المؤلفون: Jemy A. Gutierrez, Wei Liu, Sylvie Perez, Gang Xing, Gabriele Sonnenberg, Kou Kou, Matt Blatnik, Richard Allen, Yan Weng, Nicholas B. Vera, Kristin Chidsey, Arthur Bergman, Veena Somayaji, Collin Crowley, Michelle F. Clasquin, Anu Nigam, Melissa A. Fulham, Derek M. Erion, Trenton T. Ross, William P. Esler, Thomas V. Magee, Jeffrey A. Pfefferkorn, Kendra K. Bence, Morris J. Birnbaum, Gregory J. Tesz

المصدر: Molecular Metabolism, Vol 48, Iss , Pp 101196- (2021)

مصطلحات موضوعية: Fructose, KHK, Insulin resistance, NAFLD, Metabolic disease, Internal medicine, RC31-1245

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877821000363; https://doaj.org/toc/2212-8778

URL الوصول: https://doaj.org/article/83d51c2650cb4492a69b4c32dbb702cc

المؤلفون: Emma L. Shepherd, Raquel Saborano, Ellie Northall, Kae Matsuda, Hitomi Ogino, Hiroaki Yashiro, Jason Pickens, Ryan E. Feaver, Banumathi K. Cole, Stephen A. Hoang, Mark J. Lawson, Matthew Olson, Robert A. Figler, John E. Reardon, Nobuhiro Nishigaki, Brian R. Wamhoff, Ulrich L. Günther, Gideon Hirschfield, Derek M. Erion, Patricia F. Lalor

المصدر: JHEP Reports, Vol 3, Iss 2, Pp 100217- (2021)

مصطلحات موضوعية: NAFLD, Metabolism, Fructose, Fibrosis, Treatment, NASH, Diseases of the digestive system. Gastroenterology, RC799-869

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555920301518; https://doaj.org/toc/2589-5559

URL الوصول: https://doaj.org/article/4340ddc01197436fbd613f61ff255144

المؤلفون: Min-Dian Li, Nicholas B. Vera, Yunfan Yang, Bichen Zhang, Weiming Ni, Enida Ziso-Qejvanaj, Sheng Ding, Kaisi Zhang, Ruonan Yin, Simeng Wang, Xu Zhou, Ethan X. Fang, Tian Xu, Derek M. Erion, Xiaoyong Yang

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/f49d2d5b81154fdfad2889c2229e7c6b

المؤلفون: Emilio P. Mottillo, Eric M. Desjardins, Andreas M. Fritzen, Vito Z. Zou, Justin D. Crane, Julian M. Yabut, Bente Kiens, Derek M. Erion, Adhiraj Lanba, James G. Granneman, Saswata Talukdar, Gregory R. Steinberg

المصدر: Molecular Metabolism, Vol 6, Iss 6, Pp 471-481 (2017)

مصطلحات موضوعية: Internal medicine, RC31-1245

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877817301527; https://doaj.org/toc/2212-8778

URL الوصول: https://doaj.org/article/fc00a74ad3ef4ecea038d1f2a69ca511

المؤلفون: Tamas L. Horvath, Derek M. Erion, John D. Elsworth, Robert H. Roth, Gerald I. Shulman, Zane B. Andrews

المصدر: Neurobiology of Disease, Vol 43, Iss 1, Pp 152-162 (2011)

مصطلحات موضوعية: AMPK, Ghrelin, Dopamine, Mitochondrial biogenesis, Mitochondrial volume, Nucleator, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996111000878; https://doaj.org/toc/1095-953X

URL الوصول: https://doaj.org/article/3f1495d59adc4eabbe998fccea824d5e

المؤلفون: Mitsuharu Matsumoto, Hiroaki Yashiro, Hitomi Ogino, Kazunobu Aoyama, Tadahiro Nambu, Sayuri Nakamura, Mayumi Nishida, Xiaolun Wang, Derek M Erion, Manami Kaneko

المصدر: PLoS ONE, Vol 15, Iss 1, p e0228212 (2020)

مصطلحات موضوعية: Medicine, Science

Relation: https://doi.org/10.1371/journal.pone.0228212; https://doaj.org/toc/1932-6203; https://doaj.org/article/92b8b33628c34fa1a58de82610b39f28

