المؤلفون: Li Wang, Kasi J. Rubadue, Jeffrey J. Alberts, Kenneth J. Ruterbories, David W. Bedwell

المصدر: Journal of Chromatography B. :356-363

مصطلحات موضوعية: Adult, Male, Proteomics, 0301 basic medicine, Adolescent, Coefficient of variation, Clinical Biochemistry, Quantitative proteomics, 030226 pharmacology & pharmacy, Biochemistry, High-performance liquid chromatography, Analytical Chemistry, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Humans, Child, Aged, Chromatography, Chemistry, Multidrug resistance-associated protein 2, Extraction (chemistry), Selected reaction monitoring, Infant, Membrane Transport Proteins, Reproducibility of Results, Transporter, Cell Biology, General Medicine, Middle Aged, Peptide Fragments, Transport protein, 030104 developmental biology, Liver, Child, Preschool, Hepatocytes, Female, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d535229c0e8cbb66bb53e106c7f273c8
https://doi.org/10.1016/j.jchromb.2017.07.051

المؤلفون: Charles H. Mitch, Aiping Zhang, Mercedes Carpintero, Bradley Condon, C. Groshong, Shane Atwell, John W. Koss, Carl D Overshiner, Jeffrey M. Schkeryantz, Stephon C. Smith, Mark G. Bures, James E. Matt, S.R. Wasserman, Adam M. Fivush, Wesley Seidel, Carlos Jaramillo, K. Conners, David W. Bedwell, Jeffrey M. Witkin, Maria-Jesus Blanco, Daniel Ray Mayhugh, Steven James Quimby, Bruce A. Dressman, Keith A. Wafford, John T. Catlow, Allie Edward Tripp, Paul L. Ornstein, Mario Barberis, José Francisco Soriano, Steven Swanson, Beverly A. Heinz, Jon A. Erickson, Xia Li, Iain MacEwan, Thomas C. Britton, James A. Monn, Susana García-Cerrada, Jing Wang, Mark Donald Chappell, Eric George Tromiczak, Renhua Li, José Eugenio de Diego, Christine Sougias, Tatiana Natali Vetman, Xushan Wang, Stephen Antonysamy

المصدر: Journal of Medicinal Chemistry. 59:10974-10993

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Metabotropic glutamate receptor 5, Hydrochloride, medicine.drug_class, Stereochemistry, Antagonist, Receptor antagonist, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Dicarboxylic acid, Metabotropic receptor, chemistry, APICA, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::812f4203afd8777afc4ec3e0d87f74f0
https://doi.org/10.1021/acs.jmedchem.6b01119

المؤلفون: Bruce A. Dressman, Charles H. Mitch, Mercedes Carpintero, Susana García-Cerrada, John T. Catlow, Tatiana Natali Vetman, Wesley Seidel, Mark Donald Chappell, Jeffrey M. Schkeryantz, Albert Khilevich, Xushan Wang, Allie Edward Tripp, Jeffrey M. Witkin, Maria-Jesus Blanco, Renhua Li, Stephon C. Smith, José Francisco Soriano, Mario Barberis, Steven Swanson, Xia Li, Carlos Jaramillo, Beverly A. Heinz, Thomas C. Britton, Carl D Overshiner, Keith A. Wafford, Eric George Tromiczak, José Eugenio de Diego, James E. Matt, David W. Bedwell, Steven James Quimby, Adam M. Fivush, Paul L. Ornstein

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:5663-5668

مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Glutamic Acid, Pharmaceutical Science, Pharmacology, Receptors, Metabotropic Glutamate, Biochemistry, Cell Line, Madin Darby Canine Kidney Cells, Bridged Bicyclo Compounds, Mice, 03 medical and health sciences, Dogs, 0302 clinical medicine, In vivo, Drug Discovery, Animals, Hexanes, Humans, Receptor, Molecular Biology, Depressive Disorder, Major, Metabotropic glutamate receptor 5, Chemistry, Organic Chemistry, Glutamate receptor, Haplorhini, Glutamic acid, Antidepressive Agents, Rats, 030104 developmental biology, Metabotropic receptor, Molecular Medicine, Metabotropic glutamate receptor 2, 030217 neurology & neurosurgery, Behavioural despair test

