المؤلفون: FitzGerald, Edward, Vagrys, Darius, Opassi, Giulia, 1988, Klein, Hanna F., Hamilton, David J., Talibov, Vladimir O, 1991, Abramsson, Mia, Moberg, Anna, Lindgren, Maria T., Holmgren, Claes, Davis, Ben, O'Brien, Peter, Wijtmans, Maikel, Hubbard, Roderick E., de Esch, Iwan J.P., Danielson, U. Helena, Professor, 1959

المصدر: SLAS Discovery. (1):40-51

مصطلحات موضوعية: Biosensors, Fragment-based drug discovery, SPR, Biophysics

وصف الملف: electronic

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-519927
https://doi.org/10.1016/j.slasd.2023.09.001
https://uu.diva-portal.org/smash/get/diva2:1825976/FULLTEXT01.pdf

المؤلفون: Kuhne, Sebastiaan, Bosma, Reggie, Kooistra, Albert J., Riemens, Rick, Stroet, Marc C.M., Vischer, Henry F., de Graaf, Chris, Wijtmans, Maikel, Leurs, Rob, de Esch, Iwan J.P.

المصدر: Kuhne , S , Bosma , R , Kooistra , A J , Riemens , R , Stroet , M C M , Vischer , H F , de Graaf , C , Wijtmans , M , Leurs , R & de Esch , I J P 2025 , ' Probing the Histamine H 1 Receptor Binding Site to Explore Ligand Binding Kinetics ' , Journal of medicinal chemistry , vol. 68 , no. 1 , pp. 448-464 . https://doi.org/10.1021/acs.jmedchem.4c02043

الاتاحة: https://research.vu.nl/en/publications/21b279f5-5aca-492b-a60e-47177c5fcda0
https://doi.org/10.1021/acs.jmedchem.4c02043
https://hdl.handle.net/1871.1/21b279f5-5aca-492b-a60e-47177c5fcda0
http://www.scopus.com/inward/record.url?scp=85213483094&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85213483094&partnerID=8YFLogxK

المؤلفون: Janssen, Mathilde A.C.H., Rappard, Rico, Dekker, Tom, Heiming, Mitchel, Beens, Marjolijn, Pieters, Dyon, Kuijpers, Brian H.M., Benningshof, Jorg C.J., Wijtmans, Maikel, de Esch, Iwan J.P., Blanco-Ania, Daniel, Rutjes, Floris P.J.T.

المصدر: Janssen , M A C H , Rappard , R , Dekker , T , Heiming , M , Beens , M , Pieters , D , Kuijpers , B H M , Benningshof , J C J , Wijtmans , M , de Esch , I J P , Blanco-Ania , D & Rutjes , F P J T 2024 , ' High-Pressure-Mediated Fragment Library Synthesis of 1,2-Disubsituted Cyclobutane Derivatives ' , European Journal of Organic Chemistry , vol. 27 , no. 45 , e202400797 , pp. 1-7 . https://doi.org/10.1002/ejoc.202400797

مصطلحات موضوعية: Cyclobutanes, Ethenesulfonyl fluoride, Fragment library, High-pressure chemistry, Hyperbaric [2+2] cycloaddition

الاتاحة: https://research.vu.nl/en/publications/2e2e1bc7-67f7-4306-9b00-e7bfefaf526f
https://doi.org/10.1002/ejoc.202400797
https://hdl.handle.net/1871.1/2e2e1bc7-67f7-4306-9b00-e7bfefaf526f
http://www.scopus.com/inward/record.url?scp=85207534181&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85207534181&partnerID=8YFLogxK

المؤلفون: Zarca, Aurelien M., Adlere, Ilze, Viciano, Cristina P., Arimont-Segura, Marta, Meyrath, Max, Simon, Icaro A., Bebelman, Jan Paul, Laan, Dennis, Custers, Hans G.J., Janssen, Elwin, Versteegh, Kobus L., Buzink, Maurice C.M.L., Nesheva, Desislava N., Bosma, Reggie, de Esch, Iwan J.P., Vischer, Henry F., Wijtmans, Maikel, Szpakowska, Martyna, Chevigné, Andy, Hoffmann, Carsten, de Graaf, Chris, Zarzycka, Barbara A., Windhorst, Albert D., Smit, Martine J., Leurs, Rob