الاتاحة: https://doi.org/10.1371/journal.pone.0228212
https://doaj.org/article/92b8b33628c34fa1a58de82610b39f28

المؤلفون: Shan Yu, Matthew Ericson, Andrea Fanjul, Derek M. Erion, Maria Paraskevopoulou, Erin N. Smith, Banumathi Cole, Ryan Feaver, Corine Holub, Narender Gavva, Shane R. Horman, Jie Huang

المصدر: ACS Chemical Biology. 17:918-929

مصطلحات موضوعية: Liver Cirrhosis, Liver, Transforming Growth Factor beta, Hepatic Stellate Cells, Humans, Molecular Medicine, General Medicine, Fibrosis, Biochemistry, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b2f5e9de8fe7b0e417d602e2240b3a
https://doi.org/10.1021/acschembio.2c00006

المؤلفون: Shinji Iwasaki, Hironobu Yasuno, Derek M. Erion, Yumiko Okano Tamura, Masako Sasaki, Jun Sugama, Kazunobu Aoyama, Hiroaki Yashiro, Masanori Watanabe

المصدر: Journal of Pharmacology and Experimental Therapeutics. 379:280-289

مصطلحات موضوعية: Liver Cirrhosis, Male, medicine.medical_specialty, digestive system, Mice, Liver disease, chemistry.chemical_compound, Non-alcoholic Fatty Liver Disease, Internal medicine, Nonalcoholic fatty liver disease, medicine, Animals, Humans, Enzyme Inhibitors, Mice, Knockout, Pharmacology, Dose-Response Relationship, Drug, Fatty acid metabolism, business.industry, Fatty liver, nutritional and metabolic diseases, Hep G2 Cells, medicine.disease, digestive system diseases, Fatty Liver, Mice, Inbred C57BL, Endocrinology, chemistry, Lipogenesis, Molecular Medicine, Steatosis, Steatohepatitis, Hepatic fibrosis, business, Acetyl-CoA Carboxylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf495925638a159c985d16b72d4c879
https://doi.org/10.1124/jpet.121.000786

المؤلفون: Keith Riccardi, Zhenhong Li, Janice A Brown, Matthew F Gorgoglione, Mark Niosi, James Gosset, Kim Huard, Derek M Erion, Li Di, M F G, J G, K H, D M E

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://dmd.aspetjournals.org/content/dmd/44/10/1633.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1075.4018; http://dmd.aspetjournals.org/content/dmd/44/10/1633.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1075.4018
http://dmd.aspetjournals.org/content/dmd/44/10/1633.full.pdf

المؤلفون: Ellie Northall, Banumathi K. Cole, John E. Reardon, Brian R. Wamhoff, Matthew W. Olson, Stephen A. Hoang, Kae Matsuda, Ulrich L. Günther, Mark J. Lawson, Ryan E. Feaver, Jason Pickens, Patricia F. Lalor, Raquel Saborano, Robert A. Figler, Hiroaki Yashiro, Derek M. Erion, Hitomi Ogino, Emma L. Shepherd, Gideon M. Hirschfield, Nobuhiro Nishigaki

المصدر: JHEP Reports, Vol 3, Iss 2, Pp 100217-(2021)
JHEP Reports

مصطلحات موضوعية: ALD, alcohol-related cirrhosis, IGF, insulin-like growth factor, PDGF, platelet-derived growth factor, chemistry.chemical_compound, Fibrosis, AST, aspartate transaminase, Immunology and Allergy, Glycolysis, Liver injury, G/F, glucose/fructose, biology, TG, triglyceride, Fatty liver, Gastroenterology, NASH, HSQC, heteronuclear single quantum coherence, CT, computed tomography, aLMF, activated liver myofibroblasts, HSCs, hepatic stellate cells, Research Article, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, ALT, alanine transaminase, NASH, non-alcoholic steatohepatitis, FIB4, fibrosis-4, DNL, de novo lipogenesis, Fructose, Internal medicine, NAFLD, Internal Medicine, medicine, TGFB, transforming growth factor beta, lcsh:RC799-869, APRI, AST to Platelet Ratio Index, NPCs, non-parenchymal cells, KO, knockout, Hepatology, business.industry, medicine.disease, WT, wild-type, KHK, ketohexokinase, HSECs, hepatic sinusoidal endothelial cells, Treatment, Endocrinology, PSC, primary sclerosing cholangitis, Metabolism, chemistry, Alanine transaminase, Hepatic stellate cell, biology.protein, BSA, bovine serum albumin, TIMP-1, Tissue Inhibitor of Matrix metalloproteinase-1, lcsh:Diseases of the digestive system. Gastroenterology, PBC, primary biliary cholangitis, Steatosis, business, BEC, biliary epithelial cells, LGLI, low glucose and insulin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e901d5e74295d49cc1586ef5be254e
http://www.sciencedirect.com/science/article/pii/S2589555920301518

