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1
المؤلفون: Andreas Reik, Sarah J. Hinkley, Nicholas A. Scarlott, Deepak P. Patil, Yuri R. Bendana, David A. Shivak, Tenzin Wangzor, Stephen Lam, Yuanyue Zhou, David Paschon, Lei Zhang, Patrick Li, Friedrich Fauser, Gary Lee, Jeffrey C. Miller, Charles B Paine, Danny F Xia, Edward J. Rebar, Hunter W. Richards
المصدر: Nature Biotechnology. 37:945-952
مصطلحات موضوعية: T-Lymphocytes, Protein domain, Biomedical Engineering, Bioengineering, Locus (genetics), Computational biology, Cleavage (embryo), Applied Microbiology and Biotechnology, 03 medical and health sciences, 0302 clinical medicine, Protein Domains, Genome editing, Humans, RNA, Messenger, DNA Cleavage, 030304 developmental biology, Gene Editing, Zinc finger, 0303 health sciences, Base Sequence, biology, Chemistry, RNA, DNA, Flow Cytometry, Hematopoietic Stem Cells, Zinc finger nuclease, FokI, biology.protein, Molecular Medicine, K562 Cells, 030217 neurology & neurosurgery, Biotechnology
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المؤلفون: Yasaman Ataei, Larry Park, D. James Surmeier, B. Joseph Vu, Seung Kwak, Richard T. Surosky, Anand Narayanan, David A. Shivak, Josee Laganiere, Christer Halldin, Andrea Varrone, Matthew C. Mendel, Karsten Tillack, Lei Zhang, Bryan Zeitler, Dmitry Guschin, Lexi Kopan, Sarah J. Hinkley, Kimberly Marlen, Jocelynn R. Pearl, Qi Yu, Taneli Heikkinen, Annette Gärtner, Yalda Sedaghat, Christina Thiede, Miklós Tóth, Jennifer M. Cherone, David Paschon, Jyothisri Kondapalli, Andrea E. Kudwa, Ladislav Mrzljak, Rainier Amora, Kimmo Lehtimäki, Edward J. Rebar, Lenke Tari, Ignacio Munoz-Sanjuan, Jeffrey C. Miller, Sylvie Ramboz, Marie Svedberg, Steven Froelich, Irina Ankoudinova, Philip D. Gregory, Stephen Lam, Michelle Day, Jonathan Bard, Hoang Oanh B. Nguyen, Fyodor D. Urnov, Davis Li, Jenny Haggkvist, H. Steve Zhang, Guijuan Qiao
المصدر: Nature Medicine. 25:1131-1142
مصطلحات موضوعية: 0301 basic medicine, Zinc finger, congenital, hereditary, and neonatal diseases and abnormalities, Mutant, General Medicine, Biology, medicine.disease, General Biochemistry, Genetics and Molecular Biology, nervous system diseases, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Huntington's disease, Transcription (biology), 030220 oncology & carcinogenesis, mental disorders, medicine, Gene silencing, Allele, Gene, Transcription factor
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المؤلفون: Kenneth Kim, Russell Dekelver, Anthony Conway, Matthew C. Mendel, Michael C. Holmes, Jeffrey C. Miller, Lei Zhang, Tom Redelmeier, Ying K. Tam, David Paschon, Kyle McGovern, Chris Barbosa, Paulo J. C. Lin, Alisa Boyko, Barbara L. Mui, Gary Lee
المصدر: Molecular Therapy. 27:866-877
مصطلحات موضوعية: Male, Transgene, Genetic Vectors, Biology, Gene Knockout Techniques, Mice, 03 medical and health sciences, PCSK9 Gene, Drug Delivery Systems, 0302 clinical medicine, Genome editing, Drug Discovery, Gene expression, Genetics, Animals, Prealbumin, RNA, Messenger, Transgenes, Molecular Biology, Cells, Cultured, 030304 developmental biology, Gene Editing, Pharmacology, 0303 health sciences, fungi, Intron, RNA, Dependovirus, Lipids, Zinc finger nuclease, Introns, Zinc Finger Nucleases, Cell biology, Mice, Inbred C57BL, 030220 oncology & carcinogenesis, Hepatocytes, Nanoparticles, Molecular Medicine, Female, Original Article, Proprotein Convertase 9
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المؤلفون: Philipp Koch, Christa E. Müller, Julius A. Steinbeck, Ruven Wilkens, Philip D. Gregory, Daniel Poppe, Marion Schneider, Julia Ladewig, Andreas Reik, David Paschon, Allison Tam, Jonas Doerr, Oliver Brüstle
