المؤلفون: Câmara, Viktor S., Soares, Ana Julia, Biscussi, Brunella, Murray, Ana Paula, Guedes, Isabella A., Dardenne, Laurent E., Ruaro, Thaís C., Zimmer, Aline R., Ceschi, Marco A.

المصدر: Journal of the Brazilian Chemical Society. June 2021 32(6)

مصطلحات موضوعية: cholinesterase inhibitor, butyrylcholinesterase, bis(n)-lophine analogues

وصف الملف: text/html

URL الوصول: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532021000601173

المؤلفون: Lopes, João P. B., Costa, Jessie S. da, Ceschi, Marco A., Gonçalves, Carlos A. S., Konrath, Eduardo L., Karl, Ana L. M., Guedes, Isabella A., Dardenne, Laurent E.

المصدر: Journal of the Brazilian Chemical Society. November 2017 28(11)

مصطلحات موضوعية: bistacrine, chiral, cholinesterases, synthesis, molecular docking

وصف الملف: text/html

URL الوصول: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017001102218

المؤلفون: Ceschi, Marco A., Pilotti, Renan M., Lopes, João P. B., Dapont, Henrique, Rocha, João B. T. da, Afolabi, Blessing A., Guedes, Isabella A., Dardenne, Laurent E.

المصدر: Journal of the Brazilian Chemical Society. May 2020 31(5)

مصطلحات موضوعية: tacrine, cholinesterase inhibitors, AChE, hybrids, squaric acid, molecular docking

وصف الملف: text/html

URL الوصول: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000500857

المؤلفون: Custódio, Fábio L., Barbosa, Hélio J. C., Dardenne, Laurent E.

المصدر: Genetics and Molecular Biology. January 2004 27(4)

مصطلحات موضوعية: HP model, genetic algorithms, protein folding

وصف الملف: text/html

URL الوصول: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000400023

المؤلفون: Dall'Igna Júnior, Alcino, Silva, Renato S., Mundim, Kleber C., Dardenne, Laurent E.

المصدر: Genetics and Molecular Biology. January 2004 27(4)

مصطلحات موضوعية: optimization, generalized simulated annealing

وصف الملف: text/html

URL الوصول: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000400024

المؤلفون: Magalhães, Camila S. de, Barbosa, Hélio J.C., Dardenne, Laurent E.

المصدر: Genetics and Molecular Biology. January 2004 27(4)

مصطلحات موضوعية: ligand-protein docking, flexible docking, genetic algorithms

وصف الملف: text/html

URL الوصول: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000400022

المؤلفون: Angelo, Jaqueline S., Guedes, Isabella A., Barbosa, Helio J. C., Dardenne, Laurent E.

المساهمون: Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

المصدر: Frontiers in Chemistry ; volume 11 ; ISSN 2296-2646

الاتاحة: http://dx.doi.org/10.3389/fchem.2023.1288626
https://www.frontiersin.org/articles/10.3389/fchem.2023.1288626/full

المؤلفون: Guedes, Isabella, A, Barreto, André, M S, Marinho, Diogo, Krempser, Eduardo, Kuenemann, Mélaine, A, Sperandio, Olivier, Dardenne, Laurent, E, Miteva, Maria, A

المساهمون: Laboratorio Nacional de Computação Cientifica Rio de Janeiro (LNCC / MCT), Molécules Thérapeutiques in silico (MTI), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Pasteur Network (Réseau International des Instituts Pasteur), Bioinformatique structurale - Structural Bioinformatics, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Chimie médicinale et recherche translationnelle (ERL Inserm U1268), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Cibles Thérapeutiques et conception de médicaments (CiTCoM - UMR 8038), Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), This research was supported by CNPq, grant numbers 307634/2019-1 and 306894/2019-0, by FAPERJ, grant numbers E-26/010.001229/2015 and E-26/210.935/2019, by PCI-LNCC grant numbers 300463/2019-7 and 312604/2016-5, by the French ANR agency (grant ToxME), by the INSERM institute and by University of Paris., ANR-16-CE18-0025,ToxME,ToxME: une approche in silico intégrative pour comprendre des mécanismes de polymorphisme et des effets secondaires de médicaments liés a des enzymes du métabolisme(2016)

المصدر: ISSN: 2045-2322.

