نتائج البحث - "Dempsey, Graham"

1

Report

Penalized matrix decomposition for denoising, compression, and improved demixing of functional imaging data

مصطلحات موضوعية: Quantitative Biology - Neurons and Cognition, Statistics - Machine Learning

URL الوصول: http://arxiv.org/abs/1807.06203

View record in Arxiv

2

Academic Journal

Developing antisense oligonucleotides for a mutation-induced, ultra-rare neurological disorder using patient-derived cellular models

المساهمون: Medicine

المصدر: Molecular therapy. Nucleic acids ; 29 ; 189 ; 203 ; United States

مصطلحات موضوعية: CNS disorder, HSAN9, Oligonucleotides: Therapies and Applications, SPG49, TECPR2, antisense oligonucleotide, human induced pluripotent stem cells

Relation: Molecular Therapy Nucleic Acids; https://doi.org/10.1016/j.omtn.2022.06.015; Williams LA, Gerber DJ, Elder A, Tseng WC, Baru V, Delaney-Busch N, Ambrosi C, Mahimkar G, Joshi V, Shah H, Harikrishnan K, Upadhyay H, Rajendran SH, Dhandapani A, Meier J, Ryan SJ, Lewarch C, Black L, Douville J, Cinquino S, Legakis H, Nalbach K, Behrends C, Sato A, Galluzzi L, Yu TW, Brown D, Agrawal S, Margulies D, Kopin A, Dempsey GT. Developing antisense oligonucleotides for a TECPR2 mutation-induced, ultra-rare neurological disorder using patient-derived cellular models. Mol Ther Nucleic Acids. 2022 Jun 22;29:189-203. doi:10.1016/j.omtn.2022.06.015. PMID: 35860385; PMCID: PMC9287140.; http://hdl.handle.net/20.500.14038/52704; Molecular therapy. Nucleic acids

الاتاحة: https://doi.org/10.1016/j.omtn.2022.06.015
https://hdl.handle.net/20.500.14038/52704

View record in BASE

Full Text Finder

3

Academic Journal

Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls

المؤلفون: Simkin, Dina, Papakis, Vasileios, Bustos, Bernabe I, Ambrosi, Christina M, Ryan, Steven J, Baru, Valeriya, Williams, Luis A, Dempsey, Graham T, McManus, Owen B, Landers, John E, Lubbe, Steven J, George, Alfred L, Kiskinis, Evangelos

المساهمون: Neurology

المصدر: Stem cell reports ; 17 ; 4 ; 993 ; 1008 ; United States

مصطلحات موضوعية: CRISPR/Cas9, KCNQ2, WGS, disease modeling, genome editing, iPSCs, isogenic control lines, mtDNA, on-target insertions/deletions

Relation: Stem Cell Reports; https://doi.org/10.1016/j.stemcr.2022.02.008; Simkin D, Papakis V, Bustos BI, Ambrosi CM, Ryan SJ, Baru V, Williams LA, Dempsey GT, McManus OB, Landers JE, Lubbe SJ, George AL Jr, Kiskinis E. Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls. Stem Cell Reports. 2022 Apr 12;17(4):993-1008. doi:10.1016/j.stemcr.2022.02.008. Epub 2022 Mar 10. PMID: 35276091; PMCID: PMC9023783.; http://hdl.handle.net/20.500.14038/52437

الاتاحة: https://doi.org/10.1016/j.stemcr.2022.02.008
https://hdl.handle.net/20.500.14038/52437

View record in BASE

Full Text Finder

4

Dissertation/ Thesis

Photoswitchable Fluorescent Probes for Localization-Based Super-Resolution Imaging

المؤلفون: Dempsey, Graham Thomas

Thesis Advisors: Zhuang, Xiaowei

مصطلحات موضوعية: Cy5, fluorescence, imaging, photoswitchable, STORM, super-resolution, biophysics

الاتاحة: http://dissertations.umi.com/gsas.harvard:10376
http://nrs.harvard.edu/urn-3:HUL.InstRepos:10330307

View record in Networked Digital Library of Theses & Dissertations

5

Academic Journal

Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-Associated Excitable Cells

المؤلفون: Borja, Gabriel B., Zhang, Hongkang, Harwood, Benjamin N., Jacques, Jane, Grooms, Jennifer, Chantre, Romina O., Zhang, Dawei, Barnett, Adam, Werley, Christopher A., Lu, Yang, Nagle, Steven F., McManus, Owen B., Dempsey, Graham T.