المصدر: Stem Cells Translational Medicine
مصطلحات موضوعية: Gene‐editing, 0301 basic medicine, Adenosine, Neurodegeneration/Neurological Disorders, Human Embryonic Stem Cells, Cellular homeostasis, Adenosine kinase, Polymorphism, Single Nucleotide, Mass Spectrometry, Cell Line, Mice, 03 medical and health sciences, 0302 clinical medicine, Translational Research Articles and Reviews, Human neurons, Neural Stem Cells, medicine, Animals, Humans, Enabling Technologies for Cell-Based Clinical Translation, Adenosine Kinase, Chromatography, High Pressure Liquid, Gene Editing, Mice, Knockout, Neurons, Enabling Technologies for Cell‐Based Clinical Translation, Adenosine secretion, biology, Cell Biology, General Medicine, Gene Delivery Systems/Gene Therapy/Gene Editing Technology, Embryonic stem cell, Zinc Finger Nucleases, Neural stem cell, Neural/Progenitor Stem Cells, ADK, Cell biology, Mice, Inbred C57BL, Neuroepithelial cell, 030104 developmental biology, Karyotyping, biology.protein, Neuroepithelial stem cells, Stem cell, 030217 neurology & neurosurgery, Developmental Biology, medicine.drug
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المؤلفون: Hua Pei, Ashley T. Haase, Jerome A. Zack, Morgan Chateau, Siyu Liu, Michael C. Holmes, Stan G. Louie, George N. Llewellyn, Eduardo Seclén, David Paschon, Stephen W. Wietgrefe, Sarah J. Hinkley, Katherine Perkey, Paula M. Cannon, Matthew D. Marsden
مصطلحات موضوعية: CD4-Positive T-Lymphocytes, T cell, Immunology, Population, Programmed Cell Death 1 Receptor, HIV Infections, Biology, Virus Replication, Microbiology, Virus, 03 medical and health sciences, Mice, 0302 clinical medicine, Immune system, Latent Virus, TIGIT, Virology, Transcription Activator-Like Effector Nucleases, HIV Seropositivity, medicine, Animals, Humans, Receptors, Immunologic, education, 030304 developmental biology, 0303 health sciences, education.field_of_study, Virus Latency, Disease Models, Animal, medicine.anatomical_structure, Anti-Retroviral Agents, Insect Science, Humanized mouse, HIV-1, Pathogenesis and Immunity, Virus Activation, 030217 neurology & neurosurgery, Ex vivo
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المؤلفون: Rasoul Pourebrahim, Bart Vandekerckhove, Xuan Shirley Li, Zhenya Ni, Zita Garate, Wei Liao, David Paschon, Manuel L. Gonzalez-Garay, Yasmine Van Caeneghem, Dan S. Kaufman, Ana M. Crane, Brian R. Davis, Chao Ma, Tamara J. Laskowski, Michael C. Holmes, José C. Segovia, Edward J. Rebar
المصدر: Stem Cell Reports, Vol 7, Iss 2, Pp 139-148 (2016)
STEM CELL REPORTS
Stem Cell Reports
Stem Cell Reports, vol 7, iss 2مصطلحات موضوعية: 0301 basic medicine, Wiskott–Aldrich syndrome, T-Lymphocytes, CD34, WASP, LYMPHOCYTES, Biochemistry, Natural killer cell differentiation, ACTIVATION, 0302 clinical medicine, Medicine and Health Sciences, Killer Cells, Induced pluripotent stem cell, lcsh:QH301-705.5, lcsh:R5-920, Lymphopoiesis, Wiskott-Aldrich Syndrome, Cell biology, Killer Cells, Natural, Haematopoiesis, Natural, lcsh:Medicine (General), PLURIPOTENT STEM-CELLS, Wiskott-Aldrich Syndrome Protein, induced pluripotent stem cells, Transgene, Clinical Sciences, T cells, Biology, ACTIN, 03 medical and health sciences, Report, Genetics, medicine, Humans, genome editing, Biology and Life Sciences, Genetic Therapy, Cell Biology, immune deficiency, Hematopoietic Stem Cells, medicine.disease, SYNDROME PROTEIN, 030104 developmental biology, lcsh:Biology (General), Immunology, Biochemistry and Cell Biology, 030217 neurology & neurosurgery, CD8, GENERATION, Developmental Biology