مصطلحات موضوعية: [CHIM.CHEM]Chemical Sciences/Cheminformatics

Relation: info:eu-repo/semantics/altIdentifier/pmid/33542326; PUBMED: 33542326

الاتاحة: https://hal.science/hal-04270789
https://hal.science/hal-04270789v1/document
https://hal.science/hal-04270789v1/file/41598_2021_Article_82410.pdf
https://doi.org/10.1038/s41598-021-82410-1

المؤلفون: Guedes, Isabella A., Costa, Leon S. C., dos Santos, Karina B., Karl, Ana L. M., Rocha, Gregório K., Teixeira, Iury M., Galheigo, Marcelo M., Medeiros, Vivian, Krempser, Eduardo, Custódio, Fábio L., Barbosa, Helio J. C., Nicolás, Marisa F., Dardenne, Laurent E.

المساهمون: PCI-LNCC, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Conselho Nacional de Desenvolvimento Científico e Tecnológico

المصدر: Scientific Reports ; volume 11, issue 1 ; ISSN 2045-2322

الاتاحة: http://dx.doi.org/10.1038/s41598-021-84700-0
https://www.nature.com/articles/s41598-021-84700-0.pdf
https://www.nature.com/articles/s41598-021-84700-0

المؤلفون: Pires, Diego A.T., Guedes, Isabella A., Pereira, Wagner L., Teixeira, Róbson R., Dardenne, Laurent E., Nascimento, Claudia J., Figueroa-Villar, José D.

المساهمون: Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

المصدر: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics ; volume 1869, issue 2, page 140580 ; ISSN 1570-9639

الاتاحة: http://dx.doi.org/10.1016/j.bbapap.2020.140580
https://api.elsevier.com/content/article/PII:S1570963920302272?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1570963920302272?httpAccept=text/plain

المؤلفون: Santos, Karina B., Guedes, Isabella A., Karl, Ana L. M., Dardenne, Laurent E.

المساهمون: Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico, Funda??o Carlos Chagas Filho de Amparo ? Pesquisa do Estado do Rio de Janeiro

المصدر: Journal of Chemical Information and Modeling ; volume 60, issue 2, page 667-683 ; ISSN 1549-9596 1549-960X

الاتاحة: https://doi.org/10.1021/acs.jcim.9b00905
https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.9b00905

المؤلفون: Dias Viegas, Flávia Pereira, de Freitas Silva, Matheus, Divino da Rocha, Miguel, Castelli, Maísa Rosa, Riquiel, Mariana Máximo, Machado, Rafael Pereira, Vaz, Sarah Macedo, Simões de Lima, Laís Medeiros, Mancini, Karla Cristine, Marques de Oliveira, Patrícia Cruz, Morais, Élida Parreira, Gontijo, Vanessa Silva, da Silva, Fernanda Motta R., D'Alincourt da Fonseca Peçanha, Dora, Castro, Newton Gonçalves, Neves, Gilda A., Giusti-Paiva, Alexandre, Vilela, Fabiana Cardoso, Orlandi, Lidiane, Camps, Ihosvany, Veloso, Márcia Paranho, Leomil Coelho, Luis Felipe, Ionta, Marisa, Ferreira-Silva, Guilherme Álvaro, Pereira, Rodrigo Machado, Dardenne, Laurent E., Guedes, Isabella Alvim, de Oliveira Carneiro Junior, Wellerson, Quaglio Bellozi, Paula Maria, Pinheiro de Oliveira, Antônio Carlos, Ferreira, Fábio Furlan, Pruccoli, Letizia, Tarozzi, Andrea, Viegas, Claudio

