المؤلفون: Nicholas A. Meanwell, Wenying Li, Jacob Swidorski, Kim A. Johnson, Zheng Liu, Sandhya Rahematpura, David J. Carini, Pin-Fang Lin, Sharon Zhang, Tao Wang, Ming Zheng, Zhiwei Yin, Lawrence G. Hamann, Dawn D. Parker, Alicia Regueiro-Ren

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:160-167

مصطلحات موضوعية: 0301 basic medicine, Indoles, Cell Survival, Stereochemistry, Clinical Biochemistry, Human immunodeficiency virus (HIV), Virus Attachment, Pharmaceutical Science, HIV Infections, HIV Envelope Protein gp120, Virus Replication, medicine.disease_cause, 01 natural sciences, Biochemistry, Piperazines, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, HIV Fusion Inhibitors, Tetrahydroisoquinolines, Drug Discovery, medicine, Humans, Structure–activity relationship, Benzamide, Molecular Biology, Aza Compounds, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Drug discovery, Tetrahydroisoquinoline, Initial screen, Organic Chemistry, 0104 chemical sciences, Piperazine, 030104 developmental biology, chemistry, Benzamides, HIV-1, Molecular Medicine, Pharmacophore, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f30cd9306deaaa544264ee575bcefa
https://doi.org/10.1016/j.bmcl.2015.11.009

المؤلفون: Nicholas A. Meanwell, Mark Krystal, David J. Carini, Sing-Yuen Sit, John F. Kadow, Tao Wang, Kap-Sun Yeung, Stanley D'andrea, Michael A. Walker, B. N. Naidu, Paul Michael Scola, Alicia Regueiro-Ren, Makonen Belema

المصدر: Current Drug Target -Infectious Disorders. 5:307-400

مصطلحات موضوعية: Microbiology (medical), Human cytomegalovirus, Anti-HIV Agents, medicine.drug_class, viruses, Molecular Sequence Data, Drug Evaluation, Preclinical, medicine.disease_cause, Antiviral Agents, Virus, Human metapneumovirus, Hepatitis Viruses, medicine, Animals, Humans, Protease Inhibitors, Amino Acid Sequence, HIV Integrase Inhibitors, Herpesviridae, Nucleic Acid Synthesis Inhibitors, Pharmacology, Clinical Trials as Topic, Ebola virus, Molecular Structure, biology, business.industry, Varicella zoster virus, virus diseases, Nucleosides, Hepatitis C, Hepatitis B, Orthomyxoviridae, medicine.disease, biology.organism_classification, Virology, Severe acute respiratory syndrome-related coronavirus, Drug Design, HIV-2, HIV-1, Reverse Transcriptase Inhibitors, Molecular Medicine, Antiviral drug, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09dded10de2a54a3f12d75ba9c4abda3
https://doi.org/10.2174/156800505774912893

المؤلفون: Angela Smallwood, Dimeo Susan, Carrie Benware, Eddy W. Yue, David J. Carini, C. Anne Higley, Lisa M. Sisk, David A. Nugiel, Chong-Hwan Chang, Catherine R. Burton, Diane M. Sharp, Pamela A. Benfield, Jodi K. Muckelbauer, Sarah Cox, Steven P. Seitz, Haiying Chen, John F. Boylan, Robert H. Grafstrom, George L. Trainor

المصدر: Journal of Medicinal Chemistry. 45:5233-5248

مصطلحات موضوعية: chemistry.chemical_classification, biology, Molecular model, Kinase, medicine.drug_class, Stereochemistry, Carboxamide, Chemical synthesis, chemistry, Enzyme inhibitor, Cyclin-dependent kinase, Drug Discovery, biology.protein, medicine, Molecular Medicine, Transferase, Alkyl

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::275f3847362bdca5f8cb1694b8f56d26
https://doi.org/10.1021/jm0201722

المؤلفون: Richard S. Alexander, Robert M. Knabb, David J. Carini, Celia Dominguez, Patricia C. Weber, Charles A. Kettner, Ruth R. Wexler

المصدر: Bioorganic & Medicinal Chemistry Letters. 7:79-84

مصطلحات موضوعية: Dipeptide, biology, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Combinatorial chemistry, Chemical synthesis, chemistry.chemical_compound, Thrombin, Enzyme inhibitor, Drug Discovery, medicine, Side chain, biology.protein, Molecular Medicine, Guanidine, Molecular Biology, Boronic acid, Discovery and development of direct thrombin inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e8d8737ccd0d5a7cd7a53e033b49f54c
https://doi.org/10.1016/s0960-894x(96)00584-7