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546651449b4bbed891b5bffae098620b
https://doi.org/10.1016/j.bmcl.2016.10.067

المؤلفون: David W. Bedwell, Luc Rougée, Michael A. Mohutsky, Kenneth J. Ruterbories, Stephen D. Hall

المصدر: Drug Metabolism and Disposition. 44:1819-1827

مصطلحات موضوعية: Intracellular pH, Pharmaceutical Science, Pharmacology, 030226 pharmacology & pharmacy, Plasma, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, In vivo, Cytochrome P-450 CYP2D6 Inhibitors, Extracellular, medicine, Humans, Drug Interactions, CYP3A4, Chemistry, Dextromethorphan, Hydrogen-Ion Concentration, Kinetics, Cytochrome P-450 CYP2D6, Liver, 030220 oncology & carcinogenesis, Hepatocytes, Intracellular, Drug metabolism, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccd3c4c2801d6e9977a7953ba0eddfd
https://doi.org/10.1124/dmd.116.071761

المؤلفون: David W. Bedwell, Luc Rougée, Jeff W Cramer, Nathan A Calvert, Nathan Yumibe, Kenneth J. Ruterbories, Kenneth C. Cassidy, Richard Moulton, Michael A. Mohutsky, Lisa A. Adams, Xin Zhou

المصدر: Drug Metabolism and Disposition. 44:1184-1192

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, endocrine system diseases, CYP3A, Pharmaceutical Science, Pharmacology, 030226 pharmacology & pharmacy, Substrate Specificity, Rats, Sprague-Dawley, Rosiglitazone, Glibenclamide, Troglitazone, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Cytochrome P-450 Enzyme System, Species Specificity, Pharmacokinetics, Internal medicine, Glyburide, medicine, Animals, Cytochrome P-450 CYP3A, Humans, Hypoglycemic Agents, Canagliflozin, Chromans, Glucuronosyltransferase, Biotransformation, business.industry, nutritional and metabolic diseases, medicine.disease, Metformin, Rats, Zucker, 030104 developmental biology, Endocrinology, Liver, Hepatocytes, Administration, Intravenous, Thiazolidinediones, Sulfotransferases, business, Drug metabolism, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e69d23677d8c4507f2e53434027c9b
https://doi.org/10.1124/dmd.116.070623

المؤلفون: Kathleen M. Hillgren, David W. Bedwell, Bridget L. Morse, Norikazu Matsunaga, Aleksandra Galetin, Michael A. Mohutsky, J. Brian Houston, Stephen D. Hall, Jingqi Bao, Ayşe Ufuk

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 47(3)

مصطلحات موضوعية: Male, Liver cytology, Metabolic Clearance Rate, Drug Evaluation, Preclinical, Pharmaceutical Science, Organic Anion Transporters, Pharmacology, 030226 pharmacology & pharmacy, Beagle, Models, Biological, 03 medical and health sciences, 0302 clinical medicine, Dogs, Species Specificity, In vivo, medicine, Animals, Humans, Pitavastatin, Infusions, Intravenous, biology, Chemistry, Cerivastatin, Repaglinide, Organic anion-transporting polypeptide, Liver, Pharmaceutical Preparations, 030220 oncology & carcinogenesis, Models, Animal, biology.protein, Hepatocytes, Telmisartan, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb817a0a084336e51ee431628a28b214
https://pubmed.ncbi.nlm.nih.gov/30593544

المؤلفون: Kenneth J. Ruterbories, David W. Bedwell, Richard Moulton, Michael A. Mohutsky

