المؤلفون: Farrukh Vohidov (2072296), Jannik N. Andersen (199563), Kyriakos D. Economides (10332160), Michail V. Shipitsin (10332163), Olga Burenkova (10332166), James C. Ackley (10332169), Bhavatarini Vangamudi (1313319), Hung V.-T. Nguyen (2885066), Nolan M. Gallagher (1795861), Peyton Shieh (1586818), Matthew R. Golder (1678135), Jenny Liu (647696), William K. Dahlberg (2188987), Deborah J. C. Ehrlich (10332172), Julie Kim (10332175), Samantha L. Kristufek (10332178), Sung Jin Huh (2401033), Allison M. Neenan (10332181), Joelle Baddour (10332184), Sattanathan Paramasivan (10332187), Elisa de Stanchina (153061), Gaurab KC (10332190), David J. Turnquist (10332193), Jennifer K. Saucier-Sawyer (10332196), Paul W. Kopesky (10332199), Samantha W. Brady (5211746), Michael J. Jessel (10332202), Lawrence A. Reiter (335508), Donald E. Chickering (4847407), Jeremiah A. Johnson (1316577), Peter Blume-Jensen (199585)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, drug development, novel BETi prodrugs, protein inhibitors, prodrug design, prodrug activation kinetics, vivo tumor pharmacokinetics, Such approaches, traceless linkers, tissues offer, Superior Efficacy, BET Inhibitor Bottlebrush Prodrugs, dose-limiting toxicities, antitumor efficacies, syngeneic triple-negative breast ca., trial-and-error design, TI, Systemic Toxicities Prodrugs, prodrug platform

Relation: https://figshare.com/articles/journal_contribution/Design_of_BET_Inhibitor_Bottlebrush_Prodrugs_with_Superior_Efficacy_and_Devoid_of_Systemic_Toxicities/14251084

الاتاحة: https://doi.org/10.1021/jacs.1c00312.s001

المؤلفون: Jeremiah A. Johnson, DeborahJ. C. Ehrlich, MatthewR. Golder, Allison M. Neenan, Peter Blume-Jensen, James C. Ackley, William K. Dahlberg, Kyriakos D. Economides, Jennifer K. Saucier-Sawyer, Lawrence A. Reiter, Paul W. Kopesky, Elisa de Stanchina, Olga Burenkova, David J. Turnquist, Jannik N. Andersen, Sattanathan Paramasivan, Jenny Liu, Bhavatarini Vangamudi, Sung Jin Huh, Nolan M. Gallagher, Samantha W. Brady, Michael J. Jessel, Donald E. Chickering, Peyton Shieh, Farrukh Vohidov, Joelle Baddour, Julie Kim, Michail Shipitsin, Hung V.-T. Nguyen, Gaurab Kc

مصطلحات موضوعية: BET inhibitor, Therapeutic index, Drug development, Tolerability, In vivo, business.industry, medicine.medical_treatment, medicine, Prodrug, Pharmacology, business, Targeted therapy, Bromodomain

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4231b129eb3966639444cef3e553ca
https://doi.org/10.26434/chemrxiv.13241966.v1

المؤلفون: Benjamin Mayes, Alfred Anderson-Villaluz, Alain C. Mita, Kimberly Sullivan, Jasgit C. Sachdev, Neal Salomon, James Shanahan, David Browning, Bradley Carver, Petersen John S, Kris Awerkamp, Johanna C. Bendell, Joe Johnson, Peter Cornelius, Michael S. Gordon, David J. Turnquist, Monica M. Mita

المصدر: Cancer Research. 80:CT153-CT153

مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, Metabolic biomarkers, Refractory, business.industry, Internal medicine, medicine, Dose escalation, Late stage, In patient, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0a1e8e2d1da2955570d3dc52fc54412c
https://doi.org/10.1158/1538-7445.am2020-ct153

المؤلفون: Peter Cornelius, James Shanahan, Bradley Carver, Sara Little, David J. Turnquist, Andrew Slee, Benjamin Mayes

المصدر: Cancer Research. 79:1226-1226

مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, business.industry, medicine.medical_treatment, Leptin, Mammary gland, Cancer, FOXP3, Immunotherapy, medicine.disease, MetAP2 Inhibitor SDX-7320, medicine.anatomical_structure, Endocrinology, Immune system, Oncology, Internal medicine, Ovariectomized rat, Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a2d24cfeb04d3e1c74e81291b9ab8ecf
https://doi.org/10.1158/1538-7445.am2019-1226

المؤلفون: Andrew Slee, Bradley Carver, Benjamin Mayes, Peter Cornelius, Alfred Anderson-Villaluz, James Shanahan, Robert J. Lutz, Petersen John S, David J. Turnquist, Sara Little, Kimberly Sullivan

المصدر: Cancer Research. 78:4919-4919

مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, business.industry, Internal medicine, medicine, Cancer, medicine.disease, business, Obesity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0d36aa290c5ac9ac7c85694de67f0acb
https://doi.org/10.1158/1538-7445.am2018-4919