المؤلفون: Arundhathi Venkatasubramaniam, Grant Liao, Eunice Cho, Rajan P. Adhikari, Tom Kort, Frederick W. Holtsberg, Karen E. Elsass, Dean J. Kobs, Thomas L. Rudge, Keith D. Kauffman, Nickiana E. Lora, Daniel L. Barber, M. Javad Aman, Hatice Karauzum

المصدر: Frontiers in Immunology, Vol 12 (2021)

مصطلحات موضوعية: safety, immunogenicity, multi-component, toxoid, staphylococcal, neutralizing antibodies, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.621754/full; https://doaj.org/toc/1664-3224

URL الوصول: https://doaj.org/article/c83a2f964899456781ac389d4bee43fb

المؤلفون: John C. Trefry, Suzanne E. Wollen, Farooq Nasar, Joshua D. Shamblin, Steven J. Kern, Jeremy J. Bearss, Michelle A. Jefferson, Taylor B. Chance, Jeffery R. Kugelman, Jason T. Ladner, Anna N. Honko, Dean J. Kobs, Morgan Q.S. Wending, Carol L. Sabourin, William D. Pratt, Gustavo F. Palacios, M. Louise M. Pitt

المصدر: Viruses, Vol 7, Iss 12, Pp 6739-6754 (2015)

مصطلحات موضوعية: Ebola virus, Kikwit, filovirus, nonhuman primate, glycoprotein, RNA editing, pathogenesis, animal model, vaccine, therapeutic, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1999-4915/7/12/2969; https://doaj.org/toc/1999-4915

URL الوصول: https://doaj.org/article/d9b9d59060924f9582b8a27951f2ee10

المؤلفون: Milan T. Tomic, Yero Espinoza, Zachary Martinez, Khanh Pham, Ronald R. Cobb, Doris M. Snow, Christopher G. Earnhart, Traci Pals, Emily S. Syar, Nancy Niemuth, Dean J. Kobs, Shauna Farr-Jones, James D. Marks

المصدر: Toxins, Vol 11, Iss 4, p 208 (2019)

مصطلحات موضوعية: botulinum neurotoxin, aerosol, monoclonal antibody, guinea pig inhalation model, oligoclonal antibody, inhalational botulism, botulism, Medicine

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2072-6651/11/4/208; https://doaj.org/toc/2072-6651

URL الوصول: https://doaj.org/article/b04e358af4e84978943d1cb454d2f44b

المؤلفون: Milan T. Tomic, Ronald R. Cobb, Doris M Snow, Zacchary Martinez, Emily S Syar, Yero Espinoza, Dean J. Kobs, Michael J Hackett, James D. Marks, Shauna Farr-Jones, Nancy A. Niemuth, Khanh Pham

المصدر: Toxins
Volume 13
Issue 9
Toxins, Vol 13, Iss 671, p 671 (2021)
Toxins, vol 13, iss 9

مصطلحات موضوعية: Botulinum Toxins, aerosol, Health, Toxicology and Mutagenesis, Pharmacology, Toxicology, Neutralization, Mice, Monoclonal, Clostridium botulinum, Botulism, neutralizing antibody concentration, guinea pig inhalation model, neutralizing antibody concentration (NAC), Neutralizing antibody, Neutralizing, biology, botulinum neurotoxin, Antibodies, Monoclonal, Pharmacology and Pharmaceutical Sciences, Foodborne Illness, Drug Combinations, Infectious Diseases, Medicine, monoclonal antibody (mAb), Antibody, Biotechnology, medicine.drug_class, Guinea Pigs, Monoclonal antibody, Serogroup, Antibodies, Article, Guinea pig, Vaccine Related, Rare Diseases, Intensive care, Biodefense, medicine, Potency, Animals, botulism, mouse neutralization assay (MNA), Animal, business.industry, Prevention, medicine.disease, Antibodies, Neutralizing, mouse neutralization assay, Disease Models, Animal, Emerging Infectious Diseases, Orphan Drug, monoclonal antibody, Disease Models, biology.protein, Immunization, oligoclonal antibody, Biochemistry and Cell Biology, Antitoxins, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffedccb448288b2b24afb5db864d669e
http://europepmc.org/articles/PMC8471557