المؤلفون: Brian L. Wells, Richard S. Alexander, Joseph Buriak, Joseph Cacciola, S.L. Lee, David J. Carini, Patricia C. Weber, Pieter F. W. Stouten, Matthew M. Abelman, John M. Fevig, Gregory Loyde Hillyer, Robert A. Galemmo, Ruth R. Wexler, Karen A. Rossi, Lori L. Bostrom, Charles A. Kettner, Richard Hilmer, Robert M. Knabb

المصدر: Bioorganic & Medicinal Chemistry Letters. 6:2913-2918

مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Chemistry, Aryl, Organic Chemistry, Clinical Biochemistry, Binding pocket, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, Thrombin, Orally active, Binding conformation, Drug Discovery, medicine, Molecular Medicine, Molecular Biology, Alkyl, Discovery and development of direct thrombin inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::69491b906e379ec101be8d95fd234caa
https://doi.org/10.1016/s0960-894x(96)00525-2

المؤلفون: Pancras C. Wong, Ardecky Rj, David J. Carini, Shiew-Mei Huang, W. M. Timmermans, M. M. Pieter, William A. Price, Allison M. Agra, Ruth R. Wexler, Andrew T. Chiu

المصدر: Clinical and Experimental Hypertension. 17:1233-1256

مصطلحات موضوعية: Male, medicine.medical_specialty, Physiology, Guinea Pigs, Tetrazoles, Blood Pressure, Angiotensin II receptor antagonist, Pharmacology, Peptide hormone, Rats, Sprague-Dawley, Angiotensin Receptor Antagonists, Radioligand Assay, Dogs, Internal medicine, Renin–angiotensin system, Internal Medicine, medicine, Animals, Receptor, Angiotensin II receptor type 1, Chemistry, Imidazoles, Antagonist, General Medicine, Angiotensin II, Rats, Hypertension, Renovascular, Endocrinology, Losartan, Biological Assay, Rabbits, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a85649fc1e2f4c4d1e56fad470674c
https://doi.org/10.3109/10641969509037406

المؤلفون: Andrew T. Chiu, Santella Joseph B, Carol L. Ensinger, Duncia John, Pieter B.M.W.M. Timmermans, Mary K. VanAtten, Pancras C. Wong, Ruth R. Wexler, David J. Carini

المصدر: Bioorganic & Medicinal Chemistry Letters. 4:2235-2240

مصطلحات موضوعية: Angiotensin receptor, Isostere, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Molecular Medicine, Imidazole, Receptor, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::666e6a9bf381bd0478df7e0bc6173ed4
https://doi.org/10.1016/s0960-894x(00)80077-3

المؤلفون: Ruth R. Wexler, Pancras C. Wong, David J. Carini, Shiew-Mei Huang, Carol L. Ensinger, Bruce J. Aungst, James Russell Pruitt, Pieter B.M.W.M. Timmermans, Ardecky Rj

المصدر: Bioorganic & Medicinal Chemistry Letters. 4:63-68

مصطلحات موضوعية: Angiotensin receptor, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Angiotensin ii antagonist, Pharmacology, Prodrug, Biochemistry, Angiotensin II, Bioavailability, Pharmacokinetics, Oral administration, Drug Discovery, Molecular Medicine, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4fe1d69ad474571b4151ccd629252c94
https://doi.org/10.1016/s0960-894x(01)81123-9

المؤلفون: Gloria J. Zingaro, William J. Greenlee, Tsing-Bau Chen, Kristie A. Faust, Pancras C. Wong, Ruth R. Wexler, Victor J. Lotti, Peter K. S. Siegl, Raymond S.L. Chang, Prasun K. Chakravarty, Elizabeth M. Naylor, Salah D. Kivlighn, Colleen A. Costello, Arthur A. Patchett, David J. Carini

المصدر: Bioorganic & Medicinal Chemistry Letters. 4:69-74

مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Angiotensin II, In vitro, Sulfonamide, chemistry.chemical_compound, chemistry, In vivo, Biological property, Drug Discovery, cardiovascular system, Molecular Medicine, Imidazole, lipids (amino acids, peptides, and proteins), Tetrazole, Molecular Biology, hormones, hormone substitutes, and hormone antagonists, circulatory and respiratory physiology, Binding affinities