المؤلفون: Derek M Erion, Amanda Lapworth, Paul A Amor, Guoyun Bai, Nicholas B Vera, Ronald W Clark, Qingyun Yan, Yimin Zhu, Trenton T Ross, Julie Purkal, Matthew Gorgoglione, Guodong Zhang, Vinicius Bonato, Levenia Baker, Nicole Barucci, Theresa D'Aquila, Alan Robertson, Robert J Aiello, Jiangli Yan, Jeff Trimmer, Timothy P Rolph, Jeffrey A Pfefferkorn

المصدر: PLoS ONE, Vol 9, Iss 5, p e97139 (2014)

مصطلحات موضوعية: Medicine, Science

Relation: http://europepmc.org/articles/PMC4032240?pdf=render; https://doaj.org/toc/1932-6203; https://doaj.org/article/646e9e91d00f42f6a75e558c5e50e7cf

الاتاحة: https://doi.org/10.1371/journal.pone.0097139
https://doaj.org/article/646e9e91d00f42f6a75e558c5e50e7cf

المؤلفون: Yasunori Nio, Takanori Takebe, Derek M. Erion, Wendy Thompson, Masaaki Funata

المصدر: Cell Death Differ

مصطلحات موضوعية: 0301 basic medicine, Pluripotent Stem Cells, Tissue Engineering, Regeneration (biology), Organogenesis, Cell Differentiation, Cell Biology, Computational biology, Review Article, Biology, Organoids, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Drug development, Liver, 030220 oncology & carcinogenesis, Organoid, Humans, Digestive tract, Cell Culture Techniques, Three Dimensional, Bile Ducts, Induced pluripotent stem cell, Molecular Biology, Pancreas

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6df77521f4a66d4bb023863373a37c1
https://pubmed.ncbi.nlm.nih.gov/33204011

المؤلفون: Stephen L. Coy, Evagelia C. Laiakis, Derek M. Erion, Zhidan Chen, Evan L. Pannkuk, Paul Vouros, Jeffrey A. Pfefferkorn, Albert J. Fornace, Nicholas B. Vera

المصدر: Journal of Mass Spectrometry. 53:548-559

مصطلحات موضوعية: Male, 0301 basic medicine, Urinary system, 01 natural sciences, Article, Matrix (chemical analysis), 03 medical and health sciences, chemistry.chemical_compound, Metabolomics, Biodosimetry, Tandem Mass Spectrometry, medicine, Animals, Acetylcarnitine, Spectroscopy, Flow injection analysis, Creatinine, Chromatography, 010401 analytical chemistry, Dose-Response Relationship, Radiation, Radiation Exposure, Macaca mulatta, 0104 chemical sciences, 030104 developmental biology, chemistry, Flow Injection Analysis, Biomarker (medicine), Biomarkers, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e6017395b77338fdf9dc87c7f78888
https://doi.org/10.1002/jms.4085

المؤلفون: Zhenhong Li, James R. Gosset, Matthew Gorgoglione, Keith Riccardi, Li Di, Derek M. Erion, Janice A. Brown, Mark Niosi, Kim Huard

المصدر: Drug Metabolism and Disposition. 44:1633-1642

مصطلحات موضوعية: Pharmaceutical Science, In Vitro Techniques, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Tandem Mass Spectrometry, In vivo, Animals, Humans, Bovine serum albumin, Cation Transport Proteins, Sodium Sulfate Cotransporter, Pharmacology, Symporters, biology, Chemistry, Biological activity, Transporter, Prodrug, In vitro, Culture Media, Rats, HEK293 Cells, Biochemistry, Cell culture, 030220 oncology & carcinogenesis, Hepatocytes, biology.protein, Intracellular, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc15d29bc763bc803d4c2d961ca04b87
https://doi.org/10.1124/dmd.116.071837