المصدر: Zarca , A M , Adlere , I , Viciano , C P , Arimont-Segura , M , Meyrath , M , Simon , I A , Bebelman , J P , Laan , D , Custers , H G J , Janssen , E , Versteegh , K L , Buzink , M C M L , Nesheva , D N , Bosma , R , de Esch , I J P , Vischer , H F , Wijtmans , M , Szpakowska , M , Chevigné , A , Hoffmann , C , de Graaf , C ....

الاتاحة: https://research.vu.nl/en/publications/e4f88deb-01a7-44e3-acae-01f60da586f8
https://doi.org/10.1124/molpharm.123.000835
https://hdl.handle.net/1871.1/e4f88deb-01a7-44e3-acae-01f60da586f8
http://www.scopus.com/inward/record.url?scp=85187961735&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85187961735&partnerID=8YFLogxK

المؤلفون: Zheng, Yang, van den Kerkhof, Magali, Ibrahim, Mohamed, De Esch, Iwan J.P., Maes, Louis, Sterk, Geert Jan, Caljon, Guy, Leurs, Rob

المصدر: Zheng , Y , van den Kerkhof , M , Ibrahim , M , De Esch , I J P , Maes , L , Sterk , G J , Caljon , G & Leurs , R 2024 , ' Lead Optimization of the 5-Phenylpyrazolopyrimidinone NPD-2975 toward Compounds with Improved Antitrypanosomal Efficacy ' , Journal of medicinal chemistry , vol. 67 , no. 4 , pp. 2849-2863 . https://doi.org/10.1021/acs.jmedchem.3c01976

الاتاحة: https://research.vu.nl/en/publications/b7e6adb9-3efe-4d0e-9640-48f869c3cb40
https://doi.org/10.1021/acs.jmedchem.3c01976
https://hdl.handle.net/1871.1/b7e6adb9-3efe-4d0e-9640-48f869c3cb40
http://www.scopus.com/inward/record.url?scp=85185702625&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85185702625&partnerID=8YFLogxK

المؤلفون: Woodhead, Andrew J., Erlanson, Daniel A., de Esch, Iwan J.P., Holvey, Rhian S., Jahnke, Wolfgang, Pathuri, Puja

المصدر: Woodhead , A J , Erlanson , D A , de Esch , I J P , Holvey , R S , Jahnke , W & Pathuri , P 2024 , ' Fragment-to-Lead Medicinal Chemistry Publications in 2022 ' , Journal of medicinal chemistry , vol. 67 , no. 4 , pp. 2287–2304 . https://doi.org/10.1021/acs.jmedchem.3c02070

وصف الملف: application/pdf

الاتاحة: https://research.vu.nl/en/publications/3667799a-fb29-4df9-9736-5250c411d03e
https://doi.org/10.1021/acs.jmedchem.3c02070
https://hdl.handle.net/1871.1/3667799a-fb29-4df9-9736-5250c411d03e
https://research.vu.nl/ws/files/364315986/woodhead-et-al-2024-fragment-to-lead-medicinal-chemistry-publications-in-2022.pdf
http://www.scopus.com/inward/record.url?scp=85184799100&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85184799100&partnerID=8YFLogxK

المؤلفون: Holvey, Rhian S., Erlanson, Daniel A., de Esch, Iwan J.P., Farkaš, Barbara, Jahnke, Wolfgang, Nishiyama, Tsuyoshi, Woodhead, Andrew J.

