المؤلفون: Marius Schulte, Klaudia Frick, Emmanuel Gnandt, Sascha Jurkovic, Sabrina Burschel, Ramona Labatzke, Karoline Aierstock, Dennis Fiegen, Daniel Wohlwend, Stefan Gerhardt, Oliver Einsle, Thorsten Friedrich

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/cbb18c1443da4b2783df8204ef6ed1bb

المؤلفون: Herbert Nar, James Hamilton, Florian Binder, Dennis Fiegen, Sven Thamm, Markus Zeeb, James C. King, Margit Bauer, Martin Rübbelke

المصدر: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: Models, Molecular, Programmed cell death, Magnetic Resonance Spectroscopy, Necroptosis, Mutant, Xanthine, drug discovery, X-ray, Inhibitory Concentration 50, Jurkat Cells, RIPK1, Protein Domains, Humans, Protein Kinase Inhibitors, Multidisciplinary, Chemistry, Effector, Kinase, Drug discovery, Correction, U937 Cells, Biological Sciences, NMR, Biophysics and Computational Biology, Helix, Biophysics, Protein Multimerization, Protein Kinases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b458cb61cb262abaac9298bd16d5bc
https://doi.org/10.1073/pnas.2017406117

المؤلفون: Dennis Fiegen, Ralf Heilker, Herbert Nar, Iain Lingard, Klaus Klinder, Michael Wolff, Heike Neubauer, Jürgen Prestle, Francois Debaene, Gisela Schnapp, Frank H. Büttner, Sandra Handschuh, Markus Zeeb, Rainer Walter

المصدر: Communications Chemistry, Vol 3, Iss 1, Pp 1-11 (2020)

مصطلحات موضوعية: 0301 basic medicine, musculoskeletal diseases, endocrine system diseases, Biochemistry, lcsh:Chemistry, 03 medical and health sciences, 0302 clinical medicine, Tetramer, Materials Chemistry, medicine, Environmental Chemistry, Endothelial dysfunction, Mode of action, Receptor, biology, integumentary system, Chemistry, Lectin, Cancer, food and beverages, General Chemistry, medicine.disease, Small molecule, Cell biology, 030104 developmental biology, lcsh:QD1-999, 030220 oncology & carcinogenesis, LDL receptor, biology.protein, lipids (amino acids, peptides, and proteins)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b344f0961aac5179823a3b09346eeb
http://link.springer.com/article/10.1038/s42004-020-0321-2

المؤلفون: Dennis Fiegen, Herbert Nar, Christian Eickmeier, Markus Zeeb, Sebastian W Draxler, Daniel Seeliger, Daniel Rangel Rojas, Margit Bauer, Simon Nadal

المصدر: Journal of Medicinal Chemistry. 63:5856-5864

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Molecular Dynamics Simulation, Crystallography, X-Ray, Ligands, 01 natural sciences, Small Molecule Libraries, Tacrolimus Binding Proteins, 03 medical and health sciences, Protein Domains, Drug Discovery, Humans, 030304 developmental biology, 0303 health sciences, Binding Sites, Drug discovery, Chemistry, X-ray, Ligand (biochemistry), Affinities, Combinatorial chemistry, Chemical space, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Pharmacophore, Heteronuclear single quantum coherence spectroscopy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d62b91ddc2050e1c966366e407e38d0
https://doi.org/10.1021/acs.jmedchem.0c00120

المؤلفون: Gisela Schnapp, Wolfgang Reindl, Carola Kleiner, Andreas H. Luippold, Robert Ries, Daniel Bischoff, Dennis Fiegen, Markus Zeeb, Martin Winter, Roman P. Simon, Michael Karnath, Tim T. Häbe, Frank Runge, Tom Bretschneider, Lucie Wehrle, Frank H. Büttner

المصدر: SLAS discovery : advancing life sciences RD. 26(1)

مصطلحات موضوعية: Automation, Laboratory, 010405 organic chemistry, Drug discovery, Chemistry, High-throughput screening, Ligand binding assay, Proteins, Computational biology, Mass spectrometry, Ligands, 01 natural sciences, Biochemistry, 0104 chemical sciences, Analytical Chemistry, High-Throughput Screening Assays, 010404 medicinal & biomolecular chemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Drug Discovery, Molecular targets, Molecular Medicine, Humans, Throughput (business), Selection (genetic algorithm), Biotechnology, Protein ligand

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4814bfaa4c4e9d7db2bb4094aafa17
https://pubmed.ncbi.nlm.nih.gov/33073664

المؤلفون: Florian Montel, Gisela Schnapp, Ralf Heilker, Supriyo Bhattacharya, Christofer S. Tautermann, Scott Hobson, Sven Thamm, Christian Eickmeier, Dennis Fiegen, Frank H. Büttner, Ulrike Gross, Nagarajan Vaidehi, Stefan Hoerer, Volker Mack, Marc Grundl, Markus Zeeb, Stefan Peters, Andreas H. Luippold, Florian Binder

المصدر: Journal of medicinal chemistry. 62(1)

