المؤلفون: Jacob J. Swidorski, Brett R. Beno, Chunjian Liu, David S. Yoon, Kaushik Ghosh, Harinath Sale, Devang Shah, Kriti Acharya, Joseph Yanchunas, Priyanka Haldar, Narasimharaju Kalidindi, Jinal K. Shukla, Matthew Argentieri, Bruce A. Ellsworth, Dong Cheng, Alicia Regueiro-Ren

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::06004e2a3b8e97e9e0861334cbf1b9b1
https://doi.org/10.21203/rs.3.rs-2757730/v1

المؤلفون: Shirin Rahmanian, David S. Yoon, Scott J. Bright, Amir Abdollahi, Steffen Greilich, Aroumougame Asaithamby, D. J. O'Brien, Gabriel O. Sawakuchi, Conor H. McFadden, David B. Flint

المصدر: Medical physicsReferences. 47(1)

مصطلحات موضوعية: Microscope, Materials science, Time Factors, Cell Survival, medicine.medical_treatment, Confocal, Linear energy transfer, Radiation, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, 0302 clinical medicine, Optics, law, Live cell imaging, Cell Line, Tumor, Microscopy, medicine, Humans, Linear Energy Transfer, Particle beam, Fluorescent Dyes, Particle therapy, business.industry, General Medicine, Carbon, Molecular Imaging, 030220 oncology & carcinogenesis, business, DNA Damage

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804f54b8f08ca5eed11539d9a8f1ebca
https://pubmed.ncbi.nlm.nih.gov/31677156

المؤلفون: Gabriel O. Sawakuchi, Sharmistha Chakraborty, Conor H. McFadden, Pavel Sumazin, Radhe Mohan, Simona F. Shaitelman, David R. Grosshans, David B. Flint, Scott J. Bright, Uwe Titt, Lawrence Bronk, Aroumougame Asaithamby, David S. Yoon

المصدر: Int J Radiat Oncol Biol Phys

مصطلحات موضوعية: Cancer Research, DNA End-Joining Repair, Time Factors, DNA repair, Cell Survival, Cell, RAD51, Genes, BRCA1, Linear energy transfer, medicine.disease_cause, Radiation Tolerance, Article, 030218 nuclear medicine & medical imaging, Histones, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, medicine, Humans, Radiology, Nuclear Medicine and imaging, DNA Breaks, Double-Stranded, Linear Energy Transfer, Radiosensitivity, Gene Silencing, Homologous Recombination, Mutation, Photons, Radiation, Cell Death, business.industry, Calcium-Binding Proteins, Non-homologous end joining, enzymes and coenzymes (carbohydrates), medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Cancer research, Rad51 Recombinase, Protons, Homologous recombination, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60aed15b763e2b242faf24c2ed51112
https://pubmed.ncbi.nlm.nih.gov/31425731

المؤلفون: Paul E. Morin, Haixia Wang, Lawrence J. Kennedy, Stephen P. O'connor, James J. Li, Akbar Nayeem, Vidhyashankar Ramamurthy, Steven Sheriff, Nathan Morgan, Steven J. Walker, Xiang-Yang Ye, Frederick Moulin, Brad D. Maxwell, Thomas Harrity, Jeffrey A. Robl, Stephanie Y. Chen, Timothy W. Harper, Rachel Zebo, Jun Li, Zhenqiu Hong, Shung Wu, Mengmeng Wang, Randolph P. Ponticiello, David A. Gordon, Rajasree Golla, Ramakrishna Seethala, Daniel M. Camac, Joseph R. Taylor, David S. Yoon

مصطلحات موضوعية: 0301 basic medicine, biology, Chemistry, Organic Chemistry, Adipose tissue, Dehydrogenase, Pharmacology, Biochemistry, Bioavailability, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Pharmacokinetics, 11β-hydroxysteroid dehydrogenase type 1, 030220 oncology & carcinogenesis, Pharmacodynamics, Drug Discovery, biology.protein, IC50, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537bf023154f9aff48423a9bc7df61b2
https://europepmc.org/articles/PMC6295842/

