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1Academic Journal
المؤلفون: Marta Vilà-González, Laetitia Pinte, Ricardo Fradique, Erika Causa, Heleen Kool, Mayuree Rodrat, Carola Maria Morell, Maha Al-Thani, Linsey Porter, Wenrui Guo, Ruhina Maeshima, Stephen L. Hart, Frank McCaughan, Alessandra Granata, David N. Sheppard, R. Andres Floto, Emma L. Rawlins, Pietro Cicuta, Ludovic Vallier
المصدر: Respiratory Research, Vol 25, Iss 1, Pp 1-13 (2024)
مصطلحات موضوعية: Airway epithelium, Ionocytes, Human induced pluripotent stem cells, Tissue modelling, FOXI1, Diseases of the respiratory system, RC705-779
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1465-993X
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2Academic Journal
المؤلفون: Alicja Urbaniak, Kenneth E. Thummel, Ayoade N. Alade, Allan E. Rettie, Bhagwat Prasad, Amedeo De Nicolò, Jennifer H. Martin, David N. Sheppard, Michael F. Jarvis
المصدر: Pharmacology Research & Perspectives, Vol 11, Iss 6, Pp n/a-n/a (2023)
مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2052-1707
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3Academic Journal
المؤلفون: Jennifer Kelly, Miran Al-Rammahi, Kristian Daly, Paul K. Flanagan, Arun Urs, Marta C. Cohen, Gabriella di Stefano, Marcel J. C. Bijvelds, David N. Sheppard, Hugo R. de Jonge, Ursula E. Seidler, Soraya P. Shirazi-Beechey
المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2045-2322
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4Academic Journal
المؤلفون: Karen S. Raraigh, Kathleen C. Paul, Jennifer L. Goralski, Erin N. Worthington, Anna V. Faino, Stanley Sciortino, Yiting Wang, Melis A. Aksit, Hua Ling, Derek L. Osorio, Frankline M. Onchiri, Shivani U. Patel, Christian A. Merlo, Kristina Montemayor, Ronald L. Gibson, Natalie E. West, Amita Thakerar, Robert J. Bridges, David N. Sheppard, Neeraj Sharma, Garry R. Cutting
المصدر: JCI Insight, Vol 7, Iss 6 (2022)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2379-3708
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5
المؤلفون: Marko Pregel, Jia Liu, Edward B. Stevens, Yiting Wang, David N. Sheppard, Walailak Jantarajit, Lishuang Cao, Allison P. Berg, Katy J. Sutcliffe
المصدر: British Journal of Pharmacology. 179:1319-1337
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Cystic Fibrosis, Mutant, Cystic Fibrosis Transmembrane Conductance Regulator, Heterologous, Gating, Pharmacology, Aminophenols, Cystic fibrosis, Cell Line, Ivacaftor, Adenosine Triphosphate, medicine, Humans, Cells, Cultured, biology, Chemistry, respiratory system, Potentiator, medicine.disease, digestive system diseases, Cystic fibrosis transmembrane conductance regulator, respiratory tract diseases, Electrophysiology, Mutation, biology.protein, medicine.drug
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6
المؤلفون: Alexandre Hinzpeter, Isabelle Sermet-Gaudelus, Sabrina Noel, A. Hatton, Hongyu Li, Aleksander Edelman, Demi R S Ng, David N. Sheppard, Iwona Pranke, Nathalie Servel, Mayuree Rodrat, A. Golec
المصدر: Noel, S, Rodrat, M, Ng, D, Li, H, Sheppard, D N & Sermet-Gaudelus, I 2021, ' Correlating genotype with phenotype using CFTR-mediated whole-cell Cl-currents in human nasal epithelial cells ', The Journal of Physiology . https://doi.org/10.1113/JP282143
مصطلحات موضوعية: epithelial ion transport, congenital, hereditary, and neonatal diseases and abnormalities, phenotype, Physiology, genotype, Cystic fibrosis, cystic fibrosis, In vivo, Sweat gland, medicine, Ussing chamber, biology, Chemistry, CFTR chloride ion channel, human nasal epithelial cells, respiratory system, medicine.disease, Molecular biology, digestive system diseases, In vitro, Cystic fibrosis transmembrane conductance regulator, respiratory tract diseases, medicine.anatomical_structure, Cell culture, biology.protein, Reprogramming
وصف الملف: application/pdf
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7Academic Journal
