST, European Committee on Antimicrobial Susceptibility Testing, IPA, invasive pulmonary aspergillosis, PCR, polymerase chain reaction, COVID-19 Testing, IFI, invasive fungal infection, QD, once daily, DM, diabetes mellitus, LPV/r, lopinavir/ritonavir, Medicine, Candida albicans, S, sensitive, po., orally (per os), Aged, 80 and over, Invasive Pulmonary Aspergillosis, LDH, lactate dehydrogenase, biology, BW, body weight, I, intermediate susceptible, CAS, caspofungin, FLU, fluconazole, CS, cytokine storm, Middle Aged, EH, essential hypertension, CT, computed tomography, FVP, favipiravir, Infectious Diseases, Cohort, CRP, C-reactive protein, M, male, Female, BAL, bronchoalveolar lavage, IVIG, intravenus immunoglobulin, AS, atherosclerosis, POS, posaconazole, DLBCL, diffuse large B-cell lymphoma, ECMM, European Confederation of Medical Mycology, Research Paper, BDG, beta-D-glucan, AMB, amphotericin-B, Adult, medicine.medical_specialty, MYC, micafungin, Critical Illness, DEX, dexamethasone, Galactomannan, Candidaemia, ANI, anidulafungin, Internal medicine, BID, twice daily, ECDC, European Centre for Disease Prevention and Control, MIC, minimal inhibitory concentration, Humans, LOS, lenght of stay, TID, three times daily, ARDS, acute respiratory distress syndrome, Aged, Retrospective Studies, Hungary, GM, galactomannan, Candida glabrata, business.industry, COVID-19, F, female, ITR, itraconazole, Candidemia, HCQ, hydroxychloroquine, R, resistant, Guideline, biology.organism_classification, medicine.disease, BAR, baricitinib, COPD, chronic obstructive pulmonary disease, chemistry, TOC, tocilizumab, BSI, bloodstream-infection, business, SARS-CoV-2, severe acute respiratory syndrome coronavirus-2, Invasive Fungal Infections
-
15
المؤلفون: Ling-Dong Kong, Haibo Li, Chenglin Song, Wei Xiao, Wen Lv, Hui Ming Ge, Jiao Qu, Yang Sun, Yitong Liu, Chenxi Yang
المصدر: Phytomedicine
مصطلحات موضوعية: Lipopolysaccharides, MAPK/ERK pathway, ARDS, medicine.medical_treatment, MAPK, Mitogen-activated protein kinase, ERK1/2, Extracellular signal regulated kinases, i.p, Intraperitoneal injection, Pharmaceutical Science, TNF-α, Tumor necrosis factor α, Pharmacology, GM-CSF, Granulocyte-macrophage Colony Stimulating Factor, Extracellular Traps, Dex, Dexamethasone, Mice, H&E., Hematoxylin-eosin, 0302 clinical medicine, BALF, bronchoalveolar lavage fluid, Drug Discovery, Re-Du-Ning injection, Respiratory system, LPS, Lipopolysaccharide, Lung, 0303 health sciences, medicine.diagnostic_test, Blot, ELISA, Enzyme-linked immunosorbent assay, COVID-19, Coronavirus Disease 2019, 030220 oncology & carcinogenesis, Molecular Medicine, RDN, Re-Du-Ning injection, Female, PMA, phorbol 12-myristate 13-acetate, IL-1β, Interleukin (IL)-1β, NETs, neutrophil extracellular