المؤلفون: Graeme W. Carlile, Qi Yang, Elizabeth Matthes, Jie Liao, Véronique Birault, Helen F. Sneddon, Darren L. Poole, Callum J. Hall, John W. Hanrahan, David Y. Thomas

المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/6c974b2051ad451a915f788a93fa1833

المؤلفون: Matthew C. Leech, Dmitrii Nagornîi, Jamie M. Walsh, Cyrille Kiaku, Darren L. Poole, Joseph Mason, Iain C. A. Goodall, Perry Devo, Kevin Lam

المصدر: Organic Letters. 25:1353-1358

مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::92587e0971d53356bdf859f4f6f7765e
https://doi.org/10.1021/acs.orglett.2c04305

المؤلفون: Jonathan A. Andrews (11565978), Loïc R. E. Pantaine (11565981), Christopher F. Palmer (11565984), Darren L. Poole (2453416), Michael C. Willis (1301676)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Plant Biology, Virology, Chemical Sciences not elsewhere classified, thermally induced single, generate sulfonyl radicals, benzylic alkyl radicals, hydrogen atom transfer, readily available amines, 2 , electron transfer, radical approach, free procedure, containing motifs

Relation: https://figshare.com/articles/journal_contribution/Sulfinates_from_Amines_A_Radical_Approach_to_Alkyl_Sulfonyl_Derivatives_via_Donor_Acceptor_Activation_of_Pyridinium_Salts/16814928

الاتاحة: https://doi.org/10.1021/acs.orglett.1c03194.s001

المؤلفون: Sayad Doobary (11688698), Darren L. Poole (2453416), Alastair J. J. Lennox (3330666)

مصطلحات موضوعية: Microbiology, Genetics, Molecular Biology, Pharmacology, Evolutionary Biology, Ecology, Inorganic Chemistry, Infectious Diseases, Plant Biology, Computational Biology, substituted chromane core, potential broader utility, phenolic ethers enabled, hypervalent iodine species, electron poor substrates, allylic phenol ethers, intramolecular alkene fluoroarylation, electrochemically generated iodane, alkene fluoroarylation, redox chemistry, high yields, gram scales, fluorinated chromanes, external oxidant, electrochemical generation

Relation: https://figshare.com/articles/journal_contribution/Intramolecular_Alkene_Fluoroarylation_of_Phenolic_Ethers_Enabled_by_Electrochemically_Generated_Iodane/17000204

الاتاحة: https://doi.org/10.1021/acs.joc.1c01946.s001

المؤلفون: Cyrille Kiaku, Jamie M. Walsh, Matthew C. Leech, Darren L. Poole, Joseph Mason, Iain C. A. Goodall, Perry Devo, Kevin Lam

المصدر: Organic Letters. 25:1147-1150

مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::83a8d2639fba06cd72074997238f7cf3
https://doi.org/10.1021/acs.orglett.3c00128

المؤلفون: Aaron J. Day, Timothy C. Jenkins, Marvin Kischkewitz, Kirsten E. Christensen, Darren L. Poole, Timothy J. Donohoe

المصدر: Organic Letters. 25:614-618

مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b5fba15712276cd32ea5c4065a4e89b5
https://doi.org/10.1021/acs.orglett.2c04149

المؤلفون: Philip G. Humphreys, Niall A. Anderson, Paul Bamborough, Andrew Baxter, Chun-wa Chung, Rosa Cookson, Peter D. Craggs, Toryn Dalton, Julie C. L. Fournier, Laurie J. Gordon, Heather F. Gray, Matthew W. Gray, Richard Gregory, David J. Hirst, Craig Jamieson, Katherine L. Jones, Hripsimee Kessedjian, David Lugo, Grant McGonagle, Vipulkumar K. Patel, Christopher Patten, Darren L. Poole, Rab K. Prinjha, Cesar Ramirez-Molina, Inmaculada Rioja, Gail Seal, Kayleigh A. J. Stafford, Rishi R. Shah, Daniel Tape, Natalie H. Theodoulou, Laura Tomlinson, Sabri Ukuser, Ian D. Wall, Natalie Wellaway, Gemma White

المصدر: Journal of Medicinal Chemistry. 65:15174-15207

مصطلحات موضوعية: Histones, Protein Domains, Lysine, Drug Discovery, Humans, Molecular Medicine, Ligands, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247c403b556d0cdc2a89bb75345904c1
https://doi.org/10.1021/acs.jmedchem.2c01102

المؤلفون: Cyrille Kiaku, Dorian Martinage, Yasemin Sicim, Matthew C. Leech, Jamie M. Walsh, Darren L. Poole, Joseph Mason, Iain C. A. Goodall, Perry Devo, Kevin Lam

المصدر: Organic Letters.

مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e099978007c0b101b9118a9202931a1a
https://doi.org/10.1021/acs.orglett.3c00976

المؤلفون: John R. Box, Mickaël E. Avanthay, Darren L. Poole, Alastair J. J. Lennox

المصدر: Angewandte Chemie. 135

مصطلحات موضوعية: General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bbbea8f4705ed533a5af3fc0d1f25656
https://doi.org/10.1002/ange.202218195

المؤلفون: Alastair J. J. Lennox, Darren L. Poole, Sayad Doobary

المصدر: Lennox, A J J, Doobary, S & Poole, D L 2021, ' Intramolecular Alkene Fluoroarylation of Phenolic Ethers Enabled by Electrochemically Generated Iodane ', Journal of Organic Chemistry, vol. 86, no. 22, pp. 16095-16103 . https://doi.org/10.1021/acs.joc.1c01946

مصطلحات موضوعية: chemistry.chemical_classification, Allylic rearrangement, Chemistry, Alkene, Organic Chemistry, Hypervalent molecule, Alkenes, Combinatorial chemistry, Redox, BCS and TECS CDTs, chemistry.chemical_compound, Phenols, Intramolecular force, Chromane, Phenol, Selectivity, Oxidation-Reduction, Ethers, Iodine

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b777a506629eac4f59537903692c368a
https://doi.org/10.1021/acs.joc.1c01946

المؤلفون: Sylvain Charvet, Nessa Carson, Alfie G. Wills, Darren L. Poole, Claudio Battilocchio, Julien C. Vantourout, Scarborough Christopher Charles, Katherine Wheelhouse

المصدر: Organic Process Research & Development. 25:2587-2600

مصطلحات موضوعية: Computer architecture, Computer science, Organic Chemistry, Perspective (graphical), State (computer science), Physical and Theoretical Chemistry, Throughput (business)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bf5ab973b84664b1bd0417c618904b30
https://doi.org/10.1021/acs.oprd.1c00167

المؤلفون: Kirsten E. Christensen, Darren L. Poole, Maxwell B. Haughey, Timothy J. Donohoe

المصدر: Chemical Science

مصطلحات موضوعية: Chemistry, Alkynylation, Intramolecular force, Heck reaction, Total synthesis, General Chemistry, Ring (chemistry), Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf297ce47c61560406a1d57ec200dc1b
https://doi.org/10.1039/d1sc04247e

المؤلفون: Darren L. Poole, William J. Kerr, Blake J. M. Baker, David M. Lindsay, Vipulkumar Kantibhai Patel

المصدر: Green Chemistry. 23:280-287

مصطلحات موضوعية: Scope (project management), Robustness (computer science), Process (engineering), business.industry, Continuous flow, Scale (chemistry), Scalability, Environmental Chemistry, QD, Pharmacophore, Process engineering, business, Pollution

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c690936156532e05db34bafc455499
https://doi.org/10.1039/d0gc03675g

المؤلفون: Stuart G. Leach, John A. Murphy, Andrew Smith, Daniela Dimitrova, Darren L. Poole, Kenneth F. Clark, Jude N. Arokianathar

المصدر: Chemical Science

مصطلحات موضوعية: Silylation, Chemistry, Hydride, Radical, Reactive intermediate, General Chemistry, Combinatorial chemistry, Electron transfer, chemistry.chemical_compound, Reagent, Molecule, QD, Triethylsilane

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1573694edc1e66888a91e721ec6a430b
http://europepmc.org/articles/PMC8162870

المؤلفون: Yoshiaki Washio, Alan Nadin, Mike Barker, Peter Pogány, Darren V. S. Green, Gemma V. White, Anthony W. J. Cooper, Stephen D. Pickett, Graham George Adam Inglis, Sebastien Andre Campos, Jacob T. Bush, Darren L Poole, John Pritchard, Vipulkumar Kantibhai Patel, Andrew Baxter, David Jonathan Hirst

المصدر: Journal of Medicinal Chemistry. 63:11964-11971

مصطلحات موضوعية: Chemistry, Pharmaceutical, 01 natural sciences, Machine Learning, 03 medical and health sciences, symbols.namesake, Component (UML), Drug Discovery, Humans, Computational design, Selection (genetic algorithm), 030304 developmental biology, 0303 health sciences, Molecular Structure, Chemistry, Chemical space, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Workflow, Computer engineering, Drug Design, Key (cryptography), Turing test, symbols, Molecular Medicine, Algorithms, Generator (mathematics)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaade1fbb3d97867eecd66229c56d4cc
https://doi.org/10.1021/acs.jmedchem.0c01148