المؤلفون: Sebastian Kirchner, Zhiwei Cai, Robert Rauscher, Nicolai Kastelic, Melanie Anding, Andreas Czech, Bertrand Kleizen, Lynda S Ostedgaard, Ineke Braakman, David N Sheppard, Zoya Ignatova
المصدر: PLoS Biology, Vol 15, Iss 5, p e2000779 (2017)
مصطلحات موضوعية: Biology (General), QH301-705.5
وصف الملف: electronic resource
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8
المؤلفون: Cédric Govaerts, Rafael Colomer Martinez, Chloe Martens, Yiting Wang, Maud Sigoillot, Abel Garcia-Pino, Els Pardon, Marie Overtus, Toon Laeremans, Jelle Hendrix, Daniel Scholl, David N. Sheppard, Jan Steyaert
المساهمون: Pardon, Els/0000-0002-2466-0172, Steyaert, Jan/0000-0002-3825-874X, Scholl, Daniel, Sigoillot, Maud, Overtus, Marie, Martinez, Rafael Colomer, Martens, Chloe, Wang, Yiting, Pardon, Els, Laeremans, Toon, Garcia-Pino, Abel, Steyaert, Jan, Sheppard, David N., HENDRIX, Jelle, Govaerts, Cedric, Department of Bio-engineering Sciences, Structural Biology Brussels
المصدر: Scholl, D, Wang, Y, Sheppard, D N, Govaerts, C & al., E 2021, ' A Topological Switch in CFTR Modulates Channel Activity and Sensitivity to Unfolding ', Nature Chemical Biology, vol. 17, no. 9, pp. 989-997 . https://doi.org/10.1038/s41589-021-00844-0
مصطلحات موضوعية: Mutation, biology, Chemistry, single-molecule biophysics, ion channels, Cell Biology, Protein degradation, Topology, medicine.disease_cause, Cystic fibrosis transmembrane conductance regulator, chemistry.chemical_compound, Protein structure, Förster resonance energy transfer, protein folding, biology.protein, medicine, Protein folding, Molecular Biology, Adenosine triphosphate, x-ray crystallography, Ion channel
وصف الملف: application/pdf
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9
المؤلفون: Han-I, Yeh, Katy J, Sutcliffe, David N, Sheppard, Tzyh-Chang, Hwang
المصدر: Handbook of experimental pharmacology.
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10
المؤلفون: Kornkamon Lertsuwan, Jarinthorn Teerapornpuntakit, Ratchaneevan Aeimlapa, Jirawan Thongbunchoo, Kannikar Wongdee, Bartholomew S.J. Harvey, Walailak Jantarajit, David N. Sheppard, Narattaphol Charoenphandhu
المصدر: Biochemical and Biophysical Research Communications. 523:816-821
مصطلحات موضوعية: Anions, 0301 basic medicine, Biophysics, Cystic Fibrosis Transmembrane Conductance Regulator, Parathyroid hormone, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Humans, Secretion, Patch clamp, Intestinal Mucosa, Molecular Biology, Ion transporter, Epithelial polarity, Ion Transport, Ussing chamber, biology, Chemistry, Cell Biology, Apical membrane, Cystic fibrosis transmembrane conductance regulator, Up-Regulation, Cell biology, 030104 developmental biology, Parathyroid Hormone, 030220 oncology & carcinogenesis, biology.protein, Caco-2 Cells
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11
المصدر: Prins, S, Corradi, V, Sheppard, D N, Tieleman, D P & Vergani, P 2022, ' Can two wrongs make a right? F508del-CFTR ion channel rescue by second-site mutations in its transmembrane domains ', Journal of Biological Chemistry, vol. 298, no. 3, 101615, pp. 1-14 . https://doi.org/10.1016/j.jbc.2022.101615
مصطلحات موضوعية: Steric effects, congenital, hereditary, and neonatal diseases and abnormalities, Cystic Fibrosis, Cystic Fibrosis Transmembrane Conductance Regulator, Biochemistry, Protein Structure, Secondary, Hydrophobic effect, cystic fibrosis, Molecular dynamics, Protein Domains, Humans, ATP-binding cassette (ABC) transporters, R1070W, Molecular Biology, Ion channel, biology, YOR1 protein, Hydrogen bond, Chemistry, Mutagenesis, Cell Biology, molecular dynamics simulations, respiratory system, domain interface, Cystic fibrosis transmembrane conductance regulator, respiratory tract diseases, Transmembrane domain, Mutation, ion channel, Biophysics, biology.protein, cystic fibrosis transmembrane conductance regulator (CFTR), cluster analysis