المصدر: Drug Metabolism and Disposition. 43:756-761

مصطلحات موضوعية: Dipeptidases, Pharmaceutical Science, Peptide, Pharmacology, GPI-Linked Proteins, Receptors, Metabotropic Glutamate, Pharmacokinetics, medicine, Humans, Prodrugs, Amino Acids, chemistry.chemical_classification, Kidney, Cilastatin, Hydrolysis, Metabolism, Prodrug, Bridged Bicyclo Compounds, Heterocyclic, In vitro, Cyclic S-Oxides, medicine.anatomical_structure, Enzyme, Biochemistry, chemistry, Peptides, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1e32a1bbb98fea5b9a2aabb2ebff79
https://doi.org/10.1124/dmd.114.062893

المؤلفون: Luc R. A. Rougée, Michael A. Mohutsky, David W. Bedwell, Kenneth J. Ruterbories, Stephen D. Hall

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 45(9)

مصطلحات موضوعية: Pharmacology, Male, Diclofenac, Midazolam, Pharmaceutical Science, Hydrogen-Ion Concentration, 030226 pharmacology & pharmacy, Dextromethorphan, 03 medical and health sciences, Kinetics, Plasma, 0302 clinical medicine, 030220 oncology & carcinogenesis, Hepatocytes, Cytochrome P-450 CYP3A, Cytochrome P-450 CYP3A Inhibitors, Humans, Computer Simulation, Drug Interactions, Female, Testosterone, Warfarin, Cytochrome P-450 CYP2C9

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79abcf7775e9ac2689dd57d7896846e
https://pubmed.ncbi.nlm.nih.gov/28679672

المؤلفون: Mark D, Chappell, Renhua, Li, Stephon C, Smith, Bruce A, Dressman, Eric G, Tromiczak, Allie E, Tripp, Maria-Jesus, Blanco, Tatiana, Vetman, Steven J, Quimby, James, Matt, Thomas C, Britton, Adam M, Fivush, Jeffrey M, Schkeryantz, Daniel, Mayhugh, Jon A, Erickson, Mark G, Bures, Carlos, Jaramillo, Mercedes, Carpintero, José Eugenio de, Diego, Mario, Barberis, Susana, Garcia-Cerrada, José F, Soriano, Stephen, Antonysamy, Shane, Atwell, Iain, MacEwan, Bradley, Condon, Christine, Sougias, Jing, Wang, Aiping, Zhang, Kris, Conners, Chris, Groshong, Stephen R, Wasserman, John W, Koss, Jeffrey M, Witkin, Xia, Li, Carl, Overshiner, Keith A, Wafford, Wesley, Seidel, Xu-Shan, Wang, Beverly A, Heinz, Steven, Swanson, John T, Catlow, David W, Bedwell, James A, Monn, Charles H, Mitch, Paul L, Ornstein

المصدر: Journal of medicinal chemistry. 59(24)

مصطلحات موضوعية: Male, Models, Molecular, Behavior, Animal, Dose-Response Relationship, Drug, Molecular Structure, Brain, Mice, Inbred Strains, Motor Activity, Receptors, Metabotropic Glutamate, Antidepressive Agents, Mice, Structure-Activity Relationship, Cyclohexanes, Drug Discovery, Animals, Humans, Swimming

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::5baf0617bc8dab1818e329dffd2bc0c6
https://pubmed.ncbi.nlm.nih.gov/28002967

المؤلفون: Uma Fogueri, David W. Bedwell, Michael A. Mohutsky, Richard Moulton, Anthony Borel, Keith Goldstein, Jayakumar Surendradoss

المصدر: Drug Metabolism and Pharmacokinetics. 34:S49

مصطلحات موضوعية: Pharmacology, RNA interference, Pharmaceutical Science, Pharmacology (medical), Biology, Term (time), Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e376a01ae70135a55fbfe636922179ed
https://doi.org/10.1016/j.dmpk.2018.09.173

المؤلفون: Julio G. Barrera Oro, Timothy L. Cannon, Kelly T. McKee, David W. Bedwell, Phillip R. Pittman, Sarah L. Norris

