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1
المؤلفون: Dennis S. Yamashita, Michael W. Lark, Kevin Schiller, Maxine Gowen, Scott M. DeWire, Jonathan D. Violin, David H. Rominger, Erin J. Whalen, Lisa Nguyen
المصدر: Journal of Pharmacology and Experimental Therapeutics. 335:572-579
مصطلحات موضوعية: Male, medicine.medical_specialty, Nitric Oxide Synthase Type III, Arrestins, Proto-Oncogene Proteins c-jun, Blood Pressure, Pharmacology, Biology, Transfection, Binding, Competitive, Receptor, Angiotensin, Type 1, Ventricular Function, Left, Cardiovascular Physiological Phenomena, Mice, GTP-Binding Proteins, Cell Line, Tumor, Internal medicine, medicine, Animals, Humans, Drug Interactions, Myocytes, Cardiac, RNA, Small Interfering, Extracellular Signal-Regulated MAP Kinases, Protein kinase A, Receptor, beta-Arrestins, Angiotensin II receptor type 1, Beta-Arrestins, Angiotensin II, Myocardial Contraction, Rats, HEK293 Cells, src-Family Kinases, Losartan, Endocrinology, Focal Adhesion Kinase 1, Molecular Medicine, Telmisartan, Angiotensin II Type 1 Receptor Blockers, Oligopeptides, Signal Transduction, medicine.drug, Proto-oncogene tyrosine-protein kinase Src
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2
المؤلفون: Hong Lin, Kristin K. Brown, Nelson Rhodes, Shu-Yun Zhang, Rakesh Kumar, Sharad K. Verma, Ren Xie, Dirk A. Heerding, Elisabeth A. Minthorn, Anthony E. Choudhry, Juan I. Luengo, Zhihong Lai, Kimberly A. Robell, Dennis S. Yamashita, Jin Zeng
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:679-683
مصطلحات موضوعية: Indazoles, Pyridines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Glycogen Synthase Kinase 3, Mice, chemistry.chemical_compound, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Phosphorylation, Protein Kinase Inhibitors, Molecular Biology, Indazole, Glycogen Synthase Kinase 3 beta, biology, Chemistry, Kinase, Organic Chemistry, Biological activity, Xenograft Model Antitumor Assays, Enzyme inhibitor, Pyrazines, biology.protein, Molecular Medicine, Signal transduction, Selectivity, Proto-Oncogene Proteins c-akt
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3
المؤلفون: Kristin K. Brown, Jack D. Leber, Sharad K. Verma, Shu-Yun Zhang, Hong Lin, Brian Donovan, Mei Li, Dirk A. Heerding, Elisabeth A. Minthorn, Louis V. LaFrance, Kimberly A. Robell, Barry S. Brown, Juan I. Luengo, Igor G. Safonov, Wenyong Wang, Dennis S. Yamashita, Michael D. Schaber, Dennis T. Takata, Dana S. Levy, Jason A. Kahana, Joseph W. Venslavsky, Jin Zeng, Rakesh Kumar, Ren Xie, Anthony E. Choudhry, Zhihong Lai
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:684-688
مصطلحات موضوعية: ERG1 Potassium Channel, Pyridines, Clinical Biochemistry, hERG, Aminopyridines, Pharmaceutical Science, Biochemistry, Glycogen Synthase Kinase 3, Mice, Structure-Activity Relationship, Dogs, Cytochrome P-450 Enzyme System, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Phosphorylation, Protein Kinase Inhibitors, Molecular Biology, GSK3B, Glycogen Synthase Kinase 3 beta, biology, Chemistry, Organic Chemistry, Biological activity, Haplorhini, Xenograft Model Antitumor Assays, Ether-A-Go-Go Potassium Channels, Rats, Enzyme inhibitor, Pyrazines, biology.protein, Molecular Medicine, Tau-protein kinase, Proto-Oncogene Proteins c-akt
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4
المؤلفون: Patricia A. Elkins, Ren Xie, Zhihong Lai, Anthony E. Choudhry, Wenyong Wang, Sirishkumar Nidarmarthy, Dennis S. Yamashita, Elisabeth A. Minthorn, Juan I. Luengo, Hong Lin, Nestor O. Concha, Jin Zeng, Nelson Rhodes, Dirk A. Heerding, Edgar R. Wood, Susan L. Strum, Victoria B. Knick
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:673-678
مصطلحات موضوعية: Pyridines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Pyridine, Humans, Molecule, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, chemistry.chemical_classification, rho-Associated Kinases, Binding Sites, biology, Organic Chemistry, Substitution (logic), Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Selectivity, Proto-Oncogene Proteins c-akt
