المؤلفون: Darlene C Deecher, Chad E Beyer, Grace Johnston, Jenifer Bray, S Shah, M Abou-Gharbia, Terrance H Andree

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jpet.aspetjournals.org/content/jpet/318/2/657.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1088.4590; http://jpet.aspetjournals.org/content/jpet/318/2/657.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1088.4590
http://jpet.aspetjournals.org/content/jpet/318/2/657.full.pdf

المؤلفون: Richard A. Insel, Darlene C. Deecher, Jeffrey Brewer

المصدر: Diabetes

مصطلحات موضوعية: Gerontology, Financing, Government, Glucose control, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Disease, Newly diagnosed, Models, Biological, Prediabetic State, 03 medical and health sciences, Government Agencies, 0302 clinical medicine, Basic research, Diabetes mellitus, Internal Medicine, medicine, Humans, 030304 developmental biology, 0303 health sciences, Type 1 diabetes, business.industry, Research, Foundation (evidence), medicine.disease, Life stage, 3. Good health, Diabetes Mellitus, Type 1, Perspectives in Diabetes, business, Foundations

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee863398cc5223a7c551625426a16f52
https://doi.org/10.2337/db11-1398

المؤلفون: G H Johnston, Eugene John Trybulski, John C. L. Erve, Brian W. Strassle, A. Adedoyin, Jeffrey D. Kennedy, James E. Harrison, Claudine Pulicicchio, Michael J. Piesla, Peimin Lu, Kathryn E. Rogers, Puwen Zhang, Brian J. Platt, Terri Cummons, Garth T. Whiteside, Liza Leventhal, Chad E. Beyer, Zoë A. Hughes, Darlene C. Deecher, L Manzino, Lilly Mark, Jason M. Dwyer

المصدر: British Journal of Pharmacology. 160:1105-1118

مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, business.industry, Dopamine Plasma Membrane Transport Proteins, Chronic pain, medicine.disease, Norepinephrine (medication), Endocrinology, Adrenergic Uptake Inhibitors, Internal medicine, Medicine, Norepinephrine Plasma Membrane Transport Proteins, Serotonin, business, Serotonin Uptake Inhibitors, 5-HT receptor, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c4f60e6b8a1f1b1cc97f891a5bd642c1
https://doi.org/10.1111/j.1476-5381.2010.00690.x

المؤلفون: Grace H. Johnston, Douglas M. Ho, Paige Erin Mahaney, Jennifer Leiter, Scott Cosmi, Darlene C. Deecher, Yingru Zhang, Kevin D. Burroughs, Eugene John Trybulski, Joseph Peter Sabatucci

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2809-2812

مصطلحات موضوعية: Chemistry, Organic Chemistry, Clinical Biochemistry, Ethylamines, Molecular Conformation, Pharmaceutical Science, Thiophenes, Pharmacology, Crystallography, X-Ray, Biochemistry, Piperazines, Selective norepinephrine reuptake inhibitor, Rats, Norepinephrine, Structure-Activity Relationship, Animal model, Norepinephrine reuptake inhibitor, Drug Discovery, Animals, Humans, Molecular Medicine, Neurotransmitter Uptake Inhibitors, Molecular Biology, Norepinephrine reuptake

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25c94a03643e2816c290a738bffcc23
https://doi.org/10.1016/j.bmcl.2010.03.059

المؤلفون: Stephen Todd Cohn, Garth T. Whiteside, Darlene C. Deecher, Grace H. Johnston, Paige Erin Mahaney, Valerie Smith, Scott Cosmi, Puwen Zhang, Elizabeth Koury, Eugene John Trybulski, Kim Callain Younghee, Jenifer A. Bray, Liza Leventhal, An T. Vu, Jeffrey D. Kennedy, James E. Harrison