المساهمون: National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke

المصدر: Frontiers in Molecular Neuroscience ; volume 15 ; ISSN 1662-5099

الاتاحة: http://dx.doi.org/10.3389/fnmol.2022.896320
https://www.frontiersin.org/articles/10.3389/fnmol.2022.896320/full

View record in BASE

6

Academic Journal

‘Channeling’ therapeutic discovery for epileptic encephalopathy through iPSC technologies

المؤلفون: Simkin, Dina, Ambrosi, Christina, Marshall, Kelly A., Williams, Luis A., Eisenberg, Jordyn, Gharib, Mennat, Dempsey, Graham T., George, Alfred L., McManus, Owen B., Kiskinis, Evangelos

المصدر: Trends in Pharmacological Sciences ; volume 43, issue 5, page 392-405 ; ISSN 0165-6147

الاتاحة: http://dx.doi.org/10.1016/j.tips.2022.03.001
https://api.elsevier.com/content/article/PII:S0165614722000517?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0165614722000517?httpAccept=text/plain

View record in BASE

7

Academic Journal

Photoswitching Mechanism of Cyanine Dyes

المؤلفون: Dempsey, Graham T, Bates, Mark, Kowtoniuk, Walter E, Liu, David R, Tsien, Roger Y, Zhuang, Xiaowei

المصدر: Journal of the American Chemical Society. 131(51)

مصطلحات موضوعية: Chemical Sciences, Physical Chemistry, Binding Sites, Carbocyanines, Electrons, Fluorescent Dyes, Hydrogen-Ion Concentration, Kinetics, Light, Mass Spectrometry, Photochemical Processes, Sulfhydryl Compounds, General Chemistry, Chemical sciences, Engineering

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4mg602p5

View record in eScholarship

8

Academic Journal

Correlation of Optical and Automated Patch Clamp Electrophysiology for Identification of NaV1.7 Inhibitors

المؤلفون: Zhang, Hongkang, Moyer, Bryan D., Yu, Violeta, McGivern, Joseph G., Jarosh, Michael, Werley, Christopher A., Hecht, Vivian C., Babcock, Ryan J., Dong, Kevin, Dempsey, Graham T., McManus, Owen B., Hempel, Chris M.

المساهمون: XXXXX

المصدر: SLAS Discovery ; volume 25, issue 5, page 434-446 ; ISSN 2472-5552

الاتاحة: http://dx.doi.org/10.1177/2472555220914532
http://journals.sagepub.com/doi/pdf/10.1177/2472555220914532
http://journals.sagepub.com/doi/full-xml/10.1177/2472555220914532
https://api.elsevier.com/content/article/PII:S2472555222065674?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2472555222065674?httpAccept=text/plain

View record in BASE

9

Academic Journal

An All-Optical Electrophysiology Screening Platform to Identify Nav Channel Modulators as Pain Therapeutics

المؤلفون: Zhang, Hongkang, Werley, Kit, Liu, Pin, Borja, Gabriel, Nagle, Steven, Dempsey, Graham, McManus, Owen

المصدر: Biophysical Journal ; volume 118, issue 3, page 325a ; ISSN 0006-3495

الاتاحة: http://dx.doi.org/10.1016/j.bpj.2019.11.1824
https://api.elsevier.com/content/article/PII:S0006349519327572?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0006349519327572?httpAccept=text/plain

View record in BASE

10

Academic Journal

Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms

المؤلفون: Pfeiffer-Kaushik, Emily R., Smith, Godfrey L., Cai, Beibei, Dempsey, Graham T., Hortigon-Vinagre, Maria P., Zamora, Victor, Feng, Shuyun, Ingermanson, Randall, Zhu, Renjun, Hariharan, Venkatesh, Nguyen, Cuong, Pierson, Jennifer, Gintant, Gary A., Tung, Leslie

وصف الملف: text

Relation: https://eprints.gla.ac.uk/190512/7/190512.pdf; Pfeiffer-Kaushik, E. R. et al. (2019) Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms. Journal of Pharmacological and Toxicological Methods , 99, 106612. (doi:10.1016/j.vascn.2019.106612 ) (PMID:31319140)

الاتاحة: https://eprints.gla.ac.uk/190512/
https://eprints.gla.ac.uk/190512/7/190512.pdf

View record in BASE