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5
المؤلفون: Dirk A. Heerding, Lihui Sun, Mark A. Seefeld, Shu-Yun Zhang, Jizhou Wang, Elisabeth A. Minthorn, Juan I. Luengo, Mcnulty Kenneth C, Rouse Meagan B, Dennis S. Yamashita, Nestor O. Concha
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:2244-2248
مصطلحات موضوعية: Thienopyridines, Pyridines, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, AKT2, Thiophenes, Crystallography, X-Ray, Biochemistry, Mice, Drug Discovery, medicine, Animals, Humans, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, chemistry.chemical_classification, biology, Kinase, Organic Chemistry, In vitro, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Phosphorylation, Proto-Oncogene Proteins c-akt
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6
المؤلفون: Michael S. McQueney, Roy A. Johanson, Elizabeth A. Capper-Spudich, Josephine H. Fox, Patricia L. Podolin, John J. Peterson, Robert W. Marquis, Edit Kurali, T. Gregg Davis, Dennis S. Yamashita, Stephen M. LoCastro, Gerald J. Terfloth, Brian R. Smith, Donald C. Carpenter, Edward Long, Xiaoyang Dong, Brian Bolognese
المصدر: The Journal of Immunology. 180:7989-8003
مصطلحات موضوعية: Male, Encephalomyelitis, Autoimmune, Experimental, Pyridines, Encephalomyelitis, T cell, Immunology, Cysteine Proteinase Inhibitors, Lymphocyte Activation, Mice, Antigen, Leucine, Cell Line, Tumor, MHC class I, medicine, Splenocyte, Animals, Humans, Immunology and Allergy, Collagen Type II, Cells, Cultured, Benzofurans, Mice, Knockout, biology, Chemistry, Experimental autoimmune encephalomyelitis, Histocompatibility Antigens Class II, Azepines, medicine.disease, Arthritis, Experimental, Cathepsins, Molecular biology, Raji cell, Antigens, Differentiation, B-Lymphocyte, Mice, Inbred C57BL, medicine.anatomical_structure, Mice, Inbred DBA, Cell culture, biology.protein, Cattle, Female, Protein Processing, Post-Translational, Spleen
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7
المؤلفون: Dennis S. Yamashita, Thaddeus A. Tomaszek, H.-J. Oh, M.W. Lark, S M Hwang, David J. Rickard, Ian E. James, Jae U. Jeong, Robert W. Marquis, George B. Stroup, M. Gowen, Shaji Kumar, Lauren Dare, Simon M. Blake, Daniel F. Veber, Janice A. Vasko-Moser
المصدر: Bone. 40:122-131
مصطلحات موضوعية: medicine.medical_specialty, Pathology, Histology, Physiology, Endocrinology, Diabetes and Metabolism, Cathepsin K, Osteoporosis, Administration, Oral, Osteoclasts, Collagen Type I, Bone resorption, Bone remodeling, chemistry.chemical_compound, In vivo, Internal medicine, medicine, Animals, Humans, Sulfones, Bone Resorption, Cells, Cultured, Cathepsin, Azepines, medicine.disease, Cathepsins, Disease Models, Animal, Macaca fascicularis, Endocrinology, chemistry, Ovariectomized rat, Peptides, Biomarkers, Odanacatib
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8
المؤلفون: Maxine Gowen, Catherine J. Gress, Shing Mei Hwang, Michael W. Lark, Michael S. McQueney, Ian E. James, Robert W. Marquis, Simon M. Blake, Ru Yu, Daniel F. Veber, Hye-Ja Oh, Denise Zembryki, Thaddeus A. Tomaszek, Dennis S. Yamashita
المصدر: Journal of Biological Chemistry. 276:11507-11511
مصطلحات موضوعية: Cathepsin L, Osteoclasts, Cathepsin D, Cysteine Proteinase Inhibitors, Biochemistry, Bone resorption, Cathepsin O, Osteoclast, Endopeptidases, Tumor Cells, Cultured, medicine, Cathepsin K, Humans, Bone Resorption, Molecular Biology, Cathepsin, biology, Chemistry, Cell Biology, Cathepsins, Resorption, Cysteine Endopeptidases, medicine.anatomical_structure, biology.protein
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9
المؤلفون: Dennis S. Yamashita, Christopher S. Brook, Lawrence Szewczuk, David G. Tew, Thaddeus A. Tomaszek, Xiaoyang Dong, Daniel F. Veber, Hye-Ja Oh
المصدر: Journal of Combinatorial Chemistry. 1:207-215