المؤلفون: Adhiraj Lanba, Yan Weng, Veena Somayaji, Ronald W. Clark, Michelle Rossulek, Jeffrey R. Chabot, Dongmei Li, Derek M. Erion, Bryan Goodwin, Martin B. Brenner, Yingjiang Zhou, Saswata Talukdar, Bryn M. Owen, Kathryn E. Gropp, Roberto A. Calle, Timothy P. Rolph, Jennifer Q. Dong, Jeffrey K. Trimmer

المصدر: Cell Metabolism. 23:427-440

مصطلحات موضوعية: Adult, Blood Glucose, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, Physiology, medicine.medical_treatment, Drug Evaluation, Preclinical, Subcutaneous Fat, Gene Expression, 030209 endocrinology & metabolism, Type 2 diabetes, Overweight, Antibodies, Monoclonal, Humanized, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Weight loss, Internal medicine, Diabetes mellitus, Weight Loss, medicine, Animals, Humans, Insulin, Glucose homeostasis, Obesity, Molecular Biology, Aged, medicine.diagnostic_test, Adiponectin, business.industry, Body Weight, Cell Biology, Middle Aged, Lipid Metabolism, medicine.disease, Fibroblast Growth Factors, Macaca fascicularis, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Female, Anti-Obesity Agents, medicine.symptom, Lipid profile, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97c7e39399f40d27c9cbf82d950cf0d
https://doi.org/10.1016/j.cmet.2016.02.001

المؤلفون: Carlin Okerberg, Timothy M. Coskran, Kou Kou, Walter F. Bobrowski, Irani Khatun, Nicholas B. Vera, Derek M. Erion, Bryan Goodwin, Ronald W. Clark

المصدر: Journal of Biological Chemistry. 291:2602-2615

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Dietary lipid, Phospholipid, Biology, Biochemistry, Bile Acids and Salts, Mice, 03 medical and health sciences, chemistry.chemical_compound, Internal medicine, medicine, Animals, Molecular Biology, Phospholipids, Triglycerides, Lipid Transport, Mice, Knockout, Lipid metabolism, Cell Biology, 1-Acylglycerol-3-Phosphate O-Acyltransferase, Lipid Metabolism, Dietary Fats, Lipids, Small intestine, Enterocytes, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, Acyltransferase, Cholesteryl ester, lipids (amino acids, peptides, and proteins), Chylomicron

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64618da321337b8626543aa83939f4e2
https://doi.org/10.1074/jbc.m115.683359

المؤلفون: Michael Herr, Daniel P. Canterbury, Derek M. Erion, Janice A. Brown, Mark Niosi, Bhagyashree Khunte, Matthew Gorgoglione, Jaclyn Siderewicz, Jana Polivkova, Carmen N. Garcia-Irizarry, Nathan E. Genung, Adam M. Gilbert, Justin I. Montgomery, Daniel P. Uccello, Timothy P. Rolph, Adhiraj Lanba, Qifang Li, Nicholas B. Vera, Kentaro Futatsugi, Gary Erik Aspnes, Zhenhong Li, James R. Gosset, Kim Huard, Matthew Merrill Hayward, Shawn Cabral, Magee Thomas Victor, Julie Purkal, Kevin B. Bahnck

المصدر: Journal of Medicinal Chemistry. 59:1165-1175

مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, Pyridines, Malates, Mice, Obese, Pharmacology, Kidney, Phenylbutyrate, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, 03 medical and health sciences, Pharmacokinetics, In vivo, Drug Discovery, Animals, Humans, Citrates, Dose-Response Relationship, Drug, Molecular Structure, Symporters, Chemistry, Kidney metabolism, Biological Transport, Citrate transport, Phenylbutyrates, In vitro, Rats, Solute carrier family, Mice, Inbred C57BL, HEK293 Cells, 030104 developmental biology, Liver, Biochemistry, Symporter, Hepatocytes, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b4cd858c5eae974c53ce91c3e64131
https://doi.org/10.1021/acs.jmedchem.5b01752