مصطلحات موضوعية: Phosphatase, Allosteric regulation, PTPN5, Protein tyrosine phosphatase, AMPA receptor, Plasma protein binding, Molecular Dynamics Simulation, Crystallography, X-Ray, 01 natural sciences, Small Molecule Libraries, 03 medical and health sciences, Mice, Allosteric Regulation, Catalytic Domain, Drug Discovery, Animals, Humans, Protein Isoforms, Enzyme Inhibitors, Nuclear Magnetic Resonance, Biomolecular, 030304 developmental biology, 0303 health sciences, Chemistry, Drug discovery, Protein Tyrosine Phosphatases, Non-Receptor, Small molecule, 0104 chemical sciences, Cell biology, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Allosteric Site, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9ae75015aa01170c721b74c0bcca15
https://pubmed.ncbi.nlm.nih.gov/30207464

المؤلفون: Radovan Dvorsky, Sicai Zhang, Eyad K. Fansa, Dennis Fiegen, Mohammad Reza Ahmadian

المصدر: Biochemical and Biophysical Research Communications. 434:785-790

مصطلحات موضوعية: Models, Molecular, rac1 GTP-Binding Protein, rho GTP-Binding Proteins, RHOA, In silico, Molecular Sequence Data, Biophysics, Rac3, Nerve Tissue Proteins, Receptors, Cell Surface, RAC1, CDC42, Biology, Binding, Competitive, Biochemistry, Humans, Amino Acid Sequence, Molecular Biology, Binding Sites, Sequence Homology, Amino Acid, Rnd3, Cell Biology, Protein Structure, Tertiary, Cell biology, Kinetics, Mutation, biology.protein, RhoG, Protein Binding, Binding domain

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d98ccb79ceb567232095fa9e86c2bc9
https://doi.org/10.1016/j.bbrc.2013.04.012

المؤلفون: Herbert Nar, Alexander Pautsch, Dirk Reinert, Dennis Fiegen, Stefan Hörer

مصطلحات موضوعية: Crystallography, Engineering, ComputingMethodologies_PATTERNRECOGNITION, Lead (geology), Process (engineering), Drug discovery, business.industry, Key (cryptography), Project management, business, Throughput (business)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b1ffafe5ab7fe095186947f6c4e23cb9
https://doi.org/10.1016/b978-0-12-409547-2.12317-0

المؤلفون: Mohammad Reza Ahmadian, Dennis Fiegen, Radovan Dvorsky, Lars Hemsath, Marie-France Carlier

المصدر: Molecular Cell. 20(2):313-324

مصطلحات موضوعية: rho GTP-Binding Proteins, Time Factors, Wiskott–Aldrich syndrome, Protein Conformation, DNA Mutational Analysis, Molecular Sequence Data, Static Electricity, Sequence alignment, macromolecular substances, CDC42, Biology, medicine.disease_cause, Protein structure, medicine, Humans, Amino Acid Sequence, cdc42 GTP-Binding Protein, Peptide sequence, Molecular Biology, Actin, Mutation, fungi, Cell Biology, medicine.disease, Cell biology, Protein Structure, Tertiary, Biochemistry, Sequence Alignment, Wiskott-Aldrich Syndrome Protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131ffac25fe946779d3d9511d6cb77bc

المؤلفون: Ingrid R. Vetter, Radovan Dvorsky, Lars Blumenstein, Ulrike Herbrand, Mohammad Reza Ahmadian, Lars Christian Haeusler, Dennis Fiegen

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Models, Molecular, rac1 GTP-Binding Protein, GTP', Protein Conformation, GTPase, In Vitro Techniques, Biology, Guanosine triphosphate, Crystallography, X-Ray, Biochemistry, DNA-binding protein, chemistry.chemical_compound, Protein structure, Humans, Binding site, Molecular Biology, Binding Sites, Effector, Hydrolysis, Alternative splicing, Cell Biology, Recombinant Proteins, Cell biology, DNA-Binding Proteins, Enzyme Activation, Alternative Splicing, Kinetics, chemistry, Guanosine Triphosphate, Transcription Factors

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f52f57f23fa03d27b05b8a7beb1210
https://doi.org/10.1074/jbc.m310281200

المؤلفون: Ingrid R. Vetter, Patricia Stege, Mohammad Reza Ahmadian, Lars Blumenstein, Dennis Fiegen

المصدر: FEBS Letters. 525:100-104

مصطلحات موضوعية: chemistry.chemical_classification, Subfamily, RHOA, biology, Rnd3, Effector, Biophysics, Cell Biology, GTPase, Crystal structure, Biochemistry, Amino acid, Cell biology, chemistry, Structural Biology, Genetics, biology.protein, Binding site, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8683557c8f381914281633a23fdfcb75
https://doi.org/10.1016/s0014-5793(02)03094-6

المؤلفون: Jeffrey A. Cole, David J. Richardson, T. H. C. Brondijk, Dennis Fiegen

المصدر: Molecular Microbiology. 44:245-255

مصطلحات موضوعية: Ubiquinol, Cytochrome, Catalytic complex, Dehydrogenase, macromolecular substances, Periplasmic space, Biology, Nitrate reductase, Microbiology, Q cycle, Electron transfer, chemistry.chemical_compound, chemistry, Biochemistry, biology.protein, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::45e407c50fcc479147f40aa68f1b0435
https://doi.org/10.1046/j.1365-2958.2002.02875.x