traps, MPO, Myeloperoxidase, Acute Lung Injury, Intraperitoneal injection, PAD4, peptidyl arginine deiminase 4, Lung injury, Immunofluorescence, Article, cit H3, Citrullinated histone H3, IL-6, Interleukin (IL)-6, 03 medical and health sciences, IL-17A, Interleukin (IL)-17A, ARDS, Acute respiratory distress syndrome, medicine, NE, neutrophil elastase, Animals, 030304 developmental biology, business.industry, ALI, Acute lung injury, NETs, Neutrophil extracellular traps, medicine.disease, MAPK, Mice, Inbred C57BL, ALI, Complementary and alternative medicine, business, Drugs, Chinese Herbal
-
16
المؤلفون: Guangyuan Zhang, Mitsuru Shimamura, Hitoshi Torii, Hideki Kizawa, Eri Nagao
المصدر: Biochemistry and Biophysics Reports, Vol 10, Iss C, Pp 186-191 (2017)
Biochemistry and Biophysics Reportsمصطلحات موضوعية: 0301 basic medicine, OAT, organic anion-transporting, medicine.medical_treatment, Biophysics, 02 engineering and technology, Biology, Biochemistry, Dex, Dexamethasone, lcsh:Biochemistry, 03 medical and health sciences, Liver disease, 8CPT-cAMP, 8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate, ECM, Extracellular matrix, MRP2, multidrug resistance-associated protein 2, medicine, lcsh:QD415-436, Protein kinase A signaling, lcsh:QH301-705.5, NASH, Non-alcoholic steatohepatitis, Bile duct, Bio-printing, Drug discovery, Insulin, HE, hematoxylin and eosin, Lipid metabolism, TUNEL, TdT-mediated dUTP nick end labeling, NAFLD, Non-alcoholic fatty liver disease, 021001 nanoscience & nanotechnology, medicine.disease, MT, Masson's trichrome, 030104 developmental biology, medicine.anatomical_structure, Metabolism, Drug development, Liver, lcsh:Biology (General), Toxicity, Scaffold-free, Liver function, 0210 nano-technology, Research Article, 3D
-
17
المؤلفون: Takayuki Izumo, Yuta Otsuka, Tomohiro Rogi, Kahori Egawa, Noriyuki Kanzaki, Hiroshi Shibata
المصدر: Biochemistry and Biophysics Reports, Vol 18, Iss, Pp-(2019)
Biochemistry and Biophysics Reportsمصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Foxo1, forkhead box O1, Biophysics, Quercetin glycosides, DEX, dexamethasone, Myostatin, Biochemistry, Dexamethasone, QGs, quercetin glycosides, lcsh:Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Internal medicine, medicine, MuRF-1, muscle ring finger protein 1, lcsh:QD415-436, Protein kinase B, lcsh:QH301-705.5, biology, Chemistry, Myogenesis, atrogin-1, atrogin-1/muscle atrophy F-box, musculoskeletal system, Muscle atrophy, 030104 developmental biology, Endocrinology, lcsh:Biology (General), 030220 oncology & carcinogenesis, biology.protein, medicine.symptom, Quercetin, Homeostasis, Research Article, medicine.drug
-
18
المؤلفون: Leitch, Alistair C., Probert, Philip M.E., Shayman, James A., Meyer, Stephanie K., Kass, George E.N., Wright, Matthew C.
