المؤلفون: Christina Vasalou, Joanna Harding, Rhys D O Jones, Niresh Hariparsad, Dermot F McGinnity

المصدر: PLoS ONE, Vol 18, Iss 5, p e0285798 (2023)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/7db92a8cdaa54db4869c9ca4393d7542

المؤلفون: Christina Vasalou (366371), Douglas Ferguson (6244943), Weimin Li (131040), Victorine Muse (6454043), Francis D. Gibbons (7972940), Silvia Sonzini (6733550), Guangnong Zhang (11824385), Petar Pop-Damkov (11824388), Eric Gangl (1585399), Srividya B. Balachander (11824391), Shenghua Wen (11824394), Alwin G. Schuller (11824397), Sanyogitta Puri (1488760), Mariarosa Mazza (1544962), Marianne Ashford (570730), Adrian J. Fretland (1893682), Dermot F. McGinnity (2949150), Rhys D. O. Jones (5782235)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Developmental Biology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tissue distribution kinetics, improved antitumor activity, tumor growth kinetics, tumor growth data, conventional api formulation, influence api exposure, 11 tumor, conventional formulations, quantitative evaluation, naked apis, efficacy relationship, dosing schedules, dendritic nanoparticle, critical parameters, biodistribution dynamics

Relation: https://figshare.com/articles/journal_contribution/Quantitative_Evaluation_of_Dendritic_Nanoparticles_in_Mice_Biodistribution_Dynamics_and_Downstream_Tumor_Efficacy_Outcomes/17159450

الاتاحة: https://doi.org/10.1021/acs.molpharmaceut.1c00715.s001

المؤلفون: Srinivasan Krishnan, Diane Ramsden, Douglas Ferguson, Simone H. Stahl, Joanne Wang, Dermot F. McGinnity, Niresh Hariparsad

المصدر: Clinical Pharmacology & Therapeutics. 112:562-572

مصطلحات موضوعية: Pharmacology, Renal Elimination, HEK293 Cells, Organic Cation Transport Proteins, Humans, Organic Cation Transporter 2, Drug Interactions, Pharmacology (medical), Kidney

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591761a554a12b03335024347cf8a4ee
https://doi.org/10.1002/cpt.2666

المؤلفون: Tamara D. Cabalu, Mengyao Li, Kenichi Umehara, Dermot F. McGinnity, Neil Parrott, Kunal S Taskar, Arian Emami Riedmaier, Micaela B Reddy, Hugues Chanteux, Martin E. Dowty, Justine Badée, Jialin Mao, Jayaprakasam Bolleddula, Loeckie de Zwart, Jessica Rehmel, Dwaipayan Mukherjee, Chandra Prakash, Niresh Hariparsad, Masakatsu Kotsuma, Diane Ramsden, Karthik Venkatakrishnan, Venkatesh Pilla Reddy, Kushal Shah

المصدر: Clinical Pharmacology & Therapeutics. 112:770-781

مصطلحات موضوعية: Pharmacology, Physiologically based pharmacokinetic modelling, Knowledge management, Computer science, business.industry, Drug-drug interaction, Pharmacokinetic modeling, Survey result, Gap analysis, Models, Biological, Workflow, Cytochrome P-450 Enzyme System, Cytochrome P-450 CYP3A, Humans, Computer Simulation, Drug Interactions, Pharmacology (medical), business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdb2828c5120894f449c5ff5d05acce
https://doi.org/10.1002/cpt.2503

المؤلفون: Christina Vasalou, Douglas Ferguson, Weimin Li, Victorine Muse, Francis D. Gibbons, Silvia Sonzini, Guangnong Zhang, Petar Pop-Damkov, Eric Gangl, Srividya B. Balachander, Shenghua Wen, Alwin G. Schuller, Sanyogitta Puri, Mariarosa Mazza, Marianne Ashford, Adrian J. Fretland, Dermot F. McGinnity, Rhys D. O. Jones