المؤلفون: Andrew Smith, Stuart G. Leach, Daniela Dimitrova, John Parkinson, Tell Tuttle, Krystian Kolodziejczak, John A. Murphy, Mark Allison, Darren L. Poole, Jude N. Arokianathar, Allan Young

المصدر: Chemical Science

مصطلحات موضوعية: Indole test, chemistry.chemical_compound, Chemistry, chemistry, Reagent, Potassium, chemistry.chemical_element, QD, General Chemistry, Hydrogen atom, Triethylsilane, Medicinal chemistry

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d57fab8f46eca4407e5018044fa98d6
http://europepmc.org/articles/PMC8152433

المؤلفون: Samuel D. L. Holman, Alfie G. Wills, Neal J. Fazakerley, Darren L. Poole, Diane M. Coe, Leonard A. Berlouis, Marc Reid

مصطلحات موضوعية: Cycloaddition Reaction, Oximes, Organic Chemistry, Electrons, QD, Isoxazoles, General Chemistry, Alkenes, Catalysis

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d328e135ccc61442e672b5d04100855
https://strathprints.strath.ac.uk/79471/7/Holman_etal_Electrochemical_synthesis_of_isoxazolines.pdf

المؤلفون: Graeme W, Carlile, Qi, Yang, Elizabeth, Matthes, Jie, Liao, Véronique, Birault, Helen F, Sneddon, Darren L, Poole, Callum J, Hall, John W, Hanrahan, David Y, Thomas

المصدر: Scientific reports. 12(1)

مصطلحات موضوعية: Arachidonic Acid, Cystic Fibrosis, Cyclooxygenase 2, Anti-Inflammatory Agents, Non-Steroidal, Mutation, Cystic Fibrosis Transmembrane Conductance Regulator, Humans, Glafenine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::070682b4642869394a56f6fafdd2f765
https://pubmed.ncbi.nlm.nih.gov/35302062

المؤلفون: Christopher F Palmer, Darren L. Poole, Jonathan A Andrews, Michael C. Willis, Loïc R E Pantaine

مصطلحات موضوعية: chemistry.chemical_classification, Sulfonyl, Primary (chemistry), 010405 organic chemistry, Radical, Organic Chemistry, Salt (chemistry), Hydrogen atom, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Polymer chemistry, Pyridinium, Physical and Theoretical Chemistry, Donor acceptor, Alkyl

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbce150044290316113c5f1cf18dd84
https://doi.org/10.1021/acs.orglett.1c03194

المؤلفون: Patricia F Medeiros, Mythily Vimal, Vipulkumar Kantibhai Patel, John Evans, Neil R Carlson, Antonia J. Lewis, Paul Bamborough, Katherine L Jones, Jane E Smith, Michael O'Sullivan, Scott McCleary, Darren J. Mitchell, Heather Barnett, Chun-wa Chung, Gang Yao, Anthony W. J. Cooper, Rab K. Prinjha, Laurie Gordon, Mahnoor Mahmood, Peter D. Craggs, Isobel L Harada, Rino A Bit, Natalie Wellaway, Armelle Le Gall, Robert J. Watson, Tony W Dean, Dominique Amans, Ian D. Wall, Kayleigh A J Stafford, Dave Lugo, Matthew J Lindon, Rishi R Shah, David Jonathan Hirst, Chris Patten, Darren L Poole, Jack A Brown, Philip G Humphreys, Robert P Davis, Christopher Roland Wellaway, Pamela J Thomas

المصدر: Journal of Medicinal Chemistry. 63:714-746

مصطلحات موضوعية: Male, Models, Molecular, Benzimidazole, Lysine, Drug Evaluation, Preclinical, Computational biology, Crystallography, X-Ray, Small Molecule Libraries, Mice, chemistry.chemical_compound, In vivo, Histone tails, Drug Discovery, Leukocytes, Animals, Humans, Chemokine CCL2, Therapeutic strategy, Interleukin-6, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Proteins, Drug Synergism, Epigenome, Small molecule, High-Throughput Screening Assays, Bromodomain, Molecular Medicine, Benzimidazoles, Protein Processing, Post-Translational

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb502737af78aed357d47636c87313d
https://doi.org/10.1021/acs.jmedchem.9b01670