وصف الملف: application/pdf
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المؤلفون: Katherine A. High, Thomas Wechsler, Jeffrey C. Miller, Philip D. Gregory, Edward J. Rebar, Robert J. Davidson, Russell Dekelver, Julianne M. Rieders, Rajiv Sharma, David Paschon, Michael C. Holmes, Yannick Doyon, Scott Sproul, Xavier M. Anguela, David A. Shivak, Shangzhen Zhou
المصدر: Blood. 126:1777-1784
مصطلحات موضوعية: Mucopolysaccharidosis I, Transgene, Genetic Vectors, Immunology, Computational biology, Biology, Hemophilia A, Real-Time Polymerase Chain Reaction, Hemophilia B, Biochemistry, Genome, Factor IX, Mice, Protein replacement therapy, Genome editing, Albumins, Animals, Humans, Enzyme Replacement Therapy, RNA, Messenger, Transgenes, Promoter Regions, Genetic, Gene, Mucopolysaccharidosis II, Zinc finger, Genetics, Factor VIII, Gaucher Disease, Reverse Transcriptase Polymerase Chain Reaction, High-Throughput Nucleotide Sequencing, Zinc Fingers, Genetic Therapy, Gene Therapy, Cell Biology, Hematology, Dependovirus, Endonucleases, Zinc finger nuclease, Mice, Inbred C57BL, Liver, RNA editing, Fabry Disease, RNA Editing, Lysosomes
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المؤلفون: Joal D. Beane, David Paschon, Richard A. Morgan, Mary A. Black, Martin A. Giedlin, Andreas Reik, Philip D. Gregory, Zhili Zheng, Jeffrey C. Miller, Gary Lee, Daniel Abate-Daga, Michael C. Holmes, Matthew C. Mendel, Edward J. Rebar, Dmitry Guschin, Zhiya Yu, Smita S. Chandran, Mini Bharathan, Steven A. Feldman, Nicholas P. Restifo, Nimisha Gandhi, Dale Ando, Steven A. Rosenberg
المصدر: Molecular Therapy. 23:1380-1390
مصطلحات موضوعية: Adoptive cell transfer, medicine.medical_treatment, Green Fluorescent Proteins, Programmed Cell Death 1 Receptor, Population, Cell Separation, Biology, Lymphocyte Activation, Immunotherapy, Adoptive, Interferon-gamma, Mice, Lymphocytes, Tumor-Infiltrating, Endoribonucleases, Drug Discovery, Genetics, medicine, Animals, Humans, Interferon gamma, Neoplasm Metastasis, education, Melanoma, Molecular Biology, Alleles, Pharmacology, Zinc finger, education.field_of_study, Tumor Necrosis Factor-alpha, Tumor-infiltrating lymphocytes, Granulocyte-Macrophage Colony-Stimulating Factor, Zinc Fingers, Immunotherapy, Flow Cytometry, medicine.disease, Zinc finger nuclease, Gene Expression Regulation, Neoplastic, Phenotype, Immunology, Cancer research, Cytokines, Molecular Medicine, Original Article, Female, Immunologic Memory, Neoplasm Transplantation, medicine.drug
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المؤلفون: Zulema Romero, Edward J. Rebar, Andrew Wilber, Roger P. Hollis, Matthew C. Mendel, Lei Zhang, Fabrizia Urbinati, David Gray, Alok V. Joglekar, Michael L. Kaufman, Allen Zhu, Shantha Senadheera, Michael C. Holmes, Aaron R. Cooper, Philip D. Gregory, David Paschon, Michelle Ho, Megan D. Hoban, Dianne Lumaquin, Donald B. Kohn, Gregory J. Cost, Andreas Reik, Georgia R. Lill, Xiaoyan Wang, Pei-Qi Liu
المصدر: Blood. 125:2597-2604
مصطلحات موضوعية: medicine.medical_treatment, Molecular Sequence Data, Immunology, CD34, Antigens, CD34, Bone Marrow Cells, Anemia, Sickle Cell, Mice, SCID, beta-Globins, Hematopoietic stem cell transplantation, Biology, Biochemistry, Mice, Mice, Inbred NOD, medicine, Animals, Humans, Progenitor cell, Cells, Cultured, Severe combined immunodeficiency, Endodeoxyribonucleases, Base Sequence, Point mutation, Hematopoietic Stem Cell Transplantation, Zinc Fingers, Genetic Therapy, Cell Biology, Hematology, Fetal Blood, Hematopoietic Stem Cells, medicine.disease, Molecular biology, Haematopoiesis, medicine.anatomical_structure, Genetic Loci, Mutation, Bone marrow, Stem cell