مصطلحات موضوعية: Models, Molecular, Ketone, Stereochemistry, Cathepsin L, Cathepsin K, Cysteine Proteinase Inhibitors, Structure-Activity Relationship, Solid-phase synthesis, Endopeptidases, Combinatorial Chemistry Techniques, Structure–activity relationship, Cathepsin, chemistry.chemical_classification, biology, General Chemistry, Cathepsins, Cysteine protease, Butanones, Cysteine Endopeptidases, Kinetics, chemistry, Drug Design, biology.protein, Cysteine
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10
المؤلفون: Ward W. Smith, Thaddeus A. Tomaszek, Cheryl A. Janson, Baoguang Zhao, Mark Alan Levy, Dennis S. Yamashita, Sherin S. Abdel-Meguid, Ru Yu, Yen Jack Hwekwo, Daniel F. Veber, Scott K. Thompson, Thomas Joseph Carr, Robert W. Marquis, Karla J. D'Alessio, Carl F. Ijames, Michael S. McQueney, Hye-Ja Oh
المصدر: Bioorganic & Medicinal Chemistry. 7:581-588
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Cathepsin L, Cathepsin K, Clinical Biochemistry, Pharmaceutical Science, Cysteine Proteinase Inhibitors, Biochemistry, Cathepsin A, Cathepsin B, Cathepsin C, Cathepsin O, Cathepsin H, Cathepsin L1, Endopeptidases, Drug Discovery, Molecular Biology, Cathepsin S, Chemistry, Organic Chemistry, Ketones, Cathepsins, Cysteine Endopeptidases, Kinetics, Models, Chemical, Molecular Medicine
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11
المؤلفون: Dennis S. Yamashita, Arthur Shu, J. Richard Heys, Dennis A. Holt
المصدر: Journal of Labelled Compounds and Radiopharmaceuticals. 38:227-237
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Cleavage (embryo), Biochemistry, Aldehyde, Chemical synthesis, Analytical Chemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Tributyltin, Radiology, Nuclear Medicine and imaging, Azide, Spectroscopy, Bond cleavage
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e7983c09718531dda0e78b91dafc4933
https://doi.org/10.1002/(sici)1099-1344(199603)38:3<227::aid-jlcr837>3.0.co;2-1 -
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المؤلفون: Martin Brandt, Andrew D. Abell, Mark Alan Levy, Dennis A. Holt, Dennis S. Yamashita, Hwa-Kwo Yen, Karl F. Erhard, Hadiza Mohammed
المصدر: Bioorganic & Medicinal Chemistry Letters. 4:1365-1368
مصطلحات موضوعية: biology, Chemistry, Stereochemistry, medicine.medical_treatment, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Reductase, Biochemistry, Isozyme, High-performance liquid chromatography, Steroid, Chiral column chromatography, Enzyme inhibitor, Drug Discovery, biology.protein, medicine, Molecular Medicine, Enantiomer, Molecular Biology, Cis–trans isomerism
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13
المؤلفون: Jeffrey K. Kerns, Widdowson Katherine L, Patricia L. Podolin, Paul M. Keller, Benoit Riflade, Neysa Nevins, Attiq Rahman, Dennis S. Yamashita, Qi Jin, Bondinell William E, Thaddeus A. Tomaszek, Xiaoyang Dong, Laura Mitchell, Hong Nie, Donald C. Carpenter
المصدر: Bioorganicmedicinal chemistry letters. 21(15)
مصطلحات موضوعية: Niacinamide, Stereochemistry, Cathepsin L, Clinical Biochemistry, Cathepsin K, Substituent, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Cathepsin O, Drug Discovery, Structure–activity relationship, Humans, Computer Simulation, Protease Inhibitors, Molecular Biology, Cathepsin S, Alanine, Binding Sites, Nicotinamide, biology, Chemistry, Organic Chemistry, Stereoisomerism, Azepines, Cathepsins, biology.protein, Molecular Medicine, Selectivity
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14
المؤلفون: Dennis A. Holt, Juan I. Luengo, Dennis S. Yamashita, Hye Ja Oh, Arda L. Konialian, Hwa Kwo Yen, Leonard W. Rozamus, Martin Brandt, Mary J. Bossard, Mark A. Levy, Drake S. Eggleston, Jun Liang, L. Wayne Schultz, Thomas J. Stout, Jon Clardy
المصدر: Journal of the American Chemical Society. 115:9925-9938
مصطلحات موضوعية: Colloid and Surface Chemistry, General Chemistry, Biochemistry, Catalysis
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15
المؤلفون: Samuel J. Danishefsky, Dennis S. Yamashita, John Haseltine, N. Iwasawa, Gayle K. Schulte, Robert Coleman, M. Paz Cabal, Nathan B. Mantlo
المصدر: ChemInform. 22