المساهمون: Dias Viegas, Flávia Pereira, de Freitas Silva, Matheu, Divino da Rocha, Miguel, Castelli, Maísa Rosa, Riquiel, Mariana Máximo, Machado, Rafael Pereira, Vaz, Sarah Macedo, Simões de Lima, Laís Medeiro, Mancini, Karla Cristine, Marques de Oliveira, Patrícia Cruz, Morais, Élida Parreira, Gontijo, Vanessa Silva, da Silva, Fernanda Motta R., D'Alincourt da Fonseca Peçanha, Dora, Castro, Newton Gonçalve, Neves, Gilda A., Giusti-Paiva, Alexandre, Vilela, Fabiana Cardoso, Orlandi, Lidiane, Camps, Ihosvany, Veloso, Márcia Paranho, Leomil Coelho, Luis Felipe, Ionta, Marisa, Ferreira-Silva, Guilherme Álvaro, Pereira, Rodrigo Machado, Dardenne, Laurent E., Guedes, Isabella Alvim, de Oliveira Carneiro Junior, Wellerson, Quaglio Bellozi, Paula Maria, Pinheiro de Oliveira, Antônio Carlo, Ferreira, Fábio Furlan, Pruccoli, Letizia, Tarozzi, Andrea, Viegas, Claudio*

مصطلحات موضوعية: Acetylcholinesterase inhibition, Alzheimer's disease, Amyloid beta oligomer, Anti-inflammatory activity, COX inhibition, Donepezil analog, Multi-target directed ligand, N-benzyl-piperidine derivative, Neuroprotection, Pharmacology, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/29421570; info:eu-repo/semantics/altIdentifier/wos/WOS:000427217100005; volume:147; firstpage:48; lastpage:65; numberofpages:18; journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; http://hdl.handle.net/11585/627678; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85041393008; https://www.sciencedirect.com/science/article/pii/S0223523418300795

الاتاحة: http://hdl.handle.net/11585/627678
https://doi.org/10.1016/j.ejmech.2018.01.066
https://www.sciencedirect.com/science/article/pii/S0223523418300795

المؤلفون: Dias, Kris Simone T., de Paula, Cynthia T., dos Santos, Thiago, Souza, Isis N. O., Boni, Marina S., Guimarães, Marcos J. R., da Silva, Fernanda M. R., Castro, Newton G., Neves, Gilda A., Veloso, Clarice C., Coelho, Márcio M., de Melo, Ivo Souza F., Giusti, Fabiana C. V., Giusti-Paiva, Alexandre, da Silva, Marcelo L., Dardenne, Laurent E., Guedes, Isabella A., Pruccoli, Letizia, Morroni, Fabiana, Tarozzi, Andrea, Viegas, Claudio

المساهمون: Dias, Kris Simone T., de Paula, Cynthia T., dos Santos, Thiago, Souza, Isis N.O., Boni, Marina S., Guimarães, Marcos J.R., da Silva, Fernanda M.R., Castro, Newton G., Neves, Gilda A., Veloso, Clarice C., Coelho, Márcio M., de Melo, Ivo Souza F., Giusti, Fabiana C.V., Giusti-Paiva, Alexandre, da Silva, Marcelo L., Dardenne, Laurent E., Guedes, Isabella A., Pruccoli, Letizia, Morroni, Fabiana, Tarozzi, Andrea, Viegas, Claudio*

مصطلحات موضوعية: Alzheimer's disease, Feruloyl-donepezil hybrid, Multitarget-directed ligand, Acrylate, Alzheimer Disease, Animal, Anti-Inflammatory Agent, Antioxidant, Cell Line, Cells, Cultured, Cholinesterase Inhibitor, Drug Design, Human, Indan, Male, Mice, Molecular Docking Simulation, Molecular Targeted Therapy, Neuron, Neuroprotective Agent, Piperidine, Structure-Activity Relationship, Pharmacology, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/28282613; info:eu-repo/semantics/altIdentifier/wos/WOS:000397180900034; volume:130; firstpage:440; lastpage:457; numberofpages:18; journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; http://hdl.handle.net/11585/623951; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85014525609; https://www.sciencedirect.com/science/article/abs/pii/S0223523417301162

الاتاحة: http://hdl.handle.net/11585/623951
https://doi.org/10.1016/j.ejmech.2017.02.043
https://www.sciencedirect.com/science/article/abs/pii/S0223523417301162

المؤلفون: Guedes, Isabella A., Pereira, Felipe S. S., Dardenne, Laurent E.

