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1
المؤلفون: Peter J. Bungay, Martin Corless, Sarah Elizabeth Skerratt, Joseph S. Warmus, Sharan K. Bagal, C. Elizabeth Payne, Miller Duncan Charles, Kemp Mark Ian, David R. Fenwick, Paul Blackwell, Yoshihisa Murata, Bruce Brown, Laia Malet Sanz, David Fengas, James Michael Crawforth, Victoria Gray, Wolfgang Klute, Alan Daniel Brown, David C. Blakemore, Edward B. Stevens
المصدر: Bioorganic & Medicinal Chemistry. 27:230-239
مصطلحات موضوعية: Benzimidazole, 010405 organic chemistry, Sodium channel, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Inflammatory pain, Highly selective, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Safety profile, chemistry, Drug Discovery, NAV1, Molecular Medicine, Molecular Biology, ADME
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2
المؤلفون: Jianmin Sun, Thomas Ryckmans, David Fengas, Colin R. Rose, M. Scott Johnson, Matthew Corbett, David James Rawson, Nigel Alan Swain, Joseph S. Warmus, Lyn H. Jones, Brian E. Marron, Aristos J. Alexandrou, David Printzenhoff, C. Elizabeth Payne, Bruce M. Bechle, Rubben Torella, Neil A. Castle, Jonathan W. Theile, Elaine Tseng, David C. Blakemore, Andrew Pike, R. Ian Storer, Neil J. Flanagan, Alan Daniel Brown
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:4805-4811
مصطلحات موضوعية: 0301 basic medicine, Voltage-gated ion channel, Chemistry, Sodium channel, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, In vivo, Drug Discovery, NAV1, Molecular Medicine, Potency, Molecular Biology, 030217 neurology & neurosurgery, Ion channel, Conjugate, ADME
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3
المؤلفون: Alan D, Brown, Sharan K, Bagal, Paul, Blackwell, David C, Blakemore, Bruce, Brown, Peter J, Bungay, Martin, Corless, James, Crawforth, David, Fengas, David R, Fenwick, Victoria, Gray, Mark, Kemp, Wolfgang, Klute, Laia, Malet Sanz, Duncan, Miller, Yoshihisa, Murata, C Elizabeth, Payne, Sarah, Skerratt, Edward B, Stevens, Joseph S, Warmus
المصدر: Bioorganicmedicinal chemistry. 27(1)
مصطلحات موضوعية: NAV1.8 Voltage-Gated Sodium Channel, Voltage-Gated Sodium Channel Blockers, Structure-Activity Relationship, HEK293 Cells, Molecular Structure, Solubility, Drug Design, Humans, Benzimidazoles
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4
المؤلفون: Michelle Kraus, James Bilsland, Neil J. Flanagan, Gareth Waldron, Linda Kitching, Indrawan James Mcalpine, Peter J. Bungay, Jingrong Jean Cui, David Fengas, Rachel L. Grimley, Joseph S. Warmus, Ciarán N. Cronin, Samantha Elizabeth Greasley, Philip J Clarke, David C. Blakemore, Asako Nagata, Eric Johnson, Sharan K. Bagal, Rebecca Dias, Kiyoyuki Omoto, Matthew Corbett
المصدر: Journal of medicinal chemistry. 62(1)
مصطلحات موضوعية: animal structures, Allosteric regulation, Drug Evaluation, Preclinical, Tropomyosin receptor kinase B, Neurotrophin-3, Tropomyosin receptor kinase A, Molecular Dynamics Simulation, Crystallography, X-Ray, Ligands, 01 natural sciences, Tropomyosin receptor kinase C, 03 medical and health sciences, Structure-Activity Relationship, Allosteric Regulation, Drug Discovery, Animals, Humans, Protein Isoforms, Amino Acid Sequence, Receptor, trkA, Protein Kinase Inhibitors, 030304 developmental biology, Brain-derived neurotrophic factor, 0303 health sciences, Binding Sites, biology, Chemistry, 0104 chemical sciences, High-Throughput Screening Assays, Protein Structure, Tertiary, Rats, 010404 medicinal & biomolecular chemistry, Nerve growth factor, nervous system, Cancer research, biology.protein, Microsomes, Liver, Molecular Medicine, Pyrazoles, Sequence Alignment, Neurotrophin, Half-Life, Protein Binding
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5
المؤلفون: R Ian, Storer, Andy, Pike, Nigel A, Swain, Aristos J, Alexandrou, Bruce M, Bechle, David C, Blakemore, Alan D, Brown, Neil A, Castle, Matthew S, Corbett, Neil J, Flanagan, David, Fengas, M Scott, Johnson, Lyn H, Jones, Brian E, Marron, C Elizabeth, Payne, David, Printzenhoff, David J, Rawson, Colin R, Rose, Thomas, Ryckmans, Jianmin, Sun, Jonathan W, Theile, Rubben, Torella, Elaine, Tseng, Joseph S, Warmus
المصدر: Bioorganicmedicinal chemistry letters. 27(21)