المصدر: Journal of Medicinal Chemistry. 53:2051-2062

مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Indoles, Magnetic Resonance Spectroscopy, Stereochemistry, Pain, Pharmacology, Propanolamines, Structure-Activity Relationship, chemistry.chemical_compound, Dopamine, Drug Discovery, medicine, Animals, Structure–activity relationship, Neurotransmitter Uptake Inhibitors, Serotonin transporter, Norepinephrine Plasma Membrane Transport Proteins, biology, Transporter, Visceral pain, Rats, Norepinephrine transporter, chemistry, Indoline, biology.protein, Molecular Medicine, Female, Serotonin, medicine.symptom, Body Temperature Regulation, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d38a82f4c68b40baf4a429e77967f7
https://doi.org/10.1021/jm901559e

المؤلفون: Paige Erin Mahaney, Elizabeth Koury, Thomas Kenney, Robert Emmett Mcdevitt, Richard C. Winneker, Gavin David Heffernan, Grace H. Johnston, Darlene C. Deecher, Eugene John Trybulski, Christine Huselton, Peter D. Alfinito, Jenifer A. Bray, Scott Cosmi, Albert J. Robichaud, Eric S. Manas, Yanfang Li, Coghlan Richard Dale

المصدر: Bioorganic & Medicinal Chemistry. 17:7802-7815

مصطلحات موضوعية: Indoles, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Cell Line, Norepinephrine (medication), Norepinephrine, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Neurotransmitter Uptake Inhibitors, Receptor, Serotonin, 5-HT2A, Neurotransmitter, Receptor, Molecular Biology, 5-HT receptor, Virtual screening, Chemistry, fungi, Organic Chemistry, Biological Transport, Serotonin 5-HT2 Receptor Antagonists, Catecholamine, Molecular Medicine, Serotonin Antagonists, Reuptake inhibitor, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438ee4ec8736e798e77eeb3492481070
https://doi.org/10.1016/j.bmc.2009.09.023

المؤلفون: Oliver J. McConnell, Paige Erin Mahaney, Darlene C. Deecher, Douglas M. Ho, Yingru Zhang, Kim Callain Younghee, Eugene John Trybulski, Eric S. Manas

المصدر: Bioorganic & Medicinal Chemistry Letters. 19:5029-5032

مصطلحات موضوعية: Propanols, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, CHO Cells, Crystallography, X-Ray, Biochemistry, Cell Line, Norepinephrine, Structure-Activity Relationship, Cricetulus, Dogs, Norepinephrine reuptake inhibitor, Cricetinae, Drug Discovery, medicine, Animals, Humans, Molecular Biology, Serotonin transporter, Dopamine transporter, Serotonin Plasma Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Adrenergic Uptake Inhibitors, biology, Chemistry, Organic Chemistry, Antidepressive Agents, Recombinant Proteins, Monoamine neurotransmitter, biology.protein, Molecular Medicine, Enantiomer, Monoamine reuptake inhibitor, Reuptake inhibitor, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c823264453717d5e6dbd38420c94af
https://doi.org/10.1016/j.bmcl.2009.07.053

المؤلفون: Casey Cameron Mccomas, Jenifer A. Bray, Cheryl A. Mugford, Puwen Zhang, Terefenko Eugene Anthony, Eugene John Trybulski, An T. Vu, Andrew Fensome, Garth T. Whiteside, Elizabeth Koury, Lilly Mark, Jim Harrison, Darlene C. Deecher, Paige Erin Mahaney, Kim Callain Younghee

المصدر: Journal of Medicinal Chemistry. 52:5703-5711

مصطلحات موضوعية: Male, Analgesic, Administration, Oral, Pharmacology, Substrate Specificity, Propanolamines, Rats, Sprague-Dawley, Norepinephrine, Structure-Activity Relationship, chemistry.chemical_compound, Oral administration, Dopamine, Drug Discovery, medicine, Animals, Humans, Neurotransmitter Uptake Inhibitors, Neurotransmitter, Serotonin Plasma Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Norepinephrine Plasma Membrane Transport Proteins, Behavior, Animal, biology, Chemistry, Atomoxetine, Biological Transport, Rats, Spinal Nerves, Norepinephrine transporter, Hyperalgesia, biology.protein, Molecular Medicine, Benzimidazoles, Female, Serotonin, Reuptake inhibitor, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc387e88a81026305a6f4d591b56022
https://doi.org/10.1021/jm900888c

المؤلفون: Aaron C. Pawlyk, Robert Mastroeni, Peter D. Alfinito, Darlene C. Deecher, Xiaohong Chen