المساهمون: Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

المصدر: Frontiers in Pharmacology ; volume 9 ; ISSN 1663-9812

الاتاحة: http://dx.doi.org/10.3389/fphar.2018.01089
https://www.frontiersin.org/article/10.3389/fphar.2018.01089/full

المؤلفون: Macedo Vaz, Sarah, de Freitas Silva, Matheus, dos Reis Rosa Franco, Graziella, Jorge R. Guimarães, Marcos, Motta R. da Silva, Fernanda, Gonçalves Castro, Newton, Alvim Guedes, Isabella, Dardenne, Laurent E., Amaral Alves, Marina, Garrett da Costa, Rafael, Beserra Pinheiro, Gabriela, Germino Veras, Letícia, Renata Mortari, Márcia, Pruccoli, Letizia, Tarozzi, Andrea, Viegas, Cláudio

المصدر: Bioorganic & Medicinal Chemistry ; volume 71, page 116952 ; ISSN 0968-0896

الاتاحة: http://dx.doi.org/10.1016/j.bmc.2022.116952
https://api.elsevier.com/content/article/PII:S0968089622003455?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0968089622003455?httpAccept=text/plain

المؤلفون: Capriles, Priscila V.S.Z., Guimarães, Ana C.R., Otto, Thomas D., Miranda, Antonio B., Dardenne, Laurent E., Degrave, Wim M.

وصف الملف: text

Relation: http://eprints.gla.ac.uk/148163/1/148163.pdf; Capriles, P. V.S.Z., Guimarães, A. C.R., Otto, T. D. , Miranda, A. B., Dardenne, L. E. and Degrave, W. M. (2010) Structural modelling and comparative analysis of homologous, analogous and specific proteins from Trypanosoma cruzi versus Homo sapiens: putative drug targets for chagas' disease treatment. BMC Genomics , 11, 610. (doi:10.1186/1471-2164-11-610 ) (PMID:21034488) (PMCID:PMC3091751)

الاتاحة: http://eprints.gla.ac.uk/148163/
http://eprints.gla.ac.uk/148163/1/148163.pdf

المؤلفون: Dardenne Laurent E, Miranda Antonio B, Otto Thomas D, Guimarães Ana CR, Capriles Priscila VSZ, Degrave Wim M

المصدر: BMC Genomics, Vol 11, Iss 1, p 610 (2010)

مصطلحات موضوعية: Biotechnology, TP248.13-248.65, Genetics, QH426-470

Relation: http://www.biomedcentral.com/1471-2164/11/610; https://doaj.org/toc/1471-2164; https://doaj.org/article/e422359b012f47b5ad9a35c72be303a3

الاتاحة: https://doi.org/10.1186/1471-2164-11-610
https://doaj.org/article/e422359b012f47b5ad9a35c72be303a3

المؤلفون: Capriles, Priscila VSZ, Guimarães, Ana CR, Otto, Thomas D, Miranda, Antonio B, Dardenne, Laurent E, Degrave, Wim M

Relation: http://www.biomedcentral.com/1471-2164/11/610

الاتاحة: http://www.biomedcentral.com/1471-2164/11/610

المؤلفون: Rocha, Gregorio K., Dos Santos, Karina B., Angelo, Jaqueline S., Custodio, Fabio L., Barbosa, Helio J.C., Dardenne, Laurent E.

المصدر: 2018 IEEE Congress on Evolutionary Computation (CEC) ; page 1-8

الاتاحة: http://dx.doi.org/10.1109/cec.2018.8477890
http://xplorestaging.ieee.org/ielx7/8466244/8477640/08477890.pdf?arnumber=8477890

المؤلفون: Lima, Emerson Correia, Custodio, Fabio Lima, Rocha, Gregorio Kappaun, Dardenne, Laurent E.

المصدر: 2018 International Joint Conference on Neural Networks (IJCNN)

الاتاحة: http://dx.doi.org/10.1109/ijcnn.2018.8489051
http://xplorestaging.ieee.org/ielx7/8465565/8488986/08489051.pdf?arnumber=8489051