المؤلفون: Daskalopoulos, Evangelos P, Deceuninck, Pierre, Whelan, Maurice, Gribaldo, Laura

المصدر: Cardiovascular Research ; volume 120, issue 7, page e26-e29 ; ISSN 0008-6363 1755-3245

الاتاحة: http://dx.doi.org/10.1093/cvr/cvae080
https://academic.oup.com/cardiovascres/advance-article-pdf/doi/10.1093/cvr/cvae080/57468232/cvae080.pdf
https://academic.oup.com/cardiovascres/article-pdf/120/7/e26/57985931/cvae080.pdf

المؤلفون: PERMIT group, Fosse, Vibeke, Oldoni, Emanuela, Bietrix, Florence, Budillon, Alfredo, Daskalopoulos, Evangelos P, Fratelli, Maddalena, Gerlach, Björn, Groenen, Peter M A, Hölter, Sabine M, Menon, Julia M L, Mobasheri, Ali, Osborne, Nikki, Ritskes-Hoitinga, Merel, Ryll, Bettina, Schmitt, Elmar, Ussi, Anton, Andreu, Antonio L, McCormack, Emmet

المساهمون: IRAS OH Toxicology

مصطلحات موضوعية: Personalised medicine, Policy, Preclinical models, Regulation, Translational methods, General Medicine

وصف الملف: application/pdf

Relation: https://dspace.library.uu.nl/handle/1874/426279

الاتاحة: https://dspace.library.uu.nl/handle/1874/426279

المؤلفون: Fosse, Vibeke, Oldoni, Emanuela, Bietrix, Florence, Budillon, Alfredo, Daskalopoulos, Evangelos P., Fratelli, Maddalena, Gerlach, Björn, Groenen, Peter M.A., Hölter, Sabine M., Menon, Julia M.L., Mobasheri, Ali, Osborne, Nikki, Ritskes-Hoitinga, Merel, Ryll, Bettina, Schmitt, Elmar, Ussi, Anton, Andreu, Antonio L., McCormack, Emmet

المصدر: Fosse , V , Oldoni , E , Bietrix , F , Budillon , A , Daskalopoulos , E P , Fratelli , M , Gerlach , B , Groenen , P M A , Hölter , S M , Menon , J M L , Mobasheri , A , Osborne , N , Ritskes-Hoitinga , M , Ryll , B , Schmitt , E , Ussi , A , Andreu , A L , McCormack , E & on behalf of The PERMIT group 2023 , ' Recommendations for robust and reproducible preclinical research in personalised medicine ' ....

مصطلحات موضوعية: Personalised medicine, Policy, Preclinical models, Regulation, Translational methods

Relation: https://pure.au.dk/portal/da/publications/recommendations-for-robust-and-reproducible-preclinical-research-in-personalised-medicine(2c256564-67b2-4fab-a07e-d4ef516af585).html

الاتاحة: https://pure.au.dk/portal/da/publications/recommendations-for-robust-and-reproducible-preclinical-research-in-personalised-medicine(2c256564-67b2-4fab-a07e-d4ef516af585).html
https://doi.org/10.1186/s12916-022-02719-0
http://www.scopus.com/inward/record.url?scp=85145972300&partnerID=8YFLogxK

المؤلفون: Pistollato, Francesca, Campia, Ivana, Daskalopoulos, Evangelos P., Bernasconi, Camilla, Desaintes, Christian, Di Virgilio, Sergio, Kyriakopoulou, Christina, Whelan, Maurice, Deceuninck, Pierre

المصدر: Health Research Policy and Systems ; volume 21, issue 1 ; ISSN 1478-4505

الاتاحة: http://dx.doi.org/10.1186/s12961-023-00981-z
https://link.springer.com/content/pdf/10.1186/s12961-023-00981-z.pdf
https://link.springer.com/article/10.1186/s12961-023-00981-z/fulltext.html

