المؤلفون: Nishiguchi, Gisele, Mascibroda, Lauren G., Young, Sarah M., Caine, Elizabeth A., Abdelhamed, Sherif, Kooijman, Jeffrey J., Miller, Darcie J., Das, Sourav, McGowan, Kevin, Mayasundari, Anand, Shi, Zhe, Barajas, Juan M., Hiltenbrand, Ryan, Aggarwal, Anup, Chang, Yunchao, Mishra, Vibhor, Narina, Shilpa, Thomas, Melvin, Loughran, Allister J., Kalathur, Ravi, Yu, Kaiwen, Zhou, Suiping, Wang, Xusheng, High, Anthony A., Peng, Junmin, Pruett-Miller, Shondra M., Daniels, Danette L., Urh, Marjeta, Shelat, Anang A., Mullighan, Charles G., Riching, Kristin M., Zaman, Guido J. R., Fischer, Marcus, Klco, Jeffery M., Rankovic, Zoran

المساهمون: Alex’s Lemonade Stand Foundation for Childhood Cancer, U.S. Department of Health & Human Services | NIH | National Cancer Institute

المصدر: Nature Communications ; volume 15, issue 1 ; ISSN 2041-1723

الاتاحة: http://dx.doi.org/10.1038/s41467-024-44698-1
https://www.nature.com/articles/s41467-024-44698-1.pdf
https://www.nature.com/articles/s41467-024-44698-1

المؤلفون: Ciulli, Alessio, O'Connor, Suzanne, Chung, Chun-Wa, Hartung, Ingo V, Testa, Andrea, Daniels, Danette, Heitman, Laura H.

المصدر: Ciulli , A , O'Connor , S , Chung , C-W , Hartung , I V , Testa , A , Daniels , D & Heitman , L H 2023 , ' The 17th EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders ' , ChemMedChem , vol. 18 , no. 20 , e202300464 . https://doi.org/10.1002/cmdc.202300464

مصطلحات موضوعية: PROTACs, drug design, medicinal chemistry, molecular glues, protein degraders, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/3000, name=Pharmacology, Toxicology and Pharmaceutics(all), /dk/atira/pure/subjectarea/asjc/3000/3004, /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry

وصف الملف: application/pdf

الاتاحة: https://discovery.dundee.ac.uk/en/publications/6c6c511b-c33d-4fba-a1fc-2b9b6ab61eb8
https://doi.org/10.1002/cmdc.202300464
https://discovery.dundee.ac.uk/ws/files/112594794/ChemMedChem_-_2023_-_Ciulli_-_The_17th_EFMC_Short_Course_on_Medicinal_Chemistry_on_Small_Molecule_Protein_Degraders.pdf
http://www.scopus.com/inward/record.url?scp=85173756223&partnerID=8YFLogxK

المؤلفون: Ma, Haili, Bizet, Martin, Soares Da Costa, Christelle, Murisier, Frédéric, de Bony, Eric James, Wang, Meng-Ke, Yoshimi, Akihide, Lin, Kuan-Ting, Riching, Kristin M., Wang, Xing, Beckman, John I., Arya, Shailee, Droin, Nathalie, Calonne, Emilie, Hassabi, Bouchra, Zhang, Qing-Yang, Li, Ang, Putmans, Pascale, Malbec, Lionel, Hubert, Céline, Lan, Jie, Mies, Frédérique, Bula Ibula Yanga, Yanga, Solary, Eric, Daniels, Danette, Gupta, Yogesh K., Deplus, Rachel, Abdel-Wahab, Omar, Yang, Yun-Gui, Fuks, François

المصدر: Molecular cell, 83 (23

مصطلحات موضوعية: Sciences bio-médicales et agricoles, Humans, Leukemia -- genetics, Myelodysplastic Syndromes -- genetics, Neoplasms -- genetics, RNA, Messenger -- genetics, RNA-Binding Proteins -- genetics, Serine-Arginine Splicing Factors -- genetics, RNA Methylation -- genetics, NSUN2, RNA methylation, RNA modification, RNA splicing, SRSF2, SRSF2(P95H), cancer, epitranscriptomics, leukemia, m(5)C

وصف الملف: 2 full-text file(s): application/pdf | application/pdf

Relation: uri/info:doi/10.1016/j.molcel.2023.11.003; uri/info:pii/S1097-2765(23)00919-X; uri/info:pmid/38065062; uri/info:scp/85178093467; https://dipot.ulb.ac.be/dspace/bitstream/2013/368902/6/Ma2023.pdf; https://dipot.ulb.ac.be/dspace/bitstream/2013/368902/1/elsevier_352546.pdf; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/368902

الاتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/368902
https://dipot.ulb.ac.be/dspace/bitstream/2013/368902/6/Ma2023.pdf
https://dipot.ulb.ac.be/dspace/bitstream/2013/368902/1/elsevier_352546.pdf

المؤلفون: Bhimsaria, Devesh, Rodríguez-Martínez, José A., Mendez-Johnson, Jacqui L., Ghoshdastidar, Debostuti, Varadarajan, Ashwin, Bansal, Manju, Daniels, Danette L., Ramanathan, Parameswaran, Ansari, Aseem Z.