وصف الملف: application/pdf
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12
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13
المؤلفون: JinHeng Lin, Livia Delpiano, Yiting Wang, Michael A. Gray, David N. Sheppard, Vinciane Saint-Criq
المساهمون: University of Bristol [Bristol], Biosciences Institute, Newcastle University, Newcastle, UK
المصدر: Saint-Criq, V, Wang, Y, Delpiano, L, Lin, J, Sheppard, D N & Gray, M A 2021, ' Extracellular phosphate enhances the function of F508del-CFTR rescued by CFTR correctors ', Journal of Cystic Fibrosis, vol. 20, no. 5, pp. 843-850 . https://doi.org/10.1016/j.jcf.2021.04.013
Journal of Cystic Fibrosis
Journal of Cystic Fibrosis, Elsevier, 2021, 20 (5), pp.843-850. ⟨10.1016/j.jcf.2021.04.013⟩مصطلحات موضوعية: 0301 basic medicine, Indoles, Pyrrolidines, Cystic Fibrosis, elexacaftor-tezacaftor-ivacaftor (Trikafta), Pyridines, Cystic Fibrosis Transmembrane Conductance Regulator, Quinolones, Aminophenols, Cystic fibrosis, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, chemistry.chemical_compound, Elexacaftor-tezacaftor-ivacaftor (Trikafta), 0302 clinical medicine, ComputingMilieux_MISCELLANEOUS, biology, CFTR correctors, respiratory system, Cystic fibrosis transmembrane conductance regulator, Cell biology, Original Article, Drug Therapy, Combination, SLC34A2, Pulmonary and Respiratory Medicine, congenital, hereditary, and neonatal diseases and abnormalities, Sodium, chemistry.chemical_element, Phosphate, Sodium-Phosphate Cotransporter Proteins, Type IIb, Phosphates, F508del-CFTR, 03 medical and health sciences, Airway epithelia, medicine, Extracellular, Animals, Humans, Benzodioxoles, Ion transporter, phosphate, Messenger RNA, Ion Transport, business.industry, Cell Membrane, medicine.disease, Rats, Inbred F344, digestive system diseases, Rats, respiratory tract diseases, 030104 developmental biology, 030228 respiratory system, chemistry, Pediatrics, Perinatology and Child Health, biology.protein, airway epithelia, Pyrazoles, business, Function (biology)
وصف الملف: application/pdf
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14
المؤلفون: Peter M. Haggie, Jae Seok Yoon, Mathias Schenkel, Samuel J. Bose, William R. Skach, David N. Sheppard, Michael Schlierf, Demi R S Ng, Georg Krainer, Hideki Shishido
المصدر: Journal of Cystic Fibrosis
مصطلحات موضوعية: 0301 basic medicine, Pulmonary and Respiratory Medicine, congenital, hereditary, and neonatal diseases and abnormalities, Rare CF mutations, Cystic Fibrosis, Cystic Fibrosis Transmembrane Conductance Regulator, Pharmacology, CFTR correction, Cystic fibrosis, Article, F508del-CFTR, 03 medical and health sciences, 0302 clinical medicine, Membrane Transport Modulators, F508del cftr, Medicine, Animals, Humans, Protein folding, Molecular Targeted Therapy, CFTR Cl− channel, biology, business.industry, Disease progression, respiratory system, Potentiator, medicine.disease, Small molecule, digestive system diseases, Cystic fibrosis transmembrane conductance regulator, respiratory tract diseases, Pharmacogenomic Testing, CFTR potentiation, 030104 developmental biology, 030228 respiratory system, Pediatrics, Perinatology and Child Health, Mutation, biology.protein, Molecular Medicine, business
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15
المؤلفون: Rima Marie Wazen, Lucy J Goudswaard, Ray W. Turner, Bartholomew S.J. Harvey, Alice Gregorie, Gemma Varley, Pina Colarusso, David N. Sheppard, Giriraj Sahu, Neil V. Marrion, James Higham
المصدر: Molecular Pharmacology. 96:115-126
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Chemistry, HEK 293 cells, Potassium channel, SK channel, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Förster resonance energy transfer, Cell culture, Biophysics, Molecular Medicine, Homomeric, Channel blocker, Heterologous expression, 030217 neurology & neurosurgery