المصدر: Toxicology
مصطلحات موضوعية: PEI, polyethylenimine, Benzylamines, Steatosis, Time Factors, Hydrocarbons, Fluorinated, NASH, non-alcoholic steatohepatitis, Methapyrilene, DEX, dexamethasone, In vitro and alternatives, Benzoates, Article, Phospholipidosis, Cell Line, PXR, pregnane X-receptor, LPLA2, lysosomal phospholipase A2, RXR, retinoid X-receptor, Animals, AR42J-B13, Phospholipids, Triglycerides, Liver X Receptors, Sulfonamides, Dose-Response Relationship, Drug, Fatty Acids, LAMP1, lysosome-associated membrane protein 1, Lipid Metabolism, Rats, Fatty Liver, DTT, dithiothreitol, PB, phenobarbital, PCN, 5-pregnen-3β-ol-20-one-16α-carbonitrile, Hepatocytes, CYP, cytochrome P450, LXR, T0901317, LXR, liver X receptor, Chemical and Drug Induced Liver Injury, B-13, AR42J-B-13, ADFP, adipose differentiation-related protein, B-13/H, AR42J-B-13 cells following treatment with 10 nM dexamethasone for 14 days, DAPI, 4’6’-diamino-2-phenylindole
-
19
المؤلفون: Hazem E. Hassan, William D. Hedrich, Hongbing Wang
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 6, Iss 5, Pp 413-425 (2016)مصطلحات موضوعية: 0301 basic medicine, CYP2B6, Review, E2, estradiol, Pharmacology, 030226 pharmacology & pharmacy, CPA, cyclophosphamide, C/EBP, CCAAT/enhancer-binding protein, chemistry.chemical_compound, 0302 clinical medicine, DDI, drug–drug interaction, RIF, rifampin, TCPOBOP, 1,4-bis[3,5-dichloropyridyloxy]benzene, Drug–drug interaction, EFV, efavirenz, Constitutive androstane receptor, ERE, estrogen responsive element, MAOI, monoamine oxidase inhibitor, General Pharmacology, Toxicology and Pharmaceutics, media_common, Pregnane X receptor, NVP, nevirapine, CITCO, (6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime), PXR, pregnane X receptor, PCN, pregnenolone 16 alpha-carbonitrile, NR1/2, nuclear receptor binding site 1/2, PBREM, phenobarbital-responsive enhancer module, SNP, single nucleotide polymorphism, CAR, CYP, cytochrome P450, UGT, UDP-glucuronosyl transferase, CAR, constitutive androstane receptor, HNF, hepatocyte nuclear factor, Drug, COUP-TF, chicken ovalbumin upstream promoter-transcription factor, PXR, media_common.quotation_subject, DEX, dexamethasone, Biology, NNRTI, non-nucleotide reverse-transcriptase inhibitor, CHOP, cyclophosphamide–doxorubicin–vincristine–prednisone, 03 medical and health sciences, CYP2B6 Gene, Polymorphism, Cyclophosphamide, GR, glucocorticoid receptor, GRE, glucocorticoid responsive element, CYP3A4, lcsh:RM1-950, HAART, highly active antiretroviral therapy, IFA, Ifosfamide, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, chemistry, PB, phenobarbital, 4-OH-CPA, 4-hydroxycyclophosphamide, Efavirenz, Xenobiotic, Drug metabolism
-
20
المؤلفون: Binfeng Cheng, Jin Tao, Yan Nie, Gang Bai, Xiaoyao Ma, Min Jiang, Yuanyuan Hou, Jie Gao
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 6, Iss 3, Pp 212-221 (2016)
Acta Pharmaceutica Sinica Bمصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Chemokine, Chronic bronchitis, NFATc1, nuclear factor of activated T cells c1, Mouse, Pharmacology, Pathogenic bacterial infection, chemistry.chemical_compound, LEV, levofloxacin, ATG, arctigenin, GA, genetic algorithm, Ras/MAPK pathway, General Pharmacology, Toxicology and Pharmaceutics, SPA, sinapic acid, Lung, biology, ESI, electrospray ionization, HE, hematoxylin and eosin, ELISA, enzyme-linked immunosorbent assay, LB, Luria–Bertani, Original Article, medicine.symptom, Signal transduction, TCM, traditional Chinese medicine, TTBS, Tween 20/Tris-buffered saline, PI3K, phosphoinositide 3-kinase, DMSO, dimethylsulfoxide, PBS, phosphate-buffered saline, Inflammation, QF, Qingfei Xiaoyan Wan, KEGG, Kyoto Encyclopedia of Genes and Genomes, UPLC, ultra-performance liquid chromatography, 03 medical and health sciences, Dex, dexamethasone, medicine, SARS, severe acute respiratory syndrome, Protein kinase B, PI3K/AKT/mTOR pathway, Arctigenin, lcsh:RM1-950, CLA, cholic acid, CGA, chlorogenic acid, PI3K/AKT pathway, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, chemistry, Immunology, biology.protein, Ninj1, ninjurin1, Anti-inflammatory, MAPK, mitogen activated protein kinase, Network pharmacology