المساهمون: U.S. Department of Health & Human Services | National Institutes of Health, National Science Foundation, American Lebanese Syrian Associated Charities

المصدر: Nature Communications ; volume 14, issue 1 ; ISSN 2041-1723

الاتاحة: http://dx.doi.org/10.1038/s41467-023-39577-0
https://www.nature.com/articles/s41467-023-39577-0.pdf
https://www.nature.com/articles/s41467-023-39577-0

المؤلفون: Ackloo, Suzanne, Antolin, Albert A., Bartolome, Jose Manuel, Beck, Hartmut, Bullock, Alex, Betz, Ulrich A. K., Böttcher, Jark, Brown, Peter J., Chaturvedi, Menorca, Crisp, Alisa, Daniels, Danette, Dreher, Jan, Edfeldt, Kristina, Edwards, Aled M., Egner, Ursula, Elkins, Jon, Fischer, Christian, Glendorf, Tine, Goldberg, Steven, Hartung, Ingo V., Hillisch, Alexander, Homan, Evert, Knapp, Stefan, Köster, Markus, Krämer, Oliver, Llaveria, Josep, Lessel, Uta, Lindemann, Sven, Linderoth, Lars, Matsui, Hisanori, Michel, Maurice, Montel, Florian, Mueller-Fahrnow, Anke, Müller, Susanne, Owen, Dafydd R., Saikatendu, Kumar Singh, Santhakumar, Vijayaratnam, Sanderson, Wendy, Scholten, Cora, Schapira, Matthieu, Sharma, Sujata, Shireman, Brock, Sundström, Michael, Todd, Matthew H., Tredup, Claudia, Venable, Jennifer, Willson, Timothy M., Arrowsmith, Cheryl H.

المساهمون: Eshelman Institute for Innovation, University of North Carolina, Pfizer, Janssen Research and Development, Boehringer Ingelheim, Ontario Genomics Institute, European Federation of Pharmaceutical Industries and Associations, Ontario Institute for Cancer Research, Genentech, Takeda Pharmaceutical Company, Merck KGaA, Kungliga Tekniska Högskolan, Pharmaceuticals Bayer, Canada Foundation for Innovation, Innovative Medicines Initiative, Horizon 2020 Framework Programme, McGill University, Diamond Light Source

المصدر: RSC Medicinal Chemistry ; volume 14, issue 6, page 1002-1011 ; ISSN 2632-8682

الاتاحة: http://dx.doi.org/10.1039/d2md00441k
http://pubs.rsc.org/en/content/articlepdf/2023/MD/D2MD00441K

المؤلفون: Ma, Hai-Li, Bizet, Martin, Soares Da Costa, Christelle, Murisier, Frédéric, de Bony, Eric James, Wang, Meng-Ke, Yoshimi, Akihide, Lin, Kuan-Ting, Riching, Kristin M., Wang, Xing, Beckman, John I., Arya, Shailee, Droin, Nathalie, Calonne, Emilie, Hassabi, Bouchra, Zhang, Qing-Yang, Li, Ang, Putmans, Pascale, Malbec, Lionel, Hubert, Céline, Lan, Jie, Mies, Frédérique, Yang, Ying, Solary, Eric, Daniels, Danette L., Gupta, Yogesh K., Deplus, Rachel, Abdel-Wahab, Omar, Yang, Yun-Gui, Fuks, François

المصدر: Molecular Cell ; volume 83, issue 23, page 4239-4254.e10 ; ISSN 1097-2765

الاتاحة: https://doi.org/10.1016/j.molcel.2023.11.003
https://api.elsevier.com/content/article/PII:S109727652300919X?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S109727652300919X?httpAccept=text/plain

المؤلفون: Taherbhoy, Asad M., Daniels, Danette L.

المساهمون: Foghorn Therapeutics

المصدر: Trends in Pharmacological Sciences ; volume 44, issue 11, page 758-761 ; ISSN 0165-6147

الاتاحة: http://dx.doi.org/10.1016/j.tips.2023.09.001
https://api.elsevier.com/content/article/PII:S0165614723001992?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0165614723001992?httpAccept=text/plain

المؤلفون: Nishiguchi, Gisele, Caine, Elizabeth A., McGowan, Kevin, Shi, Zhe, Aggarwal, Anup, Mayasundari, Anand, Price, Jeanine, Yang, Lei, Li, Yong, Fu, Xiang, Mascibroda, Lauren G., Das, Sourav, Daniels, Danette L., Urh, Marjeta, Klco, Jeffery M., Riching, Kristin M., Rankovic, Zoran

المصدر: ACS Medicinal Chemistry Letters; 10/10/2024, Vol. 15 Issue 10, p1692-1698, 7p

المؤلفون: Riching, Kristin M., Caine, Elizabeth A., Urh, Marjeta, Daniels, Danette L.