المؤلفون: Clerbaux, Laure Alix, Albertini, Maria Cristina, Amigó, Núria, Beronius, Anna, Bezemer, Gillina F.G., Coecke, Sandra, Daskalopoulos, Evangelos P., del Giudice, Giusy, Greco, Dario, Grenga, Lucia, Mantovani, Alberto, Muñoz, Amalia, Omeragic, Elma, Parissis, Nikolaos, Petrillo, Mauro, Saarimäki, Laura A., Soares, Helena, Sullivan, Kristie, Landesmann, Brigitte

المساهمون: NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Centro de Estudos de Doenças Crónicas (CEDOC), RUN

مصطلحات موضوعية: adverse outcome pathway, age, co-morbidities, COVID-19, environment, lifestyle, modulating factors, pre-existing conditions, SARS-CoV-2 infection, sex, Medicine(all), SDG 3 - Good Health and Well-being

وصف الملف: application/pdf

Relation: 2077-0383; PURE: 46498843

الاتاحة: http://hdl.handle.net/10362/143862

المؤلفون: Clerbaux, Laure-Alix, Amigó, Núria, Amorim, Maria João, Bal-Price, Anna, Batista Leite, Sofia, Beronius, Anna, Bostroem, Ann-Charlotte, Carusi, Annamaria, Coecke, Sandra, Concha, Rachel, Daskalopoulos, Evangelos P, Debernardi, Francesca, Edrosa, Eizleayne, Edwards, Steve W, Filipovska, Julija, Garcia-Reyero, Natàlia, Gavins, Felicity N E, Halappanavar, Sabina, Hargreaves, Alan J, Hogberg, Helena T, Huynh, Mylène T, Jacobson, Daniel, Josephs-Spaulding, Jonathan, Kim, Young Jun, Kong, Hyun Joon, Krebs, Catharine E, Lam, Ann, Landesmann, Brigitte, Layton, Adrienne, Lee, Yong Oh, Macmillan, Donna S, Mantovani, Alberto, Margiotta-Casaluci, Luigi, Martens, Marvin, Masereeuw, Rosalinde, Mayasich, Sally A, Mei, Liang Merlin, Mortensen, Holly, Munoz Pineiro, Amalia, Nymark, Penny, Ohayon, Elan, Ojasi, Joshi, Paini, Alicia, Parissis, Nikolaos, Parvatam, Surat, Pistollato, Francesca, Sachana, Magdalini, Sørli, Jorid Birkelund, Sullivan, Kristie M, Sund, Jukka, Tanabe, Shihori, Tsaioun, Katya, Vinken, Mathieu, Viviani, Laura, Waspe, Jennifer, Willett, Catherine, Wittwehr, Clemens

المساهمون: Afd Pharmacology, Orphan drugs development in The Netherlands: from bench to patient, Pharmacology

مصطلحات موضوعية: interdisciplinarity, COVID-19, adverse, outcome, pathway

وصف الملف: application/pdf

Relation: https://dspace.library.uu.nl/handle/1874/417822

الاتاحة: https://dspace.library.uu.nl/handle/1874/417822

المؤلفون: Blackman, Marine C N M, Capeloa, Tania, Rondeau, Justin D, Zampieri, Luca X, Benyahia, Zohra, Van de Velde, Justine A, Fransolet, Maude, Daskalopoulos, Evangelos P, Michiels, Carine, Beauloye, Christophe, Sonveaux, Pierre

المصدر: Blackman , M C N M , Capeloa , T , Rondeau , J D , Zampieri , L X , Benyahia , Z , Van de Velde , J A , Fransolet , M , Daskalopoulos , E P , Michiels , C , Beauloye , C & Sonveaux , P 2022 , ' Mitochondrial Protein Cox7b Is a Metabolic Sensor Driving Brain-Specific Metastasis of Human Breast Cancer Cells ' , Cancers , vol. 14 , no. 18 , 4371 . https://doi.org/10.3390/cancers14184371

