المؤلفون: Debra J. Wallace (1789080), Thomas Storz (2145397), Anna Balanov (11428238), William S. Kissel (2717260)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Immunology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, triazole formation reaction, thereby accelerating advancement, pot negishi coupling, novel triazole formation, noncentral nervous system, enter clinical trials, early clinical studies, penetrant sgc stimulator, increase nitric oxide, synthesis features, studied clinically, small molecules, scalable synthesis, safety considerations, rapid generation, protected amidrazone, positively impact, neurodegenerative diseases, mechanistic study, larger quantities, cyanation sequence

Relation: https://figshare.com/articles/journal_contribution/Accelerated_Development_of_a_Scalable_Synthesis_of_CY6463_a_CNS-Penetrant_sGC_Stimulator_for_the_Treatment_of_Neurodegenerative_Diseases/16614005

الاتاحة: https://doi.org/10.1021/acs.oprd.1c00204.s001

المؤلفون: Jungchul Kim (1470538), Tetsuji Itoh (1633045), Feng Xu (89016), Zachary E. X. Dance (9188932), Jacob H. Waldman (1843948), Debra J. Wallace (1789080), Feiyue Wu (2960940), Roman Kats-Kagan (1617472), Anil R. Ekkati (2316268), Andrew P. J. Brunskill (8727768), Feng Peng (400899), Patrick S. Fier (1333728), Jennifer V. Obligacion (1419949), Benjamin D. Sherry (1633036), Zhijian Liu (41544), Khateeta M. Emerson (1857049), Adam J. Fine (11262072), Anna V. Jenks (11525065), Marco Euclide Armenante (11525068)

مصطلحات موضوعية: Biophysics, Biochemistry, Developmental Biology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, robust manufacturing process, practical manufacturing process, optimal manufacturing process, oligomer impurities formed, benzyl urea intermediate, 9 , 11 , sulfate intermediate, oligomeric impurities, thoroughly studied, successfully implemented, potent β, lactamase inhibitor, detectable level

Relation: https://figshare.com/articles/journal_contribution/Development_of_a_Practical_Manufacturing_Process_to_Relebactam_via_Thorough_Understanding_of_the_Origin_and_Control_of_Oligomeric_Impurities/16613919

الاتاحة: https://doi.org/10.1021/acs.oprd.1c00149.s001