المصدر: Holvey , R S , Erlanson , D A , de Esch , I J P , Farkaš , B , Jahnke , W , Nishiyama , T & Woodhead , A J 2025 , ' Fragment-to-Lead Medicinal Chemistry Publications in 2023 ' , Journal of medicinal chemistry . https://doi.org/10.1021/acs.jmedchem.4c02593

الاتاحة: https://research.vu.nl/en/publications/6ac200c9-5434-4db9-85f9-c0c6d4498bf5
https://doi.org/10.1021/acs.jmedchem.4c02593
https://hdl.handle.net/1871.1/6ac200c9-5434-4db9-85f9-c0c6d4498bf5
http://www.scopus.com/inward/record.url?scp=85214369214&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85214369214&partnerID=8YFLogxK

المؤلفون: FitzGerald, Edward A., Butko, Margaret T., Boronat, Pierre, Cederfelt, Daniela, Abramsson, Mia, Ludviksdottir, Hildur, van Muijlwijk-Koezen, Jacqueline E., de Esch, Iwan J.P., Dobritzsch, Doreen, 1972, Young, Tracy, Danielson, U. Helena, Professor, 1959

المصدر: RSC Advances. 11(13):7527-7537

وصف الملف: electronic

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-429945
https://doi.org/10.1039/D0RA09844B
https://uu.diva-portal.org/smash/get/diva2:1514622/FULLTEXT01.pdf

المؤلفون: Kanev, Georgi K., Zhang, Yaran, Kooistra, Albert J., Bender, Andreas, Leurs, Rob, Bailey, David, Würdinger, Thomas, Graaf, Chris de, de Esch, Iwan J.P., Westerman, Bart A.

المصدر: Kanev , G K , Zhang , Y , Kooistra , A J , Bender , A , Leurs , R , Bailey , D , Würdinger , T , Graaf , C D , de Esch , I J P & Westerman , B A 2023 , ' Predicting the target landscape of kinase inhibitors using 3D convolutional neural networks ' , PLoS Computational Biology , vol. 19 , no. 9 , e1011301 . https://doi.org/10.1371/journal.pcbi.1011301

الاتاحة: https://research.vumc.nl/en/publications/e492a3ab-9c0c-43d3-a12b-017a284a4da1
https://doi.org/10.1371/journal.pcbi.1011301
http://www.scopus.com/inward/record.url?scp=85171807183&partnerID=8YFLogxK

المؤلفون: Wágner, Gábor, Mocking, Tamara A.M., Ma, Xiaoyuan, Slynko, Inna, Da Costa Pereira, Daniel, Breeuwer, Robin, Rood, Niek J.N., van der Horst, Cas, Vischer, Henry F., de Graaf, Chris, de Esch, Iwan J.P., Wijtmans, Maikel, Leurs, Rob

المصدر: Wágner , G , Mocking , T A M , Ma , X , Slynko , I , Da Costa Pereira , D , Breeuwer , R , Rood , N J N , van der Horst , C , Vischer , H F , de Graaf , C , de Esch , I J P , Wijtmans , M & Leurs , R 2023 , ' SAR exploration of the non-imidazole histamine H 3 receptor ligand ZEL-H16 reveals potent inverse agonism ' , Archiv der Pharmazie , vol. 356 , no. 1 , 2200451 . https://doi.org/10.1002/ardp.202200451

مصطلحات موضوعية: agonism, G protein-coupled receptor (GPCR), histamine H3 receptor, inverse agonism, non-imidazole

الاتاحة: https://research.vu.nl/en/publications/56a103e1-37a8-4ea1-9649-4b9ecc8ca260
https://doi.org/10.1002/ardp.202200451
https://hdl.handle.net/1871.1/56a103e1-37a8-4ea1-9649-4b9ecc8ca260
http://www.scopus.com/inward/record.url?scp=85141214528&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85141214528&partnerID=8YFLogxK

المؤلفون: Zheng, Yang, van den Kerkhof, Magali, van der Meer, Tiffany, Gul, Sheraz, Kuzikov, Maria, Ellinger, Bernhard, de Esch, Iwan J.P., Siderius, Marco, Matheeussen, An, Maes, Louis, Sterk, Geert Jan, Caljon, Guy, Leurs, Rob