المصدر: European Journal of Pharmacology. 616:334-339

مصطلحات موضوعية: medicine.medical_specialty, Time Factors, Tyrosine 3-Monooxygenase, medicine.drug_class, Dopamine, Microdialysis, Ovariectomy, Hypothalamus, Biology, Rats, Sprague-Dawley, Norepinephrine (medication), Norepinephrine, chemistry.chemical_compound, Catecholamines, Internal medicine, medicine, Animals, Pharmacology, Estradiol, Tyrosine hydroxylase, Darkness, Preoptic Area, Rats, Preoptic area, Endocrinology, chemistry, Estrogen, Catecholamine, Estradiol benzoate, Female, Extracellular Space, hormones, hormone substitutes, and hormone antagonists, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283540be28c567c50830a7de88399197
https://doi.org/10.1016/j.ejphar.2009.06.045

المؤلفون: Darlene C. Deecher, Puwen Zhang, An T. Vu, Jenifer A. Bray, Rebecca Dooley, Stephen Todd Cohn, Igor Goljer, Paige Erin Mahaney, Grace H. Johnston, Jennifer Leiter, Terefenko Eugene Anthony, Eugene John Trybulski, William Jay Moore

المصدر: Bioorganic & Medicinal Chemistry Letters. 19:2464-2467

مصطلحات موضوعية: Chemistry, Pharmaceutical, Serotonin reuptake inhibitor, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Ligands, Biochemistry, Reuptake, Propanolamines, Inhibitory Concentration 50, Norepinephrine, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, Animals, Humans, Neurotransmitter, Molecular Biology, Dopamine transporter, Dopamine Plasma Membrane Transport Proteins, Adrenergic Uptake Inhibitors, biology, Organic Chemistry, Monoamine neurotransmitter, Models, Chemical, chemistry, Norepinephrine transporter, Drug Design, biology.protein, Molecular Medicine, Serotonin, Reuptake inhibitor, Selective Serotonin Reuptake Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7db3ef438ffaa46e586b95753deb71
https://doi.org/10.1016/j.bmcl.2009.03.054

المؤلفون: Casey Cameron Mccomas, Paige E. Mahaney, Darlene C. Deecher, Grace H. Johnston, Terefenko Eugene Anthony, Eugene John Trybulski, Elizabeth Koury, Puwen Zhang, An Vu, Jenifer A. Bray

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:6067-6070

مصطلحات موضوعية: Stereochemistry, Serotonin reuptake inhibitor, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Norepinephrine (medication), Norepinephrine, Norepinephrine reuptake inhibitor, Drug Discovery, medicine, Combinatorial Chemistry Techniques, Humans, Neurotransmitter Uptake Inhibitors, Molecular Biology, Molecular Structure, Bicyclic molecule, Chemistry, Reboxetine, Organic Chemistry, Atomoxetine, Dopamine reuptake inhibitor, Stereoisomerism, Drug Design, Molecular Medicine, Benzimidazoles, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10d315d14d5a7dfa8fd5b0e8d81e04c
https://doi.org/10.1016/j.bmcl.2008.10.026

المؤلفون: Aaron C. Pawlyk, Darlene C. Deecher, Peter D. Alfinito

المصدر: European Journal of Pharmacology. 591:315-318

مصطلحات موضوعية: medicine.medical_specialty, Time Factors, medicine.drug_class, Ovariectomy, Polysomnography, Rapid eye movement sleep, Sleep, REM, Electroencephalography, Ethinyl Estradiol, Rats, Sprague-Dawley, Internal medicine, Ethinylestradiol, Animals, Medicine, Circadian rhythm, Theta Rhythm, Wakefulness, Pharmacology, medicine.diagnostic_test, business.industry, musculoskeletal, neural, and ocular physiology, Eye movement, Estrogens, Sleep in non-human animals, Rats, Endocrinology, Estrogen, Ovariectomized rat, Female, Sleep Stages, business, psychological phenomena and processes, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f709654a821a831db5b73ca34203945b
https://doi.org/10.1016/j.ejphar.2008.06.084