المصدر: Vaccine. 24:3654-3660

مصطلحات موضوعية: Adult, Male, Bacterial Toxins, education, Primary vaccination, Anthrax Vaccines, Biology, Andrology, Antigen, Neutralization Tests, Humans, Antigens, Bacterial, Anthrax vaccines, General Veterinary, General Immunology and Microbiology, Vaccination, Public Health, Environmental and Occupational Health, Half-life, Anthrax Vaccine Adsorbed, Middle Aged, Antibodies, Bacterial, Virology, Infectious Diseases, Antibody response, Protective antigen, Immunoglobulin G, biology.protein, Molecular Medicine, Female, Antibody

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6320f317538924c4a22d67aac102c763
https://doi.org/10.1016/j.vaccine.2006.01.054

المؤلفون: David W. Bedwell, J. William Higgins, Jing Q. Bao, Maciej J. Zamek-Gliszczynski

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 40(9)

مصطلحات موضوعية: Male, medicine.medical_specialty, Loperamide, Knockout rat, ATP Binding Cassette Transporter, Subfamily B, Genotype, Paclitaxel, Metabolic Clearance Rate, Pharmaceutical Science, Administration, Oral, Biological Availability, Pharmacology, Rats, Sprague-Dawley, Gene Knockout Techniques, Pharmacokinetics, Sulfasalazine, Internal medicine, medicine, Distribution (pharmacology), ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, Tissue Distribution, Rats, Wistar, Gene knockout, Biotransformation, Chemistry, Multidrug resistance-associated protein 2, Brain, Fluoresceins, Rats, Endocrinology, Phenotype, Area Under Curve, ATP-Binding Cassette Transporters, Rats, Transgenic, medicine.drug, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb871d17004f387e7c32d9fb8980e6f
https://pubmed.ncbi.nlm.nih.gov/22711747

المؤلفون: David W. Bedwell, J. William Higgins, Maciej J. Zamek-Gliszczynski

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 40(6)

مصطلحات موضوعية: Male, medicine.medical_specialty, Organic Cation Transport Proteins, Pharmaceutical Science, Pharmacology, Kidney, Mice, Pharmacokinetics, Internal medicine, medicine, Animals, Tissue Distribution, Volume of distribution, Mice, Knockout, Chemistry, Area under the curve, Kidney metabolism, Organic Cation Transporter 2, Metformin, Bioavailability, Endocrinology, Liver, Pharmacodynamics, Renal blood flow, medicine.drug, Octamer Transcription Factor-1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e97cb503ec3307455c6ad39b63fdbf
https://pubmed.ncbi.nlm.nih.gov/22407892

المؤلفون: Anthony E. Pusateri, Gerald A. Merrill, David W. Bedwell, Victor R. Rivera

المصدر: Analytical biochemistry. 284(1)

مصطلحات موضوعية: Biophysics, Ultrafiltration, Biochemistry, Sensitivity and Specificity, Nitric oxide, law.invention, Matrix (chemical analysis), chemistry.chemical_compound, Tissue culture, Blood serum, Nitrate, law, 2-Naphthylamine, Animals, Humans, Nitrite, Molecular Biology, Filtration, Nitrites, Serum Albumin, Chromatography, Nitrates, Dose-Response Relationship, Drug, Micropore Filters, Reproducibility of Results, Cell Biology, Assay sensitivity, Spectrometry, Fluorescence, chemistry, Cattle

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3e80e903a9b6c16cedb6d1aa0fd9ba
https://pubmed.ncbi.nlm.nih.gov/10933848

المؤلفون: Maciej J Zamek-Gliszczynski, David W Bedwell, Jing Q Bao, J William Higgins, Ph.D Maciej J Zamek-Gliszczynski

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://dmd.aspetjournals.org/content/dmd/early/2012/06/18/dmd.112.046508.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1086.6333; http://dmd.aspetjournals.org/content/dmd/early/2012/06/18/dmd.112.046508.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1086.6333
http://dmd.aspetjournals.org/content/dmd/early/2012/06/18/dmd.112.046508.full.pdf