المؤلفون: Stefan Gerhardt, Thorsten Friedrich, Klaudia Frick, Sascha Jurkovic, Oliver Einsle, Marius Schulte, Karoline Aierstock, Ramona Labatzke, Dennis Fiegen

المصدر: Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1857:e39

مصطلحات موضوعية: Chemistry, Respiratory Complex I, Biophysics, Cell Biology, Biochemistry, Redox

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::94cf4b6b5ba22cdbe6678f9915c4f662
https://doi.org/10.1016/j.bbabio.2016.04.118

المؤلفون: Lars Christian, Haeusler, Lars, Hemsath, Dennis, Fiegen, Lars, Blumenstein, Ulrike, Herbrand, Patricia, Stege, Radovan, Dvorsky, Mohammad Reza, Ahmadian

المصدر: Methods in enzymology. 406

مصطلحات موضوعية: rac1 GTP-Binding Protein, Kinetics, Spectrometry, Fluorescence, Hydrolysis, Guanine Nucleotide Exchange Factors, ortho-Aminobenzoates, Guanosine Diphosphate, GTP Phosphohydrolases, rac GTP-Binding Proteins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::bdc1da8f07bb16c1c39e8b1be7c75328
https://pubmed.ncbi.nlm.nih.gov/16472645

المؤلفون: Mohammad Reza Ahmadian, Lars Blumenstein, Radovan Dvorsky, Lars Christian Haeusler, Patricia Stege, Lars Hemsath, Ulrike Herbrand, Dennis Fiegen

مصطلحات موضوعية: Rac GTP-Binding Proteins, chemistry.chemical_classification, Molecular switch, GTP-binding protein regulators, chemistry, Biochemistry, Alternative splicing, Rac3, Nucleotide, GTPase, Ras superfamily, Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::56233096961074baba3ea32908fcea9f
https://doi.org/10.1016/s0076-6879(06)06001-0

المؤلفون: Dennis Fiegen, Mohammad Reza Ahmadian, Radovan Dvorsky

المصدر: RAS Family GTPases ISBN: 9781402043284

مصطلحات موضوعية: Molecular switch, G-domain, Chemistry, Effector, Component (UML), Biophysics, GTPase, Signal transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e519ebe4910b8e0f2357575ed706f960
https://doi.org/10.1007/1-4020-4708-8_3

المؤلفون: Marie-France Carlier, Radovan Dvorsky, Lars Hemsath, Mohammad Reza Ahmadian, Dennis Fiegen

المصدر: GBM Annual Fall meeting Berlin/Potsdam 2005. 2005

مصطلحات موضوعية: Physics, Chemical physics, CDC42, Mechanism (sociology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a94f6621d432624cd88e169261eefce5
https://doi.org/10.1240/sav_gbm_2005_h_001191

المؤلفون: B. Hengerer, Karoline Aierstock, Thorsten Friedrich, Lothar Kussmaul, Dennis Fiegen, Klaudia Morina

المصدر: Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1817:S49-S50

مصطلحات موضوعية: chemistry.chemical_classification, Reactive oxygen species, NADH-Ubiquinone Oxidoreductase, Biochemistry, NADH binding, Chemistry, Biophysics, Cell Biology, Site-directed mutagenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27ff767b38cb217b566d23120e8ecae
https://doi.org/10.1016/j.bbabio.2012.06.141

المؤلفون: Dennis, Fiegen, Lars, Blumenstein, Patricia, Stege, Ingrid R, Vetter, Mohammad Reza, Ahmadian

المصدر: FEBS letters. 525(1-3)

مصطلحات موضوعية: ADP Ribose Transferases, Models, Molecular, rho GTP-Binding Proteins, Binding Sites, Botulinum Toxins, Sequence Homology, Amino Acid, GTPase-Activating Proteins, Molecular Sequence Data, Crystallography, X-Ray, Protein Structure, Tertiary, Structure-Activity Relationship, Guanine Nucleotide Exchange Factors, Humans, rho-Specific Guanine Nucleotide Dissociation Inhibitors, Guanosine Triphosphate, Rho Guanine Nucleotide Exchange Factors, Guanine Nucleotide Dissociation Inhibitors, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::f6b584ce6191a07e147a547c0fdda346
https://pubmed.ncbi.nlm.nih.gov/12163169

المؤلفون: Lars Hemsath, Radovan Dvorsky, Dennis Fiegen, Marie-france Carlier, Reza Ahmadian

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://download.cell.com/molecular-cell/mmcs/journals/1097-2765/piis1097276505016023.mmc1.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.499.1491; http://download.cell.com/molecular-cell/mmcs/journals/1097-2765/piis1097276505016023.mmc1.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.499.1491
http://download.cell.com/molecular-cell/mmcs/journals/1097-2765/piis1097276505016023.mmc1.pdf