المؤلفون: Rajan P. Adhikari, Dean J. Kobs, Hatice Karauzum, Daniel L. Barber, Eunice Cho, M. Javad Aman, Tom Kort, Grant C. Liao, Keith D. Kauffman, Arundhathi Venkatasubramaniam, Frederick W. Holtsberg, Nickiana E. Lora, Karen E. Elsass, Thomas L. Rudge

المصدر: Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Methicillin-Resistant Staphylococcus aureus, 0301 basic medicine, safety, lcsh:Immunologic diseases. Allergy, Staphylococcal Toxoid, multi-component, 030106 microbiology, Immunology, immunogenicity, toxoid, Immunity, Heterologous, Lymphocyte Activation, medicine.disease_cause, staphylococcal, 03 medical and health sciences, Immunogenicity, Vaccine, Immune system, Antigen, CD4 T cells response, Superantigen, medicine, Animals, Immunology and Allergy, neutralizing antibodies, Original Research, Superantigens, biology, business.industry, Immunogenicity, Vaccination, Toxoid, Staphylococcal Vaccines, Staphylococcal Infections, Antibodies, Bacterial, Macaca mulatta, 030104 developmental biology, Antibody Formation, biology.protein, Antibody, business, lcsh:RC581-607, Broadly Neutralizing Antibodies, Exotoxin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ab23610f6fad2cc2c0acff751e7989
https://www.frontiersin.org/articles/10.3389/fimmu.2021.621754/full

المؤلفون: Juan Daniel Martínez, Nancy A. Niemuth, Emily S Syar, Shauna Farr-Jones, Roy E. Barnewall, Milan T. Tomic, Ronald R. Cobb, Doris M Snow, Dean J. Kobs, Isaac Finger-Baker, Sara J Terpening, James D. Marks, Laura J. Collins

المصدر: Toxins
Toxins, vol 13, iss 1
Toxins, Vol 13, Iss 31, p 31 (2021)
Volume 13
Issue 1

مصطلحات موضوعية: Serotype, Male, Botulinum Toxins, aerosol, Health, Toxicology and Mutagenesis, lcsh:Medicine, Pharmacology, Toxicology, Monoclonal, Medicine, Botulism, guinea pig inhalation model, Neutralizing, 0303 health sciences, biology, Antibodies, Monoclonal, botulinum neurotoxin, Pharmacology and Pharmaceutical Sciences, Foodborne Illness, Botulinum toxin, Drug Combinations, Infectious Diseases, Antitoxin, Antibody, Drug, medicine.drug, Biotechnology, medicine.drug_class, Guinea Pigs, Monoclonal antibody, Serogroup, Antibodies, Article, Guinea pig, Dose-Response Relationship, Vaccine Related, Lethal Dose 50, 03 medical and health sciences, Rare Diseases, Intensive care, Biodefense, Animals, Humans, 030304 developmental biology, Dose-Response Relationship, Drug, botulism, 030306 microbiology, business.industry, Animal, Prevention, lcsh:R, medicine.disease, Antibodies, Neutralizing, Disease Models, Animal, Emerging Infectious Diseases, monoclonal antibody, Immunoglobulin G, Disease Models, biology.protein, Immunization, oligoclonal antibody, Biochemistry and Cell Biology, Antitoxins, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd35116ff386f67a9b956136b6e08dcd
https://pubmed.ncbi.nlm.nih.gov/33466411

المؤلفون: Arundhathi Venkatasubramaniam (10192322), Grant Liao (4222036), Eunice Cho (6718562), Rajan P. Adhikari (10192325), Tom Kort (10192328), Frederick W. Holtsberg (7832168), Karen E. Elsass (10192331), Dean J. Kobs (10192334), Thomas L. Rudge (10192337), Keith D. Kauffman (10192340), Nickiana E. Lora (10192343), Daniel L. Barber (10192346), M. Javad Aman (173444), Hatice Karauzum (320222)