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16
المؤلفون: Rafael Colomer, David N. Sheppard, Jelle Hendrix, Els Pardon, Abel Garcia-Pino, Yiting Wang, Daniel Scholl, Chloe Martens, Marie Overtus, Toon Laeremans, Jan Steyaert, Maud Sigoillot, Cédric Govaerts
المصدر: Nature Chemical Biology
مصطلحات موضوعية: Pathologie générale, biology, Chemistry, Physiologie de la régulation, biology.protein, Disease-causing Mutation, Sensitivity (control systems), Channel (broadcasting), Cystic fibrosis transmembrane conductance regulator, Cell biology
وصف الملف: 1 full-text file(s): application/pdf
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17
المؤلفون: Sabrina, Noel, Nathalie, Servel, Aurélie, Hatton, Anita, Golec, Mayuree, Rodrat, Demi R S, Ng, Hongyu, Li, Iwona, Pranke, Alexandre, Hinzpeter, Aleksander, Edelman, David N, Sheppard, Isabelle, Sermet-Gaudelus
المصدر: The Journal of physiologyReferences. 600(6)
مصطلحات موضوعية: Nasal Mucosa, Phenotype, Chlorides, Cystic Fibrosis, Genotype, Cystic Fibrosis Transmembrane Conductance Regulator, Humans, Epithelial Cells
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18
المؤلفون: William J. Wilkinson, David N. Sheppard, Narattaphol Charoenphandhu, Bartholomew S.J. Harvey, Jia Liu, Walailak Jantarajit, Demi R S Ng, Mayuree Rodrat
المصدر: Rodrat, M, Jantarajit, W, Ng, D, Harvey, B S J, Liu, J, Wilkinson, W, Charoenphandhu, N & Sheppard, D N 2020, ' Carbon monoxide-releasing molecules inhibit the cystic fibrosis transmembrane conductance regulator Cl-channel ', AJP-Lung Cellular and Molecular Physiology, vol. 319, no. 6, pp. L997-L1009 . https://doi.org/10.1152/ajplung.00440.2019
مصطلحات موضوعية: 0301 basic medicine, Pulmonary and Respiratory Medicine, congenital, hereditary, and neonatal diseases and abnormalities, Physiology, Allosteric regulation, Cystic Fibrosis Transmembrane Conductance Regulator, molecule 2 (CORM-2), Ivacaftor, 03 medical and health sciences, Adenosine Triphosphate, Physiology (medical), carbon monoxide-releasing, medicine, Animals, Humans, Ion transporter, Membrane potential, Carbon Monoxide, Ion Transport, 030102 biochemistry & molecular biology, biology, Chemistry, channel inhibition, ivacaftor (VX-770), Depolarization, CFTR chloride ion channel, Cell Biology, respiratory system, Carbon monoxide-releasing molecules, Cystic fibrosis transmembrane conductance regulator, respiratory tract diseases, CFTR potentiation, 030104 developmental biology, biology.protein, Biophysics, Ion Channel Gating, Intracellular, medicine.drug
وصف الملف: application/pdf
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19
المؤلفون: Daniel, Scholl, Maud, Sigoillot, Marie, Overtus, Rafael Colomer, Martinez, Chloé, Martens, Yiting, Wang, Els, Pardon, Toon, Laeremans, Abel, Garcia-Pino, Jan, Steyaert, David N, Sheppard, Jelle, Hendrix, Cédric, Govaerts
المصدر: Nature chemical biology. 17(9)
مصطلحات موضوعية: Models, Molecular, HEK293 Cells, Protein Conformation, Fluorescence Resonance Energy Transfer, Cystic Fibrosis Transmembrane Conductance Regulator, Humans, Protein Unfolding
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20
المؤلفون: David N. Sheppard, Chloe Martens, Daniel Scholl, Jelle Hendrix, Rafael Colomer Martinez, Marie Overtus, Els Pardon, Toon Laeremans, Yiting Wang, Jan Steyaert, Maud Sigoillot, Abel Garcia-Pino, Cédric Govaerts
المصدر: bioRxiv
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, 0303 health sciences, biology, Chemistry, Genetic disorder, Transporter, Protein degradation, medicine.disease, Topology, Cystic fibrosis, Cystic fibrosis transmembrane conductance regulator, 03 medical and health sciences, 0302 clinical medicine, Förster resonance energy transfer, Cyclic nucleotide-binding domain, medicine, biology.protein, 030217 neurology & neurosurgery, 030304 developmental biology
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