مصطلحات موضوعية: brain metastasis, breast cancer, cancer metabolism, cyclooxygenase 7b (Cox7b), mitochondria, organotropism, oxidative phosphorylation (OXPHOS), tissue-specific metastasis

وصف الملف: application/pdf

الاتاحة: https://researchportal.unamur.be/en/publications/76ff4d20-e1a6-4cdf-9d6d-4b6d46cace9e
https://doi.org/10.3390/cancers14184371
https://pure.unamur.be/ws/files/67214673/cancers_14_04371_CoX7B_Sonveaux_2022.pdf
http://www.scopus.com/inward/record.url?scp=85138745966&partnerID=8YFLogxK

المؤلفون: Clerbaux, Laure-Alix, Amigó, Núria, Amorim, Maria João, Bal-Price, Anna, Batista Leite, Sofia, Beronius, Anna, Bezemer, Gillina F G, Bostroem, Ann-Charlotte, Carusi, Annamaria, Coecke, Sandra, Concha, Rachel, Daskalopoulos, Evangelos P, Debernardi, Francesca, Edrosa, Eizleayne, Edwards, Steve W, Filipovska, Julija, Garcia-Reyero, Natàlia, Gavins, Felicity N E, Halappanavar, Sabina, Hargreaves, Alan J, Hogberg, Helena T, Huynh, Mylène T, Jacobson, Daniel, Josephs-Spaulding, Jonathan, Kim, Young Jun, Kong, Hyun Joon, Krebs, Catharine E, Lam, Ann, Landesmann, Brigitte, Layton, Adrienne, Lee, Yong Oh, Macmillan, Donna S, Mantovani, Alberto, Margiotta-Casaluci, Luigi, Martens, Marvin, Masereeuw, Rosalinde, Mayasich, Sally A, Mei, Liang Merlin, Mortensen, Holly, Munoz Pineiro, Amalia, Nymark, Penny, Ohayon, Elan, Ojasi, Joshi, Paini, Alicia, Parissis, Nikolaos, Parvatam, Surat, Pistollato, Francesca, Sachana, Magdalini, Sørli, Jorid Birkelund, Sullivan, Kristie M, Sund, Jukka, Tanabe, Shihori, Tsaioun, Katya, Vinken, Mathieu, Viviani, Laura, Waspe, Jennifer, Willett, Catherine, Wittwehr, Clemens

المصدر: Clerbaux , L-A , Amigó , N , Amorim , M J , Bal-Price , A , Batista Leite , S , Beronius , A , Bezemer , G F G , Bostroem , A-C , Carusi , A , Coecke , S , Concha , R , Daskalopoulos , E P , Debernardi , F , Edrosa , E , Edwards , S W , Filipovska , J , Garcia-Reyero , N , Gavins , F N E , Halappanavar , S , Hargreaves , A J , Hogberg , H T , Huynh , M T , ....

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/0b27ed71-72db-4cb3-aa37-f50192b936cf
https://doi.org/10.14573/altex.2112161

المؤلفون: Zacchigna, Serena, Paldino, Alessia, Falcão-Pires, Inês, Daskalopoulos, Evangelos P., Dal Ferro, Matteo, Vodret, Simone, Lesizza, Pierluigi, Cannatà, Antonio, Miranda-Silva, Daniela, Lourenço, André P., Pinamonti, Bruno, Sinagra, Gianfranco, Weinberger, Florian, Eschenhagen, Thomas, Carrier, Lucie, Kehat, Izhak, Tocchetti, Carlo G., Russo, Michele, Ghigo, Alessandra, Cimino, James, Hirsch, Emilio, Dawson, Dana, Ciccarelli, Michele, Oliveti, Marco, Linke, Wolfgang A., Cuijpers, Ilona, Heymans, Stephane, Hamdani, Nazha, De Boer, Martine, Duncker, Dirk J., Kuster, Diederik, Van Der Velden, Jolanda, Beauloye, Christophe, Bertrand, Luc, Mayr, Manuel, Giacca, Mauro, Leuschner, Florian, Backs, Johannes, Thum, Thomas

المصدر: Zacchigna , S , Paldino , A , Falcão-Pires , I , Daskalopoulos , E P , Dal Ferro , M , Vodret , S , Lesizza , P , Cannatà , A , Miranda-Silva , D , Lourenço , A P , Pinamonti , B , Sinagra , G , Weinberger , F , Eschenhagen , T , Carrier , L , Kehat , I , Tocchetti , C G , Russo , M , Ghigo , A , Cimino , J , Hirsch , E , Dawson , D , Ciccarelli , M , Oliveti , M ....