المؤلفون: Xiaohong Chen, Darlene C. Deecher, James Atherton, Scott Cosmi, Peter D. Alfinito

المصدر: Endocrinology. 149:5219-5226

مصطلحات موضوعية: Narcotics, medicine.medical_specialty, Narcotic Antagonists, Ovariectomy, Central nervous system, Hypothalamus, Pharmacology, Ethinyl Estradiol, Body weight, Rats, Sprague-Dawley, Endocrinology, Internal medicine, medicine, Animals, Dosing, Fulvestrant, Dose-Response Relationship, Drug, Estradiol, Morphine, Naloxone, Chemistry, Body Weight, Uterus, Estrogen Antagonists, Antiestrogen, Rats, Disease Models, Animal, Dose–response relationship, medicine.anatomical_structure, Blood-Brain Barrier, Hot Flashes, Ovariectomized rat, Female, medicine.symptom, Skin Temperature, Weight gain, hormones, hormone substitutes, and hormone antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2ab817cd7eafb182e4bf14a648aaa9
https://doi.org/10.1210/en.2008-0532

المؤلفون: Jennifer Leiter, An T. Vu, Yingru Zhang, Sharon Rosenzweig-Lipson, Fei Ye, Valerie Smith, Stephen Todd Cohn, Douglas M. Ho, Elizabeth Koury, Justin K. Belardi, Darlene C. Deecher, Cheryl A. Mugford, Grace H. Johnston, Gary Paul Stack, Kevin D. Burroughs, Eugene John Trybulski, Scott Cosmi, Jenifer A. Bray, Joseph Peter Sabatucci, Lori Krim Gavrin, Liza Leventhal, Paige Erin Mahaney, Brian J. Platt, Arthur A. Santilli

المصدر: Journal of Medicinal Chemistry. 51:4038-4049

مصطلحات موضوعية: Male, Models, Molecular, Pain, Venlafaxine, Pharmacology, Cell Line, Norepinephrine (medication), Mice, Norepinephrine, Structure-Activity Relationship, Norepinephrine reuptake inhibitor, Dopamine, Drug Discovery, Ethylamines, medicine, Animals, Humans, Serotonin transporter, Dopamine transporter, Molecular Structure, Symporters, biology, Chemistry, Cyclohexanols, Rats, biology.protein, Molecular Medicine, Female, Serotonin, WY-46824, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1714c4c78e768fe2426cceb434cdd1c4
https://doi.org/10.1021/jm8002262

المؤلفون: Christine Huselton, Darlene C. Deecher, Peter D. Alfinito, Xiaohong Chen

المصدر: Brain Research. 1098:71-78

مصطلحات موضوعية: Serotonin, medicine.medical_specialty, Dopamine, Microdialysis, Ovariectomy, Rats, Sprague-Dawley, Stereotaxic Techniques, Norepinephrine, Norepinephrine reuptake inhibitor, Desvenlafaxine Succinate, Internal medicine, medicine, Animals, Molecular Biology, 5-HT receptor, Brain Chemistry, Adrenergic Uptake Inhibitors, Chemistry, General Neuroscience, Cyclohexanols, Preoptic Area, Rats, Desvenlafaxine, Endocrinology, Stereotaxic technique, Ovariectomized rat, Catecholamine, Female, Neurology (clinical), Reuptake inhibitor, Selective Serotonin Reuptake Inhibitors, Developmental Biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baef4b217a8c98668732b68ad50031e4
https://doi.org/10.1016/j.brainres.2006.04.057

المؤلفون: Elliott J. Mufson, Deborah C. Mash, Scott E. Counts, Sylvia E. Perez, Tamas Bartfai, Jacqueline N. Crawley, Ulrika Kahl, Darlene C. Deecher, Robert Bowser