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المؤلفون: Giulia Casorati, Pietro Genovese, Luigi Naldini, Philip D. Gregory, Angelo Lombardo, Maurilio Ponzoni, Chiara Bonini, Claudio Bordignon, Jürgen Kuball, Philip D. Greenberg, David Paschon, Victoria Chu, Andreas Reik, Michael C. Holmes, Elena Provasi, Zulma Magnani, Attilio Bondanza, Pei-Qi Liu, Lei Zhang, Fabio Ciceri, Barbara Camisa
المساهمون: Provasi, E, Genovese, P, Lombardo, ANGELO LEONE, Magnani, Z, Liu Pei, Q, Reik, A, Chu, V, Paschon, D. E., Zhang, L, Kuball, J, Camisa, B, Bondanza, Attilio, Casorati, G, Ponzoni, Maurilio, Ciceri, Fabio, Bordignon, Claudio, Greenberg, P. D., Holmes, Mc, Gregory, Pd, Naldini, Luigi, Bonini, MARIA CHIARA
المصدر: Nature Medicine
مصطلحات موضوعية: T-Lymphocytes, medicine.medical_treatment, CD3, Molecular Sequence Data, Receptors, Antigen, T-Cell, T-Cell Antigen Receptor Specificity, chemical and pharmacologic phenomena, Endogeny, Gene transfer, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Jurkat Cells, 03 medical and health sciences, 0302 clinical medicine, Cancer immunotherapy, medicine, Humans, Deoxyribonucleases, Type II Site-Specific, WT1 Proteins, 030304 developmental biology, 0303 health sciences, Leukemia, Base Sequence, Lentivirus, T-cell receptor, Gene Transfer Techniques, food and beverages, Zinc Fingers, hemic and immune systems, General Medicine, medicine.disease, Zinc finger nuclease, Molecular biology, Tumor antigen, 3. Good health, 030220 oncology & carcinogenesis, biology.protein
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المؤلفون: Xavier M. Anguela, Yannick Doyon, Rajiv Sharma, Sunnie Wong, Fayaz R. Khazi, Edward J. Rebar, Virginia Haurigot, Anand S. Bhagwat, Hojun Li, Nirav Malani, Tianjian Li, Michael C. Holmes, Philip D. Gregory, Samuel L. Murphy, Jonathan D. Finn, Shangzhen Zhou, Katherine A. High, Lacramiora Ivanciu, Frederic D. Bushman, David Paschon
المصدر: Nature
مصطلحات موضوعية: DNA Repair, Genetic enhancement, Genetic Vectors, Sequence Homology, Computational biology, Biology, Hemophilia B, Genome, Article, Factor IX, Mice, Genome editing, Cell Line, Tumor, Animals, Humans, DNA Breaks, Double-Stranded, Gene, Genetics, Hemostasis, Multidisciplinary, Base Sequence, fungi, Genetic transfer, Gene targeting, Zinc Fingers, Exons, Genetic Therapy, Endonucleases, Zinc finger nuclease, Introns, Liver Regeneration, Mice, Inbred C57BL, Disease Models, Animal, HEK293 Cells, Phenotype, Liver, Gene Targeting, Mutation, Human genome
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المؤلفون: Yannick Doyon, Aaron T. Cheng, Philip D. Gregory, Edward J. Rebar, Jeffrey B. Doyon, Thuy D Vo, Jackie Cheng, Bryan Zeitler, David G. Drubin, David Paschon, Fyodor D. Urnov, Lei Zhang, Jeffrey C. Miller, Jennifer M. Cherone, Andrew H. Lee, Yolanda Santiago
المصدر: Nature Cell Biology. 13:331-337
مصطلحات موضوعية: Green Fluorescent Proteins, Molecular Sequence Data, Endocytic cycle, Endocytosis, Polymerase Chain Reaction, Clathrin, Article, Dynamin II, Genome editing, Animals, Humans, Cell Lineage, Genome, Base Sequence, Models, Genetic, biology, Cell Membrane, Cell Biology, Receptor-mediated endocytosis, Subcellular localization, Zinc finger nuclease, Cell biology, Microscopy, Fluorescence, Cell culture, biology.protein
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المؤلفون: H. Steve Zhang, Guijuan Qiao, Sarah J. Hinkley, Fyodor D. Urnov, Jianbin Wang, Elo Leung, Gladys P Dulay, Xiangdong Meng, Michael C. Holmes, Philip D. Gregory, Kyle A. Barlow, Jeffrey C. Miller, David Paschon, Kevin Hua, Lei Zhang, Gregory J. Cost, Irina Ankoudinova, Danny F Xia, Siyuan Tan, Edward J. Rebar