المصدر: Molecular Pharmaceutics. 19:172-187

مصطلحات موضوعية: Dendrimers, Pharmaceutical Science, Antineoplastic Agents, Mice, SCID, Mice, Treatment Outcome, Cell Line, Tumor, Drug Discovery, Animals, Humans, Nanoparticles, Molecular Medicine, Female, Tissue Distribution, Neoplasm Transplantation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7b0f94146be1337e6d4c7f1e094eb4
https://doi.org/10.1021/acs.molpharmaceut.1c00715

المؤلفون: Dermot F. McGinnity, Ken Grime

المصدر: The Handbook of Medicinal Chemistry ISBN: 9781788018982

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cf0108ba2d433681f48f4fa6ede8eb0f
https://doi.org/10.1039/9781788018982-00298

المؤلفون: Dermot F. McGinnity, Diansong Zhou, Shringi Sharma, Buyun Chen, Venkatesh Pilla Reddy, Karthick Vishwanathan, Adrian J. Fretland, Joseph Ware, Yan Xu

المصدر: Cancer Chemotherapy and Pharmacology

مصطلحات موضوعية: Male, Cancer Research, p glycoprotein, Physiology, Toxicology, chemistry.chemical_compound, immune system diseases, Antineoplastic Combined Chemotherapy Protocols, Medicine, Drug Interactions, Tissue Distribution, Pharmacology (medical), Molecular Targeted Therapy, Aged, 80 and over, Peripheral Nervous System Diseases, Middle Aged, Drug modeling, Oncology, Vincristine, Area Under Curve, Ibrutinib, Acalabrutinib, Administration, Intravenous, Female, Original Article, Rituximab, medicine.drug, Adult, Physiologically based pharmacokinetic modelling, Combination therapy, Drug interaction, Models, Biological, Young Adult, Pharmacokinetics, Humans, Chemotherapy, Computer Simulation, Cyclophosphamide, Aged, Pharmacology, business.industry, Venetoclax, chemistry, Doxorubicin, Prednisone, Caco-2 Cells, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7423484d01bb4cf3c2bc3d7963e512
https://doi.org/10.1007/s00280-021-04302-5

المؤلفون: Scott W. Martin, Beth Williamson, Stephanie Harlfinger, Andrew Pike, Dermot F. McGinnity

المصدر: Drug Discovery Today. 25:1793-1800

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Mechanism (biology), business.industry, Administration, Oral, Proteins, Computational biology, 03 medical and health sciences, Drug Delivery Systems, 030104 developmental biology, 0302 clinical medicine, Pharmaceutical Preparations, Pharmacokinetics, 030220 oncology & carcinogenesis, Proteolysis, Drug Discovery, Humans, Medicine, business, Oral retinoid, Drug metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386b90be2147c5934da0dd545cc49b03
https://doi.org/10.1016/j.drudis.2020.07.013

المؤلفون: Dermot F. McGinnity, Beth Williamson, Stephanie Harlfinger

المصدر: Drug Metabolism and Disposition. 48:1137-1146

مصطلحات موضوعية: Male, Drug Evaluation, Preclinical, Extrapolation, Datasets as Topic, Pharmaceutical Science, Pharmacology, Models, Biological, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, medicine, Cytochrome P-450 CYP3A, Humans, In vitro in vivo, Human liver, Chemistry, Target engagement, Recombinant Proteins, Hepatobiliary Elimination, medicine.anatomical_structure, Liver, 030220 oncology & carcinogenesis, Hepatocyte, Hepatocytes, Microsomes, Liver, Microsome, Female, Drug metabolism, Oral retinoid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ee63503e9e698986d5025960432a99
https://doi.org/10.1124/dmd.120.000131

المؤلفون: Tashinga E. Bapiro, Scott Martin, Stephen D Wilkinson, Alexandra L. Orton, Niresh Hariparsad, Stephanie Harlfinger, Dermot F McGinnity