الاتاحة: https://research.vumc.nl/en/publications/87f0ee27-5505-41fb-b285-0433892257b7
https://doi.org/10.1093/cvr/cvaa110
http://www.scopus.com/inward/record.url?scp=85099721822&partnerID=8YFLogxK

المؤلفون: IRAS OH Toxicology, PERMIT group, Fosse, Vibeke, Oldoni, Emanuela, Bietrix, Florence, Budillon, Alfredo, Daskalopoulos, Evangelos P, Fratelli, Maddalena, Gerlach, Björn, Groenen, Peter M A, Hölter, Sabine M, Menon, Julia M L, Mobasheri, Ali, Osborne, Nikki, Ritskes-Hoitinga, Merel, Ryll, Bettina, Schmitt, Elmar, Ussi, Anton, Andreu, Antonio L, McCormack, Emmet

URL: https://doi.org/10.1186/s12916-022-02719-0
http://hdl.handle.net/1874/426279
https://dspace.library.uu.nl/handle/1874/426279
http://www.scopus.com/inward/record.url?scp=85145972300&partnerID=8YFLogxK
1741-7015
BMC Medicine
21
1
14

المؤلفون: Daskalopoulos, Evangelos P., Hermans, Kevin C. M., Debets, Jacques, Strzelecka, Agnieszka, Leenders, Peter, Vervoort-Peters, Lily, Janssen, Ben J. A., Blankesteijn, W. Matthijs

المصدر: Daskalopoulos , E P , Hermans , K C M , Debets , J , Strzelecka , A , Leenders , P , Vervoort-Peters , L , Janssen , B J A & Blankesteijn , W M 2019 , ' The Beneficial Effects of UM206 on Wound Healing After Myocardial Infarction in Mice Are Lost in Follow-Up Experiments ' , Frontiers in cardiovascular medicine , vol. 6 , 118 . https://doi.org/10.3389/fcvm.2019.00118

مصطلحات موضوعية: myocardial infarction, cardiac remodeling, heart failure, Wnt/frizzled signaling, receptor blockade, peptide fragment

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/3098d7e0-646d-49bc-9813-8c651efcedfe
https://doi.org/10.3389/fcvm.2019.00118

المؤلفون: Pistollato, Francesca, Campia, Ivana, Daskalopoulos, Evangelos P., Bernasconi, Camilla, Desaintes, Christian, Di Virgilio, Sergio, Kyriakopoulou, Christina, Whelan, Maurice, Deceuninck, Pierre

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af59612726967bd23cb4f7d9e768c0f

المؤلفون: Pistollato, Francesca, Campia, Ivana, Daskalopoulos, Evangelos P., Bernasconi, Camilla, Desaintes, Christian, Di Virgilio, Sergio, Kyriakopoulou, Christina, Whelan, Maurice, Deceuninck, Pierre

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18d84002d9be6407b1ef3c526c9bc4c

المؤلفون: Clerbaux, Laure-Alix, Albertini, Maria Cristina, Amigó, Núria, Beronius, Anna, Bezemer, Gillina F G, Coecke, Sandra, Daskalopoulos, Evangelos P, Del Giudice, Giusy, Greco, Dario, Grenga, Lucia, Mantovani, Alberto, Muñoz, Amalia, Omeragic, Elma, Parissis, Nikolaos, Petrillo, Mauro, Saarimäki, Laura A, Soares, Helena, Sullivan, Kristie, Landesmann, Brigitte