المصدر: Chemical Society Reviews ; volume 51, issue 14, page 6210-6221 ; ISSN 0306-0012 1460-4744

الاتاحة: http://dx.doi.org/10.1039/d2cs00339b
http://pubs.rsc.org/en/content/articlepdf/2022/CS/D2CS00339B

المؤلفون: Daniels, Danette L., Winter, Georg E.

المساهمون: Pfizer, Engineering Research Centers

المصدر: Current Research in Chemical Biology ; volume 2, page 100033 ; ISSN 2666-2469

الاتاحة: http://dx.doi.org/10.1016/j.crchbi.2022.100033
https://api.elsevier.com/content/article/PII:S2666246922000155?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2666246922000155?httpAccept=text/plain

المؤلفون: Bai, Nan, Riching, Kristin M., Makaju, Aman, Wu, Hao, Acker, Timothy M., Ou, Shu-Ching, Zhang, Yaru, Shen, Xiaomeng, Bulloch, Daryl N., Rui, Huan, Gibson, Bradford W., Daniels, Danette L., Urh, Marjeta, Rock, Brooke M., Humphreys, Sara C.

المصدر: Journal of Biological Chemistry ; volume 298, issue 4, page 101653 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1016/j.jbc.2022.101653
https://api.elsevier.com/content/article/PII:S002192582200093X?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S002192582200093X?httpAccept=text/plain

المؤلفون: Imaide, Satomi, Riching, Kristin M., Makukhin, Nikolai, Vetma, Vesna, Whitworth, Claire, Hughes, Scott J., Trainor, Nicole, Mahan, Sarah D., Murphy, Nancy, Cowan, Angus, Chan, Kwok-Ho, Craigon, Conner, Test, Andrea, Maniai, Chiara, Urh, Marjeta, Daniels, Danette L., Ciulli, Alessio

المصدر: Imaide , S , Riching , K M , Makukhin , N , Vetma , V , Whitworth , C , Hughes , S J , Trainor , N , Mahan , S D , Murphy , N , Cowan , A , Chan , K-H , Craigon , C , Test , A , Maniai , C , Urh , M , Daniels , D L & Ciulli , A 2021 , ' Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity ' , Nature Chemical Biology , vol. 17 , no. 11 , pp. 1157-1167 . ....

مصطلحات موضوعية: Mechanism of action, Pharmacology, Small molecules, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1307, name=Cell Biology

وصف الملف: application/pdf

الاتاحة: https://discovery.dundee.ac.uk/en/publications/eb42f62e-1310-4179-bb81-4fc4c8f4ceef
https://doi.org/10.1038/s41589-021-00878-4
https://discovery.dundee.ac.uk/ws/files/70260494/Trivalent_manuscript_AIP_NCHEMB_A201112362A_accepted.pdf
http://www.scopus.com/inward/record.url?scp=85117530862&partnerID=8YFLogxK

المؤلفون: Riching, Kristin M., Vasta, James D., Hughes, Scott J., Zoppi, Vittoria, Maniaci, Chiara, Testa, Andrea, Urh, Marjeta, Ciulli, Alessio, Daniels, Danette L.

المصدر: Riching , K M , Vasta , J D , Hughes , S J , Zoppi , V , Maniaci , C , Testa , A , Urh , M , Ciulli , A & Daniels , D L 2021 , ' Translating PROTAC chemical series optimization into functional outcomes underlying BRD7 and BRD9 protein degradation ' , Current Research in Chemical Biology , vol. 1 , 100009 . https://doi.org/10.1016/j.crchbi.2021.100009

مصطلحات موضوعية: PROTACs, medicinal chemistry, degradation, BRD7/9, cellular function

Relation: https://discovery.dundee.ac.uk/en/publications/949904af-617b-401b-ac52-19e325a23f8b

الاتاحة: https://discovery.dundee.ac.uk/en/publications/949904af-617b-401b-ac52-19e325a23f8b
https://doi.org/10.1016/j.crchbi.2021.100009

المؤلفون: Riching, Kristin M., Schwinn, Marie K., Vasta, James D., Robers, Matthew B., Machleidt, Thomas, Urh, Marjeta, Daniels, Danette L.