المصدر: Drug Metabolism and Disposition. :DMD-AR

مصطلحات موضوعية: Pharmacology, Pharmaceutical Science

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::012c7e50c11486943a74a394d0b4eb43
https://doi.org/10.1124/dmd.123.001323

المؤلفون: Haixia Wang, Stefan Kavanagh, Radoslaw Polanski, Eric Gangl, Michael J. Tucker, Jason Breed, Thomas Anthony Hunt, Paul R. J. Davey, Mandy Lawson, Darren Stead, Oona Delpuech, Ye Wu, J. Willem M. Nissink, Barlaam Bernard Christophe, Dedong Wu, Sudhir M. Hande, Amber Balazs, Dermot F. McGinnity, Wenzhan Yang, Thomas A. Moss, Bin Yang, Sladjana Gagrica, Kumar Thakur, Stacey Marden, Tyler Grebe, Daniel Hillebrand O'donovan, Teresa Klinowska, Samantha Jayne Hughes, Kara Herlihy, David I Fisher, Stephen Stokes, Holia Hatoum-Mokdad, Tony Johnson, James S. Scott, Elisabetta Chiarparin, Bo Peng, Sophie L. M. Janbon, Scott Throner, Ryan Greenwood, David Matthew Wilson, Andrew Lister, Stephen Fawell, Hoan Huynh, Jeffrey G. Varnes, Christopher J. Morrow, Rodrigo J. Carbajo

المصدر: Journal of medicinal chemistry. 63(23)

مصطلحات موضوعية: Selective Estrogen Receptor Modulators, Estrogen receptor, Administration, Oral, Biological Availability, Antineoplastic Agents, Breast Neoplasms, Pharmacology, Crystallography, X-Ray, 01 natural sciences, 03 medical and health sciences, Structure-Activity Relationship, In vivo, Oral administration, Cell Line, Tumor, Drug Discovery, medicine, Structure–activity relationship, Humans, 030304 developmental biology, Cell Proliferation, 0303 health sciences, Fulvestrant, Molecular Structure, Chemistry, Drug discovery, Antagonist, Lipids, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Cyclization, Lipophilicity, Molecular Medicine, Female, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307a07ad198923d95942c131a39083de
https://pubmed.ncbi.nlm.nih.gov/32910656

المؤلفون: Dermot F Mcginnity, Nigel J Waters, James Tucker, Robert J Riley

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://dmd.aspetjournals.org/content/dmd/36/6/1126.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1080.2378; http://dmd.aspetjournals.org/content/dmd/36/6/1126.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1080.2378
http://dmd.aspetjournals.org/content/dmd/36/6/1126.full.pdf

المؤلفون: Dermot F. Mcginnity, James Tucker, Steve Trigg, Robert J. Riley

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.cypex.co.uk/presentationpdfs/AstraMcGinnityDMD2005.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.585.8837; http://www.cypex.co.uk/presentationpdfs/AstraMcGinnityDMD2005.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.585.8837
http://www.cypex.co.uk/presentationpdfs/AstraMcGinnityDMD2005.pdf

المؤلفون: Ken Grime, Susanne Winiwarter, Rasmus Jansson-Löfmark, Michael Davies, Adrian J. Fretland, Rhys D.O. Jones, Paul Morgan, Dermot F. McGinnity

المصدر: Trends in pharmacological sciences. 41(6)

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Drug, Computer science, Drug discovery, media_common.quotation_subject, Area under the curve, Cmax, Experimental data, Computational biology, Toxicology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Drug development, Pharmacokinetics, Drug Discovery, Humans, Drug pipeline, 030217 neurology & neurosurgery, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f23152cd6345839320948ed47fc343f
https://pubmed.ncbi.nlm.nih.gov/32359836

المؤلفون: Barry Jones, Beth Williamson, Nicola Colclough, Rhys Dafydd Owen Jones, Adrian J. Fretland, Dermot F. McGinnity