مصطلحات موضوعية: Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, safety, immunogenicity, multi-component, toxoid, staphylococcal, neutralizing antibodies, CD4 T cells response

Relation: https://figshare.com/articles/dataset/DataSheet_1_Safety_and_Immunogenicity_of_a_4-Component_Toxoid-Based_Staphylococcus_aureus_Vaccine_in_Rhesus_Macaques_pdf/14111744

الاتاحة: https://doi.org/10.3389/fimmu.2021.621754.s001

المؤلفون: Krystle N. Agans, Michael A. Egan, Theresa E. Latham, Ayuko Ota-Setlik, Amanda Burnaugh, Thomas L. Rudge, Chad E. Mire, Carol L. K. Sabourin, Morgan Q. S. Wendling, Rong Xu, David K. Clarke, Joan B. Geisbert, John H. Eldridge, Dean J. Kobs, Thomas W. Geisbert, Demetrius Matassov

المصدر: Journal of virology. 92(3)

مصطلحات موضوعية: 0301 basic medicine, Zaire ebolavirus, Immunology, Sudan ebolavirus, medicine.disease_cause, Antibodies, Viral, Vaccines, Attenuated, Microbiology, Injections, Intramuscular, 03 medical and health sciences, Mice, Viral Proteins, Virology, Vaccines and Antiviral Agents, medicine, Animals, Marburg Virus Disease, Glycoproteins, Ebolavirus, Vaccines, Synthetic, Ebola virus, biology, Vaccination, Viral Vaccines, Vesiculovirus, Hemorrhagic Fever, Ebola, Marburgvirus, biology.organism_classification, Macaca fascicularis, 030104 developmental biology, Marburg marburgvirus, Vesicular stomatitis virus, architecture, Insect Science, Immunoglobulin G, architecture.house

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b781e4a9318398b55cb1b9b93792ffe7
https://pubmed.ncbi.nlm.nih.gov/29142131

المؤلفون: Jerry D. Johnson, S. Peter Hong, Merrill R. Osheroff, Dean J. Kobs, Seth Gibbs, Brian L. Burback

المصدر: International Journal of Toxicology. 32:30S-37S

مصطلحات موضوعية: Male, Pralidoxime, Antidotes, Cmax, Pharmacology, Toxicology, Beagle, Rats, Sprague-Dawley, Dogs, Pharmacokinetics, Oximes, medicine, Animals, New zealand white, Nerve agent, Molecular Structure, business.industry, PK Parameters, Rats, Area Under Curve, Injections, Intravenous, Toxicity, Female, Rabbits, business, Half-Life, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77347e7b9a10b93a550f31ddd616f914
https://doi.org/10.1177/1091581813488954

المؤلفون: S. Peter Hong, Dean J. Kobs, Jerry D. Johnson, Brian L. Burback, Bozena D. Lusiak

المصدر: International Journal of Toxicology. 32:88S-98S

مصطلحات موضوعية: Male, Antidotes, Pilot Projects, Absorption (skin), Pharmacology, Toxicology, Injections, Intramuscular, Rats, Sprague-Dawley, Excretion, Feces, Random Allocation, Oximes, Sprague dawley rats, medicine, Animals, Distribution (pharmacology), Tissue Distribution, Carbon Radioisotopes, New zealand white, Nerve agent, ADME, Molecular Structure, Chemistry, Metabolism, Rats, Female, Rabbits, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5deae1365c7f081b61ed199042efc8
https://doi.org/10.1177/1091581813487227

المؤلفون: Dean J. Kobs, Michael Springer, Ashley V. DiMarco, Ronald R. Cobb, Isaac Finger-Baker, Jessica Hahn, Bobbi Jo Horne, Yawei Ni, James D. Talton, Jordan P. Ball