المؤلفون: Steven J. Walker, Vidyhashankar Ramamurthy, Jun Li, Shung Wu, David K. Leahy, John D. Dimarco, Brad D. Maxwell, Daniel M. Camac, Joseph R. Taylor, Akbar Nayeem, Zhiwei Guo, James J. Li, Xiang-Yang Ye, Frederick Moulin, Paul E. Morin, Stepen P O’Connor, Haixia Wang, Jeffrey A. Robl, Rachel Zebo, Mark S. Kirby, Thomas Harrity, Joel C. Barrish, Timothy W. Harper, Lawrence L Kennedy, Rajasree Golla, Atsu Apedo, Bogdan Sleczka, Yi-Xin Li, David S. Yoon, Bin He, Steven Sheriff, Ramakrishna Seethala, Nathan Morgan, Mengmeng Wang, Randolph P. Ponticiello, Raymond P. Scaringe, Stephanie Y. Chen, Jianqing Li, Zhenqiu Hong, Ronald L. Hanson, David A. Gordon

المصدر: Journal of medicinal chemistry. 60(12)

مصطلحات موضوعية: 0301 basic medicine, Male, Hypothalamo-Hypophyseal System, Administration, Oral, Biological Availability, Mice, Obese, Dehydrogenase, Adamantane, Pharmacology, Crystallography, X-Ray, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Dogs, Pharmacokinetics, 11β-hydroxysteroid dehydrogenase type 1, Drug Discovery, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Animals, Humans, Enzyme Inhibitors, IC50, ED50, ADME, chemistry.chemical_classification, biology, Chemistry, Actins, Rats, Macaca fascicularis, 030104 developmental biology, Enzyme, biology.protein, Molecular Medicine, Azetidines, Female, Acetamide, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86602b708c78e42f5648acb482b306b
https://pubmed.ncbi.nlm.nih.gov/28537398

المؤلفون: Lawrence G. Hamann, John G. Everlof, Ramakrishna Seethala, Shung C. Wu, Akbar Nayeem, Rajasree Golla, David S. Yoon, Jeffrey A. Robl, David A. Gordon

المصدر: Bioorganicmedicinal chemistry letters. 24(21)

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, Metabolic Diseases, 11-beta-Hydroxysteroid Dehydrogenase Type 2, Drug Discovery, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Structure–activity relationship, Potency, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Sulfonyl, Sulfonamides, Binding Sites, biology, Organic Chemistry, Sulfonamide, Protein Structure, Tertiary, Molecular Docking Simulation, chemistry, Enzyme inhibitor, Lipophilicity, Microsome, biology.protein, Microsomes, Liver, Molecular Medicine, Pharmacophore, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afcfc10f66ee3fee1f2c3c23d02884ff
https://pubmed.ncbi.nlm.nih.gov/25266782

المؤلفون: Mark S. Kirby, Ramakrishna Seethala, Bin He, David S. Yoon, Xiang-Yang Ye, Yi-Xin Li, David A. Gordon, Stephanie Y. Chen, Timothy W. Harper, Atsu Apedo, Jeffrey A. Robl, Bogdan Sleczka, Mengmeng Wang, Rajasree Golla, Akbar Nayeem

المصدر: Bioorganicmedicinal chemistry letters. 24(2)

مصطلحات موضوعية: Stereochemistry, Adamantane, Clinical Biochemistry, Pharmaceutical Science, Tetrazoles, Mice, Transgenic, Crystallography, X-Ray, Biochemistry, Protein Structure, Secondary, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Discovery, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Structure–activity relationship, Moiety, Animals, Humans, Tetrazole, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Enzyme, Docking (molecular), Enzyme inhibitor, biology.protein, Microsomes, Liver, Molecular Medicine, Pharmacophore, hormones, hormone substitutes, and hormone antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7622994a8aef2fe8323b3bd00eb39fc4
https://pubmed.ncbi.nlm.nih.gov/24360604

المؤلفون: David S. Yoon, James C. Haber, Brian T. Gregg, Ying Han, Sara B. Stankovich, Todd M. Stark

المصدر: ChemInform. 36

مصطلحات موضوعية: Solvent, Reaction conditions, Chemical substance, Chemistry, Organic Chemistry, Microwave irradiation, Organic chemistry, General Medicine, 4-aminoquinazoline, Physical and Theoretical Chemistry, Biochemistry, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be376d35a954be14be770f2dd0d8acd7
https://doi.org/10.1002/chin.200514165