مصطلحات موضوعية: Chemistry, Organic chemistry, Total synthesis, General Medicine, Calicheamicinone
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16
المؤلفون: Vincent P. Rocco, Dennis S. Yamashita, Samuel J. Danishefsky
المصدر: Tetrahedron Letters. 32:6667-6670
مصطلحات موضوعية: biology, Bicyclic molecule, Organic Chemistry, Acetal, Biochemistry, Kinetic resolution, chemistry.chemical_compound, chemistry, Homogeneous, Drug Discovery, biology.protein, Organic chemistry, Lipase, Enone
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17
المؤلفون: Anthony E. Choudhry, Igor G. Safonov, Dirk A. Heerding, Jack D. Leber, Nelson Rhodes, Susan L. Strum, Mei Li, Michael D. Schaber, Peter J. Tummino, Derek J. Eberwein, Victoria B. Knick, Louis V. LaFrance, Robert A. Copeland, Timothy J. Lansing, Derek R. Duckett, Edgar R. Wood, Richard M. Keenan, Gregory L. Warren, Zhihong Lai, Joseph W. Venslavsky, Randy T. McConnell, Dennis S. Yamashita, Dennis T. Takata, Nestor O. Concha, Rakesh Kumar, Elisabeth A. Minthorn, Tammy J. Clark, Shu-Yun Zhang
المصدر: Journal of medicinal chemistry. 51(18)
مصطلحات موضوعية: Models, Molecular, Oxadiazoles, Magnetic Resonance Spectroscopy, biology, Kinase, Chemistry, AKT1, AKT2, Mice, SCID, Mass Spectrometry, Substrate Specificity, Mice, Biochemistry, Protein kinase domain, Enzyme inhibitor, Drug Discovery, biology.protein, Molecular Medicine, Phosphorylation, Animals, Female, Signal transduction, Protein kinase B, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt
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18
المؤلفون: Hideo Kikkawa, Toshihiko Kaise, Masahiro Kanematsu, Dennis S. Yamashita, Sanjay Kumar, Mine Kinoshita, Anbo Xiang, Satoshi Asano
المصدر: Bone. 40(5)
مصطلحات موضوعية: medicine.medical_specialty, Histology, Bone density, Physiology, Pyridines, Endocrinology, Diabetes and Metabolism, Ovariectomy, Osteoporosis, Cathepsin K, Osteoclasts, Bone resorption, Mice, Bone Density, Osteogenesis, Internal medicine, medicine, Animals, Humans, Protease Inhibitors, Bone Resorption, Rolipram, Cells, Cultured, Cathepsin, Mice, Inbred BALB C, Molecular Structure, Chemistry, medicine.disease, Cathepsins, medicine.anatomical_structure, Endocrinology, Ovariectomized rat, Cortical bone, Female, Tomography, X-Ray Computed, medicine.drug
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19
المؤلفون: Michael W. Lark, Ted Tomaszek, Kevin L. Salyers, David G. Tew, Chao-Pin Lee, Michael S. McQueney, George B. Stroup, Ian E. James, Antonia Marzulli, Hye-Ja Oh, Mark Alan Levy, Dennis S. Yamashita, Maxine Gowen, Brian R. Smith, Daniel F. Veber, Phil Smith
المصدر: Peptides for the New Millennium ISBN: 0792364457
مصطلحات موضوعية: medicine.anatomical_structure, Cathepsin O, Osteoclast, Preclinical pharmacokinetics, medicine, Cathepsin K, Theology, Cysteine protease, SmithKline Beecham, Active site cysteine
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20
المؤلفون: Jae U. Jeong, Keith W. Ward, Enoch Gao, Dennis S. Yamashita, Bing Wang, § H-Y. Cheng, Baoguang Zhao, Martha S. Head, Amy A. Sarjeant, § Louise M. Liable-Sands, Ian E. James, Neysa Nevins, Ren Xie, and Michael W. Lark, Karl F. Erhard, Denise Zembryki, Daniel F. Veber, Theresa J. Roethke, Robert W. Marquis, Brian R. Smith, Xiaoliu Geng, Michael S. McQueney, R. Curtis Haltiwanger, Ward W. Smith, Sirishkumar D. Nidamarthy, Catherine J. Gress, Priscilla H. Offen, Hye-Ja Oh, Cheryl A. Janson, Thaddeus A. Tomaszek, Fan Lin
المصدر: Journal of medicinal chemistry. 49(5)
مصطلحات موضوعية: Cell Membrane Permeability, Stereochemistry, medicine.drug_class, Cathepsin K, Molecular Conformation, Biological Availability, Carboxamide, Crystallography, X-Ray, Chemical synthesis, Cell Line, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Humans, Sulfones, chemistry.chemical_classification, biology, Bone Density Conservation Agents, Stereoisomerism, Azepines, Blood Proteins, Haplorhini, Cathepsins, In vitro, Bioavailability, Rats, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Protein Binding