المؤلفون: W. David Nes, Minu Chaudhuri, David J. Leaver

المصدر: Biomolecules, Vol 14, Iss 3, p 249 (2024)

مصطلحات موضوعية: ergosterol-dependent diseases, trypanosomes, fungi, irreversible enzyme inhibitors, sterol methyltransferase, CYP51, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2218-273X/14/3/249; https://doaj.org/toc/2218-273X

URL الوصول: https://doaj.org/article/32268203d6b44c92945cf415e8ba7261

المؤلفون: Wenxu Zhou, Paxtyn M. Fisher, Boden H. Vanderloop, Yun Shen, Huazhong Shi, Adrian J. Maldonado, David J. Leaver, W. David Nes

المصدر: Journal of Lipid Research, Vol 61, Iss 2, Pp 192-204 (2020)

مصطلحات موضوعية: 8(14)-lophenol, Caenorhabditis elegans • biosynthesis, evolution, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520435369; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/02378f2c8d70426382e780781511bfb5

المؤلفون: Brad A. Haubrich, Ujjal K. Singha, Matthew B. Miller, Craigen R. Nes, Hosanna Anyatonwu, Laurence Lecordier, Presheet Patkar, David J. Leaver, Fernando Villalta, Benoit Vanhollebeke, Minu Chaudhuri, W. David Nes

المصدر: Journal of Lipid Research, Vol 56, Iss 2, Pp 331-341 (2015)

مصطلحات موضوعية: ergosterol biosynthesis, cholesterol, sparking function, inhibitor, ribonucleic acid interference, knockdown, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520356182; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/969e699d53874ba9bbc88e64c685f558

المؤلفون: David J. Leaver

المصدر: Molecules, Vol 23, Iss 7, p 1753 (2018)

مصطلحات موضوعية: sterol biosynthesis, sterol 14α-demethylase, sterol C24-methyltransferase, mechanism-based inactivators, antifungals, azoles, antiparasitic drugs, human African trypanosomiasis, Chagas disease, synthesis, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/23/7/1753; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/079878a0743644d5b17dafc2249a50ce

المؤلفون: Ian P. Street, Benjamin Cleary, Jonathan B. Baell, Jessica M. Strasser, Daniel L. Priebbenow, Hendrik Falk, Michael W. Parker, Susan A. Charman, H. Rachel Lagiakos, Brendon J. Monahan, Michael A. Walters, M.C. Chung, S.J. Hermans, Natalie L. Downer, Matthew E. Cuellar, Jayme L. Dahlin, Helene Jousset Sabroux, Tim Thomas, David J. Leaver, Swapna Varghese, Lian Xue, Karen L. White, Yuxin Sun, Prashant Mujumdar, Kasiram Katneni, Silvia Teguh, Anne K. Voss, Julie Sanchez, Kate E. Jarman, David M. Shackleford, Fei Huang, Ramesh Mudududdla, Nghi Nguyen

المصدر: Journal of Medicinal Chemistry. 63:4655-4684

مصطلحات موضوعية: Male, Lysine Acetyltransferases, Biological Availability, Antineoplastic Agents, 01 natural sciences, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, 03 medical and health sciences, Drug Stability, Histone Acetyltransferase KAT6A, Drug Discovery, Animals, Humans, Structure–activity relationship, Binding site, IC50, Histone Acetyltransferases, 030304 developmental biology, Sulfonamides, 0303 health sciences, Molecular Structure, Drug discovery, Chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Hydrazines, Biochemistry, Microsomes, Liver, Microsome, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eaf3a6eb34ac40b5b8c570155ff2a49
https://doi.org/10.1021/acs.jmedchem.9b02071