مصطلحات موضوعية: Voltage-Gated Sodium Channel Blockers, Sulfonamides, Binding Sites, Pyridines, NAV1.7 Voltage-Gated Sodium Channel, Pain, Protein Structure, Tertiary, Rats, Molecular Docking Simulation, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Dogs, Piperidines, Thiadiazoles, Hepatocytes, Microsomes, Liver, Animals, Humans, Infusions, Intravenous, Half-Life, Protein Binding
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6
المؤلفون: Jeremy S. Parker, Madeleine Helliwell, David House, Stuart N. Richards, David Fengas, James Faulkner, Christopher David Edlin, James Raftery, Christopher K. Knight, Peter Quayle, Ian Preece
المصدر: Journal of Organometallic Chemistry. 691:5375-5382
مصطلحات موضوعية: Bicyclic molecule, Chemistry, Stereochemistry, Organic Chemistry, chemistry.chemical_element, Metathesis, Biochemistry, Ruthenium, Catalysis, Multiple role, Inorganic Chemistry, chemistry.chemical_compound, Ring-closing metathesis, Materials Chemistry, Ring-opening metathesis polymerisation, Physical and Theoretical Chemistry, Carbene
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7
المؤلفون: Christopher K. Knight, James Raftery, David Fengas, Stuart N. Richards, Jeremy S. Parker, Peter Quayle, Madeleine Helliwell
المصدر: Tetrahedron Letters. 46:7129-7134
مصطلحات موضوعية: Eunicellin, chemistry.chemical_compound, chemistry, Tandem, Stereochemistry, Organic Chemistry, Drug Discovery, Rapid access, Nonane, Ring (chemistry), Biochemistry
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8
المؤلفون: Ian Preece, Peter Quayle, David Fengas, Stuart N. Richards, James Faulkner, Christopher David Edlin
المصدر: Tetrahedron Letters. 46:2381-2385
مصطلحات موضوعية: Chemistry, Organic Chemistry, Metathesis, Biochemistry, Combinatorial chemistry, First generation, Catalysis, Grubbs' catalyst, chemistry.chemical_compound, Ring-closing metathesis, Intramolecular force, Drug Discovery, Ring-opening metathesis polymerisation, Acyclic diene metathesis
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9
المؤلفون: Peter Quayle, Jeremy S. Parker, Ian Preece, Christopher K. Knight, James Faulkner, David Fengas, Stuart N. Richards, Christopher David Edlin
المصدر: Synlett. :572-576
مصطلحات موضوعية: chemistry.chemical_classification, Allylic rearrangement, chemistry, Olefin metathesis, Alkene, Organic Chemistry, Ring-opening metathesis polymerisation, Organic chemistry, Metathesis, Isomerization, Acyclic diene metathesis, Catalysis
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10
المؤلفون: Stuart N. Richards, David Fengas, Peter Quayle
المصدر: Synlett. :1797-1800
مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Stereochemistry, Organic Chemistry, Atom, chemistry.chemical_element, Metathesis, Medicinal chemistry, Carbene, Ruthenium, Catalysis
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11Practical Synthesis of (1s,4s)-4-(Methylamino)-1′H-spiro[cyclohexane-1,3′-furo[3,4-c]pyridin]-1′-one
المصدر: Organic Process Research & Development. 14:1269-1271
مصطلحات موضوعية: chemistry.chemical_compound, Cyclohexane, Chemistry, Organic Chemistry, Diastereomer, Physical and Theoretical Chemistry, Chemical purity, Combinatorial chemistry
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12
المصدر: Journal of Chromatography B: Biomedical Sciences and Applications. 716:95-106
مصطلحات موضوعية: Male, chemistry.chemical_classification, Chromatography, Metabolite, Electrophoresis, Capillary, Substance P, Peptide, General Chemistry, Reversed-phase chromatography, High-performance liquid chromatography, Corpus Striatum, Peptide Fragments, Rats, Kinetics, chemistry.chemical_compound, Capillary electrophoresis, chemistry, Biochemistry, In vivo, Animals, Solid phase extraction, Rats, Wistar, Chromatography, High Pressure Liquid
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13
المؤلفون: M. Jonathan Fray, Dirk Elend, David Fengas
المصدر: ChemInform. 36
مصطلحات موضوعية: chemistry.chemical_classification, chemistry, Carboxylic acid, Organic Chemistry, Lipophilicity, Organic chemistry, Halogenation, General Medicine
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14
المؤلفون: David Fengas, Stuart N. Richards, Peter Quayle
المصدر: ChemInform. 35
مصطلحات موضوعية: chemistry, Polymer chemistry, Salt metathesis reaction, Atom (order theory), chemistry.chemical_element, General Medicine, Metathesis, Pyrrole derivatives, Ruthenium, Catalysis