المصدر: CNS Drug Reviews. 7:445-470

مصطلحات موضوعية: Receptors, Neuropeptide, Genetically modified mouse, Molecular Sequence Data, Neuropeptide, Galanin, Mice, Transgenic, Biology, Ligands, Article, Adenylyl cyclase, Mice, chemistry.chemical_compound, Alzheimer Disease, GTP-Binding Proteins, Animals, Humans, Amino Acid Sequence, Cholinergic neuron, Mice, Knockout, Pharmacology, Basal forebrain, Neuronal Plasticity, Brain, Neuropsychology and Physiological Psychology, Cholinergic Fibers, nervous system, chemistry, Knockout mouse, Cholinergic, Cognition Disorders, Receptors, Galanin, Neuroscience, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32951ba8079aef8dc1e55e5939c5bd61
https://doi.org/10.1111/j.1527-3458.2001.tb00210.x

المؤلفون: Darlene C Deecher

المصدر: Expert Opinion on Investigational Drugs. 14:435-448

مصطلحات موضوعية: Central Nervous System, Physiology, Body Temperature, Neurochemical, Homeostasis, Humans, Medicine, Pharmacology (medical), Estrogen replacement therapy, Ovarian steroid, Antihypertensive Agents, Skin, Pharmacology, Clinical Trials as Topic, Vasomotor, business.industry, Estrogen Replacement Therapy, Treatment options, General Medicine, medicine.disease, Antidepressive Agents, Vasodilation, Vasomotor System, Menopause, Hot Flashes, Anticonvulsants, Female, business, Body Temperature Regulation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c88d197db01f9a1be7133976795eafa
https://doi.org/10.1517/13543784.14.4.435

المؤلفون: Panayiotis E. Stevis, Darlene C. Deecher

المصدر: Analytical Biochemistry. 338:320-325

مصطلحات موضوعية: endocrine system, genetic structures, Drug Evaluation, Preclinical, Biophysics, Biology, Ligands, Binding, Competitive, Biochemistry, Radioligand Assay, Extracellular, Humans, Receptor, Molecular Biology, Glycoproteins, chemistry.chemical_classification, Ligand binding assay, Cell Biology, Ligand (biochemistry), Small molecule, Protein Structure, Tertiary, chemistry, Hormone receptor, Receptors, FSH, Follicle Stimulating Hormone, Human, Peptides, Follicle-stimulating hormone receptor, Glycoprotein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75afcc1688b9ae073629345675831852
https://doi.org/10.1016/j.ab.2004.11.036

المؤلفون: Darlene C. Deecher, Ramesh A. Bhat, Pamela Daoud, Lawrence T. O'Connor

المصدر: Journal of Cellular Biochemistry. 95:302-312

مصطلحات موضوعية: Glutamic Acid, Estrogen receptor, Endogeny, Hippocampal formation, Biology, Pharmacology, Hippocampus, Biochemistry, Neuroprotection, Cell Line, Mice, Radioligand Assay, Neurotrophic factors, Animals, Receptor, Molecular Biology, Estrogen receptor beta, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction, Estrogens, Cell Biology, Immunohistochemistry, Cell biology, Neuroprotective Agents, Receptors, Estrogen, Cell culture, hormones, hormone substitutes, and hormone antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc909988592fbaa89bfe31f2e93da592
https://doi.org/10.1002/jcb.20413

المؤلفون: Scott Cosmi, Kevin D. Burroughs, Grace H. Johnston, Liza Leventhal, Kimberly Jean Sipe, Darlene C. Deecher

المصدر: Brain Research. 1028:191-202

مصطلحات موضوعية: Agonist, medicine.medical_specialty, Time Factors, medicine.drug_class, Ovariectomy, Receptor expression, Amidines, Biology, Endocrine System Diseases, chemistry.chemical_compound, Piperidines, Internal medicine, Reaction Time, medicine, Animals, Telemetry, Drug Interactions, Receptor, Serotonin, 5-HT2A, Xylamidine, Receptor, Molecular Biology, 5-HT receptor, Dose-Response Relationship, Drug, Estradiol, Naloxone, General Neuroscience, Amphetamines, Estrogens, Thermoregulation, Receptor antagonist, Rats, Serotonin Receptor Agonists, Substance Withdrawal Syndrome, Fluorobenzenes, Disease Models, Animal, Endocrinology, chemistry, Ovariectomized rat, Female, Serotonin Antagonists, Neurology (clinical), Skin Temperature, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec881c39258e29c45a2031907fd0ffa5
https://doi.org/10.1016/j.brainres.2004.09.012