المصدر: SLAS Discovery ; volume 26, issue 4, page 560-569 ; ISSN 2472-5552

الاتاحة: http://dx.doi.org/10.1177/2472555220973602
http://journals.sagepub.com/doi/pdf/10.1177/2472555220973602
http://journals.sagepub.com/doi/full-xml/10.1177/2472555220973602
https://api.elsevier.com/content/article/PII:S2472555222066965?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2472555222066965?httpAccept=text/plain

المؤلفون: Caine, Elizabeth A., Mahan, Sarah D., Johnson, Rebecca L., Nieman, Amanda N., Lam, Ngan, Warren, Curtis R., Riching, Kristin M., Urh, Marjeta, Daniels, Danette L.

المصدر: Current Protocols in Pharmacology ; volume 91, issue 1 ; ISSN 1934-8282 1934-8290

الاتاحة: http://dx.doi.org/10.1002/cpph.81
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpph.81
https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cpph.81
https://currentprotocols.onlinelibrary.wiley.com/doi/pdf/10.1002/cpph.81

المؤلفون: Cacace, Angela (AUTHOR), Daniels, Danette (AUTHOR), Ferguson, Fleur M. (AUTHOR), Mayor-Ruiz, Cristina (AUTHOR), Woo, Christina (AUTHOR)

المصدر: Cell Chemical Biology. Jun2024, Vol. 31 Issue 6, p1036-1038. 3p.

مصطلحات موضوعية: *CHEMICAL biology, *RESEARCH personnel, *CYTOLOGY

المؤلفون: Zoppi, Vittoria, Hughes, Scott J., Maniaci, Chiara, Testa, Andrea, Gmaschitz, Teresa, Wieshofer, Corinna, Koegl, Manfred, Riching, Kristin M., Daniels, Danette L., Spallarossa, Andrea, Ciulli, Alessio

المصدر: Zoppi , V , Hughes , S J , Maniaci , C , Testa , A , Gmaschitz , T , Wieshofer , C , Koegl , M , Riching , K M , Daniels , D L , Spallarossa , A & Ciulli , A 2019 , ' Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7 ' , Journal of Medicinal Chemistry , vol. 62 , no. 2 , pp. 699-726 . https://doi.org/10.1021/acs.jmedchem.8b01413

مصطلحات موضوعية: PROTACs, protein degradation, E3 ubiquitin ligases, bromodomain, von Hippel-Lindau, BRD7, BRD9

وصف الملف: application/pdf

الاتاحة: https://discovery.dundee.ac.uk/en/publications/6bfbec6b-c787-4494-8c68-d86be56788ba
https://doi.org/10.1021/acs.jmedchem.8b01413
https://discovery.dundee.ac.uk/ws/files/30133158/Final_Published_Version.pdf

المؤلفون: Jung, Su Myung, Hung, Chien-Min, Hildebrand, Samuel R., Sanchez-Gurmaches, Joan, Martinez-Pastor, Barbara, Gengatharan, Jivani M., Wallace, Martina, Mukhopadhyay, Dimpi, Martinez Calejman, Camila, Luciano, Amelia K., Hsiao, Wen-Yu, Tang, Yuefeng, Li, Huawei, Daniels, Danette L., Mostoslavsky, Raul, Metallo, Christian M., Guertin, David A.

المساهمون: NIH, Leukemia and Lymphoma Society, American Diabetes Association, American Heart Association, American Cancer Society

المصدر: Molecular Cell ; volume 75, issue 4, page 807-822.e8 ; ISSN 1097-2765

الاتاحة: http://dx.doi.org/10.1016/j.molcel.2019.07.023
https://api.elsevier.com/content/article/PII:S1097276519305532?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1097276519305532?httpAccept=text/plain

المؤلفون: Daniels, Danette L., Riching, Kristin M., Urh, Marjeta

المصدر: Drug Discovery Today: Technologies ; volume 31, page 61-68 ; ISSN 1740-6749

الاتاحة: http://dx.doi.org/10.1016/j.ddtec.2018.12.001
https://api.elsevier.com/content/article/PII:S1740674918300271?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1740674918300271?httpAccept=text/plain

المؤلفون: Daniels, Danette, Sapkota, Gopal, Jones, Lyn

المصدر: Daniels , D , Sapkota , G & Jones , L 2023 , ' The promise of targeted protein degradation approaches ' , Trends in Pharmacological Sciences , vol. 44 , no. 11 , pp. 746-749 . https://doi.org/10.1016/j.tips.2023.08.015

مصطلحات موضوعية: /dk/atira/pure/subjectarea/asjc/3000/3005, name=Toxicology, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology

الاتاحة: https://discovery.dundee.ac.uk/en/publications/f9630f15-9c13-4aed-b097-146c7d8f64c9
https://doi.org/10.1016/j.tips.2023.08.015
http://www.scopus.com/inward/record.url?scp=85172213062&partnerID=8YFLogxK