المصدر: Vaccine. 34(12)

مصطلحات موضوعية: 0301 basic medicine, Mucosal Immune Responses, Mucociliary clearance, medicine.medical_treatment, viruses, Guinea Pigs, Dose-Response Relationship, Immunologic, Biology, medicine.disease_cause, Antibodies, Viral, complex mixtures, Article, 03 medical and health sciences, Random Allocation, 0302 clinical medicine, fluids and secretions, Antigen, Neutralization Tests, medicine, Animals, 030212 general & internal medicine, Vaccines, Virus-Like Particle, Immunity, Mucosal, Administration, Intranasal, General Veterinary, General Immunology and Microbiology, Immunogenicity, Norovirus, Vaccination, Public Health, Environmental and Occupational Health, virus diseases, Viral Vaccines, Virology, 030104 developmental biology, Infectious Diseases, Dry powder, Immunoglobulin G, Immunology, Molecular Medicine, Nasal administration, Female, Powders, Adjuvant

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb9a9eff274800019094fa544e78232
https://pubmed.ncbi.nlm.nih.gov/26873053

المؤلفون: Lee Jia, Sarah A. Buhrow, Joel M. Reid, Irrna M. Grossi, Matthew M. Ames, Dean J. Kobs, Joseph M. Covey, Renee M. McGovern

المصدر: Journal of Chromatography B. 840:56-62

مصطلحات موضوعية: Electrospray ionization, Clinical Biochemistry, Pyrrolobenzodiazepine, Biochemistry, High-performance liquid chromatography, Mass Spectrometry, Analytical Chemistry, Mice, chemistry.chemical_compound, Dogs, Pharmacokinetics, In vivo, Liquid chromatography–mass spectrometry, Animals, Humans, Pyrroles, Solid phase extraction, Chromatography, High Pressure Liquid, Benzodiazepinones, Chromatography, Chemistry, Cell Biology, General Medicine, Reference Standards, Rats, Standard curve, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb73b513d56fb03c5957c021e26f4d47
https://doi.org/10.1016/j.jchromb.2006.04.031

المؤلفون: Claire R. Croutch, Dean J. Kobs, Matthew Buccellato, Merrill R. Osheroff, Laura E. Elcock, Brian L. Burback, Jerry D. Johnson

المصدر: International journal of toxicology. 32

مصطلحات موضوعية: Male, medicine.medical_specialty, No-observed-adverse-effect level, Antidotes, Renal function, Toxicology, Rats, Sprague-Dawley, Eating, Random Allocation, Internal medicine, Acetylglucosaminidase, Oximes, Sprague dawley rats, Medicine, Animals, Platelet, New zealand white, Creatine Kinase, Kidney, biology, Dose-Response Relationship, Drug, business.industry, Myoglobin, Body Weight, Troponin I, Macaca mulatta, Rats, Endocrinology, medicine.anatomical_structure, Gene Expression Regulation, Anesthesia, Toxicity, biology.protein, Creatine kinase, Female, Rabbits, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b4c2323625215669622784ce8f6fed
https://pubmed.ncbi.nlm.nih.gov/23929451

المؤلفون: Seth Gibbs, Merrill R. Osheroff, Brian L. Burback, Dean J. Kobs, Claire R. Croutch, Michael A. Hawk, Jerry D. Johnson, S. Peter Hong

المصدر: International journal of toxicology. 32

مصطلحات موضوعية: Volume of distribution, Male, Chemistry, Antidotes, Area under the curve, Pharmacology, Toxicology, Beagle, Systemic circulation, Injections, Intramuscular, Macaca mulatta, Drug Administration Schedule, Rats, Toxicology studies, Rats, Sprague-Dawley, Dogs, Oximes, medicine, Toxicokinetics, Animals, Female, Rabbits, Absolute bioavailability, Nerve agent, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bda83c39817b4cf2c371fa9a0fbb007
https://pubmed.ncbi.nlm.nih.gov/23929448