المصدر: Zheng , Y , van den Kerkhof , M , van der Meer , T , Gul , S , Kuzikov , M , Ellinger , B , de Esch , I J P , Siderius , M , Matheeussen , A , Maes , L , Sterk , G J , Caljon , G & Leurs , R 2023 , ' Discovery of 5-Phenylpyrazolopyrimidinone Analogs as Potent Antitrypanosomal Agents with In Vivo Efficacy ' , Journal of medicinal chemistry , vol. 66 , no. 15 , pp. 10252–10264 . https://doi.org/10.1021/acs.jmedchem.3c00161

الاتاحة: https://research.vu.nl/en/publications/2a60ef90-35f6-488c-82ca-cc6d99e82799
https://doi.org/10.1021/acs.jmedchem.3c00161
https://hdl.handle.net/1871.1/2a60ef90-35f6-488c-82ca-cc6d99e82799
http://www.scopus.com/inward/record.url?scp=85166428037&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85166428037&partnerID=8YFLogxK

المؤلفون: Dekker, Tom, Janssen, Mathilde A.C.H., Sutherland, Christina, Aben, Rene W.M., Scheeren, Hans W., Blanco-Ania, Daniel, Rutjes, Floris P.J.T., Wijtmans, Maikel, de Esch, Iwan J.P.

المصدر: Dekker , T , Janssen , M A C H , Sutherland , C , Aben , R W M , Scheeren , H W , Blanco-Ania , D , Rutjes , F P J T , Wijtmans , M & de Esch , I J P 2023 , ' An Automated, Open-Source Workflow for the Generation of (3D) Fragment Libraries ' , ACS medicinal chemistry letters , vol. 14 , no. 5 , pp. 583-590 . https://doi.org/10.1021/acsmedchemlett.2c00503

مصطلحات موضوعية: 3D fragments, cheminformatics, cyclopropane, FBDD, KNIME, library design

الاتاحة: https://research.vu.nl/en/publications/8c86198e-bf5a-4daf-9d72-9198101027f4
https://doi.org/10.1021/acsmedchemlett.2c00503
https://hdl.handle.net/1871.1/8c86198e-bf5a-4daf-9d72-9198101027f4
http://www.scopus.com/inward/record.url?scp=85159636734&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85159636734&partnerID=8YFLogxK

المؤلفون: Dekker, Tom, Harteveld, Jaap W., Wágner, Gábor, de Vries, Max C.M., Custers, Hans, van de Stolpe, Andrea C., de Esch, Iwan J.P., Wijtmans, Maikel

المصدر: Dekker , T , Harteveld , J W , Wágner , G , de Vries , M C M , Custers , H , van de Stolpe , A C , de Esch , I J P & Wijtmans , M 2023 , ' Green Drug Discovery : Novel Fragment Space from the Biomass-Derived Molecule Dihydrolevoglucosenone (Cyrene TM ) ' , Molecules (Basel, Switzerland) , vol. 28 , no. 4 , 1777 , pp. 1-19 . https://doi.org/10.3390/molecules28041777

مصطلحات موضوعية: biomass, CyreneTM, drug discovery, fragment-based drug discovery, organic synthesis, sustainability, /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy, name=SDG 7 - Affordable and Clean Energy

الاتاحة: https://research.vu.nl/en/publications/720e28c6-0b97-486a-9ca5-ebc6a993e7b2
https://doi.org/10.3390/molecules28041777
https://hdl.handle.net/1871.1/720e28c6-0b97-486a-9ca5-ebc6a993e7b2
http://www.scopus.com/inward/record.url?scp=85149053622&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85149053622&partnerID=8YFLogxK

المؤلفون: Walsh, Louise, Erlanson, Daniel A., de Esch, Iwan J.P., Jahnke, Wolfgang, Woodhead, Andrew, Wren, Ella