المصدر: Current drug metabolism. 21(2)

مصطلحات موضوعية: Pharmacology, Drug, business.industry, Drug discovery, media_common.quotation_subject, In silico, Clinical Biochemistry, Drug Evaluation, Preclinical, Phases of clinical research, Administration, Oral, Antineoplastic Agents, Computational biology, Metabolic stability, Intestinal Absorption, Drug Discovery, Dose escalation, Medicine, Oncology drug, Animals, Humans, Drug Interactions, business, ADME, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe55ab60d2a092e7883c11f311be6a4c
https://pubmed.ncbi.nlm.nih.gov/32164508

المؤلفون: Dermot F. Mcginnity, Sarah J. Griffin, Graeme C. Moody, Mike Voice, Stephen Hanlon, Thomas Friedberg, Robert, J. Riley

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.cypex.co.uk/presentationpdfs/Astra1999.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.586.2874; http://www.cypex.co.uk/presentationpdfs/Astra1999.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.586.2874
http://www.cypex.co.uk/presentationpdfs/Astra1999.pdf

المؤلفون: Pablo Morentin Gutierrez, Eric Gangl, Dermot F. McGinnity, Pradeep Sharma, Andy Sykes, Teresa Klinowska, Petar Pop-Damkov, James S. Scott, Roshini Markandu, Adrian J. Fretland

المصدر: Cancer Research. 80:1042-1042

مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, business.industry, Estrogen receptor, Cancer, medicine.disease, Metastatic breast cancer, Pharmacokinetics, Internal medicine, medicine, In patient, Dosing, Once daily, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5dc8b6a91c4a5ad4c701678bbbad1068
https://doi.org/10.1158/1538-7445.am2020-1042

المؤلفون: Nicola Colclough, Dermot F. McGinnity, Kan Chen, Peter Johnström, Markus Fridén

المصدر: Drug discovery today. 24(5)

مصطلحات موضوعية: 0301 basic medicine, Antineoplastic Agents, Bioinformatics, Piperazines, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Medicine, Animals, Humans, Osimertinib, Pharmaceutical sciences, Protein Kinase Inhibitors, Pharmacology, Acrylamides, Aniline Compounds, business.industry, Drug discovery, Brain Neoplasms, Brain, Limiting, Preclinical data, 030104 developmental biology, 030220 oncology & carcinogenesis, Quinazolines, Oncology drug, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ffe7bcdb5668fcf7653a74d75e71e61
https://pubmed.ncbi.nlm.nih.gov/30710641

المؤلفون: Iain Walters, John Steele, Timothy Johnson, Andrew Baxter, Nicholas Kindon, David Cheshire, Antonio Mete, John Unitt, Glen Andrews, Yu-Zhen Liu, Dermot F. McGinnity, Bryan Roberts, Michael J. Stocks, Paul Hemsley, Barry Teobald, Mark McHale, James Reuberson, Deborah Vaughan

المصدر: ACS medicinal chemistry letters. 8(9)

مصطلحات موضوعية: 0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, CCR4 Receptor, Chemistry, Organic Chemistry, Drug Discovery, Antagonist, CCR4, Pharmacology, Biochemistry, Bioavailability

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf60bc07dc526ae8f2f4763a991e6eaa
https://pubmed.ncbi.nlm.nih.gov/28947948

المؤلفون: Ravindra Alluri, Nicola Colclough, Yumei Yan, Danxi Li, Kan Chen, Dermot F. McGinnity

المصدر: Drug Metabolism and Pharmacokinetics. 35:S39

مصطلحات موضوعية: Pharmacology, medicine.anatomical_structure, Cell culture, Chemistry, medicine, Pharmaceutical Science, Pharmacology (medical), Transporter, Efflux, Blood–brain barrier, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b3dfb7f79799db12acf2f9f56dfd9aa4
https://doi.org/10.1016/j.dmpk.2020.04.059