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2f1bd5f8936506268fac7d94f6e8eea2
https://doi.org/10.1016/s0960-894x(01)81124-0

المؤلفون: Andrew T. Chiu, Pieter B.M.W.M. Timmermans, Alexander L. Johnson, Pancras C. Wong, David J. Carini, Ruth R. Wexler

المصدر: Bioorganic & Medicinal Chemistry Letters. 3:895-898

مصطلحات موضوعية: medicine.medical_specialty, Angiotensin receptor, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Selective antagonist, Biochemistry, Angiotensin II, Blood pressure, Endocrinology, Internal medicine, Drug Discovery, dup, medicine, Molecular Medicine, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f11bef201ae39dd552c2a8617911e51f
https://doi.org/10.1016/s0960-894x(00)80688-5

المؤلفون: David J. Carini, Ruth R. Wexler, P. C. Wong, William A. Price, Andrew T. Chiu, S. E. Yoo, J. B. Iii Santella, Michael E. Pierce, J. V. Duncia, Alexander L. Johnson, P. B. M. W. M. Timmermans, Paul E. Aldrich, Gregory James Wells

المصدر: ChemInform. 22

مصطلحات موضوعية: Angiotensin receptor, Orally active, Chemistry, General Medicine, Pharmacology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::133a763dc712ea46bd627111c22f8a14
https://doi.org/10.1002/chin.199152187

المؤلفون: Carol L. Ensinger, Bruce J. Aungst, Ruth R. Wexler, Pieter B.M.W.M. Timmermans, David J. Carini, Ardecky Rj, Shiew-Mei Huang, Pancras C. Wong, James Russell Pruitt

المصدر: ChemInform. 25

مصطلحات موضوعية: Angiotensin receptor, Chemistry, General Medicine, Pharmacology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::89b1d08809ab029204274b2a0be2c088
https://doi.org/10.1002/chin.199426158

المؤلفون: David J. Carini, Patricia C. Weber, Charles A. Kettner, Robert M. Knabb, Richard S. Alexander, Ruth R. Wexler, Celia Dominguez

المصدر: ChemInform. 28

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Side chain, General Medicine, Guanidine, Combinatorial chemistry, Boronic acid, Discovery and development of direct thrombin inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7c31563d6fff47b27a1ab0575117b534
https://doi.org/10.1002/chin.199720166

المؤلفون: Patricia C. Weber, R. A. Jun. Galemmo, Joseph Cacciola, R. Hilmer, Ruth R. Wexler, Matthew M. Abelman, Gregory Loyde Hillyer, Petrus Fredericus Wilhelmus Stouten, John M. Fevig, S.L. Lee, Richard S. Alexander, Charles A. Kettner, Brian L. Wells, J. Jun. Buriak, Robert M. Knabb, Karen A. Rossi, Lori L. Bostrom, David J. Carini

المصدر: ChemInform. 28

مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Chemistry, General Medicine, Combinatorial chemistry, Alkyl, Discovery and development of direct thrombin inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8acf5adfe57f4c0468eabe41b94f6a7c
https://doi.org/10.1002/chin.199723221

المؤلفون: David J. Carini, et al. et al.

المصدر: ChemInform. 32

مصطلحات موضوعية: biology, Chemistry, Cyclin-dependent kinase 4, biology.protein, Identification (biology), General Medicine, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::aabc2cd79dc99e564c720f2ccf60ef03
https://doi.org/10.1002/chin.200145134

المؤلفون: Pancras C. Wong, Alexander L. Johnson, John V. Duncia, David J. Carini, Ruth R. Wexler, Pieter B.M.W.M. Timmermans, Andrew T. Chiu, Gregory James Wells

المصدر: American Journal of Hypertension. 5:209S-220S

مصطلحات موضوعية: medicine.medical_specialty, Angiotensin receptor, medicine.drug_class, Tetrazoles, Losartan, Renin-Angiotensin System, Angiotensin Receptor Antagonists, Internal medicine, Renin–angiotensin system, Internal Medicine, medicine, Humans, Mode of action, Antihypertensive Agents, Angiotensin II receptor type 1, business.industry, Angiotensin II, Biphenyl Compounds, Imidazoles, Receptor antagonist, Endocrinology, Drug Design, Hypertension, business, hormones, hormone substitutes, and hormone antagonists, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fbee25c1355f252283be76f204b2654
https://doi.org/10.1093/ajh/5.12.209s