المصدر: Walsh , L , Erlanson , D A , de Esch , I J P , Jahnke , W , Woodhead , A & Wren , E 2023 , ' Fragment-to-Lead Medicinal Chemistry Publications in 2021 ' , Journal of medicinal chemistry , vol. 66 , no. 2 , pp. 1137-1156 . https://doi.org/10.1021/acs.jmedchem.2c01827

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

وصف الملف: application/pdf

الاتاحة: https://research.vu.nl/en/publications/8fc956d8-215d-4e83-9c80-3475faba9c96
https://doi.org/10.1021/acs.jmedchem.2c01827
https://hdl.handle.net/1871.1/8fc956d8-215d-4e83-9c80-3475faba9c96
https://research.vu.nl/ws/files/297558453/Walsh-et-al-2023_Fragment-to-lead-medicinal-chemistry-publications-in-2021.pdf
http://www.scopus.com/inward/record.url?scp=85146124026&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85146124026&partnerID=8YFLogxK

المؤلفون: Simon, Icaro A., Homan, Evert J., Wijtmans, Maikel, Sundström, Michael, Leurs, Rob, De Esch, Iwan J.P., Zarzycka, Barbara A.

المصدر: Simon , I A , Homan , E J , Wijtmans , M , Sundström , M , Leurs , R , De Esch , I J P & Zarzycka , B A 2023 , ' PSW-Designer : An Open-Source Computational Platform for the Design and Virtual Screening of Photopharmacological Ligands ' , Journal of chemical information and modeling , vol. 63 , no. 21 , pp. 6696–6705 . https://doi.org/10.1021/acs.jcim.3c01050

الاتاحة: https://research.vu.nl/en/publications/470a62c1-96d1-4c56-9966-18eed48f0603
https://doi.org/10.1021/acs.jcim.3c01050
https://hdl.handle.net/1871.1/470a62c1-96d1-4c56-9966-18eed48f0603
http://www.scopus.com/inward/record.url?scp=85176976959&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85176976959&partnerID=8YFLogxK

المؤلفون: Zheng, Yang, Schroeder, Susanne, Kanev, Georgi K., Botros, Sanaa S., William, Samia, Sabra, Abdel Nasser A., Maes, Louis, Caljon, Guy, Gil, Carmen, Martinez, Ana, Salado, Irene G., Augustyns, Koen, Edink, Ewald, Sijm, Maarten, de Heuvel, Erik, de Esch, Iwan J.P., van der Meer, Tiffany, Siderius, Marco, Sterk, Geert Jan, Brown, David, Leurs, Rob

المصدر: Zheng , Y , Schroeder , S , Kanev , G K , Botros , S S , William , S , Sabra , A N A , Maes , L , Caljon , G , Gil , C , Martinez , A , Salado , I G , Augustyns , K , Edink , E , Sijm , M , de Heuvel , E , de Esch , I J P , van der Meer , T , Siderius , M , Sterk , G J , Brown , D & Leurs , R 2023 , ' To ....

مصطلحات موضوعية: drug target, phosphodiesterase, Schistosoma mansoni, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

Relation: https://research.vu.nl/en/publications/018c77d9-2184-4776-a46d-73d48e1bea16

الاتاحة: https://research.vu.nl/en/publications/018c77d9-2184-4776-a46d-73d48e1bea16
https://doi.org/10.3390/ijms24076817
https://hdl.handle.net/1871.1/018c77d9-2184-4776-a46d-73d48e1bea16
http://www.scopus.com/inward/record.url?scp=85152305942&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85152305942&partnerID=8YFLogxK

المؤلفون: Ma, Zhongxuan, Augustijn, Kevin, de Esch, Iwan J.P., Bossink, Bart

المصدر: Ma , Z , Augustijn , K , de Esch , I J P & Bossink , B 2022 , ' Collaborative university–industry R &D practices supporting the pharmaceutical innovation process : Insights from a bibliometric review ' , Drug Discovery Today , vol. 27 , no. 8 , pp. 2333-2341 . https://doi.org/10.1016/j.drudis.2022.05.001