المساهمون: Clerbaux, Laure-Alix, Albertini, Maria Cristina, Amigó, Núria, Beronius, Anna, Bezemer, Gillina F G, Coecke, Sandra, Daskalopoulos, Evangelos P, Del Giudice, Giusy, Greco, Dario, Grenga, Lucia, Mantovani, Alberto, Muñoz, Amalia, Omeragic, Elma, Parissis, Nikolao, Petrillo, Mauro, Saarimäki, Laura A, Soares, Helena, Sullivan, Kristie, Landesmann, Brigitte

مصطلحات موضوعية: COVID-19, SARS-CoV-2 infection, adverse outcome pathway, age, co-morbiditie, environment, lifestyle, modulating factor, pre-existing condition, sex

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000838973300001; volume:11; issue:15; firstpage:4464; journal:JOURNAL OF CLINICAL MEDICINE; http://hdl.handle.net/11576/2703950; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85136912033

الاتاحة: http://hdl.handle.net/11576/2703950
https://doi.org/10.3390/jcm11154464

المؤلفون: Daskalopoulos, Evangelos P., Blankesteijn, W. Matthijs

المصدر: Comprehensive Pharmacology ; page 373-402

الاتاحة: http://dx.doi.org/10.1016/b978-0-12-820472-6.00097-9
https://api.elsevier.com/content/article/PII:B9780128204726000979?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:B9780128204726000979?httpAccept=text/plain

المؤلفون: Gélinas, Roselle, Mailleux, Florence, Dontaine, Justine, Bultot, Laurent, Demeulder, Bénédicte, Ginion, Audrey, Daskalopoulos, Evangelos P., Esfahani, Hrag, Dubois-Deruy, Emilie, Lauzier, Benjamin, Gauthier, Chantal, Olson, Aaron K., Bouchard, Bertrand, Des Rosiers, Christine, Viollet, Benoit, Sakamoto, Kei, Balligand, Jean-Luc, Vanoverschelde, Jean-Louis, Beauloye, Christophe, Horman, Sandrine, Bertrand, Luc

المساهمون: Université Catholique de Louvain = Catholic University of Louvain (UCL), Institut de Recherche Expérimentale et Clinique (IREC), ITX - unité de recherche de l'institut du thorax (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Sorbonne Paris Cité (USPC), Advanced Institute of Industrial Technology, Pôle d’Imagerie Médicale, Radiothérapie et Oncologie (MIRO), Pôle de Recherche Cardiovasculaire (CARD), Division of Cardiology, Cliniques Universitaires Saint-Luc Bruxelles, Pole of Cardiovascular Pathology and Cliniques Universitaires Saint-Luc, Division of cardiology

المصدر: ISSN: 2041-1723.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/29371602; PUBMED: 29371602; PUBMEDCENTRAL: PMC5785516

الاتاحة: https://hal.science/hal-01833329
https://hal.science/hal-01833329v1/document
https://hal.science/hal-01833329v1/file/41467_2017_Article_2795.pdf
https://doi.org/10.1038/s41467-017-02795-4

المؤلفون: Foulquier, Sebastien, Daskalopoulos, Evangelos P., Lluri, Gentian, Hermans, Kevin C. M., Deb, Arjun, Blankesteijn, W. Matthijs

المصدر: Foulquier , S , Daskalopoulos , E P , Lluri , G , Hermans , K C M , Deb , A & Blankesteijn , W M 2018 , ' WNT Signaling in Cardiac and Vascular Disease ' , Pharmacological Reviews , vol. 70 , no. 1 , pp. 68-141 . https://doi.org/10.1124/pr.117.013896