المصدر: Nature Biotechnology. 29:143-148
مصطلحات موضوعية: Vascular Endothelial Growth Factor A, Transcription Activator-Like Effectors, Xanthomonas, Receptors, CCR5, Molecular Sequence Data, Biomedical Engineering, Bioengineering, Biology, Applied Microbiology and Biotechnology, Genome, Genome engineering, Bacterial Proteins, TAL effector, Genome editing, Combinatorial Chemistry Techniques, Humans, Deoxyribonucleases, Type II Site-Specific, Gene, Genetics, Transcription activator-like effector nuclease, Binding Sites, Base Sequence, DNA, Zinc finger nuclease, Mutagenesis, Site-Directed, Molecular Medicine, Genetic Engineering, K562 Cells, Transcription Factors, Biotechnology
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المؤلفون: Edward J. Rebar, Rachel Mardjuki, C. Bruce A. Whitelaw, Lei Zhang, Alan J. Mileham, David Paschon, Tim King, Fyodor D. Urnov, Simon G. Lillico, David G. McLaren, Wenfang Tan, Christopher Proudfoot
المصدر: Scientific Reports
Lillico, S, Proudfoot, C, King, T, Tan, W, Zhang, L, Mardjuki, R, Paschon, D E, Rebar, E J, Urnov, F D, Mileham, A J, McLaren, D G & Whitelaw, C 2016, ' Mammalian interspecies substitution of immune modulatory alleles by genome editing ', Scientific Reports, vol. 6, 21645 . https://doi.org/10.1038/srep21645مصطلحات موضوعية: 0301 basic medicine, Swine, Introgression, Locus (genetics), Genome, African swine fever virus, Article, Ligases, 03 medical and health sciences, Genome editing, Animals, Allele, African Swine Fever, Alleles, Disease Resistance, 2. Zero hunger, Genetics, Gene Editing, Multidisciplinary, biology, Haplotype, 0402 animal and dairy science, 04 agricultural and veterinary sciences, biology.organism_classification, 040201 dairy & animal science, Zinc finger nuclease, African Swine Fever Virus, 030104 developmental biology, Haplotypes, Genetic Engineering
وصف الملف: application/pdf
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المؤلفون: Colin L. Sweeney, Jocelynn R. Pearl, David Paschon, Sherry Koontz, Andreas Reik, Fyodor D. Urnov, Uimook Choi, Suk See De Ravin, Alexander H. Song, Xiaolin Wu, Janet Lee, Castle Raley, Kol A. Zarember, Andy Chan, Linhong Li, Philip D. Gregory, Ling Su, Hannah Newcombe, Pei-Qi Liu, David A. Shivak, Harry L. Malech, Madhusudan Peshwa, Narda Theobald
المصدر: Nature biotechnology
مصطلحات موضوعية: 0301 basic medicine, Genetic enhancement, Transgene, Biomedical Engineering, CD34, Genetic transduction, Bioengineering, Antigens, CD34, Mice, Transgenic, Biology, Granulomatous Disease, Chronic, Applied Microbiology and Biotechnology, Article, 03 medical and health sciences, Mice, Chronic granulomatous disease, medicine, Animals, Humans, Progenitor cell, Cells, Cultured, Hematopoietic Stem Cell Transplantation, Genetic Therapy, medicine.disease, Hematopoietic Stem Cells, Molecular biology, 3. Good health, Haematopoiesis, 030104 developmental biology, medicine.anatomical_structure, Molecular Medicine, Bone marrow, Biotechnology
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المؤلفون: Edward J. Rebar, Fyodor D. Urnov, Andrea Mich, David Paschon, Daniel E. Bauer, Michael C. Holmes, Gary Lee, Alexander H. Song, Andreas Reik, John A. Stamatoyannopoulos, Sarah J. Hinkley, Colleen M. O'Neil, Thalia Papayannopoulou, Nikoletta Psatha, Stuart H. Orkin, Yuri R. Bendana, Yuanyue Zhou, Lei Zhang, Sandra Stehling-Sun, Pei-Qi Liu, Kai Hsin Chang, George Stamatoyannopoulos, Philip D. Gregory, Jeff Vierstra