المؤلفون: Shawn Cabral, Ronald W. Clark, Philip A. Carpino, Csilla C. Jorgensen, Wenhua Jiao, Julie Purkal, Matthew S. Dowling, Suvi T. M. Orr, David Hepworth, Steven B. Coffey, Mark Niosi, Gary Erik Aspnes, Michael Herr, James R. Gosset, Kentaro Futatsugi, Theunis C. Goosen, Derek M. Erion, Bryan Goodwin, Kou Kou, Kay Ahn, Qifang Li, John C. Pettersen, Sylvie Perez, Sophie Y. Lavergne, Brandon Pabst, Daniel W. Kung, Scott Bader, Jeffrey A. Pfefferkorn, Kyuha Lee, Jianwei Bian, Markus Boehm

المصدر: Journal of Medicinal Chemistry. 58:7173-7185

مصطلحات موضوعية: Cyclopropanes, Male, Imidazopyridine, Pyrrolidines, Pyridines, Stereoisomerism, Spodoptera, Pharmacology, Pyrrolidine, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, Sf9 Cells, Animals, Humans, Structure–activity relationship, Diacylglycerol O-Acyltransferase, Receptor, Dyslipidemias, Mice, Knockout, Imidazoles, Lipid metabolism, Lipid Metabolism, Rats, Receptors, LDL, Biochemistry, chemistry, Lipophilic efficiency, Hepatocytes, Molecular Medicine, Diacylglycerol Acyltransferase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658effc9f945cdc7324e33a364d6f1c4
https://doi.org/10.1021/acs.jmedchem.5b01006

المؤلفون: Kevin C. Corbit, Rachel J. Perry, Rahul C. Deo, Nicholas B. Vera, Ethan J. Weiss, Lia R. Edmunds, Jennifer L. Tran, Gerald I. Shulman, Joao Paulo Camporez, Michael J. Jurczak, Derek M. Erion

المصدر: Diabetes, vol 67, iss 2
Diabetes

مصطلحات موضوعية: 0301 basic medicine, Threonine, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Adipose tissue, Inbred C57BL, Medical and Health Sciences, Transgenic, Oral and gastrointestinal, chemistry.chemical_compound, Mice, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, Adipocyte, 2.1 Biological and endogenous factors, Phosphorylation, Aetiology, Adiposity, Mice, Knockout, biology, Chemistry, Liver Disease, Fatty liver, Diabetes, Liver, Adipose Tissue, Organ Specificity, Signal Transduction, medicine.medical_specialty, Knockout, Chronic Liver Disease and Cirrhosis, Mice, Transgenic, 030209 endocrinology & metabolism, Diet, High-Fat, 03 medical and health sciences, Endocrinology & Metabolism, Insulin resistance, Internal medicine, Internal Medicine, medicine, Animals, Obesity, Protein Processing, Metabolic and endocrine, Nutrition, Insulin, Post-Translational, Lipid metabolism, Janus Kinase 2, medicine.disease, Phosphoproteins, Lipid Metabolism, Diet, Mice, Inbred C57BL, Insulin receptor, High-Fat, Metabolism, 030104 developmental biology, Endocrinology, biology.protein, Steatosis, Insulin Resistance, Digestive Diseases, Protein Processing, Post-Translational, Proto-Oncogene Proteins c-akt

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::242165a462b7ba9a19643933cd9b5749
https://escholarship.org/uc/item/40f3h614

المؤلفون: Zhouji Chen, Nisreen Soufi, Mark J. Graham, Angela M. Hall, Kari T. Chambers, Derek M. Erion, Brian N. Finck, Kyle S. McCommis, George G. Schweitzer, Xiong Su

المصدر: Diabetes

مصطلحات موضوعية: Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Gene Expression, Mice, Obese, Mice, Transgenic, Biology, Diet, High-Fat, Diglycerides, Mice, Insulin resistance, Internal medicine, Nonalcoholic fatty liver disease, Internal Medicine, medicine, Animals, Insulin, Obesity, Protein kinase C, Triglycerides, Diacylglycerol kinase, Oligonucleotides, Antisense, medicine.disease, 3. Good health, Monoacylglycerol lipase, Mice, Inbred C57BL, Insulin receptor, Endocrinology, Metabolism, Glucose, Liver, biology.protein, lipids (amino acids, peptides, and proteins), Steatosis, Acyltransferases, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500656db99ee2b45098d67efa6336f50
http://europepmc.org/articles/PMC4066334