المؤلفون: Babita Madan, David M. Virshup, W. David Nes, David J. Leaver

المصدر: Biochemical pharmacology. 196

مصطلحات موضوعية: 0301 basic medicine, Benzylamines, Druggability, Antineoplastic Agents, Thiophenes, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Squalene, Lanosterol, 0302 clinical medicine, Neoplasms, medicine, Animals, Humans, Terbinafine, Pharmacology, chemistry.chemical_classification, Cholesterol, Anticholesteremic Agents, Cancer, Metabolism, medicine.disease, Cell biology, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, Cancer cell, lipids (amino acids, peptides, and proteins), Function (biology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fce28c5aceaf81134a10a101357508c
https://pubmed.ncbi.nlm.nih.gov/34010597

المؤلفون: Helen M. McRae, Ian P. Street, John D. Bentley, Edwin D. Hawkins, Brandon J. Aubrey, Karen L. White, Bin Ren, Matthew L. Dennis, Meghan Hattarki, Stephen Mieruszynski, Natasha Zamudio, Gordon K. Smyth, M.C. Chung, Andrew J. Sealey, Maria I. Bergamasco, Guido Pacini, Natalie L. Downer, Jonathan B. Baell, Andreas Strasser, Jai Rautela, Ricky W. Johnstone, Nghi H. Nguyen, Alexandra L. Garnham, Bilal N. Sheikh, Andrea Newbold, Gemma L. Kelly, David J. Leaver, Pat Pilling, Rose E. May, Nicholas D. Huntington, Johannes Wichmann, Yuquing Yang, Tim Thomas, S.J. Hermans, Hannah K. Vanyai, Anne K. Voss, Beinan Wang, H. Rachel Lagiakos, Brendon J. Monahan, Bethany K. Davey, Stephen Wilcox, Melanie de Silva, Olan Dolezal, Michael W. Parker, Susan A. Charman, Margs S. Brennan, Kimberly J. Morgan, Karen Doggett, Joan K. Heath, Thomas S. Peat, Benjamin Cleary, Hendrik Falk

المصدر: Nature. 560:253-257

مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Senescence, Lysine Acetyltransferases, Lymphoma, Histones, Mice, 03 medical and health sciences, Drug Development, Animals, Epigenetics, Cells, Cultured, Cellular Senescence, Cell Proliferation, Histone Acetyltransferases, Regulation of gene expression, Sulfonamides, Multidisciplinary, biology, Lysine, Benzenesulfonates, Acetylation, Fibroblasts, Cell biology, Chromatin, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, Hydrazines, 030104 developmental biology, Histone, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72783118ee7d6182bff8b36cfd55635
https://doi.org/10.1038/s41586-018-0387-5

المؤلفون: Melanie de Silva, Stewart D. Nuttall, Chen Fang Weng, Bin Ren, Paul Stupple, Mark A. Dawson, Annabelle Hoegl, Tim Thomas, Kathy Knezevic, Ian P. Street, George S. Vassiliou, Catalina Carrasco-Pozo, Yuqing Yang, Marnie E. Blewitt, Tracy A. Willson, Christopher J. Burns, Kah Lok Chan, Juliana Anokye, Linden J. Gearing, Thomas S. Peat, Janet Newman, Olan Dolezal, Oliver M. Dovey, Regina Surjadi, Miriam S. Butler, Laura MacPherson, Paul Yeh, Vicky M. Avery, Jonathan B. Baell, Enid Y.N. Lam, Yuxin Sun, Anne K. Voss, Nghi H. Nguyen, Ming Zhang, Matthew L. Dennis, Hendrik Falk, Rebecca A. Bilardi, Poh Sim Khoo, Marian L. Burr, Brendon J. Monahan, Miriam M. Yeung, Jarny Choi, Yih-Chih Chan, Chunaram Choudhary, Florian Grebien, Sarah-Jane Dawson, Joy Liu, David J. Leaver

المساهمون: Burr, Marian [0000-0002-8995-3398], Vassiliou, George [0000-0003-4337-8022], Apollo - University of Cambridge Repository