المؤلفون: Paul E. Aldrich, William A. Price, J V Duncia, J B Santella rd, Ruth R. Wexler, Michael E. Pierce, Gregory J. Wells, Andrew T. Chiu, David J. Carini, Alexander L. Johnson

المصدر: Journal of Medicinal Chemistry. 34:2525-2547

مصطلحات موضوعية: Male, Angiotensin receptor, Chemical Phenomena, Stereochemistry, Carboxylic acid, Administration, Oral, Tetrazoles, Losartan, Angiotensin Receptor Antagonists, Structure-Activity Relationship, chemistry.chemical_compound, Oral administration, Adrenal Glands, Drug Discovery, medicine, Animals, Tetrazole, Hydroxymethyl, Antihypertensive Agents, chemistry.chemical_classification, Receptors, Angiotensin, Molecular Structure, Biphenyl Compounds, Imidazoles, Rats, Inbred Strains, Angiotensin II, Rats, Chemistry, chemistry, Hypertension, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4311658e4883941f1a0ae7028699d88
https://doi.org/10.1021/jm00112a031

المؤلفون: William F. Herblin, Andrew T. Chiu, Dale E. McCall, Robert J. Ardecky, David J. Carini, John V. Duncia, Lori J. Pease, Pancras C. Wong, Ruth R. Wexler, Alexander L Johnson, Pieter B.M.W.M. Timmermans

المصدر: American Journal of Hypertension. 4:299S-302S

مصطلحات موضوعية: Angiotensin receptor, medicine.medical_specialty, Receptors, Angiotensin, Adrenal cortex, Angiotensin III, Biology, Angiotensin II, Iodine Radioisotopes, chemistry.chemical_compound, medicine.anatomical_structure, Endocrinology, chemistry, Microsomes, Internal medicine, Cardiovascular agent, Renin–angiotensin system, Internal Medicine, medicine, Animals, Autoradiography, Humans, sense organs, Adrenal medulla, hormones, hormone substitutes, and hormone antagonists, Saralasin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11d33f744a5405bfde7b08599904817
https://doi.org/10.1093/ajh/4.4.299s

المؤلفون: Ruth R. Wexler, William A. Price, J. V. Duncia, Alexander L. Johnson, P. B. M. W. M. Timmermans, David J. Carini, Andrew T. Chiu, P. C. Wong

المصدر: Hypertension. 15:823-834

مصطلحات موضوعية: Azoles, medicine.medical_specialty, Angiotensin receptor, Hypertension, Renal, Guinea Pigs, Tetrazoles, Pharmacology, Losartan, chemistry.chemical_compound, Ileum, In vivo, Internal medicine, Internal Medicine, medicine, Animals, Receptor, Antihypertensive Agents, Aorta, Receptors, Angiotensin, Aldosterone, Chemistry, Angiotensin II, Biphenyl Compounds, Imidazoles, Rats, Endocrinology, Rabbits, Antagonism, medicine.drug, Saralasin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7f130a1b3109ce2e1bba745eefdf0d
https://doi.org/10.1161/01.hyp.15.6.823

المؤلفون: Pieter B.M.W.M. Timmermans, Gregory J. Wells, George B. Gregory, John V. Duncia, Joseph C. Calabrese, Alexander L. Johnson, Andrew T. Chiu, David J. Carini, William A. Price, Pancras C. Wong

المصدر: Journal of Medicinal Chemistry. 33:1312-1329

مصطلحات موضوعية: Male, Models, Molecular, Angiotensin receptor, Chemical Phenomena, Stereochemistry, Blood Pressure, Pharmacology, Chemical synthesis, Angiotensin Receptor Antagonists, Structure-Activity Relationship, Drug Discovery, Animals, Structure–activity relationship, Binding site, Receptor, Antihypertensive Agents, Binding Sites, Crystallography, Receptors, Angiotensin, Chemistry, Angiotensin II, Imidazoles, Rats, Inbred Strains, Biological activity, Rats, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1953a036a74e54f12c761369f21c8b
https://doi.org/10.1021/jm00167a007