مصطلحات موضوعية: MESENCHYMAL STEM-CELLS, PULMONARY ARTERIAL-HYPERTENSION, GLYCOGEN-SYNTHASE KINASE-3, SMALL-MOLECULE INHIBITORS, WNT/BETA-CATENIN PATHWAY, FRIZZLED-RELATED PROTEIN-1, RECEPTOR-RELATED PROTEIN-5, SMOOTH-MUSCLE-CELLS, RIGHT-VENTRICULAR CARDIOMYOPATHY, ENDOTHELIAL GROWTH-FACTOR, Humans, Wnt Signaling Pathway/drug effects, Molecular Targeted Therapy, Animals, Cardiovascular Diseases/drug therapy

وصف الملف: application/pdf

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/77c9a3e2-bc06-47bf-a9cb-479286e9c91f
https://doi.org/10.1124/pr.117.013896
https://cris.maastrichtuniversity.nl/ws/files/93222353/Blankesteijn_2018_WNT_signaling_in_cardiac_and.pdf

المؤلفون: Clerbaux, Laure Alix, Albertini, Maria Cristina, Amigó, Núria, Beronius, Anna, Bezemer, Gillina F.G., Coecke, Sandra, Daskalopoulos, Evangelos P., del Giudice, Giusy, Greco, Dario, Grenga, Lucia, Mantovani, Alberto, Muñoz, Amalia, Omeragic, Elma, Parissis, Nikolaos, Petrillo, Mauro, Saarimäki, Laura A., Soares, Helena, Sullivan, Kristie, Landesmann, Brigitte

المساهمون: Tampere University, BioMediTech

مصطلحات موضوعية: 3111 Biomedicine

وصف الملف: fulltext

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______4853::ca1bf0330a300ff68353a52eb4c40c01
https://trepo.tuni.fi/handle/10024/142308

المؤلفون: Uitterdijk, André, Springeling, Tirza, Hermans, Kevin C.M., Merkus, Daphne, de Beer, Vincent J., Gorsse-Bakker, Charlotte, Mokelke, Eric, Daskalopoulos, Evangelos P., Wielopolski, Piotr A., Cleutjens, Jack P.M., Blankesteijn, W. Matthijs, Prinzen, Frits W., van der Giessen, Willem J., van Geuns, Robert Jan M., Duncker, Dirk J.

المصدر: Uitterdijk , A , Springeling , T , Hermans , K C M , Merkus , D , de Beer , V J , Gorsse-Bakker , C , Mokelke , E , Daskalopoulos , E P , Wielopolski , P A , Cleutjens , J P M , Blankesteijn , W M , Prinzen , F W , van der Giessen , W J , van Geuns , R J M & Duncker , D J 2017 , ' Intermittent pacing therapy favorably modulates infarct remodeling ' , Basic Research in Cardiology , vol. 112 , no. 3 , ....

مصطلحات موضوعية: /dk/atira/pure/keywords/researchprograms/AFL001000/EMCNIHES033002, name=EMC NIHES-03-30-02

وصف الملف: application/pdf

Relation: https://pure.eur.nl/en/publications/5e468b8e-c7b2-48ff-9cac-9a9e93139974

الاتاحة: https://pure.eur.nl/en/publications/5e468b8e-c7b2-48ff-9cac-9a9e93139974
https://doi.org/10.1007/s00395-017-0616-3
https://pure.eur.nl/ws/files/47812175/REPUB_99204.pdf
http://www.scopus.com/inward/record.url?scp=85017094801&partnerID=8YFLogxK
http://hdl.handle.net/1765/99204

المؤلفون: Kontonika, Marianthi, Barka, Eleonora, Roumpi, Maria, La Rocca, Vassilios, Lekkas, Panagiotis, Daskalopoulos, Evangelos P., Vilaeti, Agapi D., Baltogiannis, Giannis G., Vlahos, Antonios P., Agathopoulos, Simeon, Kolettis, Theofilos M.

المصدر: Growth Factors ; volume 35, issue 1, page 1-11 ; ISSN 0897-7194 1029-2292

الاتاحة: http://dx.doi.org/10.1080/08977194.2017.1297432
https://www.tandfonline.com/doi/pdf/10.1080/08977194.2017.1297432