المصدر: MacPherson, L, Anokye, J, Yeung, M M, Lam, E Y N, Chan, Y-C, Weng, C-F, Yeh, P, Knezevic, K, Butler, M S, Hoegl, A, Chan, K-L, Burr, M L, Gearing, L J, Willson, T, Liu, J, Choi, J, Yang, Y, Bilardi, R A, Falk, H, Nghi Nguyen, Stupple, P A, Peat, T S, Zhang, M, De Silva, M, Carrasco-Pozo, C, Avery, V M, Khoo, S, Dolezal, O, Dennis, M L, Nuttall, S, Surjadi, R, Newman, J, Ren, B, Leaver, D J, Sun, Y, Baell, J B, Dovey, O, Vassiliou, G S, Grebien, F, Dawson, S-J, Street, I P, Monahan, B J, Burns, C J, Choudhary, C, Blewitt, M E, Voss, A K, Thomas, T & Dawson, M A 2020, ' HBO1 is required for the maintenance of leukaemia stem cells ', Nature, vol. 577, no. 7789, pp. 266-270 . https://doi.org/10.1038/s41586-019-1835-6

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, BRD4, Biology, 03 medical and health sciences, Histone H3, Mice, 0302 clinical medicine, Cell Line, Tumor, Animals, Humans, KAT7, Epigenetics, Histone Acetyltransferases, Multidisciplinary, Histone acetyltransferase, Chromatin, Protein Structure, Tertiary, Mice, Inbred C57BL, Leukemia, Myeloid, Acute, 030104 developmental biology, 030220 oncology & carcinogenesis, Acetyltransferase, Cancer research, biology.protein, Neoplastic Stem Cells, Stem cell

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3bc6f449feaabadd1fab4f6f8e7cdc

المؤلفون: Ujjal K. Singha, Laurence Lecordier, Matthew B. Miller, Benoit Vanhollebeke, Hosanna Anyatonwu, Minu Chaudhuri, Craigen R. Nes, Fernando Villalta, David J. Leaver, Brad A. Haubrich, Presheet Patkar, W. David Nes

المصدر: Journal of Lipid Research, Vol 56, Iss 2, Pp 331-341 (2015)
Journal of lipid research, 56 (2

مصطلحات موضوعية: Male, Trypanosoma brucei brucei, Protozoan Proteins, QD415-436, Trypanosoma brucei, ergosterol biosynthesis, Biochemistry, sparking function, anti-parasite drugs, chemistry.chemical_compound, Mice, Endocrinology, RNA interference, Ergosterol, parasitic diseases, polycyclic compounds, Gene silencing, Animals, Research Articles, chemistry.chemical_classification, Gene knockdown, Mice, Inbred BALB C, biology, ribonucleic acid interference, RNA, cholesterol, knockdown, Cell Biology, Methyltransferases, Sciences bio-médicales et agricoles, biology.organism_classification, Sterol, inhibitor, Enzyme, chemistry, lipids (amino acids, peptides, and proteins), Itraconazole

وصف الملف: 2 full-text file(s): application/pdf; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346cd35ad4957b33d473c19c6156c32d
http://www.sciencedirect.com/science/article/pii/S0022227520356182

المؤلفون: Fabio R. Santori, Gregor Lorbek, Pengxiang Huang, Rok Keber, Alain Rahier, Brittany N. Rosales, W. David Nes, Simon Horvat, Damjana Rozman, Serge A. van de Pavert, David J. Leaver, Brad A. Haubrich, Dan R. Littman, Eugene F. Douglass, Fraydoon Rastinejad, Reina E. Mebius, Tanja Konijn

المساهمون: Molecular cell biology and Immunology, CCA - Immuno-pathogenesis

المصدر: Santori, F R, Huang, P X, van de Pavert, S A, Douglass, E F, Leaver, D J, Haubrich, B A, Keber, R, Lorbek, G, Konijn, T, Rosales, B N, Rozman, D, Horvat, S, Rahier, A, Mebius, R E, Rastinejad, F, Nes, W D & Littman, D R 2015, ' Identification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells ', Cell Metabolism, vol. 21, no. 2, pp. 286-297 . https://doi.org/10.1016/j.cmet.2015.01.004
Cell Metabolism, 21(2), 286-297. Cell Press