مصطلحات موضوعية: Big pharma, Drug development, Innovation ecosystem, Strategic management, University–industry collaboration, /dk/atira/pure/sustainabledevelopmentgoals/industry_innovation_and_infrastructure, name=SDG 9 - Industry, Innovation, and Infrastructure

الاتاحة: https://research.vu.nl/en/publications/41551b59-d3ec-4027-96bc-0a80d401db94
https://doi.org/10.1016/j.drudis.2022.05.001
https://hdl.handle.net/1871.1/41551b59-d3ec-4027-96bc-0a80d401db94
http://www.scopus.com/inward/record.url?scp=85130417413&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85130417413&partnerID=8YFLogxK

المؤلفون: Klein, Hanna F., Hamilton, David J., de Esch, Iwan J.P., Wijtmans, Maikel, O'Brien, Peter

المصدر: Klein , H F , Hamilton , D J , de Esch , I J P , Wijtmans , M & O'Brien , P 2022 , ' Escape from planarity in fragment-based drug discovery : A synthetic strategy analysis of synthetic 3D fragment libraries ' , Drug Discovery Today , vol. 27 , no. 9 , pp. 2484-2496 . https://doi.org/10.1016/j.drudis.2022.05.021

مصطلحات موضوعية: 3D, Fragment, Fragment-based drug discovery, Library, Synthesis

الاتاحة: https://research.vu.nl/en/publications/227e0052-f7e5-4d7d-bc86-bbc6aeacb8cf
https://doi.org/10.1016/j.drudis.2022.05.021
https://hdl.handle.net/1871.1/227e0052-f7e5-4d7d-bc86-bbc6aeacb8cf
http://www.scopus.com/inward/record.url?scp=85131806215&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85131806215&partnerID=8YFLogxK

المؤلفون: Hamilton, David J., Beemsterboer, Marieke, Carter, Caroline M., Elsayed, Jasmina, Huiberts, Rilana E.M., Klein, Hanna F., O'Brien, Peter, de Esch, Iwan J.P., Wijtmans, Maikel

المصدر: Hamilton , D J , Beemsterboer , M , Carter , C M , Elsayed , J , Huiberts , R E M , Klein , H F , O'Brien , P , de Esch , I J P & Wijtmans , M 2022 , ' Puckering the Planar Landscape of Fragments : Design and Synthesis of a 3D Cyclobutane Fragment Library ' , ChemMedChem , vol. 17 , no. 9 , e202200113 . https://doi.org/10.1002/cmdc.202200113

مصطلحات موضوعية: Cyclobutane, Drug design, Fragment-based drug discovery (FBDD), Library design, Three-dimensional (3D)

الاتاحة: https://research.vu.nl/en/publications/83ee49cb-2be4-449b-9080-6b5e058ea836
https://doi.org/10.1002/cmdc.202200113
https://hdl.handle.net/1871.1/83ee49cb-2be4-449b-9080-6b5e058ea836
http://www.scopus.com/inward/record.url?scp=85127516902&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85127516902&partnerID=8YFLogxK

المؤلفون: De Esch, Iwan J.P., Erlanson, Daniel A., Jahnke, Wolfgang, Johnson, Christopher N., Walsh, Louise

المصدر: De Esch , I J P , Erlanson , D A , Jahnke , W , Johnson , C N & Walsh , L 2022 , ' Fragment-to-Lead Medicinal Chemistry Publications in 2020 ' , Journal of medicinal chemistry , vol. 65 , no. 1 , pp. 84-99 . https://doi.org/10.1021/acs.jmedchem.1c01803

الاتاحة: https://research.vu.nl/en/publications/59912b8b-78f3-4d66-adcf-125f22806752
https://doi.org/10.1021/acs.jmedchem.1c01803
https://hdl.handle.net/1871.1/59912b8b-78f3-4d66-adcf-125f22806752
http://www.scopus.com/inward/record.url?scp=85121930664&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85121930664&partnerID=8YFLogxK