المصدر: Nature methods
مصطلحات موضوعية: Erythrocytes, DNA Repair, DNA Footprinting, DNA footprinting, Genomics, Computational biology, Biology, Regulatory Sequences, Nucleic Acid, Biochemistry, Article, Humans, DNA Breaks, Double-Stranded, Erythropoiesis, Enhancer, Molecular Biology, Transcription factor, Genetics, Binding Sites, Base Sequence, Genome, Human, Nuclear Proteins, Cell Biology, Footprinting, Repressor Proteins, Enhancer Elements, Genetic, Regulatory sequence, Mutation, Human genome, Carrier Proteins, Functional genomics, Biotechnology, Transcription Factors
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المؤلفون: BONINI , MARIA CHIARA, C, Pietro Genovese, Philip D. Gregory, Michael C. Holmes, Luigi Naldini, David Paschon, Elena Provasi, Lei Zhang
المساهمون: Bonini, MARIA CHIARA, Pietro, Genovese, Gregory, Philip D., Holmes, Michael C., Naldini, Luigi, David, Paschon, Elena, Provasi, Lei, Zhang
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المؤلفون: Irina Ankoudinova, Philip D. Gregory, Gladys P Dulay, Fyodor D. Urnov, Stephen Lam, Sarah J. Hinkley, Jeffrey C. Miller, John J Campo, Elo Leung, Joshua E. Babiarz, Kyle A. Barlow, Danny F Xia, Rainier Amora, Anna I Vincent, Edward J. Rebar, David Paschon, Dmitry Guschin, David A. Shivak, Jinwon D Kim, Xiangdong Meng, Lei Zhang
المصدر: Nature methods. 12(5)
مصطلحات موضوعية: Genetic Markers, Enzyme-Linked Immunosorbent Assay, Computational biology, Biology, Biochemistry, Genome, Genome editing, Dna genetics, Animals, Base sequence, Molecular Biology, Dna recognition, Genetics, Shuffling, Base Sequence, business.industry, Repertoire, Cell Biology, DNA, Modular design, Gene Expression Regulation, RNA Editing, business, Biotechnology, Transcription Factors
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المؤلفون: H. Steve Zhang, Josee Laganiere, Philip D. Gregory, B. Joseph Vu, Y. Anne Huang, Sally K. Mak, David Paschon, Birgitt Schüle, J. Timothy Greenamyre, Ramya Sundararajan, Fyodor D. Urnov, Malini Vangipuram, J. William Langston, Laurie H. Sanders, Oliver Cooper, Ole Isacson
المصدر: Neurobiology of Disease, Vol 62, Iss, Pp 381-386 (2014)
مصطلحات موضوعية: Adult, Male, Mitochondrial DNA, DNA Repair, DNA damage, DNA repair, Parkinson's disease, Induced Pluripotent Stem Cells, Mitochondrial DNA damage, Stem cells, Biology, Protein Serine-Threonine Kinases, medicine.disease_cause, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, DNA, Mitochondrial, Article, lcsh:RC321-571, Neural Stem Cells, medicine, Humans, Induced pluripotent stem cell, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Aged, Genetics, Mutation, LRRK2, Parkinson Disease, Zinc Fingers, Middle Aged, Neural stem cell, nervous system diseases, Neurology, Cancer research, Female, Stem cell, DNA Damage, Targeted Gene Repair
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المؤلفون: Bryan Zeitler, Omar L. Francone, David Thomson, Kimberly Marlen, Chiocco Matthew, David Paschon, H. Steve Zhang, Steven Froelich, Qi Yu, Jeffrey C. Miller, Debra Klatte, Vivian Choi, Anne-Renee Graham, Fyodor D. Urnov, Philip D. Gregory, Edward J. Rebar
المصدر: Journal of Neurology, Neurosurgery & Psychiatry. 87:A2.4-A3
مصطلحات موضوعية: 0301 basic medicine, Huntingtin, Genetic enhancement, Disease, Biology, Bioinformatics, medicine.disease, 03 medical and health sciences, Psychiatry and Mental health, Exon, 030104 developmental biology, 0302 clinical medicine, Huntington's disease, Mutant protein, medicine, Surgery, Neurology (clinical), Trinucleotide repeat expansion, Gene, 030217 neurology & neurosurgery