مصطلحات موضوعية: Zymosterol, Male, Physiology, Transgene, Mice, Transgenic, Biology, Ligands, Article, Cell Line, chemistry.chemical_compound, Mice, Sterol 14-Demethylase, RNA interference, RAR-related orphan receptor gamma, Coactivator, Animals, Humans, Lymphocytes, Molecular Biology, Mice, Knockout, HEK 293 cells, Innate lymphoid cell, Cell Biology, Nuclear Receptor Subfamily 1, Group F, Member 3, Sterols, Cholesterol, Drosophila melanogaster, HEK293 Cells, Nuclear receptor, Biochemistry, chemistry, Th17 Cells, lipids (amino acids, peptides, and proteins)

وصف الملف: Print; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9954ffd3b62b7c6a9ee55d203f9cea
https://doi.org/10.1016/j.cmet.2015.01.004

المؤلفون: David J. Leaver, Raymond M. Dawson, Almar Postma, Anastasios Polyzos, Nino Malic, Andrew B. Hughes

المصدر: RSC Adv.. 4:14868-14871

مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, General Chemical Engineering, Cholera toxin, Chain transfer, General Chemistry, Raft, Polymer, medicine.disease_cause, Bivalent (genetics), Biochemistry, chemistry, medicine, IC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ea437c77528869274666f73171a46993
https://doi.org/10.1039/c3ra47500j

المؤلفون: David J. Leaver, Jonathan M. White, Andrew B. Hughes, Anastasios Polyzos

المصدر: Journal of Carbohydrate Chemistry. 29:379-385

مصطلحات موضوعية: Crystallography, chemistry.chemical_compound, Trimethylsilyl, Chemistry, Organic Chemistry, X-ray, Crystal structure, Biochemistry, Transformation (music), Cycloaddition

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::35547b0ef727a6ee7c7d934297ebc4b1
https://doi.org/10.1080/07328303.2011.554935

المؤلفون: Ujjal K. Singha, Brad A. Haubrich, Matthew B. Miller, Presheet Patkar, David J. Leaver, W. David Nes, Minu Chaudhuri

المصدر: Chemistrybiology. 22(10)

مصطلحات موضوعية: Halogenation, Clinical Biochemistry, Trypanosoma brucei brucei, Trypanosoma brucei, Biochemistry, Gas Chromatography-Mass Spectrometry, Article, chemistry.chemical_compound, Ergosterol, Drug Discovery, polycyclic compounds, Humans, Enzyme kinetics, Molecular Biology, Pharmacology, chemistry.chemical_classification, biology, Antiparasitic Agents, Molecular Structure, Active site, General Medicine, Methylation, biology.organism_classification, Antiparasitic agent, Sterol, Sterols, Enzyme, HEK293 Cells, chemistry, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5468bbd47b8ae94ea4af4258f2556af6
https://pubmed.ncbi.nlm.nih.gov/26496686

المؤلفون: Anastasios Polyzos, Jonathan M. White, David J. Leaver, Raymond M. Dawson, Andrew B. Hughes

المصدر: Organicbiomolecular chemistry. 9(24)

مصطلحات موضوعية: Cholera Toxin, 1,2,3-Triazole, Molecular Structure, Stereochemistry, Organic Chemistry, Cholera toxin, Galactose, Stereoisomerism, Heat-labile enterotoxin, Carbohydrate, Triazoles, medicine.disease_cause, Biochemistry, Bivalent (genetics), chemistry.chemical_compound, chemistry, medicine, Physical and Theoretical Chemistry, IC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31544c92406862188a3e8d45641c2c90
https://pubmed.